7
Views
21
CrossRef citations to date
0
Altmetric
Cell Growth and Development

v-Jun Overrides the Mitogen Dependence of S-Phase Entry by Deregulating Retinoblastoma Protein Phosphorylation and E2F-Pocket Protein Interactions as a Consequence of Enhanced Cyclin E-cdk2 Catalytic Activity

, , , , , & show all
Pages 2529-2542 | Received 02 Sep 1999, Accepted 21 Dec 1999, Published online: 27 Mar 2023

REFERENCES

  • Amati, B., Alevizopoulos, K., and Vlach, J.. 1998. Myc and the cell cycle. Front. Biosci. 3:D250–D268
  • Bouchard, C., Thieke, K., Maier, A., Saffrich, R., Hanley-Hyde, J., Ansorge, W., Reed, S., Sicinski, P., Bartek, J., and Eilers, M.. 1999. Direct induction of cyclin D2 by myc contributes to cell cycle progression and sequestration of p27. EMBO J. 18:5321–5333
  • Buck, V., Allen, K. E., Sorensen, T., Bybee, A., Hijmans, E. M., Voorhoeve, P. M., Bernards, R., and La Thangue, N. B.. 1995. Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene 11:31–38
  • Clark, W., and Gillespie, D. A.. 1997. Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors. Cell Growth Differ. 8:371–380
  • Coats, S., Flanagan, W. M., Nourse, J., and Roberts, J. M.. 1996. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877–880
  • Dyson, N.. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245–2262
  • Eilers, M., Picard, D., Yamamoto, K. R., and Bishop, J. M.. 1989. Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340:66–68
  • Fu, S., Bottoli, I., Goller, M., and Vogt, P. K.. 1999. Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation. Proc. Natl. Acad. Sci. USA 96:5716–5721
  • Fuerstenberg, S., Beug, H., Introna, M., Khazaie, K., Munoz, A., Ness, S., Nordstrom, K., Sap, J., Stanley, I., Zenke, M. et al. 1990. Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector. J. Virol. 64:5891–5902
  • Gao, M., Morgan, I., and Vogt, P. K.. 1996. Differential and antagonistic effects of v-Jun and c-Jun. Cancer Res. 56:4229–4235
  • Girling, R., Partridge, J. F., Bandara, L. R., Burden, N., Totty, N. F., Hsuan, J. J., and La Thangue, N. B.. 1993. A new component of the transcription factor DRTF1/E2F. Nature 362:83–87
  • Hadman, M., Gabos, L., Loo, M., Sehgal, A., and Bos, T. J.. 1996. Isolation and cloning of JTAP-1: a cathepsin like gene upregulated in response to V-Jun induced cell transformation. Oncogene 12:135–142
  • Hadman, M., Lin, W., Bush, L., and Bos, T. J.. 1998. Apolipoprotein A-1 is a negative target of v-Jun overexpression. Oncogene 16:655–660
  • Hartl, M., and Bister, K.. 1998. Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation. Oncogene 17:2901–2913
  • Helin, K.. 1998. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8:28–35
  • Herber, B., Truss, M., Beato, M., and Muller, R.. 1994. Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:1295–1304
  • Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A.. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993–1006
  • Hussain, S., Kilbey, A., and Gillespie, D. A.. 1998. v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter. Cell Growth Differ. 9:677–686
  • Jansen-Durr, P.. 1996. How viral oncogenes make the cell cycle. Trends Genet. 12:270–275
  • Johnson, D. G., Schwarz, J. K., Cress, W. D., and Nevins, J. R.. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349–352
  • Johnson, R. S., van Lingen, B., Papaioannou, V. E., and Spiegelman, B. M.. 1993. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7:1309–1317
  • Kilbey, A., Black, E. J., Unlu, M., and Gillespie, D. A. F.. 1996. The v-Jun oncoprotein replaces p39 c-Jun as the predominant AP-1 constituent in ASV17-transformed fibroblasts: implications for SAPK/JNK-mediated signal transduction. Oncogene 12:2409–2418
  • Kovary, K., and Bravo, R.. 1991. The Jun and Fos protein families are both required for cell cycle progression in fibroblasts. Mol. Cell. Biol. 11:4466–4472
  • Kruse, U., Iacovoni, J. S., Goller, M. E., and Vogt, P. K.. 1997. Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera. Proc. Natl. Acad. Sci. USA 94:12396–12400
  • Lahti, J. M., Li, H., and Kidd, V. J.. 1997. Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype, which is rescued by overexpression of murine cyclins D1, D2, or D3 but not by a mutant cyclin D1. J. Biol. Chem. 272:10859–10869
  • La Rocca, S. A., Crouch, D. H., and Gillespie, D. A.. 1994. c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation. Oncogene 9:3499–3508
  • Ludlow, J. W., Shon, J., Pipas, J. M., Livingston, D. M., and DeCaprio, J. A.. 1990. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60:387–396
  • Lukas, J., Bartkova, J., Rohde, M., Strauss, M., and Bartek, J.. 1995. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15:2600–2611
  • Lukas, J., Petersen, B. O., Holm, K., Bartek, J., and Helin, K.. 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16:1047–1057
  • Lundberg, A. S., and Weinberg, R. A.. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:753–761
  • Maki, Y., Bos, T. J., Davis, C., Starbuck, M., and Vogt, P. K.. 1987. Avian sarcoma virus 17 carries the jun oncogene. Proc. Natl. Acad. Sci. USA 84:2848–2852
  • May, G. H., Funk, M., Black, E. J., Clark, W., Hussain, S., Woodgett, J. R., and Gillespie, D. A.. 1998. An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo. Curr. Biol. 8:117–120
  • Medema, R. H., Herrera, R. E., Lam, F., and Weinberg, R. A.. 1995. Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA 92:6289–6293
  • Mittnacht, S.. 1998. Control of pRB phosphorylation. Curr. Opin. Genet. Dev. 8:21–27
  • Morgan, D. O.. 1995. Principles of CDK regulation. Nature 374:131–134
  • Morgan, I. M., Asano, M., Havarstein, L. S., Ishikawa, H., Hiiragi, T., Ito, Y., and Vogt, P. K.. 1993. Amino acid substitutions modulate the effect of Jun on transformation, transcriptional activation and DNA replication. Oncogene 8:1135–1140
  • Nead, M. A., Baglia, L. A., Antinore, M. J., Ludlow, J. W., and McCance, D. J.. 1998. Rb binds c-Jun and activates transcription. EMBO J. 17:2342–2352
  • Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B., Serrano, M., Beach, D. H. et al. 1994. Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. USA 91:11045–11049
  • Perez-Roger, I., Kim, S. H., Griffiths, B., Sewing, A., and Land, H.. 1999. Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J. 18:5310–5320
  • Pusch, O., Bernaschek, G., Eilers, M., and Hengstschlager, M.. 1997. Activation of c-Myc uncouples DNA replication from activation of G1-cyclin-dependent kinases. Oncogene 15:649–656
  • Rudolph, B., Saffrich, R., Zwicker, J., Henglein, B., Muller, R., Ansorge, W., and Eilers, M.. 1996. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. EMBO J. 15:3065–3076
  • Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Mohle-Steinlein, U., Tian, J., Karin, M., Angel, P., and Wagner, E. F.. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607–619
  • Sherr, C. J.. 1996. Cancer cell cycles. Science 274:1672–1677
  • Sherr, C. J., and Roberts, J. M.. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512
  • Shimizu, M., Nomura, Y., Suzuki, H., Ichikawa, E., Takeuchi, A., Suzuki, M., Nakamura, T., Nakajima, T., and Oda, K.. 1998. Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. Exp. Cell Res. 239:93–103
  • Smith, E. J., Leone, G., DeGregori, J., Jakoi, L., and Nevins, J. R.. 1996. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol. Cell. Biol. 16:6965–6976
  • Smith, M. J., and Prochownik, E. V.. 1992. Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle. Blood 79:2107–2115
  • Steiner, P., Philipp, A., Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartek, J., and Eilers, M.. 1996. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14:4814–4826
  • Weinberg, R. A.. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330
  • Wisdom, R., Johnson, R. S., and Moore, C.. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18:188–197
  • Zetterberg, A., Larsson, O., and Wiman, K. G.. 1995. What is the restriction point? Curr. Opin. Cell Biol. 7:835–842

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.