Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

REFERENCES

• Ahn, M. Y., G. Huang, S. C. Bae, H. J. Wee, W. Y. Kim, and Y. Ito. 1998. Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO. Proc. Natl. Acad. Sci. USA 95:1812–1817.
   PubMed Web of Science ®Google Scholar
• Banker, D. E., J. Radich, A. Becker, K. Kerkof, T. Norwood, C. Willman, and F. R. Appelbaum. 1998. The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults. Clin. Cancer Res. 4:3051–3062.
   PubMed Web of Science ®Google Scholar
• Boer, J., J. Bonten-Surtel, and G. Grosveld. 1998. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Mol. Cell. Biol. 18:1236–1247.
   PubMedGoogle Scholar
• Borner, C.. 1996. Diminished cell proliferation associated with the death-protective activity of Bcl-2. J. Biol. Chem. 271:12695–12698.
   PubMed Web of Science ®Google Scholar
• Buchholz, F., Y. Refaeli, A. Trumpp, and J. M. Bishop. 2000. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 1:133–139.
   PubMed Web of Science ®Google Scholar
• Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3–L1 cells. Genes Dev. 5:1538–1552.
   PubMed Web of Science ®Google Scholar
• Chao, D. T., and S. J. Korsmeyer. 1998. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16:395–419.
   PubMed Web of Science ®Google Scholar
• Downing, J. R.. 1999. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance. Br. J. Haematol. 106:296–308.
   PubMed Web of Science ®Google Scholar
• Frank, R. C., X. Sun, F. J. Berguido, A. Jakubowiak, and S. D. Nimer. 1999. The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1. Oncogene 18:1701–1710.
   PubMedGoogle Scholar
• Friedman, A. D.. 1999. Leukemogenesis by CBF oncoproteins. Leukemia 13:1932–1942.
   PubMed Web of Science ®Google Scholar
• Gamou, T., E. Kitamura, F. Hosoda, K. Shimizu, K. Shinohara, Y. Hayashi, T. Nagase, Y. Yokoyama, and M. Ohki. 1998. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 91:4028–4037.
   PubMed Web of Science ®Google Scholar
• Gavrieli, Y., Y. Sherman, and S. A. Ben Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493–501.
   PubMed Web of Science ®Google Scholar
• Gelmetti, V., J. Zhang, M. Fanelli, S. Minucci, P. G. Pelicci, and M. A. Lazar. 1998. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol. Cell. Biol. 18:7185–7191.
   PubMed Web of Science ®Google Scholar
• Golub, T. R., G. F. Barker, S. K. Bohlander, S. W. Hiebert, D. C. Ward, P. Bray-Ward, E. Morgan, S. C. Raimondi, J. D. Rowley, and D. G. Gilliland. 1995. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 92:4917–4921.
   PubMed Web of Science ®Google Scholar
• Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547–5551.
   PubMed Web of Science ®Google Scholar
• Hawley, R. G., T. S. Hawley, A. Z. Fong, C. Quinto, M. Collins, J. P. Leonard, and S. J. Goldman. 1996. Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11. Proc. Natl. Acad. Sci. USA 93:10297–10302.
   PubMedGoogle Scholar
• Hawley, R. G., F. H. Lieu, A. Z. Fong, and T. S. Hawley. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1:136–138.
   PubMed Web of Science ®Google Scholar
• Hermeking, H., C. Rago, M. Schuhmacher, Q. Li, J. F. Barrett, A. J. Obaya, B. C. O'Connell, M. K. Mateyak, W. Tam, F. Kohlhuber, C. V. Dang, J. M. Sedivy, D. Eick, B. Vogelstein, and K. W. Kinzler. 2000. Identification of CDK4 as a target of c-MYC. Proc. Natl. Acad. Sci. USA 97:2229–2234.
   PubMed Web of Science ®Google Scholar
• Hohaus, S., M. S. Petrovick, M. T. Voso, Z. Sun, D.-E. Zhang, and D. G. Tenen. 1995. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol. Cell. Biol. 15:5830–5845.
   PubMed Web of Science ®Google Scholar
• Iwama, A., P. Zhang, G. J. Darlington, S. R. McKercher, R. Maki, and D. G. Tenen. 1998. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 26:3034–3043.
   PubMed Web of Science ®Google Scholar
• Kinsella, T. M., and G. P. Nolan. 1996. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7:1405–1413.
   PubMed Web of Science ®Google Scholar
• Kitabayashi, I., K. Ida, F. Morohoshi, A. Yokoyama, N. Mitsuhashi, K. Shimizu, N. Nomura, Y. Hayashi, and M. Ohki. 1998. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. Mol. Cell. Biol. 18:846–858.
   PubMedGoogle Scholar
• Klampfer, L., J. Zhang, A. O. Zelenetz, H. Uchida, and S. D. Nimer. 1996. The AML1/ETO fusion protein activates transcription of BCL-2. Proc. Natl. Acad. Sci. USA 93:14059–14064.
   PubMed Web of Science ®Google Scholar
• Kohzaki, H., K. Ito, G. Huang, H. J. Wee, Y. Murakami, and Y. Ito. 1999. Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2. Oncogene 18:4055–4062.
   PubMed Web of Science ®Google Scholar
• Kurokawa, M., T. Tanaka, K. Tanaka, S. Ogawa, K. Mitani, Y. Yazaki, and H. Hirai. 1996. Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies. Oncogene 12:883–892.
   PubMed Web of Science ®Google Scholar
• Le, X. F., D. Claxton, S. Kornblau, Y. H. Fan, Z. M. Mu, and K. S. Chang. 1998. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia. Eur. J. Haematol. 60:217–225.
   PubMed Web of Science ®Google Scholar
• Lekstrom-Himes, J., and K. G. Xanthopoulos. 1998. Biological role of the CCAAT/Enhancer-binding protein family of transcription factors. J. Biol. Chem. 273:28545–28548.
   PubMed Web of Science ®Google Scholar
• Liu, L.-Q., R. Ilaria Jr., P. D. Kingsley, A. Iwama, R. van Etten, J. Palis, and D.-E. Zhang. 1999. A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol. Cell. Biol. 19:3029–3038.
   PubMed Web of Science ®Google Scholar
• Lou, J., W. Cao, F. Bernardin, K. Ayyanathan, F. J. Rauscher III, and A. D. Friedman. 2000. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF—a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 19:2695–2703.
   PubMedGoogle Scholar
• Lutterbach, B., and S. W. Hiebert. 2000. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 245:223–235.
   PubMed Web of Science ®Google Scholar
• Lutterbach, B., D. Sun, J. Schuetz, and S. W. Hiebert. 1998. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol. Cell. Biol. 18:3604–3611.
   PubMed Web of Science ®Google Scholar
• Lutterbach, B., J. J. Westendorf, B. Linggi, A. Patten, M. Moniwa, J. R. Davie, K. D. Huynh, V. J. Bardwell, R. M. Lavinsky, M. G. Rosenfeld, C. Glass, E. Seto, and S. W. Hiebert. 1998. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol. Cell. Biol. 18:7176–7184.
   PubMed Web of Science ®Google Scholar
• Mazel, S., D. Burtrum, and H. T. Petrie. 1996. Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. J. Exp. Med. 183:2219–2226.
   PubMed Web of Science ®Google Scholar
• Melnick, A. M., J. J. Westendorf, A. Polinger, G. W. Carlile, S. Arai, H. J. Ball, B. Lutterbach, S. W. Hiebert, and J. D. Licht. 2000. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 20:2075–2086.
   PubMed Web of Science ®Google Scholar
• Meyers, S., J. R. Downing, and S. W. Hiebert. 1993. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336–6345.
   PubMed Web of Science ®Google Scholar
• Mishell, B. B., S. M. Shiigi, C. Henry, E. L. Chan, J. North, R. Gallily, M. Slomich, K. Miller, J. Marbrook, D. Parks, and A. H. Good. 1980. Preparation of mouse cell suspensions. Selected methods in cellular immunology. W. H.. B. B. Mishell, and S. M. Shiigi. 21–22. Freeman, New York, N.Y
   Google Scholar
• Mitani, K., S. Ogawa, T. Tanaka, H. Miyoshi, M. Kurokawa, H. Mano, Y. Yazaki, M. Ohki, and H. Hirai. 1994. Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 13:504–510.
   PubMed Web of Science ®Google Scholar
• Miyashita, T., M. Harigai, M. Hanada, and J. C. Reed. 1994. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 54:3131–3135.
   PubMed Web of Science ®Google Scholar
• Miyoshi, H., T. Kozu, K. Shimizu, K. Enomoto, N. Maseki, Y. Kaneko, N. Kamada, and M. Ohki. 1993. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 12:2715–2721.
   PubMed Web of Science ®Google Scholar
• Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88:10431–10434.
   PubMed Web of Science ®Google Scholar
• Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271–279.
   PubMed Web of Science ®Google Scholar
• Nucifora, G., C. R. Begy, P. Erickson, H. A. Drabkin, and J. D. Rowley. 1993. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Proc. Natl. Acad. Sci. USA 90:7784–7788.
   PubMed Web of Science ®Google Scholar
• Nucifora, G., D. J. Birn, R. Espinosa III, P. Erickson, M. M. LeBeau, D. Roulston, T. W. McKeithan, H. Drabkin, and J. D. Rowley. 1993. Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood 81:2728–2734.
   PubMed Web of Science ®Google Scholar
• Nucifora, G., and J. D. Rowley. 1995. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86:1–14.
   PubMed Web of Science ®Google Scholar
• Oelgeschlager, M., I. Nuchprayoon, B. Luscher, and A. D. Friedman. 1996. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol. Cell. Biol. 16:4717–4725.
   PubMed Web of Science ®Google Scholar
• Ogawa, E., M. Inuzuka, M. Maruyama, M. Satake, M. Naito-Fujimoto, Y. Ito, and K. Shigesada. 1993. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology 194:314–331.
   PubMed Web of Science ®Google Scholar
• Okuda, T., Z. Cai, S. Yang, N. Lenny, C. J. Lyu, J. M. van Deursen, H. Harada, and J. R. Downing. 1998. Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood 91:3134–3143.
   PubMed Web of Science ®Google Scholar
• Okuda, T., J. van Deursen, S. W. Hiebert, G. Grosveld, and J. R. Downing. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321–330.
   PubMed Web of Science ®Google Scholar
• O'Reilly, L. A., D. C. Huang, and A. Strasser. 1996. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 15:6979–6990.
   PubMed Web of Science ®Google Scholar
• Pabst, T., B. U. Mueller, N. Harakawa, T. Schoch, G. Haferlach, G. Behre, W. Hiddemann, D.-E. Zhang, and D. G. Tenen. 2001. AML1–ETO downregulates the granulocytic differentiation factor C/EBP-α in t(8;21) myeloid leukemia. Nat. Med. 7:444–451.
   PubMed Web of Science ®Google Scholar
• Pabst, T., B. U. Mueller, P. Zhang, H. S. Radomska, S. Narravula, S. Schnittger, G. Behre, W. Hiddemann, and D. G. Tenen. 2001. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat. Genet. 27:263–270.
   PubMed Web of Science ®Google Scholar
• Petrovick, M. S., S. W. Hiebert, A. D. Friedman, C. J. Hetherington, D. G. Tenen, and D.-E. Zhang. 1998. Multiple functional domains of AML1: PU.1 and C/EBPα synergize with different regions of AML1. Mol. Cell. Biol. 18:3915–3925.
   PubMedGoogle Scholar
• Radomska, H. S., C. S. Huettner, P. Zhang, T. Cheng, D. T. Scadden, and D. G. Tenen. 1998. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18:4301–4314.
   PubMed Web of Science ®Google Scholar
• Reed, J. C.. 1998. Bcl-2 family proteins. Oncogene 17:3225–3236.
   PubMed Web of Science ®Google Scholar
• Rhoades, K. L., C. J. Hetherington, N. Harakawa, D. A. Yergeau, L. Zhou, L. Q. Liu, M. T. Little, D. G. Tenen, and D.-E. Zhang. 2000. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood 96:2108–2115.
   PubMed Web of Science ®Google Scholar
• Romana, S. P., M. Mauchauffe, M. Le Coniat, I. Chumakov, D. Le Paslier, R. Berger, and O. A. Bernard. 1995. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662–3670.
   PubMed Web of Science ®Google Scholar
• Shikami, M., H. Miwa, K. Nishii, T. Takahashi, T. Sekine, N. Mahmud, M. Nishikawa, H. Shiku, N. Kamada, and K. Kita. 1999. Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality. Leukemia 13:358–368.
   PubMed Web of Science ®Google Scholar
• Shimizu, K., I. Kitabayashi, N. Kamada, T. Abe, N. Maseki, K. Suzukawa, and M. Ohki. 2000. AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood 96:288–296.
   PubMed Web of Science ®Google Scholar
• Shurtleff, S. A., A. Buijs, F. G. Behm, J. E. Rubnitz, S. C. Raimondi, M. L. Hancock, G. C. Chan, C. H. Pui, G. Grosveld, and J. R. Downing. 1995. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985–1989.
   PubMed Web of Science ®Google Scholar
• Smith, L. T., S. Hohaus, D. A. Gonzalez, S. E. Dziennis, and D. G. Tenen. 1996. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88:1234–1247.
   PubMed Web of Science ®Google Scholar
• Speck, N. A., T. Stacy, Q. Wang, T. North, T. L. Gu, J. Miller, M. Binder, and M. Marin-Padilla. 1999. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 59:1789s–1793s.
   PubMed Web of Science ®Google Scholar
• Strom, D. K., J. Nip, J. J. Westendorf, B. Linggi, B. Lutterbach, J. R. Downing, N. Lenny, and S. W. Hiebert. 2000. Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J. Biol. Chem. 275:3438–3445.
   PubMedGoogle Scholar
• Thottassery, J. V., G. P. Zambetti, K. Arimori, E. G. Schuetz, and J. D. Schuetz. 1997. p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc. Natl. Acad. Sci. USA 94:11037–11042.
   PubMed Web of Science ®Google Scholar
• Timchenko, N. A., M. Wilde, M. Nakanishi, J. R. Smith, and G. J. Darlington. 1996. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10:804–815.
   PubMed Web of Science ®Google Scholar
• Wang, J., T. Hoshino, R. L. Redner, S. Kajigaya, and J. M. Liu. 1998. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc. Natl. Acad. Sci. USA 95:10860–10865.
   PubMed Web of Science ®Google Scholar
• Wang, J., Y. Saunthararajah, R. L. Redner, and J. M. Liu. 1999. Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. Cancer Res. 59:2766–2769.
   PubMed Web of Science ®Google Scholar
• Wang, Q., T. Stacy, M. Binder, M. Marin-Padilla, A. H. Sharpe, and N. A. Speck. 1996. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl. Acad. Sci. USA 93:3444–3449.
   PubMed Web of Science ®Google Scholar
• Wang, S. W., and N. A. Speck. 1992. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol. Cell. Biol. 12:89–102.
   PubMedGoogle Scholar
• Wang, X., E. Scott, C. L. Sawyers, and A. D. Friedman. 1999. C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood 94:560–571.
   PubMed Web of Science ®Google Scholar
• Westendorf, J. J., and S. W. Hiebert. 1999. Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia. J. Cell Biochem. 32–33(Suppl.):51–58.
   Google Scholar
• Westendorf, J. J., C. M. Yamamoto, N. Lenny, J. R. Downing, M. E. Selsted, and S. W. Hiebert. 1998. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation. Mol. Cell. Biol. 18:322–333.
   PubMed Web of Science ®Google Scholar
• Williams, S. C., Y. Du, R. C. Schwartz, S. R. Weiler, M. Ortiz, J. R. Keller, and P. F. Johnson. 1998. C/EBPepsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes. J. Biol. Chem. 273:13493–13501.
   PubMed Web of Science ®Google Scholar
• Yamanaka, R., C. Barlow, J. Lekstrom-Himes, L. H. Castilla, P. P. Liu, M. Eckhaus, T. Decker, A. Wynshaw-Boris, and K. G. Xanthopoulos. 1997. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc. Natl. Acad. Sci. USA 94:13187–13192.
   PubMed Web of Science ®Google Scholar
• Yamanaka, R., G. D. Kim, H. S. Radomska, J. Lekstrom-Himes, L. T. Smith, P. Antonson, D. G. Tenen, and K. G. Xanthopoulos. 1997. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc. Natl. Acad. Sci. USA 94:6462–6467.
   PubMedGoogle Scholar
• Yergeau, D. A., C. J. Hetherington, Q. Wang, P. Zhang, A. H. Sharpe, M. Binder, M. Marin-Padilla, D. G. Tenen, N. A. Speck, and D.-E. Zhang. 1997. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat. Genet. 15:303–306.
   PubMed Web of Science ®Google Scholar
• Zhang, D.-E., C. J. Hetherington, D. A. Gonzalez, H. M. Chen, and D. G. Tenen. 1994. Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3. J. Immunol. 153:3276–3284.
   PubMed Web of Science ®Google Scholar
• Zhang, D.-E., C. J. Hetherington, S. Meyers, K. L. Rhoades, C. J. Larson, H.-M. Chen, S. W. Hiebert, and D. G. Tenen. 1996. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell. Biol. 16:1231–1240.
   PubMed Web of Science ®Google Scholar
• Zhang, D.-E., P. Zhang, N. D. Wang, C. J. Hetherington, G. J. Darlington, and D. G. Tenen. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl. Acad. Sci. USA 94:569–574.
   PubMed Web of Science ®Google Scholar