Disruption of γ-Glutamyl Leukotrienase Results in Disruption of Leukotriene D₄ Synthesis In Vivo and Attenuation of the Acute Inflammatory Response

REFERENCES

• Bradley, P. P., D. A. Priebat, R. D. Christensen, and G. Rothstein. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Investig. Dermatol. 78:206–209.
   PubMed Web of Science ®Google Scholar
• Buckner, C. K., R. D. Krell, R. B. Laravuso, D. B. Coursin, P. R. Bernstein, and J. A. Will. 1986. Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4. J. Pharmacol. Exp. Ther. 237:558–562.
   PubMed Web of Science ®Google Scholar
• Byrum, R. S., J. L. Goulet, J. N. Snouwaert, R. J. Griffiths, and B. H. Koller. 1999. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J. Immunol. 163:6810–6819.
   PubMed Web of Science ®Google Scholar
• Carter, B. Z., A. L. Wiseman, R. Orkiszewski, K. D. Ballard, C. N. Ou, and M. W. Lieberman. 1997. Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice. J. Biol. Chem. 272:12305–12310.
   PubMed Web of Science ®Google Scholar
• Carter, B. Z., Z. Z. Shi, R. Barrios, and M. W. Lieberman. 1998. γ-Glutamyl leukotrienase, a γ-glutamyl transpeptidase gene family member, is expressed primarily in spleen. J. Biol. Chem. 273:28277–28285.
   PubMed Web of Science ®Google Scholar
• Chen, X.-S., J. R. Sheller, E. N. Johnson, and C. D. Funk. 1994. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 372:179–182.
   PubMed Web of Science ®Google Scholar
• Chevez-Barrios, P., A. L. Wiseman, E. Rojas, C. N. Ou, and M. W. Lieberman. 2000. Cataract development in γ-glutamyl transpeptidase-deficient mice. Exp. Eye Res. 71:575–582.
   PubMedGoogle Scholar
• Devillier, P., N. Baccard, and C. Advenier. 1999. Leukotrienes, leukotriene receptor antagonists and leukotriene synthesis inhibitors in asthma: an update. Part I: synthesis, receptors and role of leukotrienes in asthma. Pharmacol. Res. 40:3–13.
   PubMed Web of Science ®Google Scholar
• Devillier, P., N. Baccard, and C. Advenier. 1999. Leukotrienes, leukotriene receptor antagonists and leukotriene synthesis inhibitors in asthma: an update. Part II: clinical studies with leukotriene receptor antagonists and leukotriene synthesis inhibitors in asthma. Pharmacol. Res. 40:15–29.
   PubMed Web of Science ®Google Scholar
• Doherty, N. S., P. Poubelle, P. Borgeat, T. H. Beaver, G. L. Westrich, and N. L. Schrader. 1985. Intraperitoneal injection of Zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2. Prostaglandins 30:769–789.
   PubMed Web of Science ®Google Scholar
• Drazen, J. M.. 1988. Comparative contractile responses to sulfidopeptide leukotrienes in normal and asthmatic human subjects. Ann. N. Y. Acad. Sci. 524:289–297.
   PubMed Web of Science ®Google Scholar
• Goulet, J. L., R. S. Byrum, M. L. Key, M. Nguyen, V. A. Wagoner, and B. H. Koller. 2000. Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. J. Immunol. 164:4899–4907.
   PubMedGoogle Scholar
• Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. 1994. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. Sci. USA 91:12852–12856.
   PubMed Web of Science ®Google Scholar
• Habib, G. M., and M. W. Lieberman. 1999. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Adv. Exp. Med. Biol. 469:295–300.
   PubMedGoogle Scholar
• Habib, G. M., Z. Z. Shi, A. A. Cuevas, Q. Guo, M. M. Matzuk, and M. W. Lieberman. 1998. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc. Natl. Acad. Sci. USA 95:4859–4863.
   PubMed Web of Science ®Google Scholar
• Heise, C. E., B. F. O'Dowd, D. J. Figueroa, N. Sawyer, T. Nguyen, D. S. Im, R. Stocco, J. N. Bellefeuille, M. Abramovitz, R. Cheng, D. L. Williams Jr., Z. Zeng, Q. Liu, L. Ma, M. K. Clements, N. Coulombe, Y. Liu, C. P. Austin, S. R. George, G. P. O'Neill, K. M. Metters, K. R. Lynch, and J. F. Evans. 2000. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275:30531–30536.
   PubMed Web of Science ®Google Scholar
• Henderson, W. R. Jr.. 1994. The role of leukotrienes in inflammation. Ann. Intern. Med. 183:1–5.
   Google Scholar
• Hogaboom, G. K., S. Mong, H. L. Wu, and S. T. Crooke. 1983. Peptidoleukotrienes: distinct receptors for leukotriene C4 and D4 in the guinea-pig lung. Biochem. Biophys. Res. Commun. 116:1136–1143.
   PubMed Web of Science ®Google Scholar
• Holgate, S. T., P. Bradding, and A. P. Sampson. 1996. Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy. J. Allergy Clin. Immunol. 98:1–13.
   PubMed Web of Science ®Google Scholar
• Horwitz, R. J., K. A. McGill, and W. W. Busse. 1998. The role of leukotriene modifiers in the treatment of asthma. Am. J. Respir. Crit. Care Med. 157:1363–1371.
   PubMed Web of Science ®Google Scholar
• Kanwar, S., B. Johnston, and P. Kubes. 1995. Leukotriene C4/D4 induces P-selectin and sialyl Lewisx-dependent alterations in leukocyte kinetics in vivo. Circ. Res. 77:879–887.
   PubMed Web of Science ®Google Scholar
• Kumar, T. R., A. L. Wiseman, G. Kala, S. V. Kala, M. M. Matzuk, and M. W. Lieberman. 2000. Reproductive defects in γ-glutamyl transpeptidase-deficient mice. Endocrinology 141:4270–4277.
   PubMed Web of Science ®Google Scholar
• Lieberman, M. W., A. L. Wiseman, Z. Z. Shi, B. Z. Carter, R. Barrios, C. N. Ou, P. Chevez-Barrios, Y. Wang, G. M. Habib, J. C. Goodman, S. L. Huang, R. M. Lebovitz, and M. M. Matzuk. 1996. Growth retardation and cysteine deficiency in γ-glutamyl transpeptidase-deficient mice. Proc. Natl. Acad. Sci. USA 93:7923–7926.
   PubMed Web of Science ®Google Scholar
• Lieberman, M. W., J. E. Shields, Y. Will, D. J. Reed, and B. Z. Carter. 1999. γ-Glutamyl leukotrienase cleavage of leukotriene C4. Adv. Exp. Med. Biol. 469:301–306.
   PubMed Web of Science ®Google Scholar
• Liu, D., M. M. Matzuk, W. K. Sung, Q. Guo, P. Wang, and D. J. Wolgemuth. 1998. Cyclin A1 is required for meiosis in the male mouse. Nat. Genet. 20:377–380.
   PubMed Web of Science ®Google Scholar
• Lynch, K. R., G. P. O'Neill, Q. Liu, D. S. Im, N. Sawyer, K. M. Metters, N. Coulombe, M. Abramovitz, D. J. Figueroa, Z. Zeng, B. M. Connolly, C. Bai, C. P. Austin, A. Chateauneuf, R. Stocco, G. M. Greig, S. Kargman, S. B. Hooks, E. Hosfield, D. L. Williams Jr., A. W. Ford-Hutchinson, C. T. Caskey, and J. F. Evans. 1999. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399:789–793.
   PubMed Web of Science ®Google Scholar
• Meister, A., and A. Larsson. 1995. Glutathione synthesis deficiency and other disorders of the γ-glutamyl cycle. The metabolic basis of inherited diseases, 7th ed. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle. 1461–1477. McGraw-Hill Book Co., New York, N.Y
   Google Scholar
• Orning, L., and S. Hammarstrom. 1980. Inhibition of leukotriene C and leukotriene D biosynthesis. J. Biol. Chem. 255:8023–8026.
   PubMed Web of Science ®Google Scholar
• Pong, S. S., R. N. DeHaven, F. A. Kuehl Jr., and R. W. Egan. 1983. Leukotriene C4 binding to rat lung membranes. J. Biol. Chem. 258:9616–9619.
   PubMed Web of Science ®Google Scholar
• Rao, T. S., J. L. Currie, A. F. Shaffer, and P. C. Isakson. 1994. In vivo characterization of zymosan-induced mouse peritoneal inflammation. J. Pharmacol. Exp. Ther. 269:917–925.
   PubMedGoogle Scholar
• Sarau, H. M., R. S. Ames, J. Chambers, C. Ellis, N. Elshourbagy, J. J. Foley, D. B. Schmidt, R. M. Muccitelli, O. Jenkins, P. R. Murdock, N. C. Herrity, W. Halsey, G. Sathe, A. I. Muir, P. Nuthulaganti, G. M. Dytko, P. T. Buckley, S. Wilson, D. J. Bergsma, and D. W. Hay. 1999. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56:657–663.
   PubMed Web of Science ®Google Scholar