Protein Kinase A Regulates Sexual Development and Gluconeogenesis through Phosphorylation of the Zn Finger Transcriptional Activator Rst2p in Fission Yeast

REFERENCES

• Alfa, C., P. A. Fantes, J. Hyams, M. McLeod, and E. Warbrick. 1993. Experiments with fission yeast: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Bähler, J., J. Q. Wu, M. S. Longtine, N. G. Shah, A. McKenzie III, A. B. Steever, A. Wach, P. Philippsen, and J. R. Pringle. 1998. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14: 943–951.
   PubMed Web of Science ®Google Scholar
• Byrne, S. M., and C. S. Hoffman. 1993. Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 105: 1095–1100.
   PubMed Web of Science ®Google Scholar
• Cherry, J. R., T. R. Johnson, C. Dollard, J. R. Shuster, and C. L. Denis. 1989. Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1. Cell 56: 409–419.
   PubMedGoogle Scholar
• Denis, C. L., and E. T. Young. 1983. Isolation and characterization of the positive regulatory gene ADR1 from Saccharomyces cerevisiae. Mol. Cell. Biol. 3: 360–370.
   PubMedGoogle Scholar
• DeVoti, J., G. Seydoux, D. Beach, and M. McLeod. 1991. Interaction between ran1 + protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J. 10: 3759–3768.
   PubMed Web of Science ®Google Scholar
• Egel, R., and M. Egel-Mitani. 1974. Premeiotic DNA synthesis in fission yeast. Exp. Cell Res. 88: 127–134.
   PubMedGoogle Scholar
• Estruch, F., and M. Carlson. 1993. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 3872–3881.
   PubMedGoogle Scholar
• Forsburg, S. L. 1993. Comparison of Schizosaccharomyces pombe expression systems. Nucleic Acids Res. 21: 2955–2956.
   PubMed Web of Science ®Google Scholar
• Gaits, F., G. Degols, K. Shiozaki, and P. Russell. 1998. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev. 12: 1464–1473.
   PubMed Web of Science ®Google Scholar
• Garreau, H., R. N. Hasan, G. Renault, F. Estruch, E. Boy-Marcotte, and M. Jacquet. 2000. Hyperphosphorylation of Msn2p and Msn4p in response to heat shock and the diauxic shift is inhibited by cAMP in Saccharomyces cerevisiae. Microbiology 146: 2113–2120.
   PubMedGoogle Scholar
• Görner, W., E. Durchschlag, M. T. Martinez-Pastor, F. Estruch, G. Ammerer, B. Hamilton, H. Ruis, and C. Schüller. 1998. Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12: 586–597.
   PubMed Web of Science ®Google Scholar
• Gutz, H., H. Heslot, U. Leupold, and N. Loprieno. 1974. Schizosaccharomyces pombe, p. 395–446. In R. D. King (ed.), Handbook of genetics. Plenum Press, New York, N.Y.
   Google Scholar
• Hoffman, C. S., and F. Winston. 1991. Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Genes Dev. 5: 561–571.
   PubMedGoogle Scholar
• Hoffman, C. S., and F. Winston. 1990. Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe. Genetics 124: 807–816.
   PubMed Web of Science ®Google Scholar
• Isshiki, T., N. Mochizuki, T. Maeda, and M. Yamamoto. 1992. Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev. 6: 2455–2462.
   PubMedGoogle Scholar
• Janoo, R. T., L. A. Neely, B. R. Braun, S. K. Whitehall, and C. S. Hoffman. 2001. Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex. Genetics 157: 1205–1215.
   PubMed Web of Science ®Google Scholar
• Kanoh, J., Y. Watanabe, M. Ohsugi, Y. Iino, and M. Yamamoto. 1996. Schizosaccharomyces pombe gad7 + encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells 1: 391–408.
   PubMed Web of Science ®Google Scholar
• Kato, T., Jr., K. Okazaki, H. Murakami, S. Stettler, P. A. Fantes, and H. Okayama. 1996. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. FEBS Lett. 378: 207–212.
   PubMedGoogle Scholar
• Kunitomo, H., T. Higuchi, Y. Iino, and M. Yamamoto. 2000. A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11 + gene, which encodes a pivotal transcription factor for sexual development. Mol. Biol. Cell 11: 3205–3217.
   PubMed Web of Science ®Google Scholar
• Kunkel, T. A., K. Bebenek, and J. McClary. 1991. Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol. 204: 125–139.
   PubMed Web of Science ®Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685.
   PubMed Web of Science ®Google Scholar
• Maeda, T., N. Mochizuki, and M. Yamamoto. 1990. Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 87: 7814–7818.
   PubMedGoogle Scholar
• Maeda, T., Y. Watanabe, H. Kunitomo, and M. Yamamoto. 1994. Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J. Biol. Chem. 269: 9632–9637.
   PubMed Web of Science ®Google Scholar
• Mochizuki, N., and M. Yamamoto. 1992. Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mol. Gen. Genet. 233: 17–24.
   PubMedGoogle Scholar
• Moreno, S., A. Klar, and P. Nurse. 1990. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194: 795–826.
   Google Scholar
• Neely, L. A., and C. S. Hoffman. 2000. Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites. Mol. Cell. Biol. 20: 6426–6434.
   PubMed Web of Science ®Google Scholar
• Nocero, M., T. Isshiki, M. Yamamoto, and C. S. Hoffman. 1994. Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8). Genetics 138: 39–45.
   PubMedGoogle Scholar
• Sherman, F., G. Fink, and J. Hicks. 1986. Methods in yeast genetics: laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Shiozaki, K., and P. Russell. 1996. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev. 10: 2276–2288.
   PubMed Web of Science ®Google Scholar
• Shiozaki, K., and P. Russell. 1997. Stress-activated protein kinase pathway in cell cycle control of fission yeast. Methods Enzymol. 283: 506–520.
   PubMedGoogle Scholar
• Sipiczki, M., and L. Ferenczy. 1977. Protoplast fusion of Schizosaccharomyces pombe auxotrophic mutants of identical mating-type. Mol. Gen. Genet. 151: 77–81.
   PubMedGoogle Scholar
• Smith, A., M. P. Ward, and S. Garrett. 1998. Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J. 17: 3556–3564.
   PubMed Web of Science ®Google Scholar
• Stettler, S., E. Warbrick, S. Prochnik, S. Mackie, and P. Fantes. 1996. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. J. Cell Sci. 109: 1927–1935.
   PubMedGoogle Scholar
• Sugimoto, A., Y. Iino, T. Maeda, Y. Watanabe, and M. Yamamoto. 1991. Schizosaccharomyces pombe ste11 + encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev. 5: 1990–1999.
   PubMed Web of Science ®Google Scholar
• Takeda, T., T. Toda, K. Kominami, A. Kohnosu, M. Yanagida, and N. Jones. 1995. Schizosaccharomyces pombe atf1 + encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 14: 6193–6208.
   PubMedGoogle Scholar
• Taylor, W. E., and E. T. Young. 1990. cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding Proc. Natl. Acad. Sci. USA 87: 4098–4102.
   PubMedGoogle Scholar
• Ullman, K. S., M. A. Powers, and D. J. Forbes. 1997. Nuclear export receptors: from importin to exportin. Cell 90: 967–970.
   PubMedGoogle Scholar
• Vassarotti, A., and J. D. Friesen. 1985. Isolation of the fructose-1,6-bisphosphatase gene of the yeast Schizosaccharomyces pombe: evidence for transcriptional regulation. J. Biol. Chem. 260: 6348–6353.
   PubMedGoogle Scholar
• Watanabe, Y., Y. Iino, K. Furuhata, C. Shimoda, and M. Yamamoto. 1988. The S. pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J. 7: 761–767.
   PubMedGoogle Scholar
• Watanabe, Y., and M. Yamamoto. 1996. Schizosaccharomyces pombe pcr1 + encodes a CREB/ATF protein involved in regulation of gene expression for sexual development. Mol. Cell. Biol. 16: 704–711.
   PubMed Web of Science ®Google Scholar
• Wolfe, S. A., L. Nekludova, and C. O. Pabo. 2000. DNA recognition by Cys2His2 zinc finger proteins. Annu. Rev. Biophys. Biomol. Struct. 29: 183–212.
   PubMedGoogle Scholar
• Yamamoto, M. 1996. The molecular control mechanisms of meiosis in fission yeast. Trends Biochem. Sci. 21: 18–22.
   PubMed Web of Science ®Google Scholar
• Yamawaki-Kataoka, Y., T. Tamaoki, H. R. Choe, H. Tanaka, and T. Kataoka. 1989. Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 86: 5693–5697.
   PubMedGoogle Scholar
• Young, D., M. Riggs, J. Field, A. Vojtek, D. Broek, and M. Wigler. 1989. The adenylyl cyclase gene from Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 86: 7989–7993.
   PubMedGoogle Scholar