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Mammalian Genetic Models with Minimal or Complex Phenotypes

Gene Targeting Reveals a Crucial Role forMTG8 in the Gut

, &
Pages 5658-5666 | Received 07 Feb 2001, Accepted 23 May 2001, Published online: 28 Mar 2023

REFERENCES

  • Albright, S. R., and R. Tjian. 2000. TAFs revisited: more data reveal new twists and confirm old ideas. Gene 242:1–13.
  • Beck, F., F. Tata, and K. Chawengsaksophak. 2000. Homeobox genes and gut development. Bioessays 22:431–441.
  • Bienz, M.. 1994. Homeotic genes and positional signalling in the Drosophila viscera. Trends Genet. 10:22–26.
  • Calabi, F., and V. Cilli. 1998. CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics 52:332–341.
  • Chawengsaksophak, K., R. James, V. E. Hammond, F. Kontgen, and F. Beck. 1997. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386:84–87.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156–159.
  • Davis, J. N., B. J. Williams, J. T. Herron, F. J. Galiano, and S. Meyers. 1999. ETO-2, a new member of the ETO-family of nuclear proteins. Oncogene 18:1375–1383.
  • Erickson, P. F., G. Dessev, R. S. Lasher, G. Philips, M. Robinson, and H. A. Drabkin. 1996. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors—implications for t(8;21) leukemogenesis and monitoring residual disease. Blood 88:1813–1823.
  • Feinstein, P. G., K. Kornfeld, D. S. Hogness, and R. S. Mann. 1995. Identification of homeotic target genes in Drosophila melanogaster including nervy, a protooncogene homolog. Genetics 140:573–586.
  • Fracchiolla, N. S., G. Colombo, P. Finelli, A. T. Maiolo, and A. Neri. 1998. EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias. Blood 92:3481–3484.
  • Gelmetti, V., J. S. Zhang, M. Fanelli, S. Minucci, P. G. Pelicci, and M. A. Lazar. 1998. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol. Cell. Biol. 18:7185–7191.
  • Green, F. R., P. Greenwell, L. Dickson, B. Griffiths, J. Noades, and D. M. Swallow. 1988. Expression of the ABH, Lewis and related antigens on the glycoproteins of the jejunal brush border. Subcellular biochemistry. J. R. Harris. 12:119–153. Plenum Publishing, New York, N.Y
  • Kaestner, K. H., D. G. Silberg, P. G. Traber, and G. Schutz. 1997. The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 11:1583–1595.
  • Kagoshima, H., K. Shigesada, M. Satake, Y. Ito, H. Miyoshi, M. Ohki, M. Pepling, and P. Gergen. 1993. The runt domain identifies a new family of heteromeric transcriptional regulators. Trends Genet. 9:338–341.
  • Kitabayashi, I., K. Ida, F. Morohoshi, A. Yokoyama, N. Mitsuhashi, K. Shimizu, N. Nomura, Y. Hayashi, and M. Ohki. 1998. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. Mol. Cell. Biol. 18:846–858.
  • Komori, T., H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R. T. Bronson, Y. H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, and T. Kishimoto. 1997. Targeted disruption of CBFA1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755–764.
  • Korinek, V., N. Barker, P. Moerer, E. van Donselaar, G. Huls, P. J. Peters, and H. Clevers. 1998. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:379–383.
  • Le, X. F., D. Claxton, S. Kornblau, Y. H. Fan, Z. M. Mu, and K. S. Chang. 1998. Characterization of the ETO and AML1-ETO proteins involved in the 8;21 translocation in acute myelogenous leukemia. Eur. J. Haematol. 60:217–225.
  • Lutterbach, B., J. J. Westendorf, B. Linggi, A. Patten, M. Moniwa, J. R. Davie, K. D. Huynh, V. J. Bardwell, R. M. Lavinsky, M. G. Rosenfeld, C. Glass, E. Seto, and S. W. Hiebert. 1998. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol. Cell. Biol. 18:7176–7184.
  • Miyoshi, H., T. Kozu, K. Shimizu, K. Enomoto, N. Maseki, Y. Kaneko, N. Kamada, and M. Ohki. 1993. The t(8;21) translocation in acute myeloid-leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 12:2715–2721.
  • Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8;21) breakpoints on chromosome-21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88:10431–10434.
  • Mundlos, S., F. Otto, C. Mundlos, J. B. Mulliken, A. S. Aylsworth, S. Albright, D. Lindhout, W. G. Cole, W. Henn, J. Knoll, M. J. Owen, R. Mertelsmann, B. U. Zabel, and B. R. Olsen. 1997. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89:773–779.
  • Okuda, T., J. Vandeursen, S. W. Hiebert, G. Grosveld, and J. R. Downing. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321–330.
  • Otto, F., A. P. Thornell, T. Crompton, A. Denzel, K. C. Gilmour, I. R. Rosewell, G. Stamp, R. Beddington, S. Mundlos, B. R. Olsen, P. B. Selby, and M. J. Owen. 1997. CBFA1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765–771.
  • Pabst, O., R. Zweigerdt, and H. H. Arnold. 1999. Targeted disruption of the homeobox transcription factor Nkx2–3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126:2215–2225.
  • Rabbitts, T. H.. 1999. Perspective: chromosomal translocations can affect genes controlling gene expression and differentiation—why are these functions targeted?. J. Pathol. 187:39–42.
  • Ramalho-Santos, M., D. A. Melton, and A. P. McMahon. 2000. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763–2772.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, New York, N.Y
  • Sanes, J. R., J. L. Rubenstein, and J. F. Nicolas. 1986. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 5:3133–3142.
  • Saunders, M. J., K. Tobal, S. Keeney, and J. Yin. 1996. Expression of diverse AML1/MTG8 transcripts is a consistent feature in acute myeloid-leukemia with t(8;21) irrespective of disease phase. Leukemia 10:1139–1142.
  • Skandalakis, J. E., S. W. Gray, R. Ricketts, and D. D. Richardson. 1994. The small intestine. Embryology for surgeons, 2nd ed. J. E. Skandalakis, and S. W. Gray. 200–212. The Williams & Wilkins Co., Baltimore, Md
  • Song, W. J., M. G. Sullivan, R. D. Legare, S. Hutchings, X. Tan, D. Kufrin, J. Ratajczak, I. C. Resende, C. Haworth, R. Hock, M. Loh, C. Felix, D. C. Roy, L. Busque, D. Kurnit, C. Willman, A. M. Gewirtz, N. A. Speck, J. H. Bushweller, F. P. Li, K. Gardiner, M. Poncz, J. M. Maris, and D. G. Gilliland. 1999. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat. Genet. 23:166–175.
  • Speck, N. A., T. Stacy, Q. Wang, T. North, T. L. Gu, J. Miller, M. Binder, and M. MarinPadilla. 1999. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 59:S1789–S1793.
  • Thomas, K. R., and M. R. Capecchi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503–512.
  • Tighe, J. E., and F. Calabi. 1994. Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative(8) chromosome in the t(8;21) of acute myeloid-leukemia M2. Blood 84:2115–2121.
  • Wang, J. X., T. Hoshino, R. L. Redner, S. Kajigaya, and J. M. Liu. 1998. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc. Natl. Acad. Sci. USA 95:10860–10865.
  • Wang, Q., T. Stacy, M. Binder, M. Marinpadilla, A. H. Sharpe, and N. A. Speck. 1996. Disruption of the CBFA2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl. Acad. Sci. USA 93:3444–3449.
  • Warren, A. J., W. H. Colledge, M. B. Carlton, M. J. Evans, A. J. Smith, and T. H. Rabbitts. 1994. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 78:45–57.
  • Wells, J. M., and D. A. Melton. 1999. Vertebrate endoderm development. Annu. Rev. Cell. Dev. Biol. 15:393–410.
  • Wolford, J. K., and M. Prochazka. 1998. Structure and expression of the human MTG8/ETO gene. Gene 212:103–109.

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