Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

REFERENCES

• Ahlgren, U., Jonsson, J., and Edlund, H.. 1996. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409–1416
   PubMed Web of Science ®Google Scholar
• Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K., and Edlund, H.. 1998. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 12:1763–1768
   PubMed Web of Science ®Google Scholar
• Andersen, B., and Rosenfeld, M. G.. 1994. Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis. J. Biol. Chem. 269:29335–29338
   PubMed Web of Science ®Google Scholar
• Bradford, M. M.. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254
   PubMed Web of Science ®Google Scholar
• Chen, R. P., Ingraham, H. A., Treacy, M. N., Albert, V. R., Wilson, L., and Rosenfeld, M. G.. 1990. Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583–586
   PubMed Web of Science ®Google Scholar
• Clark, K. L., Halay, E. D., Lai, E., and Burley, S. K.. 1993. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364:412–420
   PubMed Web of Science ®Google Scholar
• DiMattia, G. E., Rhodes, S. J., Krones, A., Carriere, C., O'Connell, S., Kalla, K., Arias, C., Sawchenko, P., and Rosenfeld, M. G.. 1997. The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev. Biol. 182:180–190
   PubMedGoogle Scholar
• Edlund, H.. 1999. Pancreas: how to get there from the gut? Curr. Opin. Cell Biol. 11:663–668
   PubMedGoogle Scholar
• Edlund, H.. 1998. Transcribing pancreas. Diabetes 47:1817–1823
   PubMedGoogle Scholar
• Ellmeier, W., Sunshine, M. J., Losos, K., and Littman, D. R.. 1998. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 9:485–496
   PubMedGoogle Scholar
• Gerrish, K., Gannon, M., Shih, D., Henderson, E., Stoffel, M., Wright, C. V., and Stein, R.. 2000. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J. Biol. Chem. 275:3485–3492
   PubMedGoogle Scholar
• Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., and Zaret, K. S.. 1996. Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes Dev. 10:1670–1682
   PubMed Web of Science ®Google Scholar
• Guz, Y., Montminy, M. R., Stein, R., Leonard, J., Gamer, L. W., Wright, C. V., and Teitelman, G.. 1995. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11–18
   PubMedGoogle Scholar
• Larsson, L. I., St.-Onge, L., Hougaard, D. M., Sosa-Pineda, B., and Gruss, P.. 1998. Pax 4 and 6 regulate gastrointestinal endocrine cell development. Mech. Dev. 79:153–159
   PubMed Web of Science ®Google Scholar
• Madsen, O. D., Jensen, J., Petersen, H. V., Pedersen, E. E., Oster, A., Andersen, F. G., Jorgensen, M. C., Jensen, P. B., Larsson, L. I., and Serup, P.. 1997. Transcription factors contributing to the pancreatic beta-cell phenotype. Horm. Metab. Res. 29:265–270
   PubMedGoogle Scholar
• Mahlapuu, M., Pelto-Huikko, M., Aitola, M., Enerback, S., and Carlsson, P.. 1998. FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. Dev. Biol. 202:183–195 (Erratum, 207:476, 1999.)
   PubMedGoogle Scholar
• Marshak, S., Totary, H., Cerasi, E., and Melloul, D.. 1996. Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc. Natl. Acad. Sci. USA 93:15057–15062
   PubMedGoogle Scholar
• Maxam, A. M., and Gilbert, W.. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499–560
   PubMedGoogle Scholar
• Melloul, D., Ben-Neriah, Y., and Cerasi, E.. 1993. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc. Natl. Acad. Sci. USA 90:3865–3869
   PubMedGoogle Scholar
• Ohneda, K., Mirmira, R. G., Wang, J., Johnson, J. D., and German, M. S.. 2000. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol. Cell. Biol. 20:900–911
   PubMedGoogle Scholar
• Overdier, D. G., Porcella, A., and Costa, R. H.. 1994. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:2755–2766
   PubMedGoogle Scholar
• Peers, B., Leonard, J., Sharma, S., Teitelman, G., and Montminy, M. R.. 1994. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8:1798–1806
   PubMedGoogle Scholar
• Peers, B., Sharma, S., Johnson, T., Kamps, M., and Monteminy, M.. 1995. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol. Cell. Biol. 15:7091–7097
   PubMed Web of Science ®Google Scholar
• Pierrou, S., Hellqvist, M., Samuelsson, L., Enerback, S., and Carlsson, P.. 1994. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13:5002–5012
   PubMed Web of Science ®Google Scholar
• Sambrook, J., Fritsch, E. F., and Maniatis, T.. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
   Google Scholar
• Sander, M., and German, M. S.. 1989. 1997. The beta cell transcription factors and development of the pancreas. J. Mol. Med. 75:327–340
   Google Scholar
• Sharma, S., Jhala, U. S., Johnson, T., Ferreri, K., Leonard, J., and Montminy, M.. 1997. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol. Cell. Biol. 17:2598–2604
   PubMedGoogle Scholar
• Sharma, S., Leonard, J., Lee, S., Chapman, H. D., Leiter, E. H., and Montminy, M. R.. 1996. Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF. J. Biol. Chem. 271:2294–2299
   PubMedGoogle Scholar
• Shim, E. Y., Woodcock, C., and Zaret, K. S.. 1998. Nucleosome positioning by the winged helix transcription factor HNF3. Genes Dev. 12:5–10
   PubMed Web of Science ®Google Scholar
• Slack, J. M.. 1995. Developmental biology of the pancreas. Development 121:1569–1580
   PubMed Web of Science ®Google Scholar
• Sussel, L., Kalamaras, J., Hartigan-O'Connor, D. J., Meneses, J. J., Pedersen, R. A., Rubenstein, J. L., and German, M. S.. 1998. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125:2213–2221
   PubMed Web of Science ®Google Scholar
• Theill, L. E., and Karin, M.. 1993. Transcriptional control of GH expression and anterior pituitary development. Endocr. Rev. 14:670–689
   PubMed Web of Science ®Google Scholar
• Wu, K. L., Gannon, M., Peshavaria, M., Offield, M. F., Henderson, E., Ray, M., Marks, A., Gamer, L. W., Wright, C. V., and Stein, R.. 1997. Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 17:6002–6013
   PubMedGoogle Scholar
• Zaret, K. S.. 1996. Molecular genetics of early liver development. Annu. Rev. Physiol. 58:231–251
   PubMed Web of Science ®Google Scholar