The Max Network Gone Mad

REFERENCES

• Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, R. D. Palmiter, and R. L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533–538.
   PubMed Web of Science ®Google Scholar
• Alitalo, K., P. Koskinen, T. P. Makela, K. Saksela, L. Sistonen, and R. Winqvist. 1987. myc oncogenes: activation and amplification. Biochim. Biophys. Acta 907:1–32.
   PubMed Web of Science ®Google Scholar
• Alland, L., R. Muhle, H. Hou Jr., J. Potes, L. Chin, N. Schreiber-Agus, and R. A. DePinho. 1997. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387:49–55.
   PubMed Web of Science ®Google Scholar
• Amati, B., M. W. Brooks, N. Levy, T. D. Littlewood, G. I. Evan, and H. Land. 1993. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72:233–245.
   PubMed Web of Science ®Google Scholar
• Amati, B., S. Dalton, M. W. Brooks, T. D. Littlewood, G. I. Evan, and H. Land. 1992. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359:423–426.
   PubMed Web of Science ®Google Scholar
• Amati, B., and H. Land. 1994. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation, and death. Curr. Opin. Genet. Dev. 4:102–108.
   PubMed Web of Science ®Google Scholar
• Amati, B., T. D. Littlewood, G. I. Evan, and H. Land. 1993. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 12:5083–5087.
   PubMed Web of Science ®Google Scholar
• Armelin, H. A., M. C. S. Armelin, K. Kelly, T. Stewart, P. Leder, B. H. Cochran, and C. D. Stiles. 1984. Functional role of c-myc in mitogenic response to platelet-derived growth factor. Nature 310:655–660.
   PubMed Web of Science ®Google Scholar
• Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915–1922.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E., and R. N. Eisenman. 1993. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:2110–2119.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211–222.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767–776.
   PubMed Web of Science ®Google Scholar
• Bartsch, D., S. L. Peiffer, Z. Kaleem, S. A. Wells Jr., and P. J. Goodfellow. 1996. Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma. Cancer Lett. 102:73–76.
   PubMed Web of Science ®Google Scholar
• Bello-Fernandez, C., G. Packham, and J. L. Cleveland. 1993. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA 90:7804–7808.
   PubMed Web of Science ®Google Scholar
• Berberich, S., and M. D. Cole. 1992. Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers. Genes Dev. 6:166–176.
   PubMed Web of Science ®Google Scholar
• Berberich, S., N. Hyde-DeRuyscher, P. Espenshade, and M. Cole. 1992. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene 7:775–779.
   PubMed Web of Science ®Google Scholar
• Berk, M., S. Y. Desai, H. C. Heyman, and C. Colmenares. 1997. Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development. Genes Dev. 11:2029–2039.
   PubMed Web of Science ®Google Scholar
• Billin, A. N., A. L. Eilers, C. Queva, and D. E. Ayer. 1999. Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. J. Biol. Chem. 274:36344–36350.
   PubMed Web of Science ®Google Scholar
• Bissonnette, R. P., F. Echeverri, A. Mahboubi, and D. R. Green. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552–556.
   PubMed Web of Science ®Google Scholar
• Blackwell, T. K., J. Huang, A. Ma, L. Kretzner, F. W. Alt, R. N. Eisenman, and H. Weintraub. 1993. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol. Cell. Biol. 13:5216–5224.
   PubMed Web of Science ®Google Scholar
• Blackwood, E. M., and R. N. Eisenman. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA binding complex with Myc. Science 251:1211–1217.
   PubMed Web of Science ®Google Scholar
• Blackwood, E. M., B. Luscher, and R. N. Eisenman. 1992. Myc and Max associate in vivo. Genes Dev. 6:71–80.
   PubMed Web of Science ®Google Scholar
• Bouchard, C., P. Staller, and M. Eilers. 1998. Control of cell proliferation by Myc. Trends Cell Biol. 8:202–206.
   PubMed Web of Science ®Google Scholar
• Boyd, K. E., and P. J. Farnham. 1999. Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol. Cell. Biol. 19:8393–8399.
   PubMed Web of Science ®Google Scholar
• Brandvold, K. A., P. Neiman, and A. Ruddell. 2000. Angiogenesis is an early event in the generation of myc-induced lymphomas. Oncogene 19:2780–2785.
   PubMed Web of Science ®Google Scholar
• Charron, J., B. A. Malynn, P. Fisher, V. Stewart, L. Jeannotte, S. P. Goff, E. J. Robertson, and F. W. Alt. 1992. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 6:2248–2257.
   PubMed Web of Science ®Google Scholar
• Cheng, S. W., K. P. Davies, E. Yung, R. J. Beltran, J. Yu, and G. V. Kalpana. 1999. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nat. Genet. 22:102–105.
   PubMed Web of Science ®Google Scholar
• Chin, L., J. Pomerantz, and R. A. DePinho. 1998. The INK4a/ARF tumor suppressor: one gene—two products—two pathways. Trends Biochem. Sci. 23:291–296.
   PubMed Web of Science ®Google Scholar
• Cohen, S. B., G. Zheng, H. C. Heyman, and E. Stavnezer. 1999. Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Nucleic Acids Res. 27:1006–1014.
   PubMed Web of Science ®Google Scholar
• Colmenares, C., and E. Stavnezer. 1989. The ski oncogene induces muscle differentiation in quail embryo cells. Cell 59:293–303.
   PubMed Web of Science ®Google Scholar
• Coppola, J. A., and M. D. Cole. 1986. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 320:760–763.
   PubMed Web of Science ®Google Scholar
• Daksis, J. I., R. Y. Lu, L. M. Facchini, W. W. Marhin, and L. J. Z. Penn. 1994. Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 9:3635–3645.
   PubMed Web of Science ®Google Scholar
• Dang, C. V.. 1999. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 19:1–11.
   PubMed Web of Science ®Google Scholar
• Davis, A. C., M. Wims, G. D. Spotts, S. R. Hann, and A. Bradley. 1993. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7:671–682.
   PubMed Web of Science ®Google Scholar
• Downs, K. M., G. R. Martin, and J. M. Bishop. 1989. Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. Genes Dev. 3:860–869.
   PubMed Web of Science ®Google Scholar
• Eagle, L. R., X. Yin, A. R. Brothman, B. J. Williams, N. B. Atkin, and E. V. Prochownik. 1995. Mutation of the MXI1 gene in prostate cancer. Nat. Genet. 9:249–255.
   PubMed Web of Science ®Google Scholar
• Eberhardy, S. R., C. A. D'Cunha, and P. J. Farnham. 2000. Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation. J. Biol. Chem. 275:33798–33805.
   PubMed Web of Science ®Google Scholar
• Edwards, S. M., D. P. Dearnaley, A. Ardern-Jones, R. A. Hamoudi, D. F. Easton, D. Ford, R. Shearer, A. Dowe, and R. A. Eeles. 1997. No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. Br. J. Cancer 76:992–1000.
   PubMed Web of Science ®Google Scholar
• Eilers, A. L., A. N. Billin, J. Liu, and D. E. Ayer. 1999. A 13-amino acid amphipathic alpha-helix is required for the functional interaction between the transcriptional repressor Mad1 and mSin3A. J. Biol. Chem. 274:32750–32756.
   PubMed Web of Science ®Google Scholar
• Eilers, M., S. Schirm, and J. M. Bishop. 1991. The MYC protein activates transcription of the a-prothymosin gene. EMBO J. 10:133–141.
   PubMed Web of Science ®Google Scholar
• Eischen, C. M., J. D. Weber, M. F. Roussel, C. J. Sherr, and J. L. Cleveland. 1999. Disruption of the ARF-Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13:2658–2669.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., and T. D. Littlewood. 1993. The role of c-myc in cell growth. Curr. Opin. Genet. Dev. 3:44–49.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128.
   PubMed Web of Science ®Google Scholar
• Facchini, L. M., and L. Z. Penn. 1998. The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J. 12:633–651.
   PubMed Web of Science ®Google Scholar
• Flinn, E. M., C. M. C. Busch, and A. P. H. Wright. 1998. Myc boxes, which are conserved in Myc family proteins, are signals for protein degradation via the proteasome. Mol. Cell. Biol. 18:5961–5969.
   PubMed Web of Science ®Google Scholar
• Gesk, S., R. Siebert, H. H. Wacker, N. Nurnberg, L. Harder, J. Lehman, G. Kloppel, W. Grote, M. Stockle, and B. Schlegelberger. 2000. Lack of deletions of PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics. Cancer Genet. Cytogenet. 118:87–88.
   PubMedGoogle Scholar
• Grandori, C., S. M. Cowley, L. P. James, and R. N. Eisenman. 2000. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16:653–699.
   PubMed Web of Science ®Google Scholar
• Gregory, M. A., and S. R. Hann. 2000. c-Myc proteolysis by the ubiquitin-proteosome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell. Biol. 20:2423–2435.
   PubMed Web of Science ®Google Scholar
• Gupta, K., G. Anand, X. Yin, L. Grove, and E. V. Prochownik. 1998. Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene 16:1149–1159.
   PubMed Web of Science ®Google Scholar
• Hanson, K. D., M. Shichiri, M. R. Follansbee, and J. M. Sedivy. 1994. Effects of c-myc expression on cell cycle progression. Mol. Cell. Biol. 14:5748–5755.
   PubMed Web of Science ®Google Scholar
• Harper, S. E., Y. Qiu, and P. A. Sharp. 1996. Sin3 corepressor function in Myc-induced transcription and transformation. Proc. Natl. Acad. Sci. USA 93:8536–8540.
   PubMed Web of Science ®Google Scholar
• Hassig, C. A., T. C. Fleischer, A. N. Billin, S. L. Schreiber, and D. E. Ayer. 1997. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89:341–347.
   PubMed Web of Science ®Google Scholar
• Hatton, K. S., K. Mahon, L. Chin, F. C. Chiu, H. W. Lee, D. Peng, S. D. Morgenbesser, J. Horner, and R. A. DePinho. 1996. Expression and activity of L-Myc in normal mouse development. Mol. Cell. Biol. 16:1794–1804.
   PubMed Web of Science ®Google Scholar
• Heikkila, R., G. Schwab, E. Wickstrom, S. L. Loke, D. H. Pluznik, R. Watt, and L. M. Neckers. 1987. A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1. Nature 328:445–449.
   PubMed Web of Science ®Google Scholar
• Heinzel, T., R. M. Lavinsky, T.-M. Mullen, M. Soderstrom, C. D. Laherty, J. Torchia, W.-M. Yang, G. Brard, S. D. Ngo, J. R. Davie, E. Seto, R. N. Eisenman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1997. A complex containing N-CoR, mSin3, and histone deacetylase mediates transcriptional repression. Nature 387:43–47.
   PubMed Web of Science ®Google Scholar
• Henriksson, M., A. Barkardjiev, G. Klein, and B. Luscher. 1993. Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. Oncogene 8:3199–3209.
   PubMed Web of Science ®Google Scholar
• Henriksson, M., and B. Luscher. 1996. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv. Cancer Res. 68:109–182.
   PubMed Web of Science ®Google Scholar
• Herbst, R. A., E. K. Podewski, S. Mommert, A. Kapp, and J. Weiss. 1999. PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo. Arch. Dermatol. Res. 291:567–569.
   PubMed Web of Science ®Google Scholar
• Herrmann, B. G., and A. Kispert. 1994. The T genes in embryogenesis. Trends Genet. 10:280–286.
   PubMed Web of Science ®Google Scholar
• Hirning, U., P. Schmid, W. A. Schulz, G. Retternberger, and H. Hameister. 1991. A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis. Mech. Dev. 33:119–126.
   PubMed Web of Science ®Google Scholar
• Hurlin, P. J., K. P. Foley, D. E. Ayer, R. N. Eisenman, D. Hanahan, and J. M. Arbeit. 1995. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Oncogene 11:2487–2501.
   PubMed Web of Science ®Google Scholar
• Hurlin, P. J., C. Queva, and R. N. Eisenman. 1997. Mnt, a novel Max-interacting protein, is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 11:44–58.
   PubMed Web of Science ®Google Scholar
• Hurlin, P. J., C. Queva, P. J. Koskinen, E. Steingrimsson, D. E. Ayer, N. G. Copeland, N. A. Jenkins, and R. N. Eisenman. 1995. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14:5646–5659.
   PubMed Web of Science ®Google Scholar
• Hurlin, P. J., E. Steingrimsson, N. G. Copeland, N. A. Jenkins, and R. N. Eisenman. 1999. Mga, a dual specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. EMBO J. 18:7019–7028.
   PubMed Web of Science ®Google Scholar
• Jansen-Durr, P., A. Meichle, P. Steiner, M. Pagano, K. Finke, J. Botz, J. Wessbecher, G. Draetta, and M. Eilers. 1993. Differential modulation of cyclin gene expression by MYC. Proc. Natl. Acad. Sci. USA 90:3685–3689.
   PubMed Web of Science ®Google Scholar
• Jepsen, K., O. Hermanson, T. M. Onami, A. S. Gleiberman, V. Lunyak, R. J. McEvilly, R. Kurokawa, V. Kumar, F. Liu, E. Seto, S. M. Hedrick, G. Mandel, C. K. Glass, D. W. Rose, and M. G. Rosenfeld. 2000. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102:753–763.
   PubMed Web of Science ®Google Scholar
• Johnston, L. A., D. A. Prober, B. A. Edgar, R. N. Eisenman, and P. Gallant. 1999. Drosophila myc regulates cellular growth during development. Cell 98:779–790.
   PubMed Web of Science ®Google Scholar
• Kamijo, T., F. Zindy, M. F. Roussel, D. E. Quelle, J. R. Downing, R. A. Ashmun, G. Grosveld, and C. J. Sherr. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649–659.
   PubMed Web of Science ®Google Scholar
• Kato, G. J., W. M. F. Lee, L. Chen, and C. V. Dang. 1992. Max: functional domains and interaction with c-Myc. Genes Dev. 6:81–92.
   PubMed Web of Science ®Google Scholar
• Kawamata, N., D. Park, S. Wilczynski, J. Yokota, and H. P. Koeffler. 1996. Point mutations of the Mxi1 gene are rare in prostate cancers. Prostate 29:191–193.
   PubMed Web of Science ®Google Scholar
• Kelly, K., B. H. Cochran, C. D. Stiles, and P. Leder. 1982. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platlet-derived growth factor. Cell 35:603–610.
   Web of Science ®Google Scholar
• Kerkhoff, E., K. Bister, and K. H. Klempnauer. 1991. Sequence-specific DNA binding by Myc proteins. Proc. Natl. Acad. Sci. USA 88:4323–4327.
   PubMed Web of Science ®Google Scholar
• Kim, S. K., J. Y. Ro, B. L. Kemp, J. S. Lee, T. J. Kwon, W. K. Hong, and L. Mao. 1998. Identifications of two distinct tumor-suppressor loci on the long arm of chromosome 10 in small cell lung cancer. Oncogene 17:1749–1753.
   PubMed Web of Science ®Google Scholar
• Koskinen, P. J., D. E. Ayer, and R. N. Eisenman. 1995. Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions. Cell Growth Differ. 6:623–629.
   PubMedGoogle Scholar
• Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359:426–429.
   PubMed Web of Science ®Google Scholar
• Kuczyk, M. A., J. Serth, C. Bokemeyer, J. Schwede, R. Herrmann, S. Machtens, V. Gruneweld, K. Hofner, and U. Jonas. 1998. The Mxi1 tumor supressor gene is not mutated in primary prostate cancer. Oncol. Rep. 5:213–216.
   PubMed Web of Science ®Google Scholar
• Laherty, C. D., A. N. Billin, R. M. Lavinsky, G. S. Yochum, A. C. Bush, J.-M. Sun, T.-M. Mullen, J. R. Davie, D. W. Rose, C. K. Glass, M. G. Rosenfeld, D. E. Ayer, and R. N. Eisenman. 1998. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol. Cell 2:33–42.
   PubMed Web of Science ®Google Scholar
• Laherty, C. D., W.-M. Yang, J.-M. Sun, J. R. Davie, E. Seto, and R. N. Eisenman. 1997. Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89:349–356.
   PubMed Web of Science ®Google Scholar
• Langdon, W. Y., A. W. Harris, S. Cory, and J. M. Adams. 1986. The c-myc oncogene perturbs B lymphocyte development in E m-myc transgenic mice. Cell 47:11–18.
   PubMed Web of Science ®Google Scholar
• Leder, A., P. K. Pattengale, A. Kuo, T. A. Stewart, and P. Leder. 1986. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45:485–495.
   PubMed Web of Science ®Google Scholar
• Li, X. J., D. Y. Wang, Y. Zhu, R. J. Guo, X. D. Wang, K. Lubomir, K. Mukai, H. Sasaki, H. Yoshida, T. Oka, R. Machinami, K. Shinmura, M. Tanaka, and H. Sugimara. 1999. Mxi1 mutations in human neurofibrosarcomas. Jpn. J. Cancer Res. 90:740–746.
   PubMedGoogle Scholar
• Li, Y., C. M. Turck, J. K. Teumer, and E. Stavnezer. 1986. Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene. J. Virol. 57:1065–1072.
   PubMed Web of Science ®Google Scholar
• Lindeman, G. J., A. W. Harris, M. L. Bath, R. N. Eisenman, and J. M. Adams. 1995. Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice. Oncogene 10:1013–1017.
   PubMed Web of Science ®Google Scholar
• Littlewood, T. D., B. Amati, H. Land, and G. I. Evan. 1992. Max and c-Myc/Max DNA-binding activities in cell extracts. Oncogene 7:1783–1792.
   PubMed Web of Science ®Google Scholar
• Makela, T. P., P. J. Koskinen, I. Vastrik, and K. Aitalo. 1992. Alternative forms of Max as enhancers or suppressors of Myc-Ras cotransformation. Science 256:373–377.
   PubMed Web of Science ®Google Scholar
• Malynn, B. A., I. Moreno de Alboran, R. C. O'Hagan, R. Bronson, L. Davidson, R. A. DePinho, and F. W. Alt. 2000. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 14:1390–1399.
   PubMed Web of Science ®Google Scholar
• Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:835–839.
   PubMed Web of Science ®Google Scholar
• Marcu, K. B., S. A. Bossone, and A. J. Patel. 1992. Myc function and regulation. Annu. Rev. Biochem. 61:809–860.
   PubMed Web of Science ®Google Scholar
• McMahon, S. B., H. A. Van Buskirk, K. A. Dugan, T. D. Copeland, and M. D. Cole. 1998. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94:363–374.
   PubMed Web of Science ®Google Scholar
• McMahon, S. B., M. A. Wood, and M. D. Cole. 2000. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol. Cell. Biol. 20:556–562.
   PubMed Web of Science ®Google Scholar
• Meroni, G., S. Cairo, G. Merla, S. Messali, R. Brent, A. Ballabio, and A. Reymond. 2000. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factor regulatory pathway?. Oncogene 19:3266–3277.
   PubMed Web of Science ®Google Scholar
• Meroni, G., A. Reymond, M. Alcalay, G. Borsani, A. Tanigami, R. Tonlorenzi, C. Lo Nigro, S. Messali, M. Zollo, D. H. Ledbetter, R. Brent, A. Ballabio, and R. Carrozzo. 1997. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box, and acts as a transcriptional repressor. EMBO J. 16:2892–2906.
   PubMed Web of Science ®Google Scholar
• Metzstein, M. M., G. M. Stanfield, and H. R. Horvitz. 1998. Genetics of programmed cell death in C. elegans: past, present, and future. Trends Genet. 14:410–416.
   PubMed Web of Science ®Google Scholar
• Miltenberger, R. J., K. A. Sukow, and P. J. Farnham. 1995. An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants. Mol. Cell. Biol. 15:2527–2535.
   PubMed Web of Science ®Google Scholar
• Moens, C. B., B. R. Stanton, L. F. Parada, and J. Rossant. 1993. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 119:485–499.
   PubMed Web of Science ®Google Scholar
• Muller, D., C. Bouchard, B. Rudolph, P. Steiner, I. Stuckmann, R. Saffrich, W. Ansorge, W. Huttner, and M. Eilers. 1997. Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes. Oncogene 15:2561–2576.
   PubMed Web of Science ®Google Scholar
• Nicol, R., G. Zheng, P. Sutrave, D. N. Foster, and E. Stavnezer. 1999. Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski. Cell Death Differ. 10:243–254.
   Google Scholar
• Niklinski, J., G. Claassen, C. Meyers, M. A. Gregory, C. J. Allegra, F. J. Kaye, S. R. Hann, and M. Zajac-Kaye. 2000. Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma. Mol. Cell. Biol. 20:5276–5284.
   PubMed Web of Science ®Google Scholar
• Nomura, T., M. M. Khan, S. C. Kaul, H.-D. Dong, R. Wadhwa, C. Colmenares, I. Kohno, and S. Ishii. 1999. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13:412–423.
   PubMed Web of Science ®Google Scholar
• O'Hagen, R. C., M. Ohh, G. David, I. M. de Alboran, F. W. Alt, W. G. Kaelin Jr., and R. A. DePinho. 2000. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 14:2185–2191.
   PubMed Web of Science ®Google Scholar
• O'Hagen, R. C., N. Schreiber-Agus, K. Chen, G. David, J. A. Engelman, R. Schwab, L. Alland, C. Thomson, D. R. Ronning, J. C. Sacchettini, P. Meltzer, and R. A. DePinho. 2000. Gene-target recognition among members of the Myc superfamily and implications for oncogenesis. Nat. Genet. 24:113–119.
   PubMed Web of Science ®Google Scholar
• Packham, G., and J. L. Cleveland. 1995. c-Myc and apoptosis. Biochim. Biophys. Acta 1242:11–28.
   PubMed Web of Science ®Google Scholar
• Packham, G., and J. L. Cleveland. 1997. Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways. Oncogene 15:1219–1232.
   PubMed Web of Science ®Google Scholar
• Packham, G., C. W. Porter, and J. L. Cleveland. 1996. c-Myc induces apoptosis and cell cycle progression by seperable, yet overlapping, pathways. Oncogene 13:461–469.
   PubMed Web of Science ®Google Scholar
• Papaioannou, V. E., and L. M. Silver. 1998. The T-box gene family. Bioessays 20:9–19.
   PubMed Web of Science ®Google Scholar
• Pearson-White, S.. 1993. SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno. Nucleic Acids Res. 21:4632–4638.
   PubMed Web of Science ®Google Scholar
• Pearson-White, S., and R. Crittenden. 1997. Proto-oncogene Sno expression, alternative isoforms and immediate early serum response. Nucleic Acids Res. 25:2930–2937.
   PubMed Web of Science ®Google Scholar
• Pelengaris, S., T. Littlewood, M. Khan, G. Elia, and G. Evan. 1999. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3:565–577.
   PubMed Web of Science ®Google Scholar
• Pelzer, T., G. E. Lyons, S. Kim, and R. W. Moreadith. 1996. Cloning and characterization of the murine homolog of the sno proto-oncogene reveals a novel splice variant. Dev. Dyn. 205:114–125.
   PubMed Web of Science ®Google Scholar
• Pennetta, G., and D. Pauli. 1998. The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability. Dev. Genes Evol. 208:531–536.
   PubMed Web of Science ®Google Scholar
• Peukert, K., P. Staller, A. Schneider, G. Carmichael, F. Hanel, and M. Eilers. 1997. An alternative pathway for gene regulation by Myc. EMBO J. 16:5672–5682.
   PubMed Web of Science ®Google Scholar
• Pomerantz, J., N. Schreiber-Agus, N. J. Liegeois, A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H.-W. Lee, C. Cordon-Cardo, and R. A. DePinho. 1998. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92:713–723.
   PubMed Web of Science ®Google Scholar
• Prendergast, G. C.. 1997. Myc structure and function. Oncogenes as transcriptional regulators. M. Yaniv, and J. Ghysdael. 1. Retroviral oncogenes:1–28. Birkhauser Verlag, Basel, Switzerland
   Google Scholar
• Prendergast, G. C., D. Lawe, and E. B. Ziff. 1991. Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell 65:395–407.
   PubMed Web of Science ®Google Scholar
• Prochownik, E. V., G. L. Eagle, D. Deubler, X. L. Zhu, R. A. Stephenson, L. R. Rohr, X. Yin, and A. R. Brothman. 1998. Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. Genes Chromosomes Cancer 22:295–304.
   PubMed Web of Science ®Google Scholar
• Prochownik, E. V., J. Kukowska, and C. Rodgers. 1988. c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells. Mol. Cell. Biol. 8:3683–3695.
   PubMed Web of Science ®Google Scholar
• Pulverer, B. J., C. Fisher, K. Vousden, T. Littlewood, G. Evan, and J. R. Woodjett. 1994. Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene 9:59–70.
   PubMed Web of Science ®Google Scholar
• Queva, C., P. J. Hurlin, K. P. Foley, and R. N. Eisenman. 1998. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene 16:967–977.
   PubMed Web of Science ®Google Scholar
• Queva, C., G. A. McArthur, B. M. Iritani, and R. N. Eisenman. 2001. Targeted deletion of the S-phase specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol. Cell. Biol. 21:703–712.
   PubMed Web of Science ®Google Scholar
• Queva, C., G. A. McArthur, L. S. Ramos, and R. N. Eisenman. 1999. Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1. Cell Growth Differ. 10:785–796.
   PubMedGoogle Scholar
• Rao, U. N., A. Bakker, P. A. Swalsky, and S. D. Finkelstein. 1999. Max interacting protein 1: loss of heterozygosity is frequent in desmoplastic melanoma. Mod. Pathol. 12:344–350.
   PubMed Web of Science ®Google Scholar
• Rosenbaum, H., E. Webb, J. M. Adams, S. Cory, and A. W. Harris. 1989. N-myc transgene promotes B lymphoid proliferation, elicts lymphomas and reveals cross-regulation with c-myc. EMBO J. 8:749–755.
   PubMed Web of Science ®Google Scholar
• Sakamuro, D., and G. C. Prendergast. 1999. New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:2942–2954.
   PubMed Web of Science ®Google Scholar
• Sawai, A., A. Shimono, Y. Wakamatsu, C. Palmes, K. Hanaoka, and H. Kondoh. 1993. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development 117:1445–1455.
   PubMed Web of Science ®Google Scholar
• Schreiber-Agus, N., L. Chin, K. Chen, R. Torres, G. Rao, P. Guida, A. I. Skoultchi, and R. A. DePinho. 1995. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:777–786.
   PubMed Web of Science ®Google Scholar
• Schreiber-Agus, N., Y. Meng, T. Hoang, H. Hou Jr., K. Chen, R. Greenberg, C. Cordon-Cardo, H.-W. Lee, and R. A. DePinho. 1998. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature 393:483–487.
   PubMed Web of Science ®Google Scholar
• Schreiber-Agus, N., D. Stein, K. Chen, J. S. Goltz, L. Stevens, and R. A. DePinho. 1997. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc. Natl. Acad. Sci. USA 94:1235–1240.
   PubMed Web of Science ®Google Scholar
• Serrano, M.. 1997. The tumor suppressor protein p16INK4a. Exp. Cell Res. 237:7–13.
   PubMed Web of Science ®Google Scholar
• Shen-Li, H., R. C. O'Hagan, H. Hou, J. W. Horner II, H.-W. Lee, and R. A. DePinho. 2000. Essential role for Max in early embryonic growth and development. Genes Dev. 14:17–22.
   PubMed Web of Science ®Google Scholar
• Sherr, C. J.. 1996. Cancer cell cycles. Science 274:1672–1677.
   PubMed Web of Science ®Google Scholar
• Shinagawa, T., H.-D. Dong, M. Xu, T. Maekawa, and S. Ishii. 2000. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J. 19:2280–2291.
   PubMed Web of Science ®Google Scholar
• Siebert, R., S. Gesk, S. Harder, S. Plotz, P. Matthiesen, W. Grote, B. Schlegelberger, B. Jandrig, U. H. Grasmo-Wendler, S. Scherneck, A. Rosenwald, and G. Ott. 1998. Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor suppressor genes PTEN/MMAC and MXI1. Blood 92:4487–4489.
   PubMed Web of Science ®Google Scholar
• Smith, J.. 1999. T-box genes: what they do and how they do it. Trends Genet. 15:154–158.
   PubMed Web of Science ®Google Scholar
• Solomon, D. L. C., B. Amati, and H. Land. 1993. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372–5376.
   PubMed Web of Science ®Google Scholar
• Sommer, A., K. Bousset, E. Kremmer, M. Austen, and B. Luscher. 1998. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. J. Biol. Chem. 273:6632–6642.
   PubMed Web of Science ®Google Scholar
• Sommer, A., A. Waha, J. Tonn, N. Sorensen, P. J. Hurlin, R. N. Eisenman, B. Luscher, and T. Pietsch. 1999. Analysis of the Max-binding protein MNT in human medulloblastomas. Int. J. Cancer 82:810–816.
   PubMed Web of Science ®Google Scholar
• Stanton, B. R., A. S. Perkins, L. Tessarollo, D. A. Sassoon, and L. F. Parada. 1992. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6:2235–2247.
   PubMed Web of Science ®Google Scholar
• Vlach, J., S. Hennecke, K. Alevizopoulos, D. Conti, and B. Amati. 1996. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip is abrogated by c-Myc. EMBO J. 15:6595–6604.
   PubMed Web of Science ®Google Scholar
• Weiss, W. A., K. Aldape, G. Mohapatra, B. G. Feuerstein, and J. M. Bishop. 1997. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 16:2985–2995.
   PubMed Web of Science ®Google Scholar
• Winston, F., and M. Carlson. 1992. Yeast SNFISWI transcriptional activators and the SPT/SIN chromatin connection. Trends Genet. 8:387–391.
   PubMed Web of Science ®Google Scholar
• Yin, X., L. Grove, and E. V. Prochownik. 1998. Lack of transcriptional repression by Max homodimers. Oncogene 16:2629–2637.
   PubMed Web of Science ®Google Scholar
• Yin, X.-Y., K. Gupta, W. P. Han, E. S. Levitan, and E. V. Prochownik. 1999. Mmip-2, a novel RING finger protein that interacts with Mad members of the Myc oncoprotein network. Oncogene 18:6621–6634.
   PubMed Web of Science ®Google Scholar
• Zervos, A. S., J. Gyruis, and R. Brent. 1993. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223–232.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., R. Iratni, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 1997. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Cell 89:357–364.
   PubMed Web of Science ®Google Scholar
• Zimmerman, K. A., G. D. Yancopoulos, R. G. Collum, R. K. Smith, N. E. Kohl, K. A. Denis, M. M. Nau, O. N. Witte, D. Toran-Allerand, and C. E. Gee. 1986. Differential expression of myc family genes durning murine development. Nature 319:780–783.
   PubMed Web of Science ®Google Scholar