Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene Expression

REFERENCES

• Bailly, A., G. Spath, V. Bender, and M. C. Weiss. 1998. Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell. J. Cell Sci. 111:2411–2421.
   PubMedGoogle Scholar
• Barbacci, E., M. Reber, M. O. Ott, C. Breillat, F. Huetz, and S. Cereghini. 1999. Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Development 126:4795–4805.
   PubMed Web of Science ®Google Scholar
• Bulla, G. A.. 1997. Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids. Nucleic Acids Res. 25:2501–2508.
   PubMedGoogle Scholar
• Butler, A. J., and M. G. Parker. 1995. COUP-TF II homodimers are formed in preference to heterodimers with RXR alpha or TR beta in intact cells. Nucleic Acids Res. 23:4143–4150.
   PubMedGoogle Scholar
• Cereghini, S., M. O. Ott, S. Power, and M. Maury. 1992. Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development 116:783–797.
   PubMed Web of Science ®Google Scholar
• Chartier, F. L., J. P. Bossu, V. Laudet, J. C. Fruchart, and B. Laine. 1994. Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver. Gene 147:269–272.
   PubMedGoogle Scholar
• Chen, W. S., K. Manova, D. C. Weinstein, S. A. Duncan, A. S. Plump, V. R. Prezioso, R. F. Bachvarova, and J. E. Darnell. 1994. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8:2466–2477.
   PubMed Web of Science ®Google Scholar
• Coffinier, C., D. Thepot, C. Babinet, M. Yaniv, and J. Barra. 1999. Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development 126:4785–4794.
   PubMed Web of Science ®Google Scholar
• Dell, H., and M. Hadzopoulou-Cladaras. 1999. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. J. Biol. Chem. 274:9013–9021.
   PubMed Web of Science ®Google Scholar
• De Simone, V., L. De Magistris, D. Lazzaro, J. Gerstner, P. Monaci, A. Nicosia, and R. Cortese. 1991. LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J. 10:1435–1443.
   PubMed Web of Science ®Google Scholar
• Drewes, T., S. Senkel, B. Holewa, and G. U. Ryffel. 1996. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol. Cell. Biol. 16:925–931.
   PubMed Web of Science ®Google Scholar
• Duncan, S. A., K. Manova, W. S. Chen, P. Hoodless, D. C. Weinstein, R. F. Bachvarova, and J. E. Darnell. 1994. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl. Acad. Sci. USA 91:7598–7602.
   PubMed Web of Science ®Google Scholar
• Duncan, S. A., M. A. Navas, D. Dufort, J. Rossant, and M. Stoffel. 1998. Regulation of a transcription factor network required for differentiation and metabolism. Science 281:692–695.
   PubMed Web of Science ®Google Scholar
• Duncan, S. A.. 2000. Transcriptional regulation of liver development. Dev. Dyn. 219:131–142.
   PubMed Web of Science ®Google Scholar
• Gao, X., T. Sedgwick, Y. B. Shi, and T. Evans. 1998. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18:2901–2911.
   PubMedGoogle Scholar
• Gaub, M. P., C. Rochette-Egly, Y. Lutz, S. Ali, H. Matthes, I. Scheuer, and P. Chambon. 1992. Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation. Exp. Cell Res. 201:335–346.
   PubMedGoogle Scholar
• Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez. 2001. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21:1393–1403.
   PubMed Web of Science ®Google Scholar
• Holewa, B., E. P. Strandmann, D. Zapp, P. Lorenz, and G. U. Ryffel. 1996. Transcriptional hierarchy in Xenopus embryogenesis: HNF4 a maternal factor involved in the developmental activation of the gene encoding the tissue specific transcription factor HNF1 alpha (LFB1). Mech. Dev. 54:45–57.
   PubMedGoogle Scholar
• Jiang, G., L. Nepomuceno, Q. Yang, and F. M. Sladek. 1997. Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4. Arch. Biochem. Biophys. 340:1–9.
   PubMedGoogle Scholar
• Jimenez-Lara, A. M., and A. Aranda. 1999. Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity. J. Biol. Chem. 274:13503–13510.
   PubMedGoogle Scholar
• Kritis, A. A., A. Argyrokastritis, N. K. Moschonas, S. Power, N. Katrakili, V. I. Zannis, S. Cereghini, and I. Talianidis. 1996. Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4. Gene 173:275–280.
   PubMedGoogle Scholar
• Kritis, A. A., E. Ktistaki, D. Barda, V. I. Zannis, and I. Talianidis. 1993. An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression. Nucleic Acids Res. 21:5882–5889.
   PubMedGoogle Scholar
• Ktistaki, E., N. T. Ktistakis, E. Papadogeorgaki, and I. Talianidis. 1995. Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential. Proc. Natl. Acad. Sci. USA 92:9876–9880.
   PubMed Web of Science ®Google Scholar
• Ktistaki, E., and I. Talianidis. 1997. Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science 277:109–112.
   PubMedGoogle Scholar
• Ktistaki, E., and I. Talianidis. 1997. Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression. Mol. Cell. Biol. 17:2790–2797.
   PubMed Web of Science ®Google Scholar
• Kuo, C. J., P. B. Conley, L. Chen, F. M. Sladek, J. E. Darnell Jr., and G. R. Crabtree. 1992. A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355:457–461.
   PubMed Web of Science ®Google Scholar
• Ladias, J. A., and S. K. Karathanasis. 1991. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251:561–565.
   PubMed Web of Science ®Google Scholar
• Lahooti, H., R. White, P. S. Danielian, and M. G. Parker. 1994. Characterization of ligand-dependent phosphorylation of the estrogen receptor. Mol. Endocrinol. 8:182–188.
   PubMedGoogle Scholar
• Lai, E., V. R. Prezioso, E. Smith, O. Litvin, R. H. Costa, and J. E. Darnell. 1990. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev. 4:1427–1436.
   PubMed Web of Science ®Google Scholar
• Landry, C., F. Clotman, T. Hioki, H. Oda, J. J. Picard, F. P. Lemaigre, and G. G. Rousseau. 1997. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev. Biol. 192:247–257.
   PubMedGoogle Scholar
• Lemaigre, F. P., S. M. Durviaux, O. Truong, V. J. Lannoy, J. J. Hsuan, and G. G. Rousseau. 1996. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc. Natl. Acad. Sci. USA 93:9460–9664.
   PubMedGoogle Scholar
• Li, J., G. Ning, and S. A. Duncan. 2000. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev. 14:464–474.
   PubMed Web of Science ®Google Scholar
• Lu, T. T., M. Makishima, J. J. Repa, K. Schoonjans, T. A. Kerr, J. Auwerx, and D. J. Mangelsdorf. 2000. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell 6:507–515.
   PubMed Web of Science ®Google Scholar
• Magee, T. R., Y. Cai, M. E. El-Houseini, J. Locker, and Y. J. Wan. 1998. Retinoic acid mediates down-regulation of the alpha-fetoprotein gene through decreased expression of hepatocyte nuclear factors. J. Biol. Chem. 273:30024–30032.
   PubMedGoogle Scholar
• Morrisey, E. E., Z. Tang, K. Sigrist, M. M. Lu, F. Jiang, H. S. Ip, and M. S. Parmacek. 1998. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 12:3579–3590.
   PubMed Web of Science ®Google Scholar
• Orlando, V., H. Strutt, and R. Paro. 1997. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205–214.
   PubMed Web of Science ®Google Scholar
• Pare, J. F., S. Roy, L. Galarneau, and L. Belanger. 2001. The mouse fetoprotein transcription factor (ftf) gene promoter is regulated by three gata elements with tandem e box and nkx motifs, and ftf in turn activates the hnf3beta, hnf4alpha, and hnf1alpha gene promoters. J. Biol. Chem. 276:13136–13144.
   PubMedGoogle Scholar
• Pontoglio, M., J. Barra, M. Hadchouel, A. Doyen, C. Kress, J. P. Bach, C. Babinet, and M. Yaniv. 1996. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84:575–585.
   PubMed Web of Science ®Google Scholar
• Price, J. A., S. C. Fossey, M. M. Sale, C. S. Brewer, B. I. Freedman, J. P. Wuerth, and D. W. Bowden. 2000. Analysis of the HNF4 alpha gene in Caucasian type II diabetic nephropathic patients. Diabetologia 43:364–372.
   PubMedGoogle Scholar
• Qian, A., Y. Cai, T. R. Magee, and Y. J. Wan. 2000. Identification of retinoic acid-responsive elements on the HNF1alpha and HNF4alpha genes. Biochem. Biophys. Res. Commun. 276:837–842.
   PubMed Web of Science ®Google Scholar
• Rich, B. E., and J. A. Steitz. 1987. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Mol. Cell. Biol. 7:4065–4074.
   PubMed Web of Science ®Google Scholar
• Sladek, F. M., W. M. Zhong, E. Lai, and J. E. Darnell. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353–2365.
   PubMed Web of Science ®Google Scholar
• Sladek, F. M., M. D. Ruse, L. Nepomuceno, S. M. Huang, and M. R. Stallcup. 1999. Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4α1. Mol. Cell. Biol. 19:6509–6522.
   PubMed Web of Science ®Google Scholar
• Soutoglou, E., N. Katrakili, and I. Talianidis. 2000. Acetylation regulates transcription factor activity at multiple levels. Mol. Cell 5:745–751.
   PubMed Web of Science ®Google Scholar
• Spath, G. F., and M. C. Weiss. 1997. Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. Mol. Cell. Biol. 17:1913–1922.
   PubMed Web of Science ®Google Scholar
• Spath, G. F., and M. C. Weiss. 1998. Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells. J. Cell Biol. 140:935–946.
   PubMed Web of Science ®Google Scholar
• Taraviras, S., A. P. Monaghan, G. Schutz, and G. Kelsey. 1994. Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev. 48:67–79.
   PubMed Web of Science ®Google Scholar
• Tian, J. M., and U. Schibler. 1991. Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Dev. 5:2225–2234.
   PubMed Web of Science ®Google Scholar
• Tolon, R. M., A. I. Castillo, and A. Aranda. 1998. Activation of the prolactin gene by peroxisome proliferator-activated receptor-alpha appears to be DNA binding-independent. J. Biol. Chem. 273:26652–26661.
   PubMed Web of Science ®Google Scholar
• Viollet, B., A. Kahn, and M. Raymondjean. 1997. Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4. Mol. Cell. Biol. 17:4208–4219.
   PubMed Web of Science ®Google Scholar
• Willy, P. J., K. Umesono, E. S. Ong, R. M. Evans, R. A. Heyman, and D. J. Mangelsdorf. 1995. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1033–1045.
   PubMed Web of Science ®Google Scholar
• Yamagata, K., H. Furuta, N. Oda, P. J. Kaisaki, S. Menzel, N. J. Cox, S. S. Fajans, S. Signorini, M. Stoffel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384:458–460.
   PubMed Web of Science ®Google Scholar
• Yoshida, E., S. Aratani, H. Itou, M. Miyagishi, M. Takiguchi, T. Osumu, K. Murakami, and A. Fukamizu. 1997. Functional association between CBP and HNF4 in trans-activation. Biochem. Biophys. Res. Commun. 241:664–669.
   PubMedGoogle Scholar
• Zhong, W., J. Mirkovitch, and J. E. Darnell. 1994. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol. Cell. Biol. 14:7276–7284.
   PubMed Web of Science ®Google Scholar