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Cell Growth and Development

Sequential Requirements of the N-Terminal Palmitoylation Site and SH2 Domain of Src Family Kinases in the Initiation and Progression of FcɛRI Signaling

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Pages 1759-1771 | Received 07 Jun 1999, Accepted 10 Nov 1999, Published online: 28 Mar 2023

REFERENCES

  • Alexandropoulos, K., Cheng, G., and Baltimore, D.. 1995. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA 92:3110–3114
  • Amoui, M., Draberova, L., Tolar, P., and Draber, P.. 1997. Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fcɛ receptors. Eur. J. Immunol. 27:321–328
  • Aoki, Y., Kim, Y. T., Stillwell, R., Kim, T. J., and Pillai, S.. 1995. The SH2 domains of Src family kinases associate with Syk. J. Biol. Chem. 270:15658–15663
  • Beaven, M. A., and Metzger, H.. 1993. Signal transduction by Fc receptors: the FcɛRI case. Immunol. Today 14:222–226
  • Benhamou, M., Ryba, N. J., Kihara, H., Nishikata, H., and Siraganian, R. P.. 1993. Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor γ chain after receptor aggregation. J. Biol. Chem. 268:23318–23324
  • Benhamou, M., and Siraganian, R. P.. 1992. Protein-tyrosine phosphorylation: an essential component of FcɛRI signaling. Immunol. Today 13:195–197
  • Bijlmakers, M. J., Isobe-Nakamura, M., Ruddock, L. J., and Marsh, M.. 1997. Intrinsic signals in the unique domain target p56lck to the plasma membrane independently of CD4. J. Cell Biol. 137:1029–1040
  • Blank, U., Ra, C., Miller, L., White, K., Metzger, H., and Kinet, J. P.. 1989. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 337:187–189
  • Bolland, S., Pearse, R. N., Kurosaki, T., and Ravetch, J. V.. 1998. SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 8:509–516
  • Caron, L., Abraham, N., Pawson, T., and Veillette, A.. 1992. Structural requirements for enhancement T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Mol. Cell. Biol. 12:2720–2729
  • Chow, L. M., Fournel, M., Davidson, D., and Veillette, A.. 1993. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 365:156–60
  • Cloutier, J. F., Chow, L. M., and Veillette, A.. 1995. Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes. Mol. Cell. Biol. 15:5937–44
  • Cooper, J. A., and Howell, B.. 1993. The when and how of Src regulation. Cell 73:1051–1054
  • Cooper, J. A., and King, C. S.. 1986. Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src. Mol. Cell. Biol. 6:4467–4477
  • Crowley, M. T., Costello, P. S., Fitzer-Attas, C. J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V. L., and DeFranco, A. L.. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 186:1027–1039
  • D'Oro, U., Vacchio, M. S., Weissman, A. M., and Ashwell, J. D.. 1997. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7:619–628
  • Daeron, M.. 1997. Fc receptor biology. Annu. Rev. Immunol. 15:203–234
  • Eiseman, E., and Bolen, J. B.. 1992. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355:78–80
  • Field, K. A., Holowka, D., and Baird, B.. 1997. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J. Biol. Chem. 272:4276–4280
  • Field, K. A., Holowka, D., and Baird, B.. 1995. FcɛRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc. Natl. Acad. Sci. USA 92:9201–9205
  • Field, K. A., Holowka, D., and Baird, B.. 1999. Structural aspects of the association of FcɛRI with detergent-resistant membranes. J. Biol. Chem. 274:1753–1758
  • Fluckiger, A. C., Li, Z., Kato, R. M., Wahl, M. I., Ochs, H. D., Longnecker, R., Kinet, J. P., Witte, O. N., Scharenberg, A. M., and Rawlings, D. J.. 1998. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J. 17:1973–1985
  • Gounni, A. S., Lamkhioued, B., Ochiai, K., Tanaka, Y., Delaporte, E., Capron, A., Kinet, J. P., and Capron, M.. 1994. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367:183–186
  • Hartley, D., and Corvera, S.. 1996. Formation of c-Cbl: phosphatidyl-inositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism. J. Biol. Chem. 271:21939–21943
  • Honda, H., Oda, H., Nakamoto, T., Honda, Z., Sakai, R., Suzuki, T., Saito, T., Nakamura, K., Nakao, K., Ishikawa, T., Katsuki, M., Yazaki, Y., and Hirai, H.. 1998. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat. Genet. 19:361–365
  • Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T. et al. 1991. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349:342–346
  • Honda, Z., Suzuki, T., Hirose, N., Aihara, M., Shimizu, T., Nada, S., Okada, M., Ra, C., Morita, Y., and Ito, K.. 1997. Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling. J. Biol. Chem. 272:25753–25760
  • Imamoto, A., and Soriano, P.. 1993. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 73:1117–1124
  • Iwashima, M., Irving, B. A., van Oers, N. S., Chan, A. C., and Weiss, A.. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136–1139
  • Jouvin, M. H., Numerof, R. P., and Kinet, J. P.. 1995. Signal transduction through the conserved motifs of the high affinity IgE receptor FcɛRI. Semin. Immunol. 7:29–35
  • Kabouridis, P. S., Magee, A. I., and Ley, S. C.. 1997. S-Acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983–4998
  • Kersh, E. N., Shaw, A. S., and Allen, P. M.. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572–575
  • Kersh, G. J., and Allen, P. M.. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495–498
  • Kihara, H., and Siraganian, R. P.. 1994. Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J. Biol. Chem. 269:22427–22432
  • Kinet, J. P.. 1992. The gamma-ζ dimers of Fc receptors as connectors to signal transduction. Curr. Opin. Immunol. 4:43–48
  • Kinet, J. P., Blank, U., Ra, C., White, K., Metzger, H., and Kochan, J.. 1988. Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc. Natl. Acad. Sci. USA 85:6483–6487
  • Kurosaki, T., Takata, M., Yamanashi, Y., Inazu, T., Taniguchi, T., Yamamoto, T., and Yamamura, H.. 1994. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179:1725–1729
  • Lanzavecchia, A., Lezzi, G., and Viola, A.. 1999. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96:1–4
  • Lin, S., Cicala, C., Scharenberg, A. M., and Kinet, J. P.. 1996. The FcɛRI β subunit functions as an amplifier of FcɛRI γ-mediated cell activation signals. Cell 85:985–995
  • Lowell, C. A., and Soriano, P.. 1996. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Gen. Dev. 10:1845–1857
  • Lowell, C. A., Soriano, P., and Varmus, H. E.. 1994. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 8:387–398
  • Marais, R., Wynne, J., and Treisman, R.. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381–393
  • Maurer, D., Fiebiger, E., Reininger, B., Wolff-Winiski, B., Jouvin, M. H., Kilgus, O., Kinet, J. P., and Stingl, G.. 1994. Expression of functional high affinity immunoglobulin E receptors (FcɛRI) on monocytes of atopic individuals. J. Exp. Med. 179:745–750
  • McKeithan, T. W.. 1995. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92:5042–5046
  • Metzger, H.. 1992. The receptor with high affinity for IgE. Immunol. Rev. 125:37–48
  • Miyazaki, J., Takaki, S., Araki, K., Tashiro, F., Tominaga, A., Takatsu, K., and Yamamura, K.. 1989. Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5. Gene 79:269–277
  • Montixi, C., Langlet, C., Bernard, A. M., Thimonier, J., Dubois, C., Wurbel, M. A., Chauvin, J. P., Pierres, M., and He, H. T.. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17:5334–5348
  • Mustelin, T., and Burn, P.. 1993. Regulation of Src family tyrosine kinases in lymphocytes. Trends Biochem. Sci. 18:215–220
  • Nada, S., Okada, M., MacAuley, A., Cooper, J. A., and Nakagawa, H.. 1991. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 351:69–72
  • Nada, S., Yagi, T., Takeda, H., Tokunaga, T., Nakagawa, H., Ikawa, Y., Okada, M., and Aizawa, S.. 1993. Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73:1125–1135
  • Nishizumi, H., and Yamamoto, T.. 1997. Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J. Immunol. 158:2350–2355
  • Niwa, H., Yamamura, K., and Miyazaki, J.. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193–199
  • Okada, M., Nada, S., Yamanashi, Y., Yamamoto, T., and Nakagawa, H.. 1991. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem. 266:24249–24252
  • Paolini, R., Jouvin, M. H., and Kinet, J. P.. 1991. Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement. Nature 353:855–858
  • Pleiman, C. M., Hertz, W. M., and Cambier, J. C.. 1994. Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263:1609–1612
  • Pribluda, V. S., Pribluda, C., and Metzger, H.. 1994. Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc. Natl. Acad. Sci. USA 91:11246–11250
  • Ra, C., Jouvin, M. H., Blank, U., and Kinet, J. P.. 1989. A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit. Nature 341:752–754
  • Ra, C., Jouvin, M. H., and Kinet, J. P.. 1989. Complete structure of the mouse mast cell receptor for IgE (FcɛRI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J. Biol. Chem. 264:15323–15327
  • Ravetch, J. V., and Kinet, J. P.. 1991. Fc receptors. Annu. Rev. Immunol. 9:457–492
  • Resh, M. D.. 1993. Interaction of tyrosine kinase oncoproteins with cellular membranes. Biochim. Biophys. Acta 1155:307–322
  • Resh, M. D.. 1994. Myristylation and palmitylation of Src family members: the fats of the matter. Cell 76:411–413
  • Reth, M.. 1989. Antigen receptor tail clue. Nature 338:383–384
  • Rider, L. G., Hirasawa, N., Santini, F., and Beaven, M. A.. 1996. Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells. J. Immunol. 157:2374–2380
  • Samelson, L. E., Phillips, A. F., Luong, E. T., and Klausner, R. D.. 1990. Association of the Fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:4358–4362
  • Scharenberg, A. M., and Kinet, J. P.. 1994. Initial events in Fc epsilon RI signal transduction. J. Allergy Clin. Immunol. 94:1142–1146
  • Scharenberg, A. M., Lin, S., Cuenod, B., Yamamura, H., and Kinet, J. P.. 1995. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J. 14:3385–3394
  • Shenoy-Scaria, A. M., Gauen, L. K., Kwong, J., Shaw, A. S., and Lublin, D. M.. 1993. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol. Cell. Biol. 13:6385–6392
  • Shiue, L., Green, J., Green, O. M., Karas, J. L., Morgenstern, J. P., Ram, M. K., Taylor, M. K., Zoller, M. J., Zydowsky, L. D., and Bolen, J. B.. 1995. Interaction of p72syk with the γ and β subunits of the high-affinity receptor for immunoglobulin E, FcɛRI. Mol. Cell. Biol. 15:272–281
  • Sicheri, F., Moarefi, I., and Kuriyan, J.. 1997. Crystal structure of the Src family tyrosine kinase Hck. Nature 385:602–609
  • Simons, K., and Ikonen, E.. 1997. Functional rafts in cell membranes. Nature 387:569–572
  • Stephan, V., Benhamou, M., Gutkind, J. S., Robbins, K. C., and Siraganian, R. P.. 1992. Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. J. Biol. Chem. 267:5434–5441
  • Straus, D. B., Chan, A. C., Patai, B., and Weiss, A.. 1996. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:9976–9981
  • Suzuki, T., Shoji, S., Yamamoto, K., Nada, S., Okada, M., Yamamoto, T., and Honda, Z.. 1998. Essential roles of Lyn in fibronectin-mediated filamentous actin assembly and cell motility in mast cells. J. Immunol. 161:3694–701
  • Tamir, I., and Cambier, J. C.. 1998. Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene 17:1353–1364
  • Taniguchi, T., Kobayashi, T., Kondo, J., Takahashi, K., Nakamura, H., Suzuki, J., Nagai, K., Yamada, T., Nakamura, S., and Yamamura, H.. 1991. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J. Biol. Chem. 266:15790–15796
  • Timson Gauen, L. K., Kong, A. N., Samelson, L. E., and Shaw, A. S.. 1992. p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. Mol. Cell. Biol. 12:5438–5446
  • Torigoe, C., Inman, J. K., and Metzger, H.. 1998. An unusual mechanism for ligand antagonism. Science 281:568–572
  • Trotta, R., Kanakaraj, P., and Perussia, B.. 1996. Fc gamma R-dependent mitogen-activated protein kinase activation in leukocytes: a common signal transduction event necessary for expression of TNF-alpha and early activation genes. J. Exp. Med. 184:1027–1035
  • Veillette, A., Bookman, M. A., Horak, E. M., Samelson, L. E., and Bolen, J. B.. 1989. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338:257–259
  • Vonakis, B. M., Chen, H., Haleem-Smith, H., and Metzger, H.. 1997. The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J. Biol. Chem. 272:24072–24080
  • Wang, A. V., Scholl, P. R., and Geha, R. S.. 1994. Physical and functional association of the high affinity immunoglobulin G receptor (FcγRI) with the kinases Hck and Lyn. J. Exp. Med. 180:1165–1170
  • Wang, B., Rieger, A., Kilgus, O., Ochiai, K., Maurer, D., Fodinger, D., Kinet, J. P., and Stingl, G.. 1992. Epidermal Langerhans cells from normal human skin bind monomeric IgE via FcɛRI. J. Exp. Med. 175:1353–1365
  • Wange, R. L., Malek, S. N., Desiderio, S., and Samelson, L. E.. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J. Biol. Chem. 268:19797–19801
  • Weiss, A., and Littman, D. R.. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263–274
  • Wessel, D., and Flugge, U. I.. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138:141–143
  • Xu, W., Harrison, S. C., and Eck, M. J.. 1997. Three-dimensional structure of the tyrosine kinase c-Src. Nature 385:595–602
  • Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T., and Toyoshima, K.. 1991. Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science 251:192–194
  • Yamashita, T., Mao, S. Y., and Metzger, H.. 1994. Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. Proc. Natl. Acad. Sci. USA 91:11251–11255
  • Zhang, J., Berenstein, E. H., Evans, R. L., and Siraganian, R. P.. 1996. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J. Exp. Med. 184:71–79

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