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DNA Dynamics and Chromosome Structure

Schizosaccharomyces pombe Hsk1p Is a Potential Cds1p Target Required for Genome Integrity

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Pages 7922-7932 | Received 15 May 2000, Accepted 15 Aug 2000, Published online: 28 Mar 2023

REFERENCES

  • Bhaumik, D., and Wang, T. S. F.. 1998. Mutational effect of fission yeast polymerase α on cell cycle events. Mol. Biol. Cell. 9:2107–2123
  • Birkenbihl, R. P., and Subramani, S.. 1995. The rad21 gene product of Schizosaccharomyces pombe is a nuclear, cell cycle-regulated phosphoprotein. J. Biol. Chem. 270:7703–7711
  • Boddy, M. N., and Russell, P.. 1999. DNA replication checkpoint control. Front. Biosci. 4:D841–D848
  • Bodi, Z., Gysler-Junker, A., and Kohli, J.. 1991. A quantitative assay to measure chromosome stability in Schizosaccharomyces pombe. Mol. Gen. Genet. 229:77–80
  • Bousset, K., and Diffley, J. F.. 1998. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev. 12:480–490
  • Brown, G. W., and Kelly, T. J.. 1999. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proc. Natl. Acad. Sci. USA 96:8443–8448
  • Brown, G. W., and Kelly, T. J.. 1998. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. J. Biol. Chem. 273:22083–22090
  • Carr, A. M.. 1997. Control of cell cycle arrest by the Mec1(sc)/Rad3(sp) DNA structure checkpoint pathway. Curr. Opin. Genet. Dev. 7:93–98
  • Davey, S., Han, C. S., Ramer, S. A., Klassen, J. C., Jacobson, A., Eisenberger, A., Hopkins, K. M., Lieberman, H. B., and Freyer, G. A.. 1998. Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene. Mol. Cell. Biol. 18:2721–2728
  • Demeter, J., Morphew, M., and Sazer, S.. 1995. A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast. Proc. Natl. Acad. Sci. USA 92:1436–1440
  • Dohrmann, P. R., Oshiro, G., Tecklenburg, M., and Sclafani, R. A.. 1999. RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae. Genetics 151:965–977
  • Donaldson, A. D., Fangman, W. L., and Brewer, B. J.. 1998. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev. 12:491–501
  • D'Urso, G., Grallert, B., and Nurse, P.. 1995. DNA polymerase α, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci. 108:3109–3118
  • Fenech, M., Carr, A. M., Murray, J., Watts, F. Z., and Lehmann, A. R.. 1991. Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene. Nucleic Acids Res. 19:6737–6741
  • Forsburg, S. L., and Sherman, D. A.. 1997. General purpose tagging vectors for fission yeast. Gene 191:191–195
  • Furnari, B., Blasina, A., Boddy, M. N., McGowan, C. H., and Russell, P.. 1999. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol. Biol. Cell 10:833–845
  • Gould, K. L., Burns, C. G., Feoktistova, A., Hu, C. P., Pasion, S. G., and Forsburg, S. L.. 1998. Fission yeast cdc24+ encodes a novel replication factor required for chromosome integrity. Genetics 149:1221–1233
  • Grallert, B., and Nurse, P.. 1996. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10:2644–2654
  • Hanks, S. K., and Hunter, T.. 1995. Protein kinases. 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9:576–596
  • Hardy, C. F., Dryga, O., Seematter, S., Pahl, P. M., and Sclafani, R. A.. 1997. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Natl. Acad. Sci. USA 94:3151–3155
  • Hua, X. H., and Newport, J.. 1998. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J. Cell Biol. 140:271–281
  • Jallepalli, P. V., Brown, G. W., Muzi-Falconi, M., Tien, D., and Kelly, T. J.. 1997. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 11:2767–2779
  • Johnston, L. H., Masai, H., and Sugino, A.. 1999. First the CDKs, now the DDKs. Trends Cell Biol. 9:249–252
  • Kearsey, S. E., and Labib, K.. 1998. MCM proteins: evolution, properties, and role in DNA replication. Biochim. Biophys. Acta 1398:113–136
  • Keeney, J. B., and Boeke, J. D.. 1994. Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics 136:849–856
  • Kelly, T. J., and Brown G. W.. Replication in eukaryotes. Annu. Rev. Biochem., in press.
  • Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A., and Nurse, P.. 1993. The fission yeast cdc18+ gene product couples S phase to START and mitosis. Cell 74:371–382
  • Kelly, T. J., Nurse, P., and Forsburg, S. L.. 1993. Coupling DNA replication to the cell cycle. Cold Spring Harbor Symp. Quant. Biol. 58:637–644
  • Kim, S., and Weinert, T. A.. 1997. Characterization of the checkpoint gene RAD53/MEC2 in Saccharomyces cerevisiae. Yeast 13:735–745
  • Kitada, K., Johnston, L. H., Sugino, T., and Sugino, A.. 1992. Temperature sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 131:21–29
  • Landis, G., and Tower, J.. 1999. The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle. Development 126:4281–4293
  • Leatherwood, J.. 1998. Emerging mechanisms of eukaryotic DNA replication initiation. Curr. Opin. Cell Biol. 10:742–748
  • Lei, M., Kawasaki, Y., Young, M. R., Kihara, M., Sugino, A., and Tye, B. K.. 1997. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11:3365–3374
  • Liang, D. T., Hodson, J. A., and Forsburg, S. L.. 1999. Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay. J. Cell Sci. 112:559–567
  • Lindsay, H. D., Griffiths, D. J., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N., and Carr, A. M.. 1998. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev. 12:382–395
  • Masai, H., Miyake, T., and Arai, K.-I.. 1995. hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J. 14:3094–3104
  • Masai, H., Sato, N., Takeda, T., and Arai, K.. 1999. CDC7 kinase complex as a molecular switch for DNA replication. Front. Biosci. 4:D834–D840
  • Moreno, S., Klar, A., and Nurse, P.. 1991. Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194:795–823
  • Murakami, H., and Okayama, H.. 1995. A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374:817–819
  • Murray, J. M., Lindsay, H. D., Munday, C. A., and Carr, A. M.. 1997. Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol. Cell. Biol. 17:6868–6875
  • Okishio, N., Adachi, Y., and Yanagida, M.. 1996. Fission yeast nda1 and nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins. J. Cell Sci. 109:319–326
  • Pasion, S. G., and Forsburg, S. L.. 1999. Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly. Mol. Biol. Cell 10:4043–4057
  • Rose, M. D., and Fink, G. R.. 1987. KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast. Cell 48:1047–1060
  • Russell, P.. 1998. Checkpoints on the road to mitosis. Trends Biochem. Sci. 23:399–402
  • Sambrook, J., Fritsch, E. F., and Maniatis, T.. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
  • Santocanale, C., and Diffley, J. F.. 1989. 1998. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395:615–618
  • Sarabia, M.-J. F., McInerny, C., Harris, P., Gordon, C., and Fantes, P.. 1993. The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238:241–251
  • Sclafani, R. A.. 2000. Cdc-7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci. 113:2111–2117
  • Shellman, Y. G., Schauer, I. E., Oshiro, G., Dohrmann, P., and Sclafani, R. A.. 1998. Oligomers of the Cdc7/Dbf4 protein kinase exist in the yeast cell. Mol. Gen. Genet. 259:429–436
  • Sherman, D. A., Pasion, S. G., and Forsburg, S. L.. 1998. Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex. Mol. Biol. Cell 9:1833–1845
  • Shirahige, K., Hori, Y., Shiraishi, K., Yamashita, M., Takahashi, K., Obuse, C., Tsurimoto, T., and Yoshikawa, H.. 1998. Regulation of DNA-replication origins during cell-cycle progression. Nature 395:618–621
  • Sikorski, R. S., and Boeke, J. D.. 1991. In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast. Methods Enzymol. 194:302–318
  • Skibbens, R. V., Corson, L. B., Koshland, D., and Hieter, P.. 1999. Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev. 13:307–319
  • Snaith, H. A., and Forsburg, S. L.. 1999. Re-replication phenomenon in fission yeast requires MCM proteins and other S phase genes. Genetics 152:839–851
  • Stewart, E., Chapman, C. R., Al-Khodairy, F., Carr, A. M., and Enoch, T.. 1997. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16:2682–2692
  • Takeda, T., Ogino, K., Matsui, E., Cho, M. K., Kumagai, H., Miyake, T., Arai, K., and Masai, H.. 1999. A fission yeast gene, him1+/dfp1+, encoding a regulatory subunit for hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol. Cell. Biol. 19:5535–5547
  • Tatebayashi, K., Kato, J., and Ikeda, H.. 1998. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Genetics 148:49–57
  • Toth, A., Ciosk, R., Uhlmann, F., Galova, M., Schleiffer, A., and Nasmyth, K.. 1999. Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev. 13:320–333
  • Walworth, N., Davey, S., and Beach, D.. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368–371
  • Walworth, N. C., and Bernards, R.. 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271:353–356
  • Wang, Z., Castaño, I. B., De Las Peñas, A., Adams, C., and Christman, M. F.. 2000. Pol κ: a DNA polymerase required for sister chromatid cohesion. Science 289:774–779
  • Weinreich, M., and Stillman, B.. 1999. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J. 18:5334–5346

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