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Cell Growth and Development

Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src

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Pages 7641-7652 | Received 09 May 2001, Accepted 23 Aug 2001, Published online: 28 Mar 2023

REFERENCES

  • Alexandropoulos, K., and D. Baltimore. 1996. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin. Genes Dev. 10:1341–1355.
  • Almeida, E. A., D. Ilic, Q. Han, C. R. Hauck, F. Jin, H. Kawakatsu, D. D. Schlaepfer, and C. H. Damsky. 2000. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase. J. Cell Biol. 149:741–754.
  • Astier, A., H. Avraham, S. N. Manie, J. Groopman, T. Canty, S. Avraham, and A. S. Freedman. 1997. The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after β1 integrin stimulation in B cells and binds to p130cas. J. Biol. Chem. 272:228–232.
  • Astier, A., S. N. Manie, H. Avraham, H. Hirai, S. F. Law, Y. Zhang, E. A. Golemis, Y. Fu, B. J. Druker, N. Haghayeghi, A. S. Freedman, and S. Avraham. 1997. The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J. Biol. Chem. 272:19719–19724.
  • Auvinen, M., A. Paasinen-Sohns, H. Hirai, L. C. Andersson, and E. Hölttä. 1995. Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130Cas. Mol. Cell. Biol. 15:6513–6525.
  • Bouton, A. H., and M. R. Burnham. 1997. Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies. Hybridoma 16:403–411.
  • Boyle, W. J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:110–149.
  • Brinkman, A., S. van der Flier, E. M. Kok, and L. C. J. Dorssers. 2000. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J. Natl. Cancer Inst. 92:112–120.
  • Burnham, M. R., M. T. Harte, and A. H. Bouton. 1999. The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interactions but has no effect on cellular transformation. Mol. Carcinog. 26:20–31.
  • Burnham, M. R., M. T. Harte, A. Richardson, J. T. Parsons, and A. H. Bouton. 1996. The identification of p130cas-binding proteins and their role in cellular transformation. Oncogene 12:2467–2472.
  • Burnham, M. R., P. J. Bruce-Staskal, M. T. Harte, C. L. Weidow, A. Ma, S. A. Weed, and A. H. Bouton. 2000. Regulation of c-Src activity and function by the adaptor CAS. Mol. Cell. Biol. 20:5865–5878.
  • Calalb, M. B., T. R. Polte, and S. K. Hanks. 1995. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src-family kinases. Mol. Cell. Biol. 15:954–963.
  • Cantley, L. C., and Z. Songyang. 1994. Specificity in recognition of phosphopeptides by src-homology 2 domains. J. Cell Sci. Suppl. 18:121–126.
  • Cary, L. A., D. C. Han, T. R. Polte, S. K. Hanks, and J. L. Guan. 1998. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J. Cell Biol. 140:211–221.
  • Cheresh, D. A., J. Leng, and R. L. Klemke. 1999. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J. Cell Biol. 146:1107–1116.
  • Cho, S. Y., and R. L. Klemke. 2000. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J. Cell Biol. 149:223–236.
  • Dolfi, F., M. Garcia-Guzman, M. Ojaniemi, H. Nakamura, M. Matsuda, and K. Vuori. 1998. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. USA 95:15394–15399.
  • Garton, A. J., M. R. Burnham, A. H. Bouton, and N. K. Tonks. 1997. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene 15:877–885.
  • Gotoh, T., S. Hattori, S. Nakamura, H. Kitayama, M. Noda, Y. Takai, K. Kaibuchi, H. Matsui, O. Hatase, H. Takahashi, T. Kurata, and M. Matsuda. 1995. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 15:6746–6753.
  • Guan, K. L., and J. E. Dixon. 1991. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192:262–267.
  • Hamasaki, K., T. Mimura, N. Morino, H. Furuya, T. Nakamoto, S. I. Aizawa, C. Morimoto, Y. Yazaki, H. Hirai, and Y. Nojima. 1996. Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas. Biochem. Biophys. Res. Commun. 222:338–343.
  • Harte, M. T., J. D. Hildebrand, M. R. Burnham, A. H. Bouton, and J. T. Parsons. 1996. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem. 271:13649–13655.
  • Hasegawa, H., E. Kiyokawa, S. Tanaka, K. Nagashima, N. Gotoh, M. Shibuya, T. Kurata, and M. Matsuda. 1996. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol. 16:1770–1776.
  • Honda, H., H. Oda, T. Nakamoto, Z. Honda, R. Sakai, T. Suzuki, T. Saito, K. Nakamura, K. Nakao, T. Isikawa, M. Katsuki, Y. Yazaki, and H. Hirai. 1998. Ćardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat. Genet. 19:361–365.
  • Honda, H., T. Nakamoto, R. Sakai, and H. Hirai. 1999. P130Cas, an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts. Biochem. Biophys. Res. Commun. 262:25–30.
  • Ishino, M., T. Ohba, H. Sasaki, and T. Sasaki. 1995. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene 11:2331–2338.
  • Kanner, S. B., A. B. Reynolds, R. R. Vines, and J. T. Parsons. 1990. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc. Natl. Acad. Sci. USA 87:3328–3332.
  • Kiyokawa, E., Y. Hashimoto, S. Kobayashi, H. Sugimura, T. Kurata, and M. Matsuda. 1998. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12:3331–3336.
  • Klemke, R. L., J. Leng, R. Molander, P. C. Brooks, K. Vuori, and D. A. Cheresh. 1998. CAS/Crk coupling serves as a “molecular switch” for induction of cell migration. J. Cell Biol. 140:961–972.
  • Klinghoffer, R. A., C. Sachsenmaier, J. A. Cooper, and P. Soriano. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:2459–2471.
  • Knudsen, B. S., S. M. Feller, and H. Hanafusa. 1994. Four proline-rich sequences in the guanine nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. J. Biol. Chem. 269:32781–32787.
  • Law, S. F., J. Estojak, B. Wang, T. Mysliwiec, G. Kruh, and E. A. Golemis. 1996. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:3327–3337.
  • Li, E. G., D. G. Stupack, S. L. Brown, R. Klemke, D. D. Schlaepfer, and G. R. Nemerow. 2000. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J. Biol. Chem. 275:14729–14735.
  • Li, X., R. C. Dy, W. G. Cance, L. M. Graves, and H. S. Earp. 1999. Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase. J. Biol. Chem. 274:8917–8924.
  • Liu, F., D. E. Hill, and J. Chernoff. 1996. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the src homology 3 domain of p130Cas. J. Biol. Chem. 271:31290–31295.
  • Liu, F., M. A. Sells, and J. Chernoff. 1998. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Mol. Cell. Biol. 18:250–259.
  • Manie, S. N., A. Astier, N. Haghayeghi, T. Canty, B. J. Druker, H. Hirai, and A. S. Freedman. 1997. Regulation of integrin-mediated p130Cas tyrosine phosphorylation in human B cells. A role for p59Fyn and SHP2. J. Biol. Chem. 272:15636–15641.
  • Mayer, B. J., M. Hamaguchi, and H. Hanafusa. 1998. A novel oncogene with structural similarity to phospholipase C. Nature 332:272–275.
  • Minegishi, M., K. Tachibana, T. Sato, S. Iwata, Y. Nojima, and C. Morimoto. 1996. Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in β1 integrin-mediated signaling in lymphocytes. J. Exp. Med. 184:1365–1375.
  • Nakamoto, T., R. Sakai, K. Ozawa, Y. Yazaki, and H. Hirai. 1996. Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase. J. Biol. Chem. 271:8959–8965.
  • Nojima, Y., N. Morino, T. Mimura, K. Hamasaki, H. Furuya, R. Sakai, T. Sato, K. Tachibana, C. Morimoto, Y. Yazaki, and H. Hirai. 1995. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270:15398–15402.
  • Ohba, T., M. Ishino, H. Aoto, and T. Sasaki. 1998. Interaction of two proline-rich sequences of cell adhesion kinase β with SH3 domains of p130Cas-related proteins and a GTPase activating protein, Graf. Biochem. J. 330:1249–1254.
  • Oktay, M., K. K. Wary, M. Dans, R. B. Birge, and F. G. Giancotti. 1999. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145:1461–1469.
  • O'Neill, G. M., S. J. Fashena, and E. A. Golemis. 2000. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 10:111–119.
  • Owen, J. D., P. J. Ruest, D. W. Fry, and S. K. Hanks. 1999. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol. Cell. Biol. 19:4806–4818.
  • Petch, L. A., S. M. Bockholt, A. Bouton, J. T. Parsons, and K. Burridge. 1995. Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate. J. Cell Sci. 108:1371–1379.
  • Polte, T. R., and S. K. Hanks. 1995. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc. Natl. Acad. Sci. USA 92:10678–10682.
  • Polte, T. R., and S. K. Hanks. 1997. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130Cas) are elevated in cytoskeletal-associated fractions following adhesion and Src transformation: requirements for Src kinase activity and FAK proline-rich motifs. J. Biol. Chem. 272:5501–5509.
  • Prasad, N., R. S. Topping, and S. J. Decker. 2001. SH2-containing inositol 5′-phosphatase SHIP2 associates with the p130cas adapter protein and regulates cellular adhesion and spreading. Mol. Cell. Biol. 21:1416–1428.
  • Ren, R., B. J. Mayer, P. Cicchetti, and D. Baltimore. 1993. Identification of a ten-amino acid proline-rich SH3 binding site. Science 259:1157–1161.
  • Ruest, P. J., S. Roy, E. Shi, R. L. Mernaugh, and S. K. Hanks. 2000. Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site. Cell Growth Differ. 11:41–48.
  • Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and c-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13:3748–3756.
  • Sakai, R., T. Nakamoto, K. Ozawa, S. Aizawa, and H. Hirai. 1997. Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts. Oncogene 14:1419–1426.
  • Schaller, M. D., and J. T. Parsons. 1995. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 15:2635–2645.
  • Schaller, M. D., J. D. Hildebrand, and J. T. Parsons. 1999. Complex formation with focal adhesion kinase: a mechanism to regulate activity and subcellular localization of Src kinases. Mol. Biol. Cell 10:3489–3505.
  • Schaller, M. D., J. D. Hildebrand, J. D. Shannon, J. W. Fox, R. R. Vines, and J. T. Parsons. 1994. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14:1680–1688.
  • Schlaepfer, D. D., M. A. Broome, and T. Hunter. 1997. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol. Cell. Biol. 17:1702–1713.
  • Sieg, D. J., D. Ilic, K. C. Jones, C. H. Damsky, T. Hunter, and D. D. Schlaepfer. 1998. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration. EMBO J. 17:5933–5947.
  • Tachibana, K., T. Urano, H. Fujita, Y. Ohashi, K. Kamiguchi, S. Iwata, H. Hirai, and C. Morimoto. 1997. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase—a putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J. Biol. Chem. 272:29083–29090.
  • Tanaka, S., T. Morishita, Y. Hashimoto, S. Hattori, S. Nakamura, M. Shibuya, K. Matuoka, T. Takenawa, T. Kurata, K. Nagashima, and M. Matsuda. 1994. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc. Natl. Acad. Sci. USA 91:3443–3447.
  • Thomas, J. W., M. A. Cooley, J. M. Broome, R. Salgia, J. D. Griffin, C. R. Lombardo, and M. D. Schaller. 1999. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin. J. Biol. Chem. 274:36684–36692.
  • van der Flier, S., A. Brinkman, M. P. Look, E. M. Kok, M. E. Meijer-van Gelder, J. G. M. Klijn, L. C. J. Dorssers, and J. A. Foekens. 2000. Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J. Natl. Cancer Inst. 92:120–127.
  • Viguera, A. R., J. L. R. Arrondo, A. Musacchio, M. Saraste, and L. Serrano. 1994. Characterizatiion of the interaction of natural proline-rich peptides with five different SH3 domains. Biochemistry 33:10925–10933.
  • Vuori, K., H. Hirai, S. Aizawa, and E. Ruoslahti. 1996. Induction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol. Cell. Biol. 16:2606–2613.
  • Weidow, C. L., D. S. Black, J. B. Bliska, and A. H. Bouton. 2000. CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells. Cell Microbiol. 2:549–560.
  • Xing, Z., H. C. Chen, J. K. Nowlen, S. J. Taylor, D. Shalloway, and J. L. Guan. 1994. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol. Biol. Cell 5:413–421.
  • Zhang, X., A. Chattopadhyay, Q. S. Ji, J. D. Owen, P. J. Ruest, G. Carpenter, and S. K. Hanks. 1999. Focal adhesion kinase promotes phospholipase C-γ1 activity. Proc. Natl. Acad. Sci. USA 96:9021–9026.

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