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Mammalian Genetic Models with Minimal or Complex Phenotypes

Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice

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Pages 797-804 | Received 01 Nov 1999, Accepted 04 Nov 1999, Published online: 28 Mar 2023

REFERENCES

  • Amatruda, T. T.III, Gerard, N. P., Gerard, C., and Simon, M. I.. 1993. Specific interactions of chemoattractant factor receptors with G-proteins. J. Biol. Chem. 268:10139–10144
  • Amatruda, T. T.III, Steele, D. A., Slepak, V. Z., and Simon, M. I.. 1991. Gα16, a G-protein α subunit specifically expressed in hematopoietic cells. Proc. Natl. Acad. Sci. USA 88:5587–5591
  • Arai, H., and Charo, I. F.. 1996. Differential regulation of G-protein-mediated signaling by chemokine receptors. J. Biol. Chem. 271:21814–21819
  • Baltensperger, K., and Porzig, H.. 1997. The P2U purinoceptor obligatorily engages the heterotrimeric G-protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells. J. Biol. Chem. 272:10151–10159
  • Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V.Jr., Broxmeyer, H. E., and Charo, I. F.. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Investig. 100:2552–2561
  • Boulay, F., Mery, L., Tardif, M., Brouchon, L., and Vignais, P.. 1991. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 30:2993–2999
  • Bourne, H. R., Sanders, D. A., and McCormick, F.. 1991. The GTPase superfamily: conserved structure and molecular mechanism. Nature 349:117–127
  • Buhl, A. M., Avdi, N., Worthen, G. S., and Johnson, G. L.. 1994. Mapping of the C5a receptor signal transduction network in human neutrophils. Proc. Natl. Acad. Sci. USA 91:9190–9194
  • Buhl, A. M., Eisfelder, B. J., Worthen, G. S., Johnson, G. L., and Russell, M.. 1993. Selective coupling of the human anaphylatoxin C5a receptor and α16 in human kidney 293 cells. FEBS Lett. 323:132–134
  • Buhl, A. M., Osawa, S., and Johnson, G. L.. 1995. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. J. Biol. Chem. 270:19828–19832
  • Cacalano, G., Lee, J., Kikly, K., Ryan, A. M., Pitts-Meek, S., Hultgren, B., Wood, W. I., and Moore, M. W.. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265:682–684
  • Coward, P., Chan, S. D., Wada, H. G., Humphries, G. M., and Conklin, B. R.. 1999. Chimeric G-proteins allow a high-throughput signaling assay of Gi-coupled receptors. Anal. Biochem. 270:242–248
  • Davignon, I., Barnard, M., Gavrilova, O., Sweet, K., and Wilkie, T. M.. 1996. Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G-protein α subunit genes. Genomics 31:359–366
  • Gaudreau, R., Le Gouill, C., Metaoui, S., Lemire, S., Stankova, J., and Rola-Pleszczynski, M.. 1998. Signalling through the leukotriene B4 receptor involves both αi and α16, but not αq or α11 G-protein subunits. Biochem. J. 335:15–18
  • Ghose, S., Porzig, H., and Baltensperger, K.. 1999. Induction of erythroid differentiation by altered Gα16 activity as detected by a reporter gene assay in MB-02 cells. J. Biol. Chem. 274:12848–12854
  • Grant, K. R., Harnett, W., Milligan, G., and Harnett, M. M.. 1997. Differential G-protein expression during B- and T-cell development. Immunology 90:564–571
  • Harden, T. K., Stephens, L., Hawkins, P. T., and Downes, C. P.. 1987. Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J. Biol. Chem. 262:9057–9061
  • Hopken, U. E., Lu, B., Gerard, N. P., and Gerard, C.. 1997. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J. Exp. Med. 186:749–756
  • Jiang, H., Kuang, Y., Wu, Y., Xie, W., Simon, M. I., and Wu, D.. 1997. Roles of phospholipase C β2 in chemoattractant-elicited responses. Proc. Natl. Acad. Sci. USA 94:7971–7975
  • Jiang, M., Boulay, G., Spicher, K., Peyton, M. J., Brabet, P., Birnbaumer, L., and Rudolph, U.. 1997. Inactivation of the Gαi2 and Gαo genes by homologous recombination. Receptors Channels 5:187–192
  • Kozasa, T., Hepler, J. R., Smrcka, A. V., Simon, M. I., Rhee, S. G., Sternweis, P. C., and Gilman, A. G.. 1993. Purification and characterization of recombinant G16α from Sf9 cells: activation of purified phospholipase C isozymes by G-protein α subunits. Proc. Natl. Acad. Sci. USA 90:9176–9180
  • Kuang, Y., Wu, Y., Jiang, H., and Wu, D.. 1996. Selective G-protein coupling by C-C chemokine receptors. J. Biol. Chem. 271:3975–3978
  • Murphy, P. M.. 1993. Molecular mimicry and the generation of host defense protein diversity. Cell 72:823–826
  • Offermanns, S., Hashimoto, K., Watanabe, M., Sun, W., Kurihara, H., Thompson, R. F., Inoue, Y., Kano, M., and Simon, M. I.. 1997c. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq. Proc. Natl. Acad. Sci. USA 94:14089–14094
  • Offermanns, S., Mancino, V., Revel, J. P., and Simon, M. I.. 1997a. Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency. Science 275:533–536
  • Offermanns, S., and Simon, M. I.. 1995. Gα15 and Gα16 couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 270:15175–15180
  • Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I.. 1997b. Defective platelet activation in Gα(q)-deficient mice. Nature 389:183–186
  • Offermanns, S., Zhao, L. P., Gohla, A., Sarosi, I., Simon, M. I., and Wilkie, T. M.. 1998. Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gαq/Gα11-mutant mice. EMBO J. 17:4304–4312
  • Proost, P., Wuyts, A., and van Damme, J.. 1996. The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 26:211–223
  • Ross, E. M., and Wilkie T. M.. GTPase-activating proteins (GAPs) for heterotrimeric G proteins: regulators of G protein signaling (RGS proteins) and their relatives. Annu. Rev. Biochem., in press.
  • Smrcka, A. V., and Sternweis, P. C.. 1993. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase Cβ by G-protein α and βγ subunits. J. Biol. Chem. 268:9667–9674
  • van Willigen, G., Donath, J., Lapetina, E. G., and Akkerman, J. W.. 1995. Identification of α-subunits of trimeric GTP-binding proteins in human platelets by RT-PCR. Biochem. Biophys. Res. Commun. 214:254–262
  • Wilkie, T. M., Scherle, P. A., Strathmann, M. P., Slepak, V. Z., and Simon, M. I.. 1991. Characterization of G-protein α subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc. Natl. Acad. Sci. USA 88:10049–10053
  • Wu, D., LaRosa, G. J., and Simon, M. I.. 1993. G-protein-coupled signal transduction pathways for interleukin-8. Science 261:101–103
  • Xu, X., Croy, J. T., Zeng, W., Zhao, L. P., Davignon, I., Popov, S., Yu, K., Jiang, H., Offermanns, S., Muallem, S., and Wilkie, T. M.. 1998. Promiscuous coupling of receptors to Gq class α subunits and effector proteins in pancreatic and submandibular gland cells. J. Biol. Chem. 273:27275–27279
  • Xu, X., Zeng, W., Diaz, J., and Muallem, S.. 1996. Spacial compartmentalization of Ca2+ signaling complexes in pancreatic acini. J. Biol. Chem. 271:24684–24690
  • Zhu, X., and Birnbaumer, L.. 1996. G-protein subunits and the stimulation of phospholipase C by Gs- and Gi-coupled receptors: lack of receptor selectivity of Gα(16) and evidence for a synergic interaction between Gβγ and the α subunit of a receptor activated G-protein. Proc. Natl. Acad. Sci. USA 93:2827–2831

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