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Mammalian Genetic Models with Minimal or Complex Phenotypes

Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice

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Pages 755-759 | Received 19 Oct 1999, Accepted 27 Oct 1999, Published online: 28 Mar 2023

REFERENCES

  • Adams, J. C., and Watt, F. M.. 1991. Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J. Cell Biol. 115:829–841
  • Bader, B. L., Rayburn, H., Crowley, D., and Hynes, R. O.. 1998. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95:507–519
  • Breuss, J. M., Gillett, N., Lu, L., Sheppard, D., and Pytela, R.. 1993. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J. Histochem. Cytochem. 41:1521–1527
  • Busk, M., Pytela, R., and Sheppard, D.. 1992. Characterization of the integrin αvβ6 as a fibronectin-binding protein. J. Biol. Chem. 267:5790–5796
  • Capecchi, M. R.. 1989. Altering the genome by homologous recombination. Science 244:1288–1292
  • Cavani, A., Zambruno, G., Marconi, A., Manca, V., Marchetti, M., and Giannetti, A.. 1993. Distinctive integrin expression in the newly forming epidermis during wound healing in humans. J. Investig. Dermatol. 101:600–604
  • Clark, R., Ashcroft, G., Spencer, M., Larjava, H., and Ferguson, M.. 1996. Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins. Br. J. Dermatol. 135:46–51
  • Clark, R. A., Folkvord, J. M., and Wertz, R. L.. 1985. Fibronectin, as well as other extracellular matrix proteins, mediate human keratinocyte adherence. J. Investig. Dermatol. 84:378–383
  • Davison, E., Diaz, R. M., Hart, I. R., Santis, G., and Marshall, J. F.. 1997. Integrin α5β1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16. J. Virol. 71:6204–6207
  • Gailit, J., Welch, M. P., and Clark, R. A.. 1994. TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds. J. Investig. Dermatol. 103:221–227
  • Goldman, M., and Wilson, J. M.. 1995. Expression of αvβ5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69:5951–5958
  • Haapasalmi, K., Zhang, K., Tonnesen, M., Olerud, J., Sheppard, D., Salo, T., Kramer, R., Clark, R., Uitto, V., and Larjava, H.. 1996. Keratinocytes in human wounds express alpha v beta 6 integrin. J. Investig. Dermatol. 106:42–48
  • Hodivala-Dilke, K. M., McHugh, K. P., Tsakiris, D. A., Rayburn, H., Crowley, D., Ullman-Culleré, M., Ross, F. P., Coller, B. S., Teitelbaum, S., and Hynes, R. O.. 1999. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Investig. 103:229–238
  • Huang, X., Wu, J., Cass, D., Erle, D., Corry, D., Young, S., Farese, R. J., and Sheppard, D.. 1996. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133:921–928
  • Huang, X., Wu, J., Spong, S., and Sheppard, D.. 1998. The integrin alpha v beta 6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J. Cell Sci. 111:2189–2195
  • Hynes, R. O.. 1987. Integrins: a family of cell surface receptors. Cell 48:549–554
  • Juhasz, I., Murphy, G. F., Yan, H. C., Herlyn, M., and Albelda, S. M.. 1993. Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am. J. Pathol. 143:1458–1469
  • Kim, J. P., Zhang, K., Chen, J. D., Kramer, R. H., and Woodley, D. T.. 1994. Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J. Biol. Chem. 269:26926–26932
  • Klemke, R. L., Yebra, M., Bayna, E. M., and Cheresh, D. A.. 1994. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J. Cell Biol. 127:859–866
  • Larjava, H., Salo, T., Haapasalmi, K., Kramer, R. H., and Heino, J.. 1993. Expression of integrins and basement membrane components by wound keratinocytes. J. Clin. Investig. 92:1425–1435
  • Nishimura, S. L., Sheppard, D., and Pytela, R.. 1994. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J. Biol. Chem. 269:28708–28715
  • Prieto, A. L., Edelman, G. M., and Crossin, K. L.. 1993. Multiple integrins mediate cell attachment to cytotactin/tenascin. Proc. Natl. Acad. Sci. USA 90:10154–10158
  • Ramaswamy, H., and Hemler, M. E.. 1990. Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J. 9:1561–1568
  • Ruoslahti, E., and Pierschbacher, M. D.. 1987. New perspectives in cell adhesion: RGD and integrins. Science 238:491–497
  • Smith, J. W., Vestal, D. J., Irwin, S. V., Burke, T. A., and Cheresh, D. A.. 1990. Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. J. Biol. Chem. 265:11008–11013
  • Weinacker, A., Chen, A., Agrez, M., Cone, R. I., Nishimura, S. L., Wayner, E., Pytela, R., and Sheppard, D.. 1994. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. J. Biol. Chem. 269:6940–6948
  • Wickham, T. J., Filardo, E. J., Cheresh, D. A., and Nemerow, G. R.. 1994. Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J. Cell Biol. 127:257–264
  • Wickham, T. J., Mathias, P., Cheresh, D. A., and Nemerow, G. R.. 1993. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73:309–319
  • Yokosaki, Y., Palmer, E. L., Prieto, A. L., Crossin, K. L., Bourdon, M. A., Pytela, R., and Sheppard, D.. 1994. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J. Biol. Chem. 269:26691–26696
  • Zheng, X., Saunders, T., Camper, S., Samuelson, L., and Ginsburg, D.. 1995. Vitronectin is not essential for normal mammalian development and fertility. Proc. Natl. Acad. Sci. USA 92:12426–12430

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