A Kruüppel-Associated Box-Zinc Finger Protein, NT2, Represses Cell-Type-Specific Promoter Activity of the α2(XI) Collagen Gene

REFERENCES

• Abrink, M., J. A. Ortiz, C. Mark, C. Sanchez, C. Looman, L. Hellman, P. Chambon, and R. Losson. 2001. Conserved interaction between distinct Kruppel-associated box domains and the transcriptional intermediary factor 1 beta. Proc. Natl. Acad. Sci. USA 98: 1422–1426.
   PubMed Web of Science ®Google Scholar
• Adamson, M. C., J. Silver, and C. A. Kozak. 1991. The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents. Virology 183: 778–781.
   PubMed Web of Science ®Google Scholar
• Attar, R. M., and M. Z. Gilman. 1992. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. Mol. Cell. Biol. 12: 2432–2443.
   PubMedGoogle Scholar
• Bellefroid, E. J., D. A. Poncelet, P. J. Lecocq, O. Revelant, and J. A. Martial. 1991. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Natl. Acad. Sci. USA 88: 3608–3612.
   PubMedGoogle Scholar
• Berg, J. M., and Y. Shi. 1996. The galvanization of biology: a growing appreciation for the roles of zinc. Science 271: 1081–1085.
   PubMed Web of Science ®Google Scholar
• Bernard, M., H. Yoshioka, E. Rodriguez, M. Van der Rest, T. Kimura, Y. Ninomiya, B. R. Olsen, and F. Ramirez. 1988. Cloning and sequencing of pro-alpha 1 (XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the gene is not restricted to cartilaginous tissue. J. Biol. Chem. 263: 17159–17166.
   PubMed Web of Science ®Google Scholar
• Bridgewater, L. C., V. Lefebvre, and B. de Crombrugghe. 1998. Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J. Biol. Chem. 273: 14998–15006.
   PubMed Web of Science ®Google Scholar
• Chowdhury, K., M. Goulding, C. Walther, K. Imai, and H. Fickenscher. 1992. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription. Mech. Dev. 39: 129–142.
   PubMedGoogle Scholar
• Dawson, S. R., D. L. Turner, H. Weintraub, and S. M. Parkhurst. 1995. Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression. Mol. Cell. Biol. 15: 6923–6931.
   PubMedGoogle Scholar
• de Haan, G., S. Chusacultanachai, C. Mao, B. S. Katzenellenbogen, and D. J. Shapiro. 2000. Estrogen receptor-KRAB chimeras are potent ligand-dependent repressors of estrogen-regulated gene expression. J. Biol. Chem. 275: 13493–13501.
   PubMedGoogle Scholar
• Denny, P., and A. Ashworth. 1991. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis. Gene 106: 221–227.
   PubMedGoogle Scholar
• Deweindt, C., O. Albagli, F. Bernardin, P. Dhordain, S. Quief, D. Lantoine, J. P. Kerckaert, and D. Leprince. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6: 1495–1503.
   PubMedGoogle Scholar
• Foster, J. W., M. A. Dominguez-Steglich, S. Guioli, G. Kowk, P. A. Weller, M. Stevanovic, J. Weissenbach, S. Mansour, I. D. Young, P. N. Goodfellow, et al. 1994. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature 372: 525–530.
   PubMed Web of Science ®Google Scholar
• Friedman, J. R., W. J. Fredericks, D. E. Jensen, D. W. Speicher, X. P. Huang, E. G. Neilson, and F. J. Rauscher III. 1996. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 10: 2067–2078.
   PubMed Web of Science ®Google Scholar
• Furuto, D. K., and E. J. Miller. 1983. Different levels of glycosylation contribute to the heterogeneity of alpha 1(II) collagen chains derived from a transplantable rat chondrosarcoma. Arch. Biochem. Biophys. 226: 604–611.
   PubMed Web of Science ®Google Scholar
• Gray, S., and M. Levine. 1996. Transcriptional repression in development. Curr. Opin. Cell Biol. 8: 358–364.
   PubMedGoogle Scholar
• Grimes, H. L., T. O. Chan, P. A. Zweidler-McKay, B. Tong, and P. N. Tsichlis. 1996. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol. Cell. Biol. 16: 6263–6272.
   PubMed Web of Science ®Google Scholar
• Harley, V. R., R. Lovell-Badge, and P. N. Goodfellow. 1994. Definition of a consensus DNA binding site for SRY. Nucleic Acids Res. 22: 1500–1501.
   PubMed Web of Science ®Google Scholar
• Hirota, S., A. Ito, E. Morii, A. Wanaka, M. Tohyama, Y. Kitamura, and S. Nomura. 1992. Localization of mRNA for c-kit receptor and its ligand in the brain of adult rats: an analysis using in situ hybridization histochemistry. Brain Res. Mol. Brain Res. 15: 47–54.
   PubMedGoogle Scholar
• Jheon, A. H., B. Ganss, S. Cheifetz, and J. Sodek. 2001. Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development. J. Biol. Chem. 276: 18282–18289.
   PubMed Web of Science ®Google Scholar
• Johnson, A. D. 1995. The price of repression. Cell 81: 655–658.
   PubMedGoogle Scholar
• Kim, S. S., Y. M. Chen, E. O'Leary, R. Witzgall, M. Vidal, and J. V. Bonventre. 1996. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc. Natl. Acad. Sci. USA 93: 15299–15304.
   PubMedGoogle Scholar
• Kimura, T., K. S. Cheah, S. D. Chan, V. C. Lui, M. G. Mattei, M. van der Rest, K. Ono, E. Solomon, Y. Ninomiya, and B. R. Olsen. 1989. The human alpha 2(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization. J. Biol. Chem. 264: 13910–13916.
   PubMed Web of Science ®Google Scholar
• Klug, A., and J. W. Schwabe. 1995. Protein motifs 5. Zinc fingers. FASEB J. 9: 597–604.
   Google Scholar
• Kozak, C. A., M. Peyser, M. Krall, T. M. Mariano, C. S. Kumar, S. Pestka, and B. A. Mock. 1990. Molecular genetic markers spanning mouse chromosome 10. Genomics 8: 519–524.
   PubMed Web of Science ®Google Scholar
• Lee, P. L., T. Gelbart, C. West, M. Adams, R. Blackstone, and E. Beutler. 1997. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. Genomics 43: 191–201.
   PubMedGoogle Scholar
• Lefebvre, V., W. Huang, V. R. Harley, P. N. Goodfellow, and B. de Crombrugghe. 1997. SOX9 is a potent activator of the chondrocyte-specific enhancer of the proá1(II) collagen gene. Mol. Cell. Biol. 17: 2336–2346.
   PubMed Web of Science ®Google Scholar
• Li, J. J., and I. Herskowitz. 1993. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262: 1870–1874.
   PubMed Web of Science ®Google Scholar
• Li, Y., D. A. Lacerda, M. L. Warman, D. R. Beier, H. Yoshioka, Y. Ninomiya, J. T. Oxford, N. P. Morris, K. Andrikopoulos, F. Ramirez, et al. 1995. A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell 80: 423–430.
   PubMed Web of Science ®Google Scholar
• Liu, Y., H. Li, K. Tanaka, N. Tsumaki, and Y. Yamada. 2000. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene. J. Biol. Chem. 275: 12712–12718.
   PubMedGoogle Scholar
• Margolin, J. F., J. R. Friedman, W. K. Meyer, H. Vissing, H. J. Thiesen, and F. J. Rauscher III. 1994. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Natl. Acad. Sci. USA 91: 4509–4513.
   PubMed Web of Science ®Google Scholar
• Mendler, M., S. G. Eich-Bender, L. Vaughan, K. H. Winterhalter, and P. Bruckner. 1989. Cartilage contains mixed fibrils of collagen types II, IX, and XI. J. Cell Biol. 108: 191–197.
   PubMed Web of Science ®Google Scholar
• Moosmann, P., O. Georgiev, B. Le Douarin, J. P. Bourquin, and W. Schaffner. 1996. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res. 24: 4859–4867.
   PubMedGoogle Scholar
• Morris, N. P., and H. P. Bachinger. 1987. Type XI collagen is a heterotrimer with the composition (1 alpha, 2 alpha, 3 alpha) retaining non-triple-helical domains. J. Biol. Chem. 262: 11345–11350.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay, K., V. Lefebvre, G. Zhou, S. Garofalo, J. H. Kimura, and B. de Crombrugghe. 1995. Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J. Biol. Chem. 270: 27711–27719.
   PubMedGoogle Scholar
• Peng, H., G. E. Begg, D. C. Schultz, J. R. Friedman, D. E. Jensen, D. W. Speicher, and F. J. Rauscher III. 2000. Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J. Mol. Biol. 295: 1139–1162.
   PubMedGoogle Scholar
• Pengue, G., V. Calabro, P. C. Bartoli, A. Pagliuca, and L. Lania. 1994. Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. Nucleic Acids Res. 22: 2908–2914.
   PubMedGoogle Scholar
• Pengue, G., V. Calabro, P. Cannada-Bartoli, P. De Luca, T. Esposito, P. Taillon-Miller, S. LaForgia, T. Druck, K. Huebner, M. D'Urso, et al. 1993. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Hum. Mol. Genet. 2: 791–796.
   PubMedGoogle Scholar
• Pengue, G., and L. Lania. 1996. Kruppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements. Proc. Natl. Acad. Sci. USA 93: 1015–1020.
   PubMedGoogle Scholar
• Petit, B., M. C. Ronziere, D. J. Hartmann, and D. Herbage. 1993. Ultrastructural organization of type XI collagen in fetal bovine epiphyseal cartilage. Histochemistry 100: 231–239.
   PubMedGoogle Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Extraction, purification, and analysis of messenger RNA from eukaryotic cells, p. 7.1–7.87. In C. Noran (ed.), Molecular cloning: a laboratory manual. Cold Spring Harbor Press, New York, N.Y.
   Google Scholar
• Schiestl, R. H., and R. D. Gietz. 1989. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr. Genet. 16: 339–346.
   PubMed Web of Science ®Google Scholar
• Shukunami, C., C. Shigeno, T. Atsumi, K. Ishizeki, F. Suzuki, and Y. Hiraki. 1996. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor. J. Cell Biol. 133: 457–468.
   PubMed Web of Science ®Google Scholar
• Tanaka, K., Y. Matsumoto, F. Nakatani, Y. Iwamoto, and Y. Yamada. 2000. A zinc finger transcription factor, áA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the á1(II) collagen gene. Mol. Cell. Biol. 20: 4428–4435.
   PubMedGoogle Scholar
• Tsumaki, N., and T. Kimura. 1995. Differential expression of an acidic domain in the amino-terminal propeptide of mouse pro-alpha 2(XI) collagen by complex alternative splicing. J. Biol. Chem. 270: 2372–2378.
   PubMed Web of Science ®Google Scholar
• Tsumaki, N., T. Kimura, Y. Matsui, K. Nakata, and T. Ochi. 1996. Separable cis-regulatory elements that contribute to tissue- and site- specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage. J. Cell Biol. 134: 1573–1582.
   PubMedGoogle Scholar
• Tsumaki, N., T. Kimura, K. Tanaka, J. H. Kimura, T. Ochi, and Y. Yamada. 1998. Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha2(XI) collagen promoter. J. Biol. Chem. 273: 22861–22864.
   PubMedGoogle Scholar
• Vaughan, L., M. Mendler, S. Huber, P. Bruckner, K. H. Winterhalter, M. I. Irwin, and R. Mayne. 1988. d-Periodic distribution of collagen type IX along cartilage fibrils. J. Cell Biol. 106: 991–997.
   PubMed Web of Science ®Google Scholar
• Vikkula, M., E. C. Mariman, V. C. Lui, N. I. Zhidkova, G. E. Tiller, M. B. Goldring, S. E. van Beersum, M. C. de Waal Malefijt, F. H. van den Hoogen, H. H. Ropers, et al. 1995. Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus. Cell 80: 431–437.
   PubMed Web of Science ®Google Scholar
• Vissing, H., W. K. Meyer, L. Aagaard, N. Tommerup, and H. J. Thiesen. 1995. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett. 369: 153–157.
   PubMedGoogle Scholar
• Wagner, T., J. Wirth, J. Meyer, B. Zabel, M. Held, J. Zimmer, J. Pasantes, F. D. Bricarelli, J. Keutel, E. Hustert, et al. 1994. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 79: 1111–1120.
   PubMed Web of Science ®Google Scholar
• Wang, M. M., and R. R. Reed. 1993. Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. Nature 364: 121–126.
   PubMed Web of Science ®Google Scholar
• Williams, A. J., L. M. Khachigian, T. Shows, and T. Collins. 1995. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. J. Biol. Chem. 270: 22143–22152.
   PubMedGoogle Scholar
• Wirth, J., T. Wagner, J. Meyer, R. A. Pfeiffer, H. U. Tietze, W. Schempp, and G. Scherer. 1996. Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum. Genet. 97: 186–193.
   PubMedGoogle Scholar
• Witzgall, R., E. O'Leary, A. Leaf, D. Onaldi, and J. V. Bonventre. 1994. The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc. Natl. Acad. Sci. USA 91: 4514–4518.
   PubMed Web of Science ®Google Scholar
• Wright, E., M. R. Hargrave, J. Christiansen, L. Cooper, J. Kun, T. Evans, U. Gangadharan, A. Greenfield, and P. Koopman. 1995. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat. Genet. 9: 15–20.
   PubMed Web of Science ®Google Scholar
• Yang, X. W., R. Zhong, and N. Heintz. 1996. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Development 122: 555–566.
   PubMed Web of Science ®Google Scholar
• Yokoyama, M., M. Nakamura, K. Okubo, K. Matsubara, Y. Nishi, T. Matsumoto, and A. Fukushima. 1997. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Biochim. Biophys. Acta 1353: 13–17.
   PubMedGoogle Scholar
• Zheng, L., H. Pan, S. Li, A. Flesken-Nikitin, P. L. Chen, T. G. Boyer, and W. H. Lee. 2000. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol. Cell 6: 757–768.
   PubMedGoogle Scholar
• Zhu, Z., B. Ma, R. J. Homer, T. Zheng, and J. A. Elias. 2001. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 276: 25222–25229.
   PubMed Web of Science ®Google Scholar