DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

REFERENCES

• Agarwal, M. L., A. Agarwal, W. R. Taylor, Z.-Q. Wang, E. F. Wagner, and G. R. Stark. 1997. Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase. Oncogene 15:1035–1041.
   PubMed Web of Science ®Google Scholar
• Artandi, S. E., S. Chang, S. L. Lee, S. Alson, G. J. Gottlieb, L. Chin, and R. A. DePinho. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406:641–645.
   PubMed Web of Science ®Google Scholar
• Banin, S., L. Moyal, S. Shieh, Y. Taya, C. W. Anderson, L. Chessa, N. I. Smorodinsky, C. Prives, Y. Reiss, Y. Shiloh, and Y. Ziv. 1998. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674–1677.
   PubMed Web of Science ®Google Scholar
• Bell, D. W., J. M. Varley, T. E. Szydlo, D. H. Kang, D. C. Wahrer, K. E. Shanon, M. Lubratovich, S. J. Verselis, K. J. Issebacher, J. F. Fraumeni, J. M. Birch, F. P. Li, J. E. Garber, and D. A. Haber. 1999. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286:2528–2531.
   PubMed Web of Science ®Google Scholar
• Blackburn, E. H.. 2000. Telomere states and cell fates. Nature 408:53–56.
   PubMed Web of Science ®Google Scholar
• Bryan, T. M., A. Englezou, L. Dalla-Pozza, M. A. Dunham, and R. R. Reddel. 1997. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3:1271–1274.
   PubMed Web of Science ®Google Scholar
• Buchhop, S., M. K. Gibson, X. W. Wang, P. Wagner, H. W. Sturzbecher, and C. C. Harris. 1997. Interaction of p53 with the human Rad51 protein. Nucleic Acids Res. 25:3868–3874.
   PubMed Web of Science ®Google Scholar
• Canman, C. E., D. S. Lim, K. A. Cimprich, Y. Taya, K. Tami, K. Sakaguchi, E. Appella, M. B. Kastan, and J. D. Siliciano. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677–1679.
   PubMed Web of Science ®Google Scholar
• Chin, L., S. E. Artandi, Q. Shen, A. Tam, S. L. Lee, G. J. Gottlieb, C. W. Greider, and R. A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97:527–538.
   PubMed Web of Science ®Google Scholar
• d'Adda di Fagagna, F., M. P. Hande, W. M. Tong, P. M. Lansdorp, Z.-Q. Wang, and S. P. Jackson. 1999. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat. Genet. 23:76–80.
   PubMed Web of Science ®Google Scholar
• de Lange, T., and T. Jacks. 1999. For better or worse? Telomerase inhibition and cancer. Cell 98:273–275.
   PubMedGoogle Scholar
• Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery Jr., J. S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215–221.
   PubMed Web of Science ®Google Scholar
• Donehower, L. A., M. Harvey, H. Vogel, M. J. McArthur, C. A. Montgomery Jr., S. H. Park, T. Thompson, R. J. Ford, and A. Bradley. 1995. Effects of genetic background on tumorigenesis in p53-deficient mice. Mol. Carcinog. 14:16–22.
   PubMed Web of Science ®Google Scholar
• Greider, C. W.. 1999. Telomerase activation. One step on the road to cancer?. Trends Genet. 15:109–112.
   PubMedGoogle Scholar
• Harvey, M., M. J. McArthur, C. A. Montgomery Jr., J. S. Butel, A. Bradley, and L. A. Donehower. 1993. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5:225–229.
   PubMed Web of Science ®Google Scholar
• Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris. 1991. p53 mutations in human cancers. Science 253:49–53.
   PubMed Web of Science ®Google Scholar
• Jacks, T., L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi, R. T. Bronson, and R. A. Weinberg. 1994. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4:1–7.
   PubMed Web of Science ®Google Scholar
• Jeggo, P. A.. 1998. DNA repair: PARP—another guardian angel?. Curr. Biol. 8:R49–R51.
   PubMed Web of Science ®Google Scholar
• Jerry, D. J., F. S. Kittrell, C. Kuperwasser, R. Laucirica, E. S. Dickinson, P. J. Bonilla, J. S. Butel, and D. Medina. 2000. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene 19:1052–1058.
   PubMedGoogle Scholar
• Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321–1325.
   PubMed Web of Science ®Google Scholar
• Levine, A. J.. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323–331.
   PubMed Web of Science ®Google Scholar
• Lindahl, T., M. S. Satoh, G. G. Poirier, and A. Klungland. 1995. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci. 20:405–411.
   PubMed Web of Science ®Google Scholar
• Malanga, M., J. M. Pleschke, H. E. Kleczkowska, and F. R. Althaus. 1998. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J. Biol. Chem. 273:11839–11843.
   PubMed Web of Science ®Google Scholar
• Malkin, D.. 1998. The Li-Fraumeni syndrome. The genetic basis of human cancer.. B. Vogelstein, and K. W. Kinzler. 393–407. McGraw-Hill, New York, N.Y
   Google Scholar
• Martens, U. M., J. M. Zijlmans, S. S. Poon, W. Dragowska, J. Yui, E. A. Chavez, R. K. Ward, and P. M. Lansdorp. 1998. Short telomeres on human chromosome 17p. Nat. Genet. 18:76–80.
   PubMed Web of Science ®Google Scholar
• Menessier-de Murcia, J., C. Niedergang, C. Trucco, M. Ricoul, B. Dutrillaux, M. Mark, F. J. Oliver, M. Masson, A. Dierich, M. LeMeur, C. Walztinger, P. Chambon, and G. de Murcia. 1997. Requirement of poly (ADP-ribose) in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA 94:7303–7307.
   PubMedGoogle Scholar
• Morrison, C., G. C. M. Smith, L. Stingl, S. P. Jackson, E. F. Wagner, and Z.-Q. Wang. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat. Genet. 17:479–482.
   PubMed Web of Science ®Google Scholar
• Mummenbrauer, T., F. Janus, B. Muller, L. Wiesmuller, W. Deppert, and F. Grosse. 1996. p53 protein exhibits 3′-to-5′ exonuclease activity. Cell 85:1089–1099.
   PubMed Web of Science ®Google Scholar
• Petrini, J. H. J., M. E. Walsh, C. Dimare, X. N. Chen, J. R. Korenberg, and D. T. Weaver. 1995. Isolation and characterization of the human MRE11 homologue. Genomics 29:80–88.
   PubMedGoogle Scholar
• Petrini, J. H. J.. 1999. The mammalian Mre11-Rad50-Nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am. J. Hum. Genet. 64:1264–1269.
   PubMed Web of Science ®Google Scholar
• Pluta, A. F., and V. A. Zakian. 1989. Recombination occurs during telomere formation in yeast. Nature 337:429–433.
   PubMed Web of Science ®Google Scholar
• Rogan, E. M., T. M. Bryan, B. Hukku, K. Maclean, A. C. M. Chang, E. L. Moy, A. Englezou, S. G. Warneford, L. Dalla-Pozza, and R. R. Reddel. 1995. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell. Biol. 15:4745–4753.
   PubMed Web of Science ®Google Scholar
• Rudolph, K. L., S. Chang, H. W. Lee, M. Blasco, G. J. Gottlieb, C. W. Greider, and R. A. DePinho. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96:701–712.
   PubMed Web of Science ®Google Scholar
• Simbulan-Rosenthal, C. M., B. R. Haddad, D. S. Rosenthal, Z. Weaver, A. Coleman, R. Luo, H. M. Young, Z.-Q. Wang, T. Ried, and M. E. Smulson. 1999. Chromosomal aberrations in PARP−/− mice: genome stabilization in immortalized cells by reintroduction of PARP cDNA. Proc. Natl. Acad. Sci. USA 96:13191–13196.
   PubMedGoogle Scholar
• Smith, S., I. Giriat, A. Schmitt, and T. de Lange. 1998. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484–1487.
   PubMed Web of Science ®Google Scholar
• Sonoda, E., M. S. Sasaki, C. Morrison, Y. Yamaguchi-Iwai, M. Takata, and S. Takeda. 1999. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19:5166–5169.
   PubMed Web of Science ®Google Scholar
• Vaziri, H., M. D. West, R. C. Allsopp, T. S. Davison, Y. S. Wu, C. H. Arrowsmith, G. G. Poirier, and S. Benchimol. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16:6018–6033.
   PubMed Web of Science ®Google Scholar
• Wang, Z.-Q., B. Auer, L. Stingl, H. Berghammer, D. Haidacher, M. Schweiger, and E. F. Wagner. 1995. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9:509–520.
   PubMed Web of Science ®Google Scholar
• Wang, Z.-Q., L. Stingl, C. Morrison, M. Jantsch, M. Los, K. Schulze-Osthoff, and E. F. Wagner. 1997. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11:2347–2358.
   PubMed Web of Science ®Google Scholar
• Wesierska-Gadek, J., Z.-Q. Wang, and G. Schmid. 1999. Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts. Cancer Res. 59:28–34.
   PubMed Web of Science ®Google Scholar
• Zhu, X. D., B. Kuester, M. Mann, J. H. J. Petrini, and T. de Lange. 2000. Cell-cycle-regulated association of Rad50/Mre11/Nbs1 with TRF2 and human telomeres. Nat. Genet. 25:347–352.
   PubMed Web of Science ®Google Scholar
• Zijlmans, J. M., U. M. Martens, S. S. Poon, A. K. Raap, H. J. Tanke, R. K. Ward, and P. M. Lansdorp. 1997. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 4:7423–7428.
   Google Scholar