The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development

REFERENCES

• Abbondanzo, S. J., I. Gadi, and C. L. Stewart. 1993. Derivation of embryonic stem cell lines. Methods Enzymol. 225:803–823.
   PubMed Web of Science ®Google Scholar
• Alkema, M. J., M. Bronk, E. Verhoeven, A. Otte, L. J. van't Veer, A. Berns, and M. van Lohuizen. 1997. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex. Genes Dev. 11:226–240.
   PubMed Web of Science ®Google Scholar
• Brown, J. L., D. Mucci, M. Whiteley, M. L. Dirksen, and J. A. Kassis. 1998. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol. Cell 1:1057–1064.
   PubMed Web of Science ®Google Scholar
• Conlon, R. A., and B. G. Herrmann. 1993. Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. Methods Enzymol. 225:373–383.
   PubMedGoogle Scholar
• Cui, X., I. De Vivo, R. Slany, A. Miyamoto, R. Firestein, and M. L. Cleary. 1998. Association of SET domain and myotubularin-related proteins modulates growth control. Nat. Genet. 18:331–337.
   PubMed Web of Science ®Google Scholar
• De Vivo, I., X. Cui, J. Domen, and M. L. Cleary. 1998. Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1. Proc. Natl. Acad. Sci. USA 95:9471–9476.
   PubMedGoogle Scholar
• Donohoe, M. E., X. Zhang, L. McGinnis, J. Biggers, E. Li, and Y. Shi. 1999. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol. Cell. Biol. 19:7237–7244.
   PubMed Web of Science ®Google Scholar
• Faust, C., A. Schumacher, B. Holdener, and T. Magnuson. 1995. The eed mutation disrupts anterior mesoderm production in mice. Development 121:273–285.
   PubMed Web of Science ®Google Scholar
• Faust, C., K. A. Lawson, N. J. Schork, B. Thiel, and T. Magnuson. 1998. The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development 125:4495–4506.
   PubMed Web of Science ®Google Scholar
• Garcia, E., C. Marcos-Gutierrez, M. del Mar Lorente, J. C. Moreno, and M. Vidal. 1999. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 18:3404–3418.
   PubMed Web of Science ®Google Scholar
• Gatti, M., and B. S. Baker. 1989. Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes Dev. 3:438–453.
   PubMedGoogle Scholar
• Gutjahr, T., E. Frei, C. Spicer, S. Baumgartner, R. A. H. White, and M. Noll. 1995. The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family. EMBO J. 14:4296–4306.
   PubMedGoogle Scholar
• Herrmann, B. G., S. Labeit, A. Poustka, T. R. King, and H. Lehrach. 1990. Cloning of the T gene required in mesoderm formation in the mouse. Nature 343:617–622.
   PubMed Web of Science ®Google Scholar
• Hobert, O., B. Jallal, and A. Ullrich. 1996. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol. Cell. Biol. 16:3066–3073.
   PubMed Web of Science ®Google Scholar
• Hobert, O., I. Sures, T. Ciossek, M. Fuchs, and A. Ullrich. 1996. Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. Mech. Dev. 55:171–184.
   PubMedGoogle Scholar
• Hogan, B., R. Beddinton, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
   Google Scholar
• Holdeman, R., S. Nehrt, and S. Strome. 1998. MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Development 125:2457–2467.
   PubMedGoogle Scholar
• Jenuwein, T., G. Laible, R. Dorn, and G. Reuter. 1998. SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell. Mol. Life Sci. 54:80–93.
   PubMedGoogle Scholar
• Jones, R. S., and W. M. Gelbart. 1990. Genetic analysis of the Enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics 126:185–199.
   PubMedGoogle Scholar
• Jones, R. S., and W. M. Gelbart. 1993. The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13:6357–6366.
   PubMedGoogle Scholar
• Korf, I., Y. Fan, and S. Strome. 1998. The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development 125:2469–2478.
   PubMed Web of Science ®Google Scholar
• Laible, G., A. Wolf, R. Dorn, G. Reuter, C. Nislow, A. Lebersorger, D. Popkin, L. Pillus, and T. Jenuwein. 1997. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16:3219–3232.
   PubMed Web of Science ®Google Scholar
• Laible, G., A. R. Haynes, A. Lebersorger, D. O'Carroll, M. G. Mattei, P. Denny, S. D. Brown, and T. Jenuwein. 1999. The murine Polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6. Mamm. Genome 10:311–314.
   PubMed Web of Science ®Google Scholar
• Moazed, D., and P. H. O'Farrell. 1992. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development 116:805–810.
   PubMedGoogle Scholar
• Paro, R., H. Strutt, and G. Cavalli. 1998. Heritable chromatin states induced by the Polycomb and trithorax group genes. Novartis Found. Symp. 214:51–61.
   PubMedGoogle Scholar
• Pelegri, F., and R. Lehmann. 1994. A role of Polycomb group genes in the regulation of gap gene expression in Drosophila. Genetics 136:1341–1353.
   PubMedGoogle Scholar
• Raaphorst, F. M., F. J. van Kemenade, E. Fieret, K. M. Hamer, D. P. Satijn, A. P. Otte, and C. J. Meijer. 2000. Cutting edge: Polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers. J. Immunol. 164:1–4.
   PubMed Web of Science ®Google Scholar
• Rastelli, L., C. S. Chan, and V. Pirrotta. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 12:1513–1522.
   PubMedGoogle Scholar
• Rea, S., F. Eisenhaber, D. O'Carroll, B. D. Strahl, Z. W. Sun, M. Schmid, S. Opravil, K. Mechtler, C. P. Ponting, C. D. Allis, and T. Jenuwein. 2000. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406:593–599.
   PubMed Web of Science ®Google Scholar
• Sabath, D. E., H. E. Broome, and M. B. Prystowski. 1990. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene 91:185–191.
   PubMed Web of Science ®Google Scholar
• Satijn, D. P. E., K. M. Hamer, J. den Blaauwen, and A. P. Otte. 2001. The Polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. Mol. Cell. Biol. 21:1360–1369.
   PubMedGoogle Scholar
• Schumacher, A., C. Faust, and T. Magnuson. 1996. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 383:250–253.
   PubMedGoogle Scholar
• Sewalt, R. G., J. van der Vlag, M. J. Gunster, K. M. Hamer, J. L. den Blaauwen, D. P. Satijn, T. Hendrix, R. van Driel, and A. P. Otte. 1998. Characterization of interactions between the mammalian Polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian Polycomb-group protein complexes. Mol. Cell. Biol. 18:3586–3595.
   PubMed Web of Science ®Google Scholar
• Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467–470.
   PubMed Web of Science ®Google Scholar
• van der Vlag, J., and A. P. Otte. 1999. Transcriptional repression mediated by the human Polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23:474–478.
   PubMed Web of Science ®Google Scholar
• van Lohuizen, M.. 1998. Functional analysis of mouse Polycomb group genes. Cell. Mol. Life Sci. 54:71–79.
   PubMedGoogle Scholar
• van Lohuizen, M., M. Tijms, J. W. Voncken, A. Schumacher, T. Magnuson, and E. Wientjens. 1998. Interaction of mouse Polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol. Cell. Biol. 18:3572–3579.
   PubMedGoogle Scholar