22
Views
46
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases

, , , , , & show all
Pages 8068-8081 | Received 01 Jun 2001, Accepted 16 Aug 2001, Published online: 27 Mar 2023

REFERENCES

  • Abram, C. L., and S. A. Courtneidge. 2000. Src family tyrosine kinases and growth factor signaling. Exp. Cell Res. 254:1–13.
  • Adachi, T., K. Pazdrak, S. Stafford, and R. Alam. 1999. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J. Immunol. 162:1496–1501.
  • Anderson, S. M., and B. Jorgensen. 1995. Activation of Src-related tyrosine kinases by IL-3. J. Immunol. 155:1660–1670.
  • Aoki, Y., Y. T. Kim, R. Stillwell, T. J. Kim, and S. Pillai. 1995. The SH2 domains of Src family kinases associate with Syk. J. Biol. Chem. 270:15658–15663.
  • Avraham, H., S. Y. Park, K. Schinkmann, and S. Avraham. 2000. Raftk/Pyk2-mediated cellular signaling. Cell Signal 12:123–133.
  • Berger, L. C., T. S. Hawley, J. A. Lust, S. J. Goldman, and R. G. Hawley. 1994. Tyrosine phosphorylation of Jak-Tyk kinases in malignant plasma cell lines growth-stimulated by interleukins 6 and 11. Biochem. Biophys. Res. Commun. 202:596–605.
  • Blaukat, I. A., I. Ivankovic-Dikic, E. Gronroos, F. Dolfi, G. Tokiwa, K. Vuori, and I. Dikic. 1999. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J. Biol. Chem. 274:14893–14901.
  • Boulton, T. G., N. Stahl, and G. D. Yancopoulos. 1994. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269:11648–11655.
  • Burton, E. A., S. Hunter, S. C. Wu, and S. M. Anderson. 1997. Binding of Src-like kinases to the β-subunit of the interleukin-3 receptor. J. Biol. Chem. 272:16189–16195.
  • Chauhan, D., T. Hideshima, P. Pandey, S. Treon, G. Teoh, N. Raje, S. Rosen, N. Krett, H. Husson, S. Avraham, S. Kharbanda, and K. C. Anderson. 1999. RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells. Oncogene 18:6733–6740.
  • Chauhan, D., P. Pandey, T. Hideshima, S. Treon, N. Raje, F. E. Davies, Y. Shima, Y. T. Tai, S. Rosen, S. Avraham, S. Kharbanda, and K. C. Anderson. 2000. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. J. Biol. Chem. 275:27845–27850.
  • Corey, S. J., A. L. Burkhardt, J. B. Bolen, R. L. Geahlen, L. S. Tkatch, and D. J. Tweardy. 1994. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 91:4683–4687.
  • Dikic, I., G. Tokiwa, S. Lev, S. A. Courtneidge, and J. Schlessinger. 1996. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547–550.
  • Dittrich, E., C. R. Haft, L. Muys, P. C. Heinrich, and L. Graeve. 1996. A dileucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and downregulation of the IL-6 receptor. J. Biol. Chem. 271:5487–5494.
  • Ernst, M., U. Novak, S. E. Nicholson, J. E. Layton, and A. R. Dunn. 1999. The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation: involvement of STAT3. J. Biol. Chem. 274:9729–9737.
  • Ernst, M., D. P. Gearing, and A. R. Dunn. 1994. Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. EMBO J. 13:1574–1584.
  • Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. 1996. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5:449–460.
  • Gerhartz, C., B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin-6 signal transducer gp130. J. Biol. Chem. 271:12991–12998.
  • Gibson, R. M., W. P. Schiemann, L. B. Prichard, J. M. Reno, L. H. Ericsson, and N. M. Nathanson. 2000. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. J. Biol. Chem. 275:22574–22582.
  • Hallek, M., C. Neumann, S. Schäffer, M. Danhauser-Riedl, N. von Bubnoff, G. de Vos, B. J. Druker, K. Yasukawa, J. D. Griffin, and B. Emmerich. 1997. Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines. Exp. Hematol. 25:1367–1377.
  • Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:695–701.
  • Hatakeyama, M., T. Kono, N. Kobayashi, A. Kawahara, S. D. Levin, R. M. Perlmutter, and T. Taniguchi. 1991. Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of a novel intermolecular association. Science 252:1523–1528.
  • Hemmann, U., C. Gerhartz, B. Heesel, J. Sasse, G. Kurapkat, J. Grötzinger, A. Wollmer, Z. Zhong, J. E. Darnell Jr., L. Graeve, P. C. Heinrich, and F. Horn. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin-6 signal transducer gp130. J. Biol. Chem. 271:12999–13007.
  • Hibi, M., K. Nakajima, and T. Hirano. 1996. IL-6 cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74:1–12.
  • Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, W. E. Thierfelder, B. Kreider, and O. Silvennoinen. 1994. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci 19:222–227.
  • Kim, H., and H. Baumann. 1999. Dual signaling role of the protein tyrosine phosphatase Shp-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. Mol. Cell. Biol. 19:5326–5338.
  • Lai, C. F., J. Ripperger, K. K. Morella, Y. Wang, D. P. Gearing, G. H. Fey, and H. Baumann. 1995. Separate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp130. J. Biol. Chem. 270:14847–14850.
  • Minami, Y., T. Kono, K. Yamada, N. Kobayashi, A. Kawahara, R. M. Perlmutter, and T. Taniguchi. 1993. Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck. EMBO J. 12:759–768.
  • Murakami, M., M. Narazaki, M. Hibi, H. Yawata, K. Yasukawa, M. Hamaguchi, T. Taga, and T. Kishimoto. 1991. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 88:11349–11353.
  • Narazaki, M., B. A. Witthuhn, K. Yoshida, O. Silvennoinen, K. Yasukawa, J. N. Ihle, T. Kishimoto, and T. Taga. 1994. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc. Natl. Acad. Sci. USA 91:2285–2289.
  • Neumann, C., S. Zehentmaier, G. Danhauser-Riedl, B. Emmerich, and M. Hallek. 1996. Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. Eur. J. Immunol. 26:379–384.
  • Ogata, A., D. Chauhan, G. Teoh, S. P. Treon, M. Urashima, R. L. Schlossman, and K. C. Anderson. 1997. IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade. J. Immunol. 159:2212–2221.
  • Ohtani, T., K. Ishihara, T. Atsumi, K. Nishida, Y. Kaneko, T. Miyata, S. Itoh, M. Narimatsu, H. Maeda, T. Fukada, M. Itoh, H. Okano, M. Hibi, and T. Hirano. 2000. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12:95–105.
  • Pawson, T.. 1995. Protein modules and signaling networks. Nature 373:573–579.
  • Pelchen-Matthews, A., I. Boulet, D. R. Littman, R. Fagard, and M. Marsh. 1992. The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits. J. Cell Biol. 117:279–290.
  • Pignata, C., K. V. Prasad, M. Hallek, B. Druker, C. E. Rudd, M. J. Robertson, and J. Ritz. 1995. Phosphorylation of Src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells. Cell. Immunol. 165:211–216.
  • Rao, P., and R. A. Mufson. 1995. A membrane proximal domain of the human interleukin-3 receptor beta c subunit that signals DNA synthesis in NIH 3T3 cells specifically binds a complex of Src and Janus family tyrosine kinases and phosphatidylinositol 3-kinase. J. Biol. Chem. 270:6886–6893.
  • Schlaepfer, D. D., and T. Hunter. 1996. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol. Cell. Biol. 16:5623–5633 (Erratum, 16:7182–7184.)
  • Schlessinger, J.. 2000. New roles for Src kinases in control of cell survival and angiogenesis. Cell 100:293–296.
  • Schmitz, J., H. Dahmen, C. Grimm, G. Gendo, C. Müller-Newen, P. C. Heinrich, and F. Schaper. 2000. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. J. Immunol. 164:848–854.
  • Shi, Z. Q., W. Lu, and G. S. Feng. 1998. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J. Biol. Chem. 273:4904–4908.
  • Simpson, R. J., A. Hammacher, D. K. Smith, J. M. Matthews, and L. D. Ward. 1997. Interleukin-6: structure-function relationships. Protein Sci. 6:929–955.
  • Somers, W., M. Stahl, and J. S. Seehra. 1997. 1.9 Å crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J. 16:989–997.
  • Songyang, Z., S. E. Shoelson, M. Chauduri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, J. R. Lechleider, B. G. Neel, R. B. Birge, E. J. Fajardo, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. C. Cantley. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778.
  • Stahl, N., T. J. Farugella, T. G. Boulton, N. Y. Ip, S. Davis, B. A. Witthuhn, F. W. Quelle, O. Silvennoinen, G. Barberi, S. Pellegrini, J. N. Ihle, and G. D. Yancopoulos. 1994. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components. Science 263:92–95.
  • Takahashi-Tezuka, M., Y. Yoshida, T. FukadA, T. Ohtani, Y. Yamanaka, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano. 1998. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell. Biol. 18:4109–4117.
  • Tang, H., Z. J. Zhao, X. Y. Huang, E. J. Landon, and T. Inagami. 1999. Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. J. Biol. Chem. 274:12401–12407.
  • Tang, H., Z. J. Zhao, E. J. Landon, and T. Inagami. 2000. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells: roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. J. Biol. Chem. 275:8389–8396.
  • Taniguchi, T.. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251–255.
  • Tanner, J. W., W. Chen, R. L. Young, G. D. Longmore, and A. S. Shaw. 1995. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem. 270:6523–6530.
  • Thiel, S., I. Behrmann, E. Dittrich, L. Muys, J. Tavernier, J. Wijdenes, P. C. Heinrich, and L. Graeve. 1998. Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. Biochem. J. 330:47–54.
  • Thiel, S., U. Sommer, M. Kortylewski, C. Haan, I. Behrmann, P. C. Heinrich, and L. Graeve. 2000. Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis. FEBS Lett. 470:15–19.
  • Thomas, J. W., B. Ellis, R. J. Boerner, W. B. Knight, I. I. G. C. Withe, and M. D. Schaller. 1998. SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J. Biol. Chem. 273:577–583.
  • Venkitaraman, A. R., and R. J. Cowling. 1992. Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail. Proc. Natl. Acad. Sci. USA 89:12083–12087.
  • Ward, L. D., A. Hammacher, G. J. Howlett, J. M. Matthews, L. Fabri, R. L. Moritz, E. C. Nice, J. Weinstock, and R. J. Simpson. 1996. Influence of interleukin-6 (IL-6) dimerization on formation of the high-affinity hexameric IL-6 receptor complex. J. Biol. Chem. 271:20138–20144.
  • Warmuth, M., M. Bergmann, A. Priess, K. Häuslmann, B. Emmerich, and M. Hallek. 1997. The Src kinase HCK interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding Site of Bcr. J. Biol. Chem. 272:33260–33270.
  • Wen, Z., Z. Thong, and J. E. Darnell Jr.. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241–250.
  • Yu, H., J. K. Chen, S. Feng, D. C. Dalgarno, A. W. Brauer, and S. L. Schreiber. 1994. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933–945.
  • Zhang, X., J. C. Blenis, H. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1990–1994.
  • Zhao, J., C. Zheng, and J. Guan. 2000. Pyk2 and FAK differentially regulate progression of the cell cycle. J. Cell Sci. 113:3063–3072.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.