Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN

REFERENCES

• Anonymous Guide for the care and use of laboratory animals. National Institutes of Health, Bethesda, Md
   Google Scholar
• Bancroft, J., and A. Stevens. 1982. Theory and practice of histological techniques, 2nd ed. Churchill Livingstone, New York, N.Y
   Google Scholar
• Boute, N., O. Gribouval, S. Roselli, F. Benessy, H. Lee, A. Fuchshuber, K. Dahan, M. C. Gubler, P. Niaudet, and C. Antignac. 2000. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat. Genet. 24:349–354 (Erratum, 25:125.)
   PubMed Web of Science ®Google Scholar
• Bycroft, M., A. Bateman, J. Clarke, S. J. Hamill, R. Sandford, R. L. Thomas, and C. Chothia. 1999. The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. EMBO J. 18:297–305.
   PubMed Web of Science ®Google Scholar
• Friedrich, G., and P. Soriano. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1513–1523.
   PubMed Web of Science ®Google Scholar
• Kestila, M., U. Lenkkeri, M. Mannikko, J. Lamerdin, P. McCready, H. Putaala, V. Ruotsalainen, T. Morita, M. Nissinen, R. Herva, C. E. Kashtan, L. Peltonen, C. Holmberg, A. Olsen, and K. Tryggvason. 1998. Positionally cloned gene for a novel glomerular protein—nephrin—is mutated in congenital nephrotic syndrome. Mol. Cell 1:575–582.
   PubMed Web of Science ®Google Scholar
• Kuriyama, S., T. Sakamoto, M. Kikukawa, T. Nakatani, Y. Toyokawa, H. Tsujinoue, K. Ikenaka, H. Fukui, and T. Tsujii. 1998. Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment. Gene Ther. 5:1299–1305.
   PubMed Web of Science ®Google Scholar
• Luna, L.. 1968. Manual of histologic staining methods of the Armed Forces Institute of Pathology, 3rd ed. Blakiston Division, McGraw-Hill, New York, N.Y
   Google Scholar
• Pierschbacher, M. D., and E. Ruoslahti. 1984. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30–33.
   PubMed Web of Science ®Google Scholar
• Puri, M. C., J. Rossant, K. Alitalo, A. Bernstein, and J. Partanen. 1995. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J. 14:5884–5891.
   PubMed Web of Science ®Google Scholar
• Putaala, H., R. Soininen, P. Kilpelainen, J. Wartiovaara, and K. Tryggvason. 2001. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum. Mol. Genet. 10:1–8.
   PubMed Web of Science ®Google Scholar
• Ramos, R. G., G. L. Igloi, B. Lichte, U. Baumann, D. Maier, T. Schneider, J. H. Brandstatter, A. Frohlich, and K. F. Fischbach. 1993. The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein. Genes Dev. 7:2533–2547.
   PubMed Web of Science ®Google Scholar
• Ruotsalainen, V., P. Ljungberg, J. Wartiovaara, U. Lenkkeri, M. Kestila, H. Jalanko, C. Holmberg, and K. Tryggvason. 1999. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc. Natl. Acad. Sci. USA 96:7962–7967.
   PubMed Web of Science ®Google Scholar
• Salomon, R., M. C. Gubler, and P. Niaudet. 2000. Genetics of the nephrotic syndrome. Curr. Opin. Pediatr. 12:129–134.
   PubMedGoogle Scholar
• Schneider, T., C. Reiter, E. Eule, B. Bader, B. Lichte, Z. Nie, T. Schimansky, R. G. Ramos, and K. F. Fischbach. 1995. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron 15:259–271.
   PubMed Web of Science ®Google Scholar
• Stewart, C. L., S. Schuetze, M. Vanek, and E. F. Wagner. 1987. Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J. 6:383–388.
   PubMed Web of Science ®Google Scholar
• Tryggvason, K.. 1999. Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. J. Am. Soc. Nephrol. 10:2440–2445.
   PubMed Web of Science ®Google Scholar
• Van Adelsberg, J. S., and D. Frank. 1995. The PKD1 gene produces a developmentally regulated protein in mesenchyme and vasculature. Nat. Med. 1:359–364.
   PubMed Web of Science ®Google Scholar
• Venugopala Reddy, G., C. Reiter, S. Shanbhag, K. F. Fischbach, and V. Rodrigues. 1999. Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm. Dev. Genes Evol. 209:581–591.
   PubMed Web of Science ®Google Scholar
• Zambrowicz, B. P., G. A. Friedrich, E. C. Buxton, S. L. Lilleberg, C. Person, and A. T. Sands. 1998. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392:608–611.
   PubMed Web of Science ®Google Scholar
• Zheng, B., M. Sage, W. W. Cai, D. M. Thompson, B. C. Tavsanli, Y. C. Cheah, and A. Bradley. 1999. Engineering a mouse balancer chromosome. Nat. Genet. 22:375–378.
   PubMedGoogle Scholar