Molecular and Cellular Biology, Volume 22, Issue 12 (2002)

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Molecular and Cellular Biology, Volume 22, Issue 12 (2002)

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Gene Expression

Article
Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant
Ira Lemm & Jeff Ross
Pages: 3959-3969
Published online: 27 Mar 2023
AbstractforRegulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant | Full Text | References | PDF (380.9 KB)
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Article
SRp30c Is a Repressor of 3′ Splice Site Utilization
Martin J. Simard & Benoit Chabot
Pages: 4001-4010
Published online: 27 Mar 2023
AbstractforSRp30c Is a Repressor of 3′ Splice Site Utilization | Full Text | References | PDF (480.8 KB)
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Article
Xenopus LSm Proteins Bind U8 snoRNA via an Internal Evolutionarily Conserved Octamer Sequence
Nenad Tomasevic & Brenda A. Peculis
Pages: 4101-4112
Published online: 27 Mar 2023
AbstractforXenopus LSm Proteins Bind U8 snoRNA via an Internal Evolutionarily Conserved Octamer Sequence | Full Text | References | PDF (484.1 KB)
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Article
RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression
Tapan K. Chatterjee & Rory A. Fisher
Pages: 4334-4345
Published online: 27 Mar 2023
AbstractforRGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression | Full Text | References | PDF (934.3 KB)
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Article
UBA1 and UBA2, Two Proteins That Interact with UBP1, a Multifunctional Effector of Pre-mRNA Maturation in Plants
Mark H. L. Lambermon, Yu Fu, Dominika A. Wieczorek Kirk, Marcel Dupasquier, Witold Filipowicz & Zdravko J. Lorković
Pages: 4346-4357
Published online: 27 Mar 2023
AbstractforUBA1 and UBA2, Two Proteins That Interact with UBP1, a Multifunctional Effector of Pre-mRNA Maturation in Plants | Full Text | References | PDF (710 KB)
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Cell Growth and Development

Article
Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation
Michael Leitges, Kerstin Gimborn, Winfried Elis, Janet Kalesnikoff, Michael R. Hughes, Gerald Krystal & Michael Huber
Pages: 3970-3980
Published online: 27 Mar 2023
AbstractforProtein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation | Full Text | References | PDF (494.1 KB)
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Article
Protein Kinase A Operates a Molecular Switch That Governs Yeast Pseudohyphal Differentiation
Xuewen Pan & Joseph Heitman
Pages: 3981-3993
Published online: 27 Mar 2023
AbstractforProtein Kinase A Operates a Molecular Switch That Governs Yeast Pseudohyphal Differentiation | Full Text | References | PDF (406.6 KB)
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Article
Snf1 Protein Kinase and the Repressors Nrg1 and Nrg2 Regulate FLO11, Haploid Invasive Growth, and Diploid Pseudohyphal Differentiation
Sergei Kuchin, Valmik K. Vyas & Marian Carlson
Pages: 3994-4000
Published online: 27 Mar 2023
AbstractforSnf1 Protein Kinase and the Repressors Nrg1 and Nrg2 Regulate FLO11, Haploid Invasive Growth, and Diploid Pseudohyphal Differentiation | Full Text | References | PDF (265.7 KB)
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Article
Leukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes Gαq-Coupled Activation of RhoA
Michelle A. Booden, David P. Siderovski & Channing J. Der
Pages: 4053-4061
Published online: 27 Mar 2023
AbstractforLeukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes Gαq-Coupled Activation of RhoA | Full Text | References | PDF (369.3 KB)
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Article
Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2
Si Qing Zhang, William G. Tsiaras, Toshiyuki Araki, Gengyun Wen, Liliana Minichiello, Ruediger Klein & Benjamin G. Neel
Pages: 4062-4072
Published online: 27 Mar 2023
AbstractforReceptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2 | Full Text | References | PDF (397.2 KB)
  • 61 Views
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Article
Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade
Rachel J. Buchsbaum, Beth A. Connolly & Larry A. Feig
Pages: 4073-4085
Published online: 27 Mar 2023
AbstractforInteraction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade | Full Text | References | PDF (622.1 KB)
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Article
Apoptosis-Linked Gene 2-Deficient Mice Exhibit Normal T-Cell Development and Function
Ihn Kyung Jang, Renju Hu, Emanuela Lacaná, Luciano D'Adamio & Hua Gu
Pages: 4094-4100
Published online: 27 Mar 2023
AbstractforApoptosis-Linked Gene 2-Deficient Mice Exhibit Normal T-Cell Development and Function | Full Text | References | PDF (362.9 KB)
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Article
Type 1 Phosphatase, a Negative Regulator of Cardiac Function
Andrew N. Carr, Albrecht G. Schmidt, Yoichi Suzuki, Federica del Monte, Yoji Sato, Carita Lanner, Kristine Breeden, Shao-Ling Jing, Patrick B. Allen, Paul Greengard, Atsuko Yatani, Brian D. Hoit, Ingrid L. Grupp, Roger J. Hajjar, Anna A. DePaoli-Roach & Evangelia G. Kranias
Pages: 4124-4135
Published online: 27 Mar 2023
AbstractforType 1 Phosphatase, a Negative Regulator of Cardiac Function | Full Text | References | PDF (744.6 KB)
  • 48 Views
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Article
Activation of Ras and the Mitogen-Activated Protein Kinase Pathway Promotes Protein Degradation in Muscle Cells of Caenorhabditis elegans
Nathaniel J. Szewczyk, Brant K. Peterson & Lewis A. Jacobson
Pages: 4181-4188
Published online: 27 Mar 2023
AbstractforActivation of Ras and the Mitogen-Activated Protein Kinase Pathway Promotes Protein Degradation in Muscle Cells of Caenorhabditis elegans | Full Text | References | PDF (444.8 KB)
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Article
Membrane Targeting and Asymmetric Localization of Drosophila Partner of Inscuteable Are Discrete Steps Controlled by Distinct Regions of the Protein
Fengwei Yu, Chin Tong Ong, William Chia & Xiaohang Yang
Pages: 4230-4240
Published online: 27 Mar 2023
AbstractforMembrane Targeting and Asymmetric Localization of Drosophila Partner of Inscuteable Are Discrete Steps Controlled by Distinct Regions of the Protein | Full Text | References | PDF (2.4 MB)
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Article
Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling
Michael P. Loreto, Donna M. Berry & C. Jane McGlade
Pages: 4241-4255
Published online: 27 Mar 2023
AbstractforFunctional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling | Full Text | References | PDF (846.3 KB)
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Article
BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets
Timothy K. MacLachlan, Rishu Takimoto & Wafik S. El-Deiry
Pages: 4280-4292
Published online: 27 Mar 2023
AbstractforBRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets | Full Text | References | PDF (802.5 KB)
  • 23 Views
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Article
The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation
Latha Shivakumar, John Minna, Toshiyuki Sakamaki, Richard Pestell & Michael A. White
Pages: 4309-4318
Published online: 27 Mar 2023
AbstractforThe RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation | Full Text | References | PDF (838.5 KB)
  • 36 Views
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Article
The G1 Cyclin Cln3 Promotes Cell Cycle Entry via the Transcription Factor Swi6
Herman Wijnen, Allison Landman & Bruce Futcher
Pages: 4402-4418
Published online: 27 Mar 2023
AbstractforThe G1 Cyclin Cln3 Promotes Cell Cycle Entry via the Transcription Factor Swi6 | Full Text | References | PDF (764.1 KB)
  • 15 Views
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Article
Chk2 Activation and Phosphorylation-Dependent Oligomerization
Xingzhi Xu, Lyuben M. Tsvetkov & David F. Stern
Pages: 4419-4432
Published online: 27 Mar 2023
AbstractforChk2 Activation and Phosphorylation-Dependent Oligomerization | Full Text | References | PDF (536.2 KB)
  • 89 Views
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Transcriptional Regulation

Article
The E2 Ubiquitin Conjugase Rad6 Is Required for the ArgR/Mcm1 Repression of ARG1 Transcription
Suzanne D. Turner, Andrea R. Ricci, Helen Petropoulos, Julie Genereaux, Ilona S. Skerjanc & Christopher J. Brandl
Pages: 4011-4019
Published online: 27 Mar 2023
AbstractforThe E2 Ubiquitin Conjugase Rad6 Is Required for the ArgR/Mcm1 Repression of ARG1 Transcription | Full Text | References | PDF (211.2 KB)
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Article
Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation
Nicolas Foray, Didier Marot, Voahangy Randrianarison, Nicole Dalla Venezia, Didier Picard, Michel Perricaudet, Vincent Favaudon & Penny Jeggo
Pages: 4020-4032
Published online: 27 Mar 2023
AbstractforConstitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation | Full Text | References | PDF (656.4 KB)
  • 22 Views
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Article
Components of the SAGA Histone Acetyltransferase Complex Are Required for Repressed Transcription of ARG1 in Rich Medium
Andrea R. Ricci, Julie Genereaux & Christopher J. Brandl
Pages: 4033-4042
Published online: 27 Mar 2023
AbstractforComponents of the SAGA Histone Acetyltransferase Complex Are Required for Repressed Transcription of ARG1 in Rich Medium | Full Text | References | PDF (196.3 KB)
  • 27 Views
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Article
Chromatin Disruption and Histone Acetylation in Regulation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Thyroid Hormone Receptor
Shao-Chung Victor Hsia & Yun-Bo Shi
Pages: 4043-4052
Published online: 27 Mar 2023
AbstractforChromatin Disruption and Histone Acetylation in Regulation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Thyroid Hormone Receptor | Full Text | References | PDF (274.7 KB)
  • 14 Views
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Article
Proteasomal Inhibition Enhances Glucocorticoid Receptor Transactivation and Alters Its Subnuclear Trafficking
Bonnie J. Deroo, Claudia Rentsch, Sowmini Sampath, Janel Young, Donald B. DeFranco & Trevor K. Archer
Pages: 4113-4123
Published online: 27 Mar 2023
AbstractforProteasomal Inhibition Enhances Glucocorticoid Receptor Transactivation and Alters Its Subnuclear Trafficking | Full Text | References | PDF (715.4 KB)
  • 49 Views
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Article
Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation
Georg J. Hoppe, Jason C. Tanny, Adam D. Rudner, Scott A. Gerber, Sherwin Danaie, Steven P. Gygi & Danesh Moazed
Pages: 4167-4180
Published online: 27 Mar 2023
AbstractforSteps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation | Full Text | References | PDF (546.2 KB)
  • 63 Views
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Article
A Kruüppel-Associated Box-Zinc Finger Protein, NT2, Represses Cell-Type-Specific Promoter Activity of the α2(XI) Collagen Gene
Kazuhiro Tanaka, Noriyuki Tsumaki, Christine A. Kozak, Yoshihiro Matsumoto, Fumihiko Nakatani, Yukihide Iwamoto & Yoshihiko Yamada
Pages: 4256-4267
Published online: 27 Mar 2023
AbstractforA Kruüppel-Associated Box-Zinc Finger Protein, NT2, Represses Cell-Type-Specific Promoter Activity of the α2(XI) Collagen Gene | Full Text | References | PDF (1.1 MB)
  • 20 Views
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Article
Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid versus Megakaryocytic Maturation
Alan B. Cantor, Samuel G. Katz & Stuart H. Orkin
Pages: 4268-4279
Published online: 27 Mar 2023
AbstractforDistinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid versus Megakaryocytic Maturation | Full Text | References | PDF (1 MB)
  • 14 Views
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Article
Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity
Charles K. Kaufman, Satrajit Sinha, Diana Bolotin, Jie Fan & Elaine Fuchs
Pages: 4293-4308
Published online: 27 Mar 2023
AbstractforDissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity | Full Text | References | PDF (1.7 MB)
  • 8 Views
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Article
Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex
Timothy V. Beischlag, Song Wang, David W. Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E. Nelson, Markus R. Probst, Michael G. Rosenfeld & Oliver Hankinson
Pages: 4319-4333
Published online: 27 Mar 2023
AbstractforRecruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex | Full Text | References | PDF (730 KB)
  • 55 Views
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Article
The DNA Architectural Protein HMGB1 Displays Two Distinct Modes of Action That Promote Enhanceosome Assembly
Katherine Mitsouras, Ben Wong, Charina Arayata, Reid C. Johnson & Michael Carey
Pages: 4390-4401
Published online: 27 Mar 2023
AbstractforThe DNA Architectural Protein HMGB1 Displays Two Distinct Modes of Action That Promote Enhanceosome Assembly | Full Text | References | PDF (500.4 KB)
  • 20 Views
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Dna Dynamics and Chromosome Structure

Article
Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins
Thomas W. O'Rourke, Nicole A. Doudican, Melinda D. Mackereth, Paul W. Doetsch & Gerald S. Shadel
Pages: 4086-4093
Published online: 27 Mar 2023
AbstractforMitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins | Full Text | References | PDF (204 KB)
  • 56 Views
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Article
Mutations in DNA Replication Genes Reduce Yeast Life Span
Laura L. Mays Hoopes, Martin Budd, Wonchae Choe, Tao Weitao & Judith L. Campbell
Pages: 4136-4146
Published online: 27 Mar 2023
AbstractforMutations in DNA Replication Genes Reduce Yeast Life Span | Full Text | References | PDF (276 KB)
  • 32 Views
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Article
Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G2/M Phase, and Protection from Apoptosis
Artur Slupianek, Grazyna Hoser, Ireneusz Majsterek, Agnieszka Bronisz, Maciej Malecki, Janusz Blasiak, Richard Fishel & Tomasz Skorski
Pages: 4189-4201
Published online: 27 Mar 2023
AbstractforFusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G2/M Phase, and Protection from Apoptosis | Full Text | References | PDF (689.9 KB)
  • 10 Views
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Article
Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication
Wonchae Choe, Martin Budd, Osamu Imamura, Laura Hoopes & Judith L. Campbell
Pages: 4202-4217
Published online: 27 Mar 2023
AbstractforDynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication | Full Text | References | PDF (871.3 KB)
  • 10 Views
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Article
RSC2, Encoding a Component of the RSC Nucleosome Remodeling Complex, Is Essential for 2μm Plasmid Maintenance in Saccharomyces cerevisiae
Michael C. V. L. Wong, Suzanna R. S. Scott-Drew, Matthew J. Hayes, Philip J. Howard & James A. H. Murray
Pages: 4218-4229
Published online: 27 Mar 2023
AbstractforRSC2, Encoding a Component of the RSC Nucleosome Remodeling Complex, Is Essential for 2μm Plasmid Maintenance in Saccharomyces cerevisiae | Full Text | References | PDF (1.1 MB)
  • 16 Views
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Article
Yeast RAD26, a Homolog of the Human CSB Gene, Functions Independently of Nucleotide Excision Repair and Base Excision Repair in Promoting Transcription through Damaged Bases
Sung-Keun Lee, Sung-Lim Yu, Louise Prakash & Satya Prakash
Pages: 4383-4389
Published online: 27 Mar 2023
AbstractforYeast RAD26, a Homolog of the Human CSB Gene, Functions Independently of Nucleotide Excision Repair and Base Excision Repair in Promoting Transcription through Damaged Bases | Full Text | References | PDF (192.1 KB)
  • 19 Views
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants
Eleni Goshu, Hui Jin, Rachel Fasnacht, Mike Sepenski, Jacques L. Michaud & Chen-Ming Fan
Pages: 4147-4157
Published online: 27 Mar 2023
AbstractforSim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants | Full Text | References | PDF (1.1 MB)
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Article
Mitochondrial NAD-Dependent Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase Is Essential for Embryonic Development
E. Di Pietro, J. Sirois, M. L. Tremblay & R. E. MacKenzie
Pages: 4158-4166
Published online: 27 Mar 2023
AbstractforMitochondrial NAD-Dependent Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase Is Essential for Embryonic Development | Full Text | References | PDF (679.8 KB)
  • 55 Views
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Article
PEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function
Xiaoling Li, Eveline Baumgart, James C. Morrell, Gerardo Jimenez-Sanchez, David Valle & Stephen J. Gould
Pages: 4358-4365
Published online: 27 Mar 2023
AbstractforPEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function | Full Text | References | PDF (879.4 KB)
  • 72 Views
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Article
Cartilage Oligomeric Matrix Protein-Deficient Mice Have Normal Skeletal Development
Liz Svensson, Attila Aszódi, Dick Heinegaård, Ernst B. Hunziker, Finn P. Reinholt, Reinhard Fässler & Aåke Oldberg
Pages: 4366-4371
Published online: 27 Mar 2023
AbstractforCartilage Oligomeric Matrix Protein-Deficient Mice Have Normal Skeletal Development | Full Text | References | PDF (415.4 KB)
  • 62 Views
  • 133 CrossRef citations
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Article
A Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility
Thomas A. Natoli, Alice McDonald, Julia A. Alberta, Mary E. Taglienti, David E. Housman & Jordan A. Kreidberg
Pages: 4433-4438
Published online: 27 Mar 2023
AbstractforA Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility | Full Text | References | PDF (436.7 KB)
  • 11 Views
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Cell and Organelle Structure and Assembly

Article
Mitochondrial RNA Import in Leishmania tropica: Aptamers Homologous to Multiple tRNA Domains That Interact Cooperatively or Antagonistically at the Inner Membrane
Subhendra Nath Bhattacharyya, Saibal Chatterjee & Samit Adhya
Pages: 4372-4382
Published online: 27 Mar 2023
AbstractforMitochondrial RNA Import in Leishmania tropica: Aptamers Homologous to Multiple tRNA Domains That Interact Cooperatively or Antagonistically at the Inner Membrane | Full Text | References | PDF (620.3 KB)
  • 36 Views
  • 33 CrossRef citations
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