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Transcriptional Regulation

Yeast NC2 Associates with the RNA Polymerase II Preinitiation Complex and Selectively Affects Transcription In Vivo

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Pages 2736-2742 | Received 04 Dec 2000, Accepted 22 Jan 2001, Published online: 28 Mar 2023

REFERENCES

  • Auble, D. T., K. E. Hansen, C. G. F. Mueller, W. S. Lane, J. Thorner, and S. Hahn. 1994. Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev. 8:1920–1934.
  • Burke, T. W., and J. T. Kadonaga. 1997. The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. Genes Dev. 11:3020–3031.
  • Burley, S. K., and R. G. Roeder. 1996. Biochemistry and structural biology of transcription factor IID (TFIID). Annu. Rev. Biochem. 65:769–799.
  • Cang, V., D. T. Auble, and G. Prelich. 1999. A new regulatory domain on the TATA-binding protein. EMBO J. 18:6662–6671.
  • Castano, E., P. Gross, Z. X. Wang, R. G. Roeder, and T. Oelgeschlager. 2000. The C-terminal domain-phosphorylated II0 form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts. Proc. Natl. Acad. Sci. USA 97:7184–7189.
  • Causton, H. C., B. Ren, S. S. Koh, C. T. Harbison, E. Kanin, E. G. Jennings, T. I. Lee, H. L. True, E. S. Lander, and R. A. Young. 2001. Remodeling of yeast genome expression in response to environmental changes. Mol. Biol. Cell 12:323–337.
  • Chicca, J. J., D. T. Auble, and B. F. Pugh. 1998. Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. Mol. Cell. Biol. 18:1701–1710.
  • Cismowski, M., G. Laff, M. Soloman, and S. Reed. 1995. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol. Cell. Biol. 15:2983–2992.
  • Collart, M. A., and K. Struhl. 1994. NOT1 (CDC39), NOT2 (CDC36), NOT3, and NOT4 encode a global negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 8:525–537.
  • Gadbois, E. L., D. M. Chao, J. C. Reese, M. R. Green, and R. A. Young. 1997. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc. Natl. Acad. Sci. USA 94:3145–3150.
  • Gasch, A. P., P. T. Spellman, C. M. Kao, O. Carmel-Harel, M. B. Eisen, G. Storz, D. Botstein, and P. O. Brown. 2000. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11:4241–4257.
  • Geiger, J. H., S. Hahn, S. Lee, and P. B. Sigler. 1996. Crystal structure of the yeast TFIIA/TBP/DNA complex. Science 272:830–836.
  • Goppelt, A., G. Stelzer, F. Lottspeich, and M. Meisterernst. 1996. A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. EMBO J. 15:3105–3116.
  • Heard, D. J., T. Kiss, and W. Filipowicz. 1993. Both Arabidopsis TATA-binding protein (TBP) isoforms are functionally identical in RNA polymerase II and III transcription in plant cells: evidence for gene-specific changes in DNA binding specificity of TBP. EMBO J. 12:3519–3528.
  • Holstege, F. C., E. G. Jennings, J. J. Wyrick, T. I. Lee, C. J. Hengartner, M. R. Green, T. R. Golub, E. S. Lander, and R. A. Young. 1998. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717–728.
  • Ikeda, K., J. P. Halle, G. Stelzer, M. Meisterernst, and K. Kawakami. 1998. Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. Mol. Cell. Biol. 18:10–18.
  • Inostroza, J. A., F. H. Mermelstein, I. Ha, W. S. Lane, and D. Reinberg. 1992. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70:477–489.
  • Kim, S., K. Cabane, M. Hampsey, and D. Reinberg. 2000. Genetic analysis of the Ydr1-Bur6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast. Mol. Cell. Biol. 20:2455–2465.
  • Kim, S., J. G. Na, M. Hampsey, and D. Reinberg. 1997. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc. Natl. Acad. Sci. USA 94:820–825.
  • Kim, T. K., Y. Zhao, H. Ge, R. Bernstein, and R. G. Roeder. 1995. TATA-binding protein residues implicated in a functional interplay between negative cofactor NC2 (Dr1) and general factors TFIIA and TFIIB. J. Biol. Chem. 270:10976–10981.
  • Komarnitsky, P., E.-J. Cho, and S. Buratowski. 2000. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev. 14:2452–2460.
  • Kuras, L., P. Kosa, M. Mencia, and K. Struhl. 2000. TAF-containing and TAF-independent forms of transcriptionally active TBP in vivo. Science 288:1244–1248.
  • Kuras, L., and K. Struhl. 1999. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 389:609–612.
  • Kutach, A. K., and J. T. Kadonaga. 2000. The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters. Mol. Cell. Biol. 20:4754–4764.
  • Lee, T. I., J. J. Wyrick, S. S. Koh, E. G. Jennings, E. L. Gadbois, and R. A. Young. 1998. Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Mol. Cell. Biol. 18:4455–4462.
  • Lee, T. I., and R. A. Young. 1998. Regulation of gene expression by TBP-associated proteins. Genes Dev. 12:1398–1408.
  • Lemaire, M., J. Xie, M. Meisterernst, and M. A. Collart. 2000. The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol. Microbiol. 36:163–173.
  • Li, X.-L., A. Virbasius, X. Zhu, and M. R. Green. 1999. Enhancement of TBP binding by activators and general transcription factors. Nature 389:605–609.
  • Li, X.-Y., S. R. Bhaumik, and M. R. Green. 2000. Distinct classes of yeast promoters revealed by differential TAF recruitment. Science 288:1242–1244.
  • Liu, H.-Y., V. Badarinarayana, D. C. Audino, J. Rappsilber, M. Mann, and C. L. Denis. 1998. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J. 17:1096–1106.
  • Maldonado, E., M. Hampsey, and D. Reinberg. 1999. Repression: targeting the heart of the matter. Cell 99:455–458.
  • Meisterernst, M., and R. G. Roeder. 1991. Family of proteins that interact with TFIID and regulate promoter activity. Cell 67:557–567.
  • Mermelstein, F., K. Yeung, J. Cao, J. A. Inostroza, H. Erdjument-Bromage, K. Eagelson, D. Landsman, P. Levitt, P. Tempst, and D. Reinberg. 1996. Requirement of a corepressor for Dr1-mediated repression of transcription. Genes Dev. 10:1033–1048.
  • Nikolov, D. B., H. Chen, E. D. Halay, A. A. Usheva, K. Hisatake, D. K. Lee, R. G. Roeder, and S. K. Burley. 1995. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377:119–128.
  • Oelgeschlager, T., C. M. Chiang, and R. G. Roeder. 1996. Topology and reorganization of a human TFIID-promoter complex. Nature 382:735–738.
  • Orphanides, G., T. Lagrange, and D. Reinberg. 1996. The general initiation factors of RNA polymerase II. Genes Dev. 10:2657–2683.
  • Prelich, G.. 1997. Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2α homolog that has both positive and negative roles in transcription in vivo. Mol. Cell. Biol. 17:2057–2065.
  • Struhl, K.. 1989. Molecular mechanisms of transcriptional regulation in yeast. Annu. Rev. Biochem. 58:1051–1077.
  • Struhl, K., and Z. Moqtaderi. 1998. The TAFs in the HAT. Cell 94:1–4.
  • Tan, S., Y. Hunziker, D. F. Sargent, and T. J. Richmond. 1996. Crystal structure of a yeast TFIIA/TBP/DNA complex. Nature 381:127–134.
  • Thompson, C. M., and R. A. Young. 1995. General requirement for RNA polymerase II holoenzymes in vivo. Proc. Natl. Acad. Sci. USA 92:4587–4590.
  • Tzamarias, D., and K. Struhl. 1994. Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex. Nature 369:758–761.
  • Verrijzer, C. P., and R. Tjian. 1996. TAFs mediate transcriptional activation and promoter selectivity. Trends Biochem. Sci. 21:338–342.
  • Whitehall, S. K., G. A. Kassavetis, and E. P. Geiduschek. 1995. The symmetry of the yeast U6 RNA gene's TATA box and the orientation of the TATA-binding protein in yeast TFIIIB. Genes Dev. 9:2974–2985.
  • Willy, P. J., R. Kobayashi, and J. T. Kadonaga. 2000. A basal transcription factor that activates or represses transcription. Science 290:982–985.
  • Xie, J., M. Collart, M. Lemaire, G. Stelzer, and M. Meisterernst. 2000. A single point mutation in TFIIA suppresses NC2 requirement in vivo. EMBO J. 19:672–682.

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