Regulatory Interactions between the Reg1-Glc7 Protein Phosphatase and the Snf1 Protein Kinase

REFERENCES

• Alms, G. R., Sanz, P., Carlson, M., and Haystead, T. A.. 1999. Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase PII in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. EMBO J. 18:4157–4168
   PubMedGoogle Scholar
• Berben, G., Dumont, J., Gilliquet, V., Bolle, P. A., and Hilger, F.. 1991. The YDp plasmids: a uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae. Yeast 7:475–477
   PubMedGoogle Scholar
• Cannon, J., Pringle, J. R., Fiechter, A., and Khalil, M.. 1994. Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae. Genetics 136:485–503
   PubMedGoogle Scholar
• Carlson, M.. 1999. Glucose repression in yeast. Curr. Opin. Microbiol. 2:202–207
   PubMed Web of Science ®Google Scholar
• Celenza, J. L., and Carlson, M.. 1989. Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol. Cell. Biol. 9:5034–5044
   PubMed Web of Science ®Google Scholar
• Dale, S., Wilson, W., Edelman, A., and Hardie, D. G.. 1995. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I. FEBS Lett. 361:191–195
   PubMed Web of Science ®Google Scholar
• Dombek, K. M., Voronkova, V., Raney, A., and Young, E. T.. 1999. Functional analysis of the yeast Glc7-binding protein Reg1 identifies a PP1-binding motif as essential for repression of ADH2 expression. Mol. Cell. Biol. 19:6029–6040
   PubMedGoogle Scholar
• Egloff, M. P., Johnson, D. F., Moorhead, G., Cohen, P. T. W., Cohen, P., and Barford, D.. 1997. Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J. 16:1876–1887
   PubMed Web of Science ®Google Scholar
• Entian, K.-D.. 1980. Genetic and biochemical evidence for hexokinase PII as a key enzyme involved in carbon catabolite repression in yeast. Mol. Gen. Genet. 178:633–637
   PubMedGoogle Scholar
• Entian, K.-D., and Mecke, D.. 1982. Genetic evidence for a role of hexokinase isozyme PII in carbon catabolite repression in Saccharomyces cerevisiae. J. Biol. Chem. 257:870–874
   PubMed Web of Science ®Google Scholar
• Estruch, F., Treitel, M. A., Yang, X., and Carlson, M.. 1992. N-terminal mutations modulate yeast SNF1 protein kinase function. Genetics 132:639–650
   PubMedGoogle Scholar
• Feng, Z. H., Wilson, S. E., Peng, Z. Y., Schlender, K. K., Reimann, E. M., and Trumbly, R. J.. 1991. The yeast GLC7 gene required for glycogen accumulation encodes a type 1 protein phosphatase. J. Biol. Chem. 266:23796–23801
   PubMed Web of Science ®Google Scholar
• Fields, S., and Song, O.. 1989. A novel genetic system to detect protein-protein interactions. Nature (London) 340:245–246
   PubMed Web of Science ®Google Scholar
• Francisco, L., Wang, W., and Chan, C. S. M.. 1994. Type 1 protein phosphatase acts in opposition to Ipl1 protein kinase in regulating yeast chromosome segregation. Mol. Cell. Biol. 14:4731–4740
   PubMed Web of Science ®Google Scholar
• Frederick, D. L., and Tatchell, K.. 1996. The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol. Cell. Biol. 16:2922–2931
   PubMedGoogle Scholar
• Gancedo, J. M.. 1998. Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev. 62:334–361
   PubMed Web of Science ®Google Scholar
• Golemis, E. A., Serbriiskii, I., Gyuris, J., and Brent, R.. Interaction trap/two-hybrid system to identify interacting proteins. Current protocols in molecular biology Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. 3, 20.1: John Wiley & Sons, New York, N.Y
   Google Scholar
• Hardie, D. G., Carling, D., and Carlson, M.. 1998. 1997. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67:821–855
   PubMed Web of Science ®Google Scholar
• Harlow, E., and Lane, D.. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y
   Google Scholar
• Herrero, P., Martinez-Campa, C., and Moreno, F.. 1998. The hexokinase 2 protein participates in regulatory DNA-protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiae. FEBS Lett. 434:71–76
   PubMed Web of Science ®Google Scholar
• Hisamoto, N., Frederick, D. L., Sugimoto, K., Tatchell, K., and Matsumoto, K.. 1995. The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiae. Mol. Cell. Biol. 15:3767–3776
   PubMedGoogle Scholar
• Hisamoto, N., Sugimoto, K., and Matsumoto, K.. 1994. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M. Mol. Cell. Biol. 14:3158–3165
   PubMedGoogle Scholar
• Huang, D., Chun, K. T., Goebl, M. G., and Roach, P. J.. 1996. Genetic interactions between REG1/HEX2 and GLC7, the gene encoding the protein phosphatase type 1 catalytic subunit in Saccharomyces cerevisiae. Genetics 143:119–127
   PubMedGoogle Scholar
• Jiang, R., and Carlson, M.. 1996. Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev. 10:3105–3115
   PubMed Web of Science ®Google Scholar
• Jiang, R., and Carlson, M.. 1997. The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol. Cell. Biol. 17:2099–2106
   PubMed Web of Science ®Google Scholar
• Johnston, M.. 1999. Feasting, fasting and fermenting. Trends Genet. 15:29–33
   PubMed Web of Science ®Google Scholar
• Kriegel, T. M., Rush, J., Vojtek, A. B., Clifton, D., and Fraenkel, D. G.. 1994. In vivo phosphorylation site of hexokinase 2 in Saccharomyces cerevisiae. Biochemistry 33:148–152
   PubMedGoogle Scholar
• Laemmli, U. K.. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685
   PubMed Web of Science ®Google Scholar
• Legrain, P., Dokhelar, M.-C., and Transy, C.. 1994. Detection of protein-protein interactions using different vectors in the two-hybrid system. Nucleic Acids Res. 22:3241–3242
   PubMedGoogle Scholar
• Ludin, K., Jiang, R., and Carlson, M.. 1998. Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95:6245–6250
   PubMedGoogle Scholar
• Ma, H., Bloom, L. M., Walsh, C. T., and Botstein, D.. 1989. The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:5643–5649
   PubMedGoogle Scholar
• Ma, H., and Botstein, D.. 1986. Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression. Mol. Cell. Biol. 6:4046–4052
   PubMed Web of Science ®Google Scholar
• MacKelvie, S. H., Andrews, P. D., and Stark, M. J. R.. 1995. The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase. Mol. Cell. Biol. 15:3777–3785
   PubMedGoogle Scholar
• Matsumoto, K., Yoshimatsu, T., and Oshima, Y.. 1983. Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. J. Bacteriol. 153:1405–1414
   PubMed Web of Science ®Google Scholar
• Neigeborn, L., and Carlson, M.. 1987. Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutations. Genetics 115:247–253
   PubMedGoogle Scholar
• Niederacher, D., and Entian, K. D.. 1991. Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast. Eur. J. Biochem. 200:311–319
   PubMedGoogle Scholar
• Ozcan, S., Johnston. 1995. Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol. 15:1564–1572
   PubMed Web of Science ®Google Scholar
• Ramaswamy, N. T., Li, L., Khalil, M., and Cannon, J. F.. 1998. Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase. Genetics 149:57–72
   PubMedGoogle Scholar
• Randez-Gil, F., Herrero, P., Sanz, P., Prieto, J. A., and Moreno, F.. 1998. Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae. FEBS Lett. 425:475–478
   PubMed Web of Science ®Google Scholar
• Randez-Gil, F., Sanz, P., Entian, K.-D., and Prieto, J. A.. 1998. Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast. Mol. Cell. Biol. 18:2940–2948
   PubMedGoogle Scholar
• Rose, M. D., Winston, F., and Hieter, P.. 1990. Methods in yeast genetics, a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
   Google Scholar
• Rothstein, R. J.. 1983. One-step gene disruption in yeast. Methods Enzymol. 101C:202–210
   Google Scholar
• Ruden, D. M., Ma, J., Li, Y., Wood, K., and Ptashne, M.. 1991. Generating yeast transcriptional activators containing no yeast protein sequences. Nature (London) 350:250–252
   PubMedGoogle Scholar
• Sikorski, R. S., and Hieter, P.. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27
   PubMed Web of Science ®Google Scholar
• Song, W., and Carlson, M.. 1998. Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1. EMBO J. 17:5757–5765
   PubMed Web of Science ®Google Scholar
• Stark, M. J.. 1996. Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12:1647–1675
   PubMed Web of Science ®Google Scholar
• Treitel, M. A., Kuchin, S., and Carlson, M.. 1998. Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae. Mol. Cell. Biol. 18:6273–6280
   PubMedGoogle Scholar
• Tu, J., and Carlson, M.. 1994. The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae. Mol. Cell. Biol. 14:6789–6796
   PubMedGoogle Scholar
• Tu, J., and Carlson, M.. 1995. REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14:5939–5946
   PubMedGoogle Scholar
• Tu, J., Song, W., and Carlson, M.. 1996. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4199–4206
   PubMedGoogle Scholar
• Tung, K.-S., Norbeck, L. L., Nolan, S. L., Atkinson, N. S., and Hopper, A. K.. 1992. SRN1, a yeast gene involved in RNA processing, is identical to HEX2/REG1, a negative regulator in glucose repression. Mol. Cell. Biol. 12:2673–2680
   PubMedGoogle Scholar
• Vojtek, A. B., and Fraenkel, D. G.. 1990. Phosphorylation of yeast hexokinases. Eur. J. Biochem. 190:371–375
   PubMedGoogle Scholar
• Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A.. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205–214
   PubMed Web of Science ®Google Scholar
• Wek, R. C., Cannon, J. F., Dever, T. E., and Hinnebusch, A. G.. 1992. Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2α kinase GCN2. Mol. Cell. Biol. 12:5700–5710
   PubMedGoogle Scholar
• Wilson, W. A., Hawley, S. A., and Hardie, D. G.. 1996. Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr. Biol. 6:1426–1434
   PubMed Web of Science ®Google Scholar
• Woods, A., Munday, M. R., Scott, J., Yang, X., Carlson, M., and Carling, D.. 1994. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269:19509–19516
   PubMed Web of Science ®Google Scholar
• Zhang, S., Guha, S., and Volkert, F. C.. 1995. The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation and mitotic cell cycle progression. Mol. Cell. Biol. 15:2037–2050
   PubMedGoogle Scholar