c-Myb Binds to a Sequence in the Proximal Region of the RAG-2 Promoter and Is Essential for Promoter Activity in T-Lineage Cells

REFERENCES

• Agrawal, A., Eastman, Q., and Schatz, D. G.. 1998. Transposition mediated by RAG-1 and RAG-2 and its implications for the evolution of the immune system. Nature 394:744–751
   PubMed Web of Science ®Google Scholar
• Akashi, K., Traver, D., Miyamoto, T., and Weissman, I. L.. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193–197
   PubMed Web of Science ®Google Scholar
• Allen, R. D.III, Bender, T. P., and Siu, G.. 1999. c-Myb is essential for early T cell development. Genes Dev. 13:1073–1078
   PubMedGoogle Scholar
• Asahina, M., Ishiguro, N., Wu, D., Goryo, M., Davis, W. C., and Okada, K.. 1996. The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis. J. Vet. Med. Sci. 58:1169–1174
   PubMedGoogle Scholar
• Badiani, P., Corbella, P., Kioussis, D., Marvel, J., and Weston, K.. 1994. Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 8:770–782
   PubMedGoogle Scholar
• Bender, T. P., and Kuehl, W. M.. 1987. Differential expression of the c-myb proto-oncogene marks the pre-B cell/B cell junction in murine B lymphoid tumors. J. Immunol. 139:3822–3827
   PubMedGoogle Scholar
• Bender, T. P., Thompson, C. B., and Kuehl, W. M.. 1987. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 237:1473–1476
   PubMed Web of Science ®Google Scholar
• Biedenkapp, H., Borgmeyer, U., Sippel, A. E., and Klempnauer, K. H.. 1988. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature 335:835–837
   PubMed Web of Science ®Google Scholar
• Boyd, K. E., Wells, J., Gutman, J., Bartley, S. M., and Farnham, P. J.. 1998. c-Myc target gene specificity is determined by a post-DNA binding mechanism. Proc. Natl. Acad. Sci. USA 95:13887–13892
   PubMed Web of Science ®Google Scholar
• Chung, J. H., Whiteley, M., and Felsenfeld, G.. 1993. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74:505–514
   PubMed Web of Science ®Google Scholar
• Ess, K. C., Witte, D. P., Bascomb, C. P., and Aronow, B. J.. 1999. Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation. Oncogene 18:1103–1111
   PubMedGoogle Scholar
• Foos, G., Grimm, S., and Klempnauer, K. H.. 1992. Functional antagonism between members of the myb family: B-myb inhibits v-myb-induced gene activation. EMBO J. 11:4619–4629
   PubMed Web of Science ®Google Scholar
• Fuller, K., and Storb, U.. 1997. Identification and characterization of the murine Rag 1 promoter. Mol. Immunol. 34:939–954
   PubMed Web of Science ®Google Scholar
• Gaffney, P. M., Lund, J., and Miller, J. S.. 1998. FLT-3 ligand and bone marrow stroma-derived factors promote CD3 gamma, CD3 delta, CD3 zeta, and RAG-2 gene expression in primary human CD34+LIN−DR− marrow progenitors. Blood 91:1662–1670
   PubMedGoogle Scholar
• Gay, D., Saunders, T., Camper, S., and Weigert, M.. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999–1008
   PubMed Web of Science ®Google Scholar
• Gellert, M.. 1997. Recent advances in understanding V(D)J recombination. Adv. Immunol. 64:39–64
   PubMed Web of Science ®Google Scholar
• Golay, J., Capucci, A., Arsura, M., Castellano, M., Rizzo, V., and Introna, M.. 1991. Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells. Blood 77:149–158
   PubMed Web of Science ®Google Scholar
• Golay, J., Facchinetti, V., Ying, G., and Introna, M.. 1997. The A-myb transcription factor in neoplastic and normal B cells. Leuk. Lymphoma 26:271–279
   PubMed Web of Science ®Google Scholar
• Grawunder, U., Leu, T. M. J., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F., and Winkler, T. H.. 1995. Down-regulation of RAG-1 and RAG-2 gene expression in pre-B cells after functional immunoglobulin heavy chain rearrangement. Immunity 3:601–608
   PubMedGoogle Scholar
• Han, S., Dillon, S., Zheng, B., Shimoda, M., Schlissel, M., and Kelsoe, G.. 1997. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278:301–305
   PubMed Web of Science ®Google Scholar
• Han, S., Zheng, B., Schatz, D., Spanopoulou, E., and Kelsoe, G.. 1996. Neoteny in lymphocytes: RAG-1 and Rag 2 expression in germinal center B cells. Science 274:2094–2097
   PubMed Web of Science ®Google Scholar
• Hernandez-Munain, C., and Krangel, M. S.. 1995. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. Mol. Cell. Biol. 15:3090–3099 (Erratum, 15:4659.)
   PubMed Web of Science ®Google Scholar
• Hernandez-Munain, C., and Krangel, M. S.. 1994. Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. Mol. Cell. Biol. 14:473–483
   PubMed Web of Science ®Google Scholar
• Hikida, M., Mori, M., Takai, T., Tomochika, K., Hamatani, K., and Ohmori, H.. 1996. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274:2092–2094
   PubMed Web of Science ®Google Scholar
• Hikida, M., and Ohmori, H.. 1998. Rearrangement of λ light chains in mature B cells in vitro and in vivo. Function of reexpressed recombination-activating gene (RAG) products. J. Exp. Med. 187:795–799
   PubMed Web of Science ®Google Scholar
• Hiom, K., Melek, M., and Gellert, M.. 1998. DNA transposition by the RAG-1 and RAG-2 proteins: a possible source of oncogenic translocations. Cell 94:463–470
   PubMedGoogle Scholar
• Howe, K. M., and Watson, R. J.. 1991. Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein. Nucleic Acids Res. 19:3913–3919
   PubMed Web of Science ®Google Scholar
• Hsiang, Y. H., Goldman, J. P., and Raulet, D. H.. 1995. The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. J. Immunol. 154:5195–5204
   PubMed Web of Science ®Google Scholar
• Kamano, H., Burk, B., Noben-Trauth, K., and Klempnauer, K. H.. 1995. Differential splicing of the mouse B-myb gene. Oncogene 11:2575–2582
   PubMedGoogle Scholar
• Kishi, H., Wei, X. C., Jin, Z. X., Fujishiro, Y., Nagata, T., Matsuda, T., and Muraguchi, A.. 2000. Lineage-specific regulation of the murine RAG-2 promoter: GATA-3 in T cells and pax-5 in B cells. Blood 95:3845–3852
   PubMedGoogle Scholar
• Kurioka, H., Kishi, H., Isshiki, H., Tagoh, H., Mori, K., Kitagawa, T., Nagata, T., Dohi, K., and Muragachi, A.. 1996. Isolation and characterization of a TATA-less promoter for the human RAG-1 gene. Mol. Immunol. 33:1059–1066
   PubMed Web of Science ®Google Scholar
• Lauring, J., and Schlissel, M. S.. 1999. Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines. Mol. Cell. Biol. 19:2601–2612
   PubMed Web of Science ®Google Scholar
• Lieber, M. R., Hesse, J. E., Mizuuchi, K., and Gellert, M.. 1987. Developmental stage specificity of the lymphoid V(D)J recombination activity. Genes Dev. 1:751–761
   PubMedGoogle Scholar
• McMahan, C. J., and Fink, P. J.. 1998. RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity 9:637–647
   PubMed Web of Science ®Google Scholar
• Melamed, D., Benschop, R., Cambier, J., and Nemazee, D.. 1998. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92:173–182
   PubMedGoogle Scholar
• Mizuguchi, G., Nakagoshi, H., Nagase, T., Nomura, N., Date, T., Ueno, Y., and Ishii, S.. 1990. DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. J. Biol. Chem. 265:9280–9284
   PubMed Web of Science ®Google Scholar
• Mizushima, S., and Nagata, S.. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18: 5322
   PubMed Web of Science ®Google Scholar
• Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., and Papaioannou, V. E.. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 68:869–877
   PubMed Web of Science ®Google Scholar
• Monroe, R. J., Chen, F., Ferrini, R., Davidson, L., and Alt, F. W.. 1999. RAG-2 is regulated differentially in B and T cells by elements 5′ of the promoter. Proc. Natl. Acad. Sci. USA 96:12713–12718
   PubMedGoogle Scholar
• Mucenski, M. L., McLain, K., Kier, A. B., Swerdlow, S. H., Schreiner, C. M., Miller, T. A., Pietryga, D. W., Scott, W. J., and Potter, S. S.. 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677–689
   PubMed Web of Science ®Google Scholar
• Nakayama, K., Yamamoto, R., Ishii, S., and Nakauchi, H.. 1993. Binding of c-Myb to the core sequence of the CD4 promoter. Int. Immunol. 5:817–824
   PubMedGoogle Scholar
• Ness, S. A.. 1996. The Myb oncoprotein: regulating a regulator. Biochim. Biophys. Acta 1288:F123–F139
   PubMedGoogle Scholar
• Ness, S. A., Kowenz-Leutz, E., Casini, T., Graf, T., and Leutz, A.. 1993. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749–759
   PubMedGoogle Scholar
• Oettinger, M. A., Schatz, D. G., Gorka, C., and Baltimore, D.. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517–1523
   PubMed Web of Science ®Google Scholar
• Oh, I. H., and Reddy, E. P.. 1999. The myb gene family in cell growth, differentiation and apoptosis. Oncogene 18:3017–3033
   PubMed Web of Science ®Google Scholar
• Papavasiliou, F., Casellas, R., Suh, H., Qin, X.-F., Besmer, E., Pelanda, R., Nemazee, D., Rajewsky, K., and Nussenzweig, M.. 1997. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 278:298–301
   PubMed Web of Science ®Google Scholar
• Sala, A., and Watson, R.. 1999. B-Myb protein in cellular proliferation, transcription control, and cancer: latest developments. J. Cell. Physiol. 179:245–250
   PubMedGoogle Scholar
• Saville, M. K., and Watson, R. J.. 1998. B-Myb: a key regulator of the cell cycle. Adv. Cancer. Res. 72:109–140
   PubMed Web of Science ®Google Scholar
• Schatz, D. G., Oettinger, M. A., and Baltimore, D.. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035–1048
   PubMed Web of Science ®Google Scholar
• Schatz, D. G., Oettinger, M. A., and Schlissel, M. S.. 1992. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 10:359–383
   PubMed Web of Science ®Google Scholar
• Shinkai, Y., Rathbun, G., Lam, K., Oltz, E., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M., and Alt, F. W.. 1992. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855–867
   PubMed Web of Science ®Google Scholar
• Sitzmann, J., Noben-Trauth, K., Kamano, H., and Klempnauer, K. H.. 1996. Expression of B-Myb during mouse embryogenesis. Oncogene 12:1889–1894
   PubMed Web of Science ®Google Scholar
• Siu, G., Wurster, A. L., Lipsick, J. S., and Hedrick, S. M.. 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol. Cell. Biol. 12:1592–1604
   PubMedGoogle Scholar
• Spolski, R., Miescher, G., Erard, R., Risser, R., MacDonald, H. R., and Mak, T. W.. 1988. Regulation of expression of T cell gamma chain, L3T4 and Ly-2 messages in Abelson/Moloney virus-transformed T cell lines. Eur. J. Immunol. 18:295–300
   PubMed Web of Science ®Google Scholar
• Taylor, D., Badiani, P., and Weston, K.. 1996. A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev. 10:2732–2744
   PubMed Web of Science ®Google Scholar
• Thompson, C.. 1995. New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3:531–539
   PubMed Web of Science ®Google Scholar
• Tiegs, S., Russell, D., and Nemazee, D.. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009–1020
   PubMed Web of Science ®Google Scholar
• Tonegawa, S.. 1983. Somatic generation of antibody diversity. Nature 302:575–581
   PubMed Web of Science ®Google Scholar
• Toscani, A., Mettus, R. V., Coupland, R., Simpkins, H., Litvin, J., Orth, J., Hatton, K. S., and Reddy, E. P.. 1997. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 386:713–717
   PubMedGoogle Scholar
• Turka, L. A., Schatz, D. G., Oettinger, M. A., Chun, J. J. M., Gorka, C., Lee, K., McCormack, W. T., and Thompson, C. B.. 1991. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 253:778–781
   PubMed Web of Science ®Google Scholar
• Watson, R. J., Robinson, C., and Lam, E. W.. 1993. Transcription regulation by murine B-myb is distinct from that by c-myb. Nucleic Acids Res. 21:267–272
   PubMed Web of Science ®Google Scholar
• Weinmann, A. S., Plevy, S. E., and Smale, S. T.. 1999. Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. Immunity 11:665–675
   PubMed Web of Science ®Google Scholar
• Wilson, A., Held, W., and MacDonald, H. R.. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355–1360
   PubMed Web of Science ®Google Scholar
• Yu, W., Misulovin, Z., Suh, H., Hardy, R. R., Jankovic, M., Yannoutsos, N., and Nussenzweig, M. C.. 1999. Coordinate regulation of RAG-1 and RAG-2 by cell type-specific DNA elements 5′ of RAG-2. Science 285:1080–1084
   PubMedGoogle Scholar
• Zarrin, A., Fong, I., Malkin, L., Marsden, P., and Berinstein, N.. 1997. Cloning and characterization of the human recombination activating gene 1 (RAG-1) and RAG-2 promoter regions. J. Immunol. 159:4382–4394
   PubMedGoogle Scholar