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DNA Dynamics and Chromosome Structure

Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres

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Pages 2941-2948 | Received 19 Oct 1999, Accepted 19 Jan 2000, Published online: 27 Mar 2023

REFERENCES

  • Adams, A. K., and Holm, C.. 1996. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4614–4620
  • Ancelin, K., Brun, C., and Gilson, E.. 1998. Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends. Bioessays 20:879–883
  • Blackburn, E. H.. 1991. Structure and function of telomeres. Nature 350:569–573
  • Blasco, M. A., Lee, H. W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., and Greider, C. W.. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25–34
  • Boulton, S. J., and Jackson, S. P.. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639–4648
  • Bourns, B. D., Alexander, M. K., Smith, A. M., and Zakian, V. A.. 1998. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol. Cell. Biol. 18:5600–5608
  • Cohn, M., and Blackburn, E. H.. 1995. Telomerase in yeast. Science 269:396–400
  • Cohn, M., McEachern, M. J., and Blackburn, E. H.. 1998. Telomeric sequence diversity within the genus Saccharomyces. Curr. Genet. 33:83–91
  • Conrad, M. N., Wright, J. H., Wolf, A. J., and Zakian, V. A.. 1990. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63:739–750
  • Fan, X., and Price, C. M.. 1997. Coordinate regulation of G− and C strand length during new telomere synthesis. Mol. Biol. Cell 8:2145–2155
  • Gottschling, D. E., and Zakian, V. A.. 1986. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47:195–205
  • Gravel, S., Larrivee, M., Labrecque, P., and Wellinger, R. J.. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science 280:741–744
  • Greider, C. W.. 1996. Telomere length regulation. Annu. Rev. Biochem. 65:337–365
  • Greider, C. W.. 1998. Telomeres and senescence: the history, the experiment, the future. Curr. Biol. 8:R178–R181
  • Hande, M. P., Samper, E., Lansdorp, P., and Blasco, M. A.. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:589–601
  • Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R.. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51–59
  • Horvath, M. P., Schweiker, V. L., Bevilacqua, J. M., Ruggles, J. A., and Schultz, S. C.. 1998. Crystal structure of the Oxytricha nova telomere end binking protein complexed with single strand DNA. Cell 95:963–974
  • Hughes, T. R., Morris, D. K., Salinger, A., Walcott, N., Nugent, C. I., and Lundblad, V.. 1997. The role of the EST genes in yeast telomere replication. Ciba Found. Symp. 211:41–47
  • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T.. 1999. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321–1325
  • König, P., and Rhodes, D.. 1997. Recognition of telomeric DNA. Trends Biochem. Sci. 22:43–47
  • Krauskopf, A., and Blackburn, E. H.. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383:354–357
  • Krauskopf, A., and Blackburn, E. H.. 1998. Rap1 protein regulates telomere turnover in yeast. Proc. Natl. Acad. Sci. USA 95:12486–12491
  • Kyrion, G., Boakye, K. A., and Lustig, A. J.. 1992. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12:5159–5173
  • Li, B., and Lustig, A. J.. 1996. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev. 10:1310–1326
  • Lingner, J., Cech, T. R., Hughes, T. R., and Lundblad, V.. 1997. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. USA 94:11190–11195
  • Lundblad, V., and Blackburn, E. H.. 1993. An alternative pathway for yeast telomere maintenance rescues est1− senescence. Cell 73:347–360
  • Lundblad, V., and Szostak, J. W.. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633–643
  • Makarov, V. L., Hirose, Y., and Langmore, J. P.. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88:657–666
  • Marcand, S., Gilson, E., and Shore, D.. 1997. A protein-counting mechanism for telomere length regulation in yeast. Science 275:986–990
  • McEachern, M. J., and Blackburn, E. H.. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822–1834
  • McEachern, M. J., and Blackburn, E. H.. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403–409
  • Nugent, C. I., Hughes, T. R., Lue, N. F., and Lundblad, V.. 1996. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274:249–252
  • Prescott, J., and Blackburn, E. H.. 1997. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790–2800
  • Prescott, J., and Blackburn, E. H.. 1997. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev. 11:528–540
  • Shampay, J., and Blackburn, E. H.. 1988. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 85:534–538
  • Shore, D.. 1994. RAP1: a protean regulator in yeast. Trends Genet 10:408–412
  • Singer, M. S., and Gottschling, D. E.. 1994. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404–409
  • Smith, C. D., and Blackburn, E. H.. 1999. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J. Cell Biol. 145:203–214
  • van Steensel, B., and de Lange, T.. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740–743
  • van Steensel, B., Smogorzewska, A., and de Lange, T.. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401–413
  • Virta-Pearlman, V., Morris, D. K., and Lundblad, V.. 1996. Est1 has the properties of a single-stranded telomere end-binding protein. Genes Dev. 10:3094–3104
  • Wang, H., Gilley, D., and Blackburn, E. H.. 1998. A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase. EMBO J. 17:1152–1160
  • Wellinger, R. J., Wolf, A. J., and Zakian, V. A.. 1993. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72:51–60
  • Zakian, V. A.. 1995. Telomeres: beginning to understand the end. Science 270:1601–1607
  • Zhu, J., Wang, H., Bishop, J. M., and Blackburn, E. H.. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96:3723–3728

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