Molecular and Cellular Biology, Volume 21, Issue 12 (2001)

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Molecular and Cellular Biology, Volume 21, Issue 12 (2001)

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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase
Mei-Shya Chen, Jonathan Hurov, Lynn S. White, Terry Woodford-Thomas & Helen Piwnica-Worms
Pages: 3853-3861
Published online: 28 Mar 2023
AbstractforAbsence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase | Full Text | References | PDF (227.6 KB)
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Article
Reproductive Function in Protein Kinase Inhibitor-Deficient Mice
Mouna Belyamani, Esha A. Gangolli & Rejean L. Idzerda
Pages: 3959-3963
Published online: 28 Mar 2023
AbstractforReproductive Function in Protein Kinase Inhibitor-Deficient Mice | Full Text | References | PDF (126.8 KB)
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Article
B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses
Shengli Xu & Kong-Peng Lam
Pages: 4067-4074
Published online: 28 Mar 2023
AbstractforB-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses | Full Text | References | PDF (685.9 KB)
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Dna Dynamics and Chromosome Structure

Article
Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells
Kilian Perrem, Lorel M. Colgin, Axel A. Neumann, Thomas R. Yeager & Roger R. Reddel
Pages: 3862-3875
Published online: 28 Mar 2023
AbstractforCoexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells | Full Text | References | PDF (707.9 KB)
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Article
Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase
Bhaskar Thyagarajan, Eric C. Olivares, Roger P. Hollis, Daniel S. Ginsburg & Michele P. Calos
Pages: 3926-3934
Published online: 28 Mar 2023
AbstractforSite-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase | Full Text | References | PDF (136.8 KB)
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Article
RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination
Wenhui Li, Fu-Chung Chang & Stephen Desiderio
Pages: 3935-3946
Published online: 28 Mar 2023
AbstractforRAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination | Full Text | References | PDF (599.2 KB)
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Article
Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci
L. Julie Huber, Thomas W. Yang, Christopher J. Sarkisian, Stephen R. Master, Chu-Xia Deng & Lewis A. Chodosh
Pages: 4005-4015
Published online: 28 Mar 2023
AbstractforImpaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci | Full Text | References | PDF (891.6 KB)
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Transcriptional Regulation

Article
p300 Forms a Stable, Template-Committed Complex with Chromatin: Role for the Bromodomain
E. Tory Manning, Tsuyoshi Ikehara, Takashi Ito, James T. Kadonaga & W. Lee Kraus
Pages: 3876-3887
Published online: 28 Mar 2023
Abstractforp300 Forms a Stable, Template-Committed Complex with Chromatin: Role for the Bromodomain | Full Text | References | PDF (434.8 KB)
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Article
NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling
Sebastian Kreuz, Daniela Siegmund, Peter Scheurich & Harald Wajant
Pages: 3964-3973
Published online: 28 Mar 2023
AbstractforNF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling | Full Text | References | PDF (489.7 KB)
  • 95 Views
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Article
The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation
Jack T. Zilfou, William H. Hoffman, Michael Sank, Donna L. George & Maureen Murphy
Pages: 3974-3985
Published online: 28 Mar 2023
AbstractforThe Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation | Full Text | References | PDF (465.3 KB)
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Gene Expression

Article
The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA
Takao Imai, Akinori Tokunaga, Tetsu Yoshida, Mitsuhiro Hashimoto, Katsuhiko Mikoshiba, Gerry Weinmaster, Masato Nakafuku & Hideyuki Okano
Pages: 3888-3900
Published online: 28 Mar 2023
AbstractforThe Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA | Full Text | References | PDF (634.9 KB)
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Cell Growth and Development

Article
Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling
Kazuya Shimizu, Pierre-Yves Bourillot, Søren J. Nielsen, Aaron M. Zorn & J. B. Gurdon
Pages: 3901-3912
Published online: 28 Mar 2023
AbstractforSwift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling | Full Text | References | PDF (689.7 KB)
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Article
Characterization of mec1 Kinase-Deficient Mutants and of New Hypomorphic mec1 Alleles Impairing Subsets of the DNA Damage Response Pathway
Vera Paciotti, Michela Clerici, Maddalena Scotti, Giovanna Lucchini & Maria Pia Longhese
Pages: 3913-3925
Published online: 28 Mar 2023
AbstractforCharacterization of mec1 Kinase-Deficient Mutants and of New Hypomorphic mec1 Alleles Impairing Subsets of the DNA Damage Response Pathway | Full Text | References | PDF (1,005.2 KB)
  • 19 Views
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Article
PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2
Laura Simpson, Jing Li, Danny Liaw, Ian Hennessy, Jonathan Oliner, Fred Christians & Ramon Parsons
Pages: 3947-3958
Published online: 28 Mar 2023
AbstractforPTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2 | Full Text | References | PDF (351 KB)
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Article
The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF
Anne Devin, Yong Lin, Shoji Yamaoka, Zhiwei Li, Michael Karin & Zheng-gang Liu
Pages: 3986-3994
Published online: 28 Mar 2023
AbstractforThe α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF | Full Text | References | PDF (414.4 KB)
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Article
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
Erik Laughner, Panthea Taghavi, Kelly Chiles, Patrick C. Mahon & Gregg L. Semenza
Pages: 3995-4004
Published online: 28 Mar 2023
AbstractforHER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression | Full Text | References | PDF (428.6 KB)
  • 147 Views
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Article
Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase
Zhimin Lu, Guoqiang Jiang, Peter Blume-Jensen & Tony Hunter
Pages: 4016-4031
Published online: 28 Mar 2023
AbstractforEpidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase | Full Text | References | PDF (1.8 MB)
  • 75 Views
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Article
Retinoblastoma Tumor Suppressor Protein Signals through Inhibition of Cyclin-Dependent Kinase 2 Activity To Disrupt PCNA Function in S Phase
Zvjezdana Sever-Chroneos, Steven P. Angus, Anne F. Fribourg, Huajing Wan, Ivan Todorov, Karen E. Knudsen & Erik S. Knudsen
Pages: 4032-4045
Published online: 28 Mar 2023
AbstractforRetinoblastoma Tumor Suppressor Protein Signals through Inhibition of Cyclin-Dependent Kinase 2 Activity To Disrupt PCNA Function in S Phase | Full Text | References | PDF (2.1 MB)
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Article
DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression
Wei-Min Tong, M. Prakash Hande, Peter M. Lansdorp & Zhao-Qi Wang
Pages: 4046-4054
Published online: 28 Mar 2023
AbstractforDNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression | Full Text | References | PDF (1.6 MB)
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Article
Phospholipase D Activity Is Required for Actin Stress Fiber Formation in Fibroblasts
Yoonseok Kam & John H. Exton
Pages: 4055-4066
Published online: 28 Mar 2023
AbstractforPhospholipase D Activity Is Required for Actin Stress Fiber Formation in Fibroblasts | Full Text | References | PDF (8.1 MB)
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Article
A Pcl-Like Cyclin of Aspergillus nidulans Is Transcriptionally Activated by Developmental Regulators and Is Involved in Sporulation
Niklas Schier, Ralf Liese & Reinhard Fischer
Pages: 4075-4088
Published online: 28 Mar 2023
AbstractforA Pcl-Like Cyclin of Aspergillus nidulans Is Transcriptionally Activated by Developmental Regulators and Is Involved in Sporulation | Full Text | References | PDF (1.5 MB)
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