Site-Specific Acetylation by p300 or CREB Binding Protein Regulates Erythroid Krüppel-Like Factor Transcriptional Activity via Its Interaction with the SWI-SNF Complex

REFERENCES

• Anderson, K. P., C. B. Kern, S. C. Crable, and J. B. Lingrel. 1995. Isolation of a gene encoding a functional zinc finger protein homologous to EKLF: identification of a new multigene family. Mol. Cell. Biol. 15:5957–5965.
   PubMed Web of Science ®Google Scholar
• Armstrong, J. A., J. J. Bieker, and B. M. Emerson. 1998. A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell 95:93–104.
   PubMed Web of Science ®Google Scholar
• Baron, M. H.. 1997. Transcriptional control of globin gene switching during vertebrate development. Biochim. Biophys. Acta 1351:51–72.
   PubMedGoogle Scholar
• Berger, S. L.. 1999. Gene activation by histone and factor acetyltransferases. Curr. Opin. Cell Biol. 11:336–341.
   PubMed Web of Science ®Google Scholar
• Bieker, J. J.. 1999. EKLF and the development of the erythroid lineage. Transcription factors: normal and malignant development of blood cells.. K. Ravid, and J. D. Licht. 71–84. Wiley-Liss, New York, N.Y
   Google Scholar
• Bieker, J. J.. 1996. Isolation, genomic structure, and expression of human Erythroid Kruppel-like Factor (EKLF). DNA Cell Biol. 15:347–352.
   PubMedGoogle Scholar
• Bird, A. P., and A. P. Wolffe. 1999. Methylation-induced repression—belts, braces, and chromatin. Cell 99:451–454.
   PubMed Web of Science ®Google Scholar
• Blobel, G. A.. 2000. CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood 95:745–755.
   PubMed Web of Science ®Google Scholar
• Blobel, G. A., T. Nakajima, R. Eckner, M. Montminy, and S. H. Orkin. 1998. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. USA 95:2061–2066.
   PubMedGoogle Scholar
• Boyes, J., P. Byfield, Y. Nakatani, and V. Ogryzko. 1998. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396:594–598.
   PubMed Web of Science ®Google Scholar
• Bulger, M., and M. Groudine. 1999. Looping versus linking: toward a model for long-distance gene activation. Genes Dev. 13:2465–2477.
   PubMed Web of Science ®Google Scholar
• Caterina, J. J., D. J. Ciavatta, D. Donze, R. R. Behringer, and T. M. Townes. 1994. Multiple elements in human beta-globin locus control region 5′ HS 2 are involved in enhancer activity and position-independent, transgene expression. Nucleic Acids Res. 22:1006–1011.
   PubMed Web of Science ®Google Scholar
• Chen, H., R. J. Lin, W. Xle, D. Wilpltz, and R. M. Evans. 1999. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98:675–686.
   PubMed Web of Science ®Google Scholar
• Chen, X., and J. J. Bieker. 1996. Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J. 15:5888–5896.
   PubMedGoogle Scholar
• Cheung, W. L., S. D. Briggs, and C. D. Allis. 2000. Acetylation and chromosomal functions. Curr. Opin. Cell Biol. 12:326–333.
   PubMed Web of Science ®Google Scholar
• Chrivia, J. C., R. P. S. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855–859.
   PubMed Web of Science ®Google Scholar
• Dhalluin, C., J. E. Carlson, L. Zeng, C. He, A. K. Aggarwal, and M. M. Zhou. 1999. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399:491–496.
   PubMed Web of Science ®Google Scholar
• Donze, D., T. M. Townes, and J. J. Bieker. 1995. Role of erythroid Krüppel-like factor (EKLF) in human γ- to β-globin switching. J. Biol. Chem. 270:1955–1959.
   PubMed Web of Science ®Google Scholar
• Eckner, R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8:869–884.
   PubMed Web of Science ®Google Scholar
• Engel, J. D.. 1993. Developmental regulation of human β-globin gene transcription: a switch of loyalties?. Trends Genet. 9:304–309.
   PubMedGoogle Scholar
• Felsenfeld, G.. 1992. Chromatin as an essential part of the transcriptional mechanism. Nature 355:219–224.
   PubMed Web of Science ®Google Scholar
• Feng, W. C., C. M. Southwood, and J. J. Bieker. 1994. Analyses of β-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J. Biol. Chem. 269:1493–1500.
   PubMed Web of Science ®Google Scholar
• Gillemans, N., R. Tewari, F. Lindeboom, R. Rottier, T. de Wit, M. Wijgerde, F. Grosveld, and S. Philipsen. 1998. Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev. 12:2863–2873.
   PubMedGoogle Scholar
• Gu, W., and R. G. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595–606.
   PubMed Web of Science ®Google Scholar
• Hebbes, T. R., A. L. Clayton, A. W. Thorne, and C. Crane-Robinson. 1994. Core histone hyperacetylation comaps with generalized DNAsel sensitivity in the chicken beta-globin chromosomal domain. EMBO J. 13:1823–1830.
   PubMed Web of Science ®Google Scholar
• Horiuchi, K., and D. Fujimoto. 1975. Use of phosphocellulose paper disks for the assay of histone acetyltransferase. Anal. Biochem. 69:491–496.
   PubMedGoogle Scholar
• Hung, H. L., J. Lau, A. Y. Kim, M. J. Weiss, and G. A. Blobel. 1999. CREB-binding protein acetylates hematopoietic transcription factor GATA- 1 at functionally important sites. Mol. Cell. Biol. 19:3496–3505.
   PubMed Web of Science ®Google Scholar
• Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375–387.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., and T. Hunter. 1996. A growing coactivator network. Nature 383:22–23.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., and T. Hunter. 1999. Nuclear fusion of signaling pathways. Science 284:443–444.
   PubMedGoogle Scholar
• Janknecht, R., N. J. Wells, and T. Hunter. 1998. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 12:2114–2119.
   PubMedGoogle Scholar
• Jimenez, G., S. D. Griffiths, A. M. Ford, M. F. Greaves, and T. Enver. 1992. Activation of the beta-globin locus control region precedes commitment to the erythroid lineage. Proc. Natl. Acad. Sci. USA 89:10618–10622.
   PubMedGoogle Scholar
• Kadam, S., G. S. McAlpine, M. L. Phelan, R. E. Kingston, K. A. Jones, and B. M. Emerson. 2000. Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 14:2441–2451.
   PubMed Web of Science ®Google Scholar
• Keller, G., C. Wall, A. Z. Fong, T. S. Hawley, and R. G. Hawley. 1998. Overexpression of HOX11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential. Blood 92:877–887.
   PubMed Web of Science ®Google Scholar
• Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10:905–920.
   PubMed Web of Science ®Google Scholar
• Kingston, R. E., and G. J. Narlikar. 1999. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev. 13:2339–2352.
   PubMed Web of Science ®Google Scholar
• Kouzarides, T.. 2000. Acetylation: a regulatory modification to rival phosphorylation?. EMBO J. 19:1176–1179.
   PubMed Web of Science ®Google Scholar
• Kung, A. L., V. I. Rebel, R. T. Bronson, L. E. Ch'ng, C. A. Sieff, D. M. Livingston, and T. P. Yao. 2000. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 14:272–277.
   PubMed Web of Science ®Google Scholar
• Kuo, C. T., M. L. Veselits, K. P. Barton, M. M. Lu, C. Clendenin, and J. M. Leiden. 1997. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 11:2996–3006.
   PubMed Web of Science ®Google Scholar
• Kuo, C. T., M. L. Veselits, and J. M. Leiden. 1997. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science 277:1986–1990.
   PubMed Web of Science ®Google Scholar
• Lambert, P. F., F. Kashanchi, M. F. Radonovich, R. Shiekhattar, and J. N. Brady. 1998. Phosphorylation of p53 serine 15 increases interaction with CBP. J. Biol. Chem. 273:33048–33053.
   PubMed Web of Science ®Google Scholar
• Lee, C. H., M. R. Murphy, J. S. Lee, and J. H. Chung. 1999. Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells. Proc. Natl. Acad. Sci. USA 96:12311–12315.
   PubMedGoogle Scholar
• Lim, S. K., J. J. Bieker, C. S. Lin, and F. Costantini. 1997. A shortened life span of EKLF −/− adult erythrocytes, due to a deficiency of β-globin chains, is ameliorated by human γ-globin chains. Blood 90:1291–1299.
   PubMedGoogle Scholar
• Martinez-Balbas, M. A., A. J. Bannister, K. Martin, P. Haus-Seuffert, M. Meisterernst, and T. Kouzarides. 1998. The acetyltransferase activity of CBP stimulates transcription. EMBO J. 17:2886–2893.
   PubMedGoogle Scholar
• McCaffrey, P. G., D. A. Newsome, E. Fibach, M. Yoshida, and M. S. S. Su. 1997. Induction of γ-globin by histone deactylase inhibitors. Blood 90:2075–2083.
   PubMed Web of Science ®Google Scholar
• McMorrow, T., A. van Den Wijngaard, A. Wollenschlaeger, M. van De Corput, K. Monkhorst, T. Trimborn, P. Fraser, M. van Lohuizen, T. Jenuwein, M. Djabali, S. Philipsen, F. Grosveld, and E. Milot. 2000. Activation of the beta globin locus by transcription factors and chromatin modifiers. EMBO J. 19:4986–4996.
   PubMedGoogle Scholar
• Miller, I. J., and J. J. Bieker. 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol. Cell. Biol. 13:2776–2786.
   PubMed Web of Science ®Google Scholar
• Munshi, N., M. Merika, J. Yie, K. Senger, G. Chen, and D. Thanos. 1998. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol. Cell 2:457–467.
   PubMed Web of Science ®Google Scholar
• Neely, K. E., A. H. Hassan, A. E. Wallberg, D. J. Steger, B. R. Cairns, A. P. Wright, and J. L. Workman. 1999. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. Mol. Cell 4:649–655.
   PubMed Web of Science ®Google Scholar
• Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and F. Grosveld. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316–318.
   PubMed Web of Science ®Google Scholar
• Oike, Y., N. Takakura, A. Hata, T. Kaname, M. Akizuki, Y. Yamaguchi, H. Yasue, K. Arakl, K. Yamamura, and T. Suda. 1999. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood 93:2771–2779.
   PubMed Web of Science ®Google Scholar
• Orkin, S. H.. 1995. Regulation of globin gene expression in erythroid cells. Eur. J. Biochem. 231:271–281.
   PubMedGoogle Scholar
• Ouyang, L., X. Chen, and J. J. Bieker. 1998. Regulation of erythroid Kruppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain. J. Biol. Chem. 273:23019–23025.
   PubMed Web of Science ®Google Scholar
• Pavletich, N. P., and C. O. Pabo. 1991. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science 252:809–816.
   PubMed Web of Science ®Google Scholar
• Perkins, A.. 1999. Erythroid Kruppel like factor: from fishing expedition to gourmet meal. Int. J. Biochem. Cell Biol. 31:1175–1192.
   PubMedGoogle Scholar
• Perkins, A. C., K. M. L. Gaensler, and S. H. Orkin. 1996. Silencing of human fetal globin expression is impaired in the absence of the adult β-globin gene activator protein EKLF. Proc. Natl. Acad. Sci. USA 93:12267–12271.
   PubMedGoogle Scholar
• Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal β-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318–322.
   PubMed Web of Science ®Google Scholar
• Phelan, M. L., S. Sif, G. J. Narlikar, and R. E. Kingston. 1999. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol. Cell 3:247–253.
   PubMed Web of Science ®Google Scholar
• Puri, P. L., V. Sartorelli, X. J. Yang, Y. Hamamori, V. V. Ogryzko, B. H. Howard, L. Kedes, J. Y. J. Wang, A. Graessmann, Y. Nakatani, and M. Levrero. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1:35–45.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, K., J. E. Herrera, S. Saito, T. Miki, M. Bustin, A. Vassilev, C. W. Anderson, and E. Appella. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12:2831–2841.
   PubMed Web of Science ®Google Scholar
• Segre, J. A., C. Bauer, and E. Fuchs. 1999. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22:356–360.
   PubMed Web of Science ®Google Scholar
• Shields, J. M., R. J. Christy, and V. W. Yang. 1996. Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J. Biol. Chem. 271:20009–20017.
   PubMed Web of Science ®Google Scholar
• Southwood, C. M., K. M. Downs, and J. J. Bieker. 1996. Erythroid Kruppel-like Factor (EKLF) exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev. Dyn. 206:248–259.
   PubMed Web of Science ®Google Scholar
• Stamatoyannopoulos, G., and A. W. Nienhuis. 1994. Hemoglobin Switching. The molecular bases of blood diseases, 2nd ed. G. Stamatoyannopoulos, A. W. Nienhuis, P. W. Majerus, and H. Varmus. 107–155. W. B. Saunders Co., Philadelphia, Pa
   Google Scholar
• Stamatoyannopoulos, G., and A. W. Nienhuis. 1992. Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies. Annu. Rev. Med. 43:497–521.
   PubMed Web of Science ®Google Scholar
• Struhl, K.. 1999. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell 98:1–4.
   PubMed Web of Science ®Google Scholar
• Struhl, K.. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12:599–606.
   PubMed Web of Science ®Google Scholar
• Sudarsanam, P., and F. Winston. 2000. The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Trends Genet. 16:345–351.
   PubMed Web of Science ®Google Scholar
• Townes, T. M., and R. R. Behringer. 1990. Human globin locus activation region (LAR): role in temporal control. Trends Genet. 6:219–223.
   PubMedGoogle Scholar
• Travers, A.. 1999. An engine for nucleosome remodeling. Cell 96:311–314.
   PubMed Web of Science ®Google Scholar
• Trimborn, T., J. Gribnau, F. Grosveld, and P. Fraser. 1999. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev. 13:112–124.
   PubMedGoogle Scholar
• Turner, J., and M. Crossley. 1999. Mammalian Kruppel-like transcription factors: more than just a pretty finger. Trends Biochem. Sci. 24:236–240.
   PubMed Web of Science ®Google Scholar
• Tyler, J. K., and J. T. Kadonaga. 1999. The “dark side” of chromatin remodeling: repressive effects on transcription. Cell 99:443–446.
   PubMed Web of Science ®Google Scholar
• Vignali, M., A. H. Hassan, K. E. Neely, and J. L. Workman. 2000. ATP-dependent chromatin-remodeling complexes. Mol. Cell. Biol. 20:1899–1910.
   PubMed Web of Science ®Google Scholar
• Wade, P. A., D. Pruss, and A. P. Wolffe. 1997. Histone acetylation: chromatin in action. Trends Biochem. Sci. 22:128–132.
   PubMed Web of Science ®Google Scholar
• Wallberg, A. E., K. E. Neely, J. A. Gustafsson, J. L. Workman, A. P. Wright, and P. A. Grant. 1999. Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domain. Mol. Cell. Biol. 19:5952–5959.
   PubMedGoogle Scholar
• Waltzer, L., and M. Bienz. 1998. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395:521–525.
   PubMed Web of Science ®Google Scholar
• Wijgerde, M., J. Gribnau, T. Trimborn, B. Nuez, S. Philipsen, F. Grosveld, and P. Fraser. 1996. The role of EKLF in human β-globin gene competition. Genes Dev. 10:2894–2902.
   PubMed Web of Science ®Google Scholar
• Wolffe, A. P., and D. Pruss. 1996. Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84:817–819.
   PubMed Web of Science ®Google Scholar
• Workman, J. L., and R. E. Kingston. 1998. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu. Rev. Biochem. 67:545–579.
   PubMed Web of Science ®Google Scholar
• Zhang, W., and J. J. Bieker. 1998. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc. Natl. Acad. Sci. USA 95:9855–9860.
   PubMed Web of Science ®Google Scholar
• Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661–671.
   PubMed Web of Science ®Google Scholar
• Ziegler, B. L., R. Muller, M. Valtieri, C. P. Lamping, C. A. Thomas, M. Gabbianelli, C. Giesert, H. J. Buhring, L. Kanz, and C. Peschle. 1999. Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level. Blood 93:3355–3368.
   PubMedGoogle Scholar