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Cell Growth and Development

Increased Susceptibility to Streptozotocin-Induced β-Cell Apoptosis and Delayed Autoimmune Diabetes in Alkylpurine- DNA-N-Glycosylase-Deficient Mice

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Pages 5605-5613 | Received 15 Dec 2000, Accepted 08 May 2001, Published online: 28 Mar 2023

REFERENCES

  • Bennett, R. A., and A. E. Pegg. 1981. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41:2786–2790.
  • Burkart, V., Z.-Q. Wang, J. Radons, B. Heller, Z. Herceg, L. Stingl, E. F. Wagner, and H. Kolb. 1999. Mice lacking the poly(ADP-ribose)polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat. Med. 5:314–319.
  • Cardinal, J. W., D. J. Allan, and D. P. Cameron. 1998. Poly(ADP-ribose)polymerase activation determines strain sensitivity to streptozotocin-induced β cell death in inbred mice. J. Mol. Endocrinol. 22:65–70.
  • Cardinal, J. W., D. J. Allan, and D. P. Cameron. 1998. Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced β-cell death in inbred mice. Endocrinology 139:2885–2891.
  • Dantzer, F., G. de la Rubia, J. Ménissier-de Murcia, Z. Hostomsky, G. de Murcia, and V. Schreiber. 2000. Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1. Biochemistry 39:7559–7569.
  • Diabetes Epidemiology Research International 1987. Preventing insulin dependent diabetes mellitus: the environmental challenge. Br. Med. J. 295:479–481.
  • Eizirik, D. L., S. Sandler, A. Sener, and W. J. Malaisse. 1988. Defective catabolism of d-glucose and l-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure. Endocrinology 123:1001–1007.
  • Elder, R. H., J. G. Jansen, R. J. Weeks, M. A. Willington, B. Deans, A. J. Watson, K. J. Mynett, J. A. Bailey, D. P. Cooper, J. A. Rafferty, M. C. Heeran, S. W. Wijnhoven, A. A. van Zeeland, and G. P. Margison. 1998. Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate Mol. Cell. Biol. 18:5828–5837.
  • El Ghissassi, F., A. Barbin, J. Nair, and H. Bartsch. 1995. Formation of 1, N6-ethenoadenine and 3, N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chem. Res. Toxicol. 8:278–283.
  • Engelward, B. P., J. M. Allan, A. J. Dreslin, J. D. Kelly, M. M. Wu, and L. D. Samson. 1998. A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome. J. Biol. Chem. 273:5412–5418.
  • Felley-Bosco, E.. 1998. Role of nitric oxide in genotoxicity: implications for carcinogenesis. Cancer Metastasis Rev. 17:25–37.
  • Feutren, G., L. Papoz, R. Assan, B. Vialettes, G. Karsenty, P. Vexiau, H. Du Rostu, M. Rodier, J. Sirmai, A. Lallemand, et al.. 1986. Cyclosporin increases the rate and length of remisions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet ii:119–124.
  • Foo, S. Y., and G. P. Nolan. 1999. NF-κB to the rescue. Trends Genet. 15:229–235.
  • Gepts, W., and G. Lecompte. 1993. The pancreatic islets in diabetes. Am. J. Med. 70:105–115.
  • Gordon, C., A. P. Yates, and D. Davies. 1985. Evidence for a direct action of exogenous insulin on the pancreatic islets of diabetic mice: islet response to insulin preincubation. Diabetologia 28:291–294.
  • Ha, H. C., and S. H. Snyder. 1999. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. USA 96:13978–13982.
  • Ho, E., and T. M. Bray. 1999. Antioxidants, NF-κB activation, and diabetogenesis. Proc. Soc. Exp. Biol. Med. 222:205–213.
  • Hoorens, A., and D. Pipeleers. 1999. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 42:55–59.
  • Jansen, A., M. van Hagen, and H. A. Drexhage. 1995. Defective maturation and function of antigen presenting cells in type 1 diabetes. Lancet 345:491–492.
  • Kerr, J. F. R., G. C. Gobe, C. M. Winterford, and B. V. Harmon. 1995. Cell death, anatomical methods in cell death. Methods Cell Biol. 46:1–26.
  • Kissane, J. M., and E. Robins. 1958. The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system. J. Biol. Chem. 233:184–188.
  • Lake, S. P., J. Anderson, J. Chamberlain, S. J. Gardner, P. R. F. Bell, and R. F. L. James. 1987. Bovine serum albumin density gradient isolation of rat pancreatic islets. Transplantation 43:805–808.
  • Larson, K., J. Sahm, R. Shenkar, and B. Strauss. 1985. Methylation-induced blocks to in vitro DNA replication. Mutat. Res. 150:77–84.
  • Margison, G. P., and P. J. O'Connor. 1973. Biological implications of the instability of the N-glycosidic bond of 3-methyldeoxyadenosine in DNA. Biochim. Biophys. Acta 331:349–356.
  • Masutani, M., H. Suzuki, N. Kamada, M. Watanabe, O. Ueda, T. Nozaki, K. Jishage, T. Watanabe, T. Sugimoto, H. Nakagama, T. Ochiya, and T. Sugimura. 1999. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. USA 96:2301–2304.
  • Nair, J., A. Gal, S. Tamir, S. R. Tannenbaum, G. N. Wogan, and H. Bartsch. 1998. Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide. Carcinogenesis 19:2081–2084.
  • O'Brien, B. A., B. V. Harmon, D. P. Cameron, and D. J. Allan. 1996. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J. Pathol. 178:176–181.
  • O'Brien, B. A., B. V. Harmon, D. P. Cameron, and D. J. Allan. 1997. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:1–8.
  • O'Brien, B. A., B. V. Harmon, D. P. Cameron, and D. J. Allan. 2000. Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis. J. Pathol. 191:86–92.
  • Okamoto, H.. 1985. Molecular basis of experimental diabetes: degeneration, oncogenesis and regeneration of pancreatic B-cells of islets of langerhans. Bioessays 2:15–21.
  • Oliver, F. J., J. Ménissier-de Murcia, C. Nacci, P. Decker, R. Andriantsitohaina, S. Muller, and G. de Murcia. 1999. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 18:4446–4454.
  • Orlow, S., R. Yasunami, C. Boitard, and J. F. Bach. 1987. Early induction of diabetes in NOD mice by streptozotocin. C. R. Acad. Sci. Sec. III 304:77–78.
  • Pieper, A. A., D. J. Brat, D. K. Krug, C. C. Watkins, A. Gupta, S. Blackshaw, A. Verma, Z.-Q. Wang, and S. H. Snyder. 1999. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. USA 96:3059–3064.
  • Poynter, M. E., and R. A. Daynes. 1998. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273:32833–32841.
  • Rabinovitch, A., and W. L. Suarez-Pinzon. 1998. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol. 55:1139–1149.
  • Rakieten, N., B. S. Gordon, A. Beaty, D. A. Cooney, R. D. Davis, and P. S. Schein. 1971. Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide. Proc. Soc. Exp. Biol. Med. 137:280–283.
  • Saffhill, R., G. P. Margison, and P. J. O'Connor. 1985. Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta 823:111–145.
  • Shall, S., and G. de Murcia. 2000. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?. Mutat. Res. 460:1–15.
  • Trucco, C., F. J. Oliver, G. de Murcia, and J. Ménissier-de Murcia. 1998. DNA repair defect in poly(ADP-ribose)polymerase-deficient cell lines. Nucleic Acids Res. 26:2644–2649.
  • Yamagami, T., A. Miwa, S. Takasawa, H. Yamamoto, and H. Okamoto. 1985. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 45:1845–1849.

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