A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse

REFERENCES

• Ahmad, I., P. Zaqouras, and S. Artavanis-Tsakonas. 1995. Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech. Dev. 53:73–85.
   PubMedGoogle Scholar
• Amado, M., R. Almeida, F. Carneiro, S. B. Levery, E. H. Holmes, M. Nomoto, M. A. Hollingsworth, H. Hassan, T. Schwientek, P. A. Nielsen, E. P. Bennett, and H. Clausen. 1998. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family. J. Biol. Chem. 273:12770–12778.
   PubMedGoogle Scholar
• Amado, M., R. Almeida, T. Schwientek, and H. Clausen. 1999. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim. Biophys. Acta 1473:35–53.
   PubMed Web of Science ®Google Scholar
• Artavanis-Tsakonas, S., K. Matsuno, and M. E. Fortini. 1995. Notch signaling. Science 268:225–232.
   PubMed Web of Science ®Google Scholar
• Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1997. Current protocols in molecular biology. John Wiley and Sons, New York, N.Y
   Google Scholar
• Bailey, A. M., and J. W. Posakony. 1995. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9:2609–2622.
   PubMed Web of Science ®Google Scholar
• Bao, Z. Z., and C. L. Cepko. 1997. The expression and function of Notch pathway genes in the developing rat eye. J. Neurosci. 17:1425–1434.
   PubMedGoogle Scholar
• Berezovska, O., P. McLean, R. Knowles, M. Frosh, F. M. Lu, S. E. Lux, and B. T. Hyman. 1999. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience 93:433–439.
   PubMed Web of Science ®Google Scholar
• Bruckner, K., L. Perez, H. Clausen, and S. Cohen. 2000. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406:411–415.
   PubMed Web of Science ®Google Scholar
• Campbell, R. M., M. Metzler, M. Granovsky, J. W. Dennis, and J. D. Marth. 1995. Complex asparagine-linked oligosaccharides in Mgat1-null embryos. Glycobiology 5:535–543.
   PubMedGoogle Scholar
• Cohen, B., A. Bashirullah, L. Dagnino, C. Campbell, W. W. Fisher, C. C. Leow, E. Whiting, D. Ryan, D. Zinyk, G. Boulianne, C. C. Hui, B. Gallie, R. A. Phillips, H. D. Lipshitz, and S. E. Egan. 1997. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat. Genet. 16:283–288.
   PubMedGoogle Scholar
• Cole, S. E., M. S. Mao, S. H. Johnston, and T. F. Vogt. 2001. Identification, expression analysis, and mapping of B3galt6, a putative galactosyltransferase gene with similarity to Drosophila brainiac. Mamm. Genome 12:177–179.
   PubMedGoogle Scholar
• de Celis, J. F., J. de Celis, P. Ligoxygakis, A. Preiss, C. Delidakis, and S. Bray. 1996. Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122:2719–2728.
   PubMed Web of Science ®Google Scholar
• Deng, C., A. Wynshaw-Boris, F. Zhou, A. Kuo, and P. Leder. 1996. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84:911–921.
   PubMed Web of Science ®Google Scholar
• Deng, C. X., A. Wynshaw-Boris, M. M. Shen, C. Daugherty, D. M. Ornitz, and P. Leder. 1994. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8:3045–3057.
   PubMed Web of Science ®Google Scholar
• Dennis, J. W., M. Granovsky, and C. E. Warren. 1999. Protein glycosylation in development and disease. Bioessays 21:412–421.
   PubMed Web of Science ®Google Scholar
• Fleming, R. J., Y. Gu, and N. A. Hukriede. 1997. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124:2973–2981.
   PubMed Web of Science ®Google Scholar
• Goode, S., M. Meinick, T. B. Chou, and N. Perrimon. 1996. The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis. Development 122:3863–3879.
   PubMedGoogle Scholar
• Goode, S., M. Morgan, Y. P. Liang, and A. P. Mahowald. 1996. Brainiac encodes a novel, putative secreted protein that cooperates with Grk TGF alpha in the genesis of the follicular epithelium. Dev. Biol. 178:35–50.
   PubMedGoogle Scholar
• Goode, S., and N. Perrimon. 1997. Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development. Cold Spring Harbor Symp. Quant. Biol. 62:177–184.
   PubMedGoogle Scholar
• Goode, S., D. Wright, and A. P. Mahowald. 1992. The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity. Development 116:177–192.
   PubMedGoogle Scholar
• Greenwald, I.. 1998. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12:1751–1762.
   PubMed Web of Science ®Google Scholar
• Gridley, T.. 1997. Notch signaling in vertebrate development and disease. Mol. Cell. Neurosci. 9:103–108.
   PubMed Web of Science ®Google Scholar
• Hennet, T., A. Dinter, P. Kuhnert, T. S. Mattu, P. M. Rudd, and E. G. Berger. 1998. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta-1,3-galactosyltransferase genes. J. Biol. Chem. 273:58–65.
   PubMedGoogle Scholar
• Hicks, C., S. H. Johnston, G. diSibio, A. Collazo, T. F. Vogt, and G. Weinmaster. 2000. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat. Cell Biol. 2:515–520.
   PubMedGoogle Scholar
• Ihara, Y., Y. Sakamoto, M. Mihara, K. Shimizu, and N. Taniguchi. 1997. Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor. J. Biol. Chem. 272:9629–9634.
   PubMedGoogle Scholar
• Ioffe, E., and P. Stanley. 1994. Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc. Natl. Acad. Sci. USA 91:728–732.
   PubMed Web of Science ®Google Scholar
• Irvine, K. D.. 1999. Fringe, Notch, and making developmental boundaries. Curr. Opin. Genet. Dev. 9:434–441.
   PubMedGoogle Scholar
• Irvine, K. D., and E. Wieschaus. 1994. fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79:595–606.
   PubMedGoogle Scholar
• Ishibashi, M., S. L. Ang, K. Shiota, S. Nakanishi, R. Kageyama, and F. Guillemot. 1995. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9:3136–3148.
   PubMed Web of Science ®Google Scholar
• Jennings, B., A. Preiss, C. Delidakis, and S. Bray. 1994. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120:3537–3548.
   PubMed Web of Science ®Google Scholar
• Jiang, R., Y. Lan, H. D. Chapman, C. Shawber, C. R. Norton, D. V. Serreze, G. Weinmaster, and T. Gridley. 1998. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12:1046–1057.
   PubMedGoogle Scholar
• Johnson, J. E., K. Zimmerman, T. Saito, and D. J. Anderson. 1992. Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Development 114:75–87.
   PubMedGoogle Scholar
• Kidd, S., T. Lieber, and M. W. Young. 1998. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 12:3728–3740.
   PubMedGoogle Scholar
• Lardelli, M., R. Williams, and U. Lendahl. 1995. Notch-related genes in animal development. Int. J. Dev. Biol. 39:769–780.
   PubMedGoogle Scholar
• Laufer, E., R. Dahn, O. E. Orozco, C. Y. Yeo, J. Pisenti, D. Henrique, U. K. Abbott, J. F. Fallon, and C. Tabin. 1997. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature 386:366–373.
   PubMedGoogle Scholar
• Lecourtois, M., and F. Schweisguth. 1995. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9:2598–2608.
   PubMed Web of Science ®Google Scholar
• Lindsell, C. E., J. Boulter, G. diSibio, A. Gossler, and G. Weinmaster. 1996. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol. Cell. Neurosci. 8:14–27.
   PubMed Web of Science ®Google Scholar
• Metzler, M., A. Gertz, M. Sarkar, H. Schachter, J. W. Schrader, and J. D. Marth. 1994. Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. EMBO J. 13:2056–2065.
   PubMed Web of Science ®Google Scholar
• Moloney, D. J., V. M. Panin, S. H. Johnston, J. Chen, L. Shao, R. Wilson, Y. Wang, P. Stanley, K. D. Irvine, R. S. Haltiwanger, and T. F. Vogt. 2000. Fringe is a glycosyltransferase that modifies Notch. Nature 406:369–375.
   PubMed Web of Science ®Google Scholar
• Munro, S., and M. Freeman. 2000. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr. Biol. 10:813–820.
   PubMed Web of Science ®Google Scholar
• Nye, J. S., R. Kopan, and R. Axel. 1994. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120:2421–2430.
   PubMedGoogle Scholar
• Panin, V. M., V. Papayannopoulos, R. Wilson, and K. D. Irvine. 1997. Fringe modulates Notch-ligand interactions. Nature 387:908–912.
   PubMed Web of Science ®Google Scholar
• Priatel, J. J., M. Sarkar, H. Schachter, and J. D. Marth. 1997. Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction. Glycobiology 7:45–56.
   PubMedGoogle Scholar
• Robey, E.. 1997. Notch in vertebrates. Curr. Opin. Genet. Dev. 7:551–557.
   PubMedGoogle Scholar
• Rodriguez-Esteban, C., J. W. Schwabe, J. De La Pena, B. Foys, B. Eshelman, and J. C. Belmonte. 1997. Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb. Nature 386:360–366.
   PubMedGoogle Scholar
• Sestan, N., S. Artavanis-Tsakonas, and P. Rakic. 1999. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286:741–746.
   PubMed Web of Science ®Google Scholar
• Shawber, C., J. Boulter, C. E. Lindsell, and G. Weinmaster. 1996. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev. Biol. 180:370–376.
   PubMedGoogle Scholar
• Sidow, A., M. S. Bulotsky, A. W. Kerrebrock, R. T. Bronson, M. J. Daly, M. P. Reeve, T. L. Hawkins, B. W. Birren, R. Jaenisch, and E. S. Lander. 1997. Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 389:722–725.
   PubMedGoogle Scholar
• Struhl, G., and A. Adachi. 1998. Nuclear access and action of notch in vivo. Cell 93:649–660.
   PubMed Web of Science ®Google Scholar
• Swiatek, P. J., C. E. Lindsell, F. F. del Amo, G. Weinmaster, and T. Gridley. 1994. Notch1 is essential for postimplantation development in mice. Genes Dev. 8:707–719.
   PubMed Web of Science ®Google Scholar
• Weinmaster, G.. 1997. The ins and outs of notch signaling. Mol. Cell. Neurosci. 9:91–102.
   PubMed Web of Science ®Google Scholar
• Xu, T., L. A. Caron, R. G. Fehon, and S. Artavanis-Tsakonas. 1992. The involvement of the Notch locus in Drosophila oogenesis. Development 115:913–922.
   PubMedGoogle Scholar
• Yoshimura, M., Y. Ihara, Y. Matsuzawa, and N. Taniguchi. 1996. Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis. J. Biol. Chem. 271:13811–13815.
   PubMed Web of Science ®Google Scholar
• Yoshimura, M., A. Nishikawa, Y. Ihara, S. Taniguchi, and N. Taniguchi. 1995. Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. Proc. Natl. Acad. Sci. USA 92:8754–8758.
   PubMed Web of Science ®Google Scholar
• Yuan, Y. P., J. Schultz, M. Mlodzik, and P. Bork. 1997. Secreted fringe-like signaling molecules may be glycosyltransferases. Cell 88:9–11.
   PubMedGoogle Scholar