mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53

REFERENCES

• Adams, J. M., and S. Cory. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322–1326.
   PubMed Web of Science ®Google Scholar
• Allen, R. T., W. J. Hunter, I. I. I., and D. K. Agrawal. 1997. Morphological and biochemical characterization and analysis of apoptosis. J. Pharmacol. Toxicol. Methods 37: 215–228.
   PubMed Web of Science ®Google Scholar
• Attardi, L. D., E. E. Reczek, C. Cosmas, E. G. Demicco, M. E. McCurrach, S. W. Lowe, and T. Jacks. 2000. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 14: 704–718.
   PubMed Web of Science ®Google Scholar
• Azzoli, C. G., M. Sagar, A. Wu, D. Lowry, H. Hennings, D. L. Morgan, and W. C. Weinberg. 1998. Cooperation of p53 loss of function and v-Ha-ras in transformation of mouse keratinocyte cell lines. Mol. Carcinog. 21: 50–61.
   PubMedGoogle Scholar
• Bates, S., and K. H. Vousden. 1996. p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6: 12–18.
   PubMed Web of Science ®Google Scholar
• Berryman, M., and A. Bretscher. 2000. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol. Biol. Cell 11: 1509–1521.
   PubMedGoogle Scholar
• Brenner, C., and G. Kroemer. 2000. Apoptosis. Mitochondria-the death signal integrators. Science 289: 1150–1151.
   PubMed Web of Science ®Google Scholar
• Chuang, J. Z., T. A. Milner, M. Zhu, and C. H. Sung. 1999. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. J. Neurosci. 19: 2919–2928.
   PubMedGoogle Scholar
• Colman, M. S., C. A. Afshari, and J. C. Barrett. 2000. Regulation of p53 stability and activity in response to genotoxic stress. Mutat. Res. 462: 179–188.
   PubMed Web of Science ®Google Scholar
• Dlugosz, A. A., A. B. Glick, T. Tennenbaum, W. C. Weinberg, and S. H. Yuspa. 1995. Isolation and utilization of epidermal keratinocytes for oncogene research. Methods Enzymol. 254: 3–20.
   PubMedGoogle Scholar
• Duncan, R. R., P. K. Westwood, A. Boyd, and R. H. Ashley. 1997. Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum. J. Biol. Chem. 272: 23880–23886.
   PubMedGoogle Scholar
• Edwards, J. C. 1999. A novel p64-related Cl-channel: subcellular distribution and nephron segment-specific expression. Am. J. Physiol. 276: F398–F408.
   PubMedGoogle Scholar
• Edwards, J. C., and S. Kapadia. 2000. Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase. J. Biol. Chem. 275: 31826–31832.
   PubMedGoogle Scholar
• El-Deiry, W. S., W. S. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817–825.
   PubMed Web of Science ®Google Scholar
• Fernandez-Salas, E., M. Sagar, C. Cheng, S. H. Yuspa, and W. C. Weinberg. 1999. p53 and tumor necrosis factor α regulate the expression of a mitochondrial chloride channel protein. J. Biol. Chem. 274: 36488–36497.
   PubMed Web of Science ®Google Scholar
• Fraser, I. D., M. Cong, J. Kim, E. N. Rollins, Y. Daaka, R. J. Lefkowitz, and J. D. Scott. 2000. Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr. Biol. 10: 409–412.
   PubMed Web of Science ®Google Scholar
• Gottifredi, V., S. Shieh, Y. Taya, and C. Prives. 2001. From the Cover: p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc. Natl. Acad. Sci. USA 98: 1036–1041.
   PubMed Web of Science ®Google Scholar
• Green, D. R., and J. C. Reed. 1998. Mitochondria and apoptosis. Science 281: 1309–1312.
   PubMed Web of Science ®Google Scholar
• Gurney, E. G., R. O. Harrison, and J. Fenno. 1980. Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct subclasses of large T antigen and for similarities among nonviral T antigens. J. Virol. 34: 752–763.
   PubMed Web of Science ®Google Scholar
• Hanahan, D., and R. A. Weinberg. 2000. The hallmarks of cancer. Cell 100: 57–70.
   PubMed Web of Science ®Google Scholar
• Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805–816.
   PubMed Web of Science ®Google Scholar
• Heiss, N. S., and A. Poustka. 1997. Genomic structure of a novel chloride channel gene, CLIC2, in Xq28. Genomics 45: 224–228.
   PubMed Web of Science ®Google Scholar
• Hermeking, H., C. Lengauer, K. Polyak, T. C. He, L. Zhang, S. Thiagalingam, K. W. Kinzler, and B. Vogelstein. 1997. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell 1: 3–11.
   PubMed Web of Science ®Google Scholar
• Johnson, D. E. 2000. Programmed cell death regulation: basic mechanisms and therapeutic opportunities. Leukemia 14: 1340–1344.
   PubMed Web of Science ®Google Scholar
• Kastan, M. B., Q. Zhan, W. S. El-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587–597.
   PubMed Web of Science ®Google Scholar
• Knudson, C. M., K. S. Tung, W. G. Tourtellotte, G. A. Brown, and S. J. Korsmeyer. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96–99.
   PubMed Web of Science ®Google Scholar
• Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10: 1054–1072.
   PubMed Web of Science ®Google Scholar
• Komarova, E. A., M. V. Chernov, R. Franks, K. Wang, G. Armin, C. R. Zelnick, D. M. Chin, S. S. Bacus, G. R. Stark, and A. V. Gudkov. 1997. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J. 16: 1391–1400.
   PubMed Web of Science ®Google Scholar
• Kroemer, G., and J. C. Reed. 2000. Mitochondrial control of cell death. Nat. Med. 6: 513–519.
   PubMed Web of Science ®Google Scholar
• Lakin, N. D., and S. P. Jackson. 1999. Regulation of p53 in response to DNA damage. Oncogene 18: 7644–7655.
   PubMed Web of Science ®Google Scholar
• Landry, D., S. Sullivan, M. Nicolaides, C. Redhead, A. Edelman, M. Field, Q. al Awqati, and J. Edwards. 1993. Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes. J. Biol. Chem. 268: 14948–14955.
   PubMedGoogle Scholar
• Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323–331.
   PubMed Web of Science ®Google Scholar
• Miyashita, T., and J. C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293–299.
   PubMed Web of Science ®Google Scholar
• Nakano, K., and K. H. Vousden. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7: 683–694.
   PubMed Web of Science ®Google Scholar
• Nishizawa, T., T. Nagao, T. Iwatsubo, J. G. Forte, and T. Urushidani. 2000. Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. J. Biol. Chem. 275: 11164–11173.
   PubMedGoogle Scholar
• Oda, E., R. Ohki, H. Murasawa, J. Nemoto, T. Shibue, T. Yamashita, T. Tokino, T. Taniguchi, and N. Tanaka. 2000. Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053–1058.
   PubMed Web of Science ®Google Scholar
• Oda, K., H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya. 2000. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849–862.
   PubMed Web of Science ®Google Scholar
• Oren, M. 1994. Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol. 5: 221–227.
   PubMed Web of Science ®Google Scholar
• Peters, P. J., and W. Hunziker. 2001. Subcellular localization of Rab17 by cryo-immunogold electron microscopy in epithelial cells grown on polycarbonate filters. Methods Enzymol. 329: 210–225.
   PubMedGoogle Scholar
• Phillips, A. C., S. Bates, K. M. Ryan, K. Helin, and K. H. Vousden. 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11: 1853–1863.
   PubMedGoogle Scholar
• Polyak, K., Y. Xia, J. L. Zweier, K. W. Kinzler, and B. Vogelstein. 1997. A model for p53-induced apoptosis. Nature 389: 300–305.
   PubMed Web of Science ®Google Scholar
• Prives, C., and P. A. Hall. 1999. The p53 pathway. J. Pathol. 187: 112–126.
   PubMed Web of Science ®Google Scholar
• Qian, Z., D. Okuhara, M. K. Abe, and M. R. Rosner. 1999. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J. Biol. Chem. 274: 1621–1627.
   PubMedGoogle Scholar
• Redhead, C., S. K. Sullivan, C. Koseki, K. Fujiwara, and J. C. Edwards. 1997. Subcellular distribution and targeting of the intracellular chloride channel p64. Mol. Biol. Cell 8: 691–704.
   PubMedGoogle Scholar
• Ryan, K. M., M. K. Ernst, N. R. Rice, and K. H. Vousden. 2000. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404: 892–897.
   PubMed Web of Science ®Google Scholar
• Schmitt, C. A., and S. W. Lowe. 1999. Apoptosis and therapy. J. Pathol. 187: 127–137.
   PubMed Web of Science ®Google Scholar
• Scholl, F. A., P. McLoughlin, E. Ehler, C. de Giovanni, and B. W. Schafer. 2000. DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. J. Cell Biol. 151: 495–506.
   PubMed Web of Science ®Google Scholar
• Schuler, M., E. Bossy-Wetzel, J. C. Goldstein, P. Fitzgerald, and D. R. Green. 2000. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J. Biol. Chem. 275: 7337–7342.
   PubMed Web of Science ®Google Scholar
• Seth, P., U. Brinkmann, G. N. Schwartz, D. Katayose, R. Gress, I. Pastan, and K. Cowan. 1996. Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging. Cancer Res. 56: 1346–1351.
   PubMed Web of Science ®Google Scholar
• Sheikh, M. S., and A. J. Fornace, Jr. 2000. Role of p53 family members in apoptosis. J. Cell Physiol. 182: 171–181.
   PubMed Web of Science ®Google Scholar
• Speransky, V. V., K. L. Taylor, H. K. Edskes, R. B. Wickner, and A. C. Steven. 2001. Prion filament networks in [URE3] cells of Saccharomyces cerevisiae. J. Cell Biol. 153: 1327–1336.
   PubMedGoogle Scholar
• Strickland, J. E., D. A. Greenhalgh, A. Koceva-Chyla, H. Hennings, C. Restrepo, M. Balaschak, and S. H. Yuspa. 1988. Development of murine epidermal cell lines which contain an activated ras Ha oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res. 48: 165–169.
   PubMedGoogle Scholar
• Takimoto, R., and W. S. el Deiry. 2001. DNA replication blockade impairs p53-transactivation. Proc. Natl. Acad. Sci. USA 98: 781–783.
   PubMedGoogle Scholar
• Tulk, B. M., P. H. Schlesinger, S. A. Kapadia, and J. C. Edwards. 2000. CLIC-1 functions as a chloride channel when expressed and purified from bacteria. J. Biol. Chem. 275: 26986–26993.
   PubMedGoogle Scholar
• Valenzuela, S. M., D. K. Martin, S. B. Por, J. M. Robbins, K. Warton, M. R. Bootcov, P. R. Schofield, T. J. Campbell, and S. N. Breit. 1997. Molecular cloning and expression of a chloride ion channel of cell nuclei. J. Biol. Chem. 272: 12575–12582.
   PubMed Web of Science ®Google Scholar
• Vander Heiden, M. G., N. S. Chandel, P. T. Schumacker, and C. B. Thompson. 1999. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3: 159–167.
   PubMed Web of Science ®Google Scholar
• Weinberg, W. C., C. G. Azzoli, N. Kadiwar, and S. H. Yuspa. 1994. p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-ras Ha oncogene. Cancer Res. 54: 5584–5592.
   PubMedGoogle Scholar
• Yu, J., L. Zhang, P. M. Hwang, K. W. Kinzler, and B. Vogelstein. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7: 673–682.
   PubMed Web of Science ®Google Scholar