3
Views
40
CrossRef citations to date
0
Altmetric
Gene Expression

RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression

&
Pages 4334-4345 | Received 24 May 2001, Accepted 12 Mar 2002, Published online: 27 Mar 2023

REFERENCES

  • Akileswaran, L., J. W. Taraska, J. A. Sayer, J. M. Gettemy, and V. M. Coghlan. 2001. A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. J. Biol. Chem. 276: 17448–17454.
  • Almeida, F., R. Saffrich, W. Ansorge, and M. Carmo-Fonseca. 1998. Microinjection of anti-coilin antibodies affects the structure of coiled bodies. J. Cell Biol. 142: 899–912.
  • Burgon, P. G., W. L. Lee, A. B. Nixon, E. G. Peralta, and P. J. Casey. 2001. Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). J. Biol. Chem. 276: 32828–32834.
  • Bushmeyer, S. M., and M. L. Atchison. 1998. Identification of YY1 sequences necessary for association with the nuclear matrix and for transcriptional repression functions. J. Cell. Biochem. 68: 484–499.
  • Chatterjee, T. K., and R. A. Fisher. 2000. Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275: 24013–24021.
  • Chatterjee, T. K., and R. A. Fisher. 2000. Novel alternative splicing and nuclear localization of human RGS12 gene products. J. Biol. Chem. 275: 29660–29671.
  • De Vries, L., B. Zheng, T. Fischer, E. Elenko, and M. G. Farquhar. 2000. The regulator of G protein signaling family. Annu. Rev. Pharmacol. Toxicol. 40: 235–271.
  • Dulin, N. O., P. Pratt, C. Tiruppathi, J. Niu, T. Voyno-Yasenetskaya, and M. J. Dunn. 2000. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J. Biol. Chem. 275: 21317–21323.
  • Edgar, B. A., and T. L. Orr-Weaver. 2001. Endoreplication cell cycles: more for less. Cell 105: 297–306.
  • Frohme, M., B. Scharm, H. Delius, R. Knecht, and J. D. Hoheisel. 2000. Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. Ann. N. Y. Acad. Sci. 910: 85–104.
  • Heximer, S. P., H. Lim, J. L. Bernard, and K. J. Blumer. 2001. Mechanisms governing subcellular localization and function of human RGS2. J. Biol. Chem. 276: 14195–14203.
  • Kanai, F., P. A. Marignani, D. Sarbassova, R. Yagi, R. A. Hall, M. Donowitz, A. Hisaminato, T. Fujiwara, Y. Ito, L. C. Cantley, and M. B. Yaffe. 2000. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 19: 6778–6791.
  • Lamond, A. I., and W. C. Earnshaw. 1998. Structure and function in the nucleus. Science 280: 547–553.
  • Mancini, M. G., B. Liu, Z. D. Sharp, and M. A. Mancini. 1999. Subnuclear partitioning and functional regulation of the Pit-1 transcription factor. J. Cell. Biochem. 72: 322–338.
  • Matera, A. G. 1999. Nuclear bodies: multifaceted subdomains of the interchromatin space. Trends Cell Biol. 9: 302–309.
  • Misteli, T. 2000. Cell biology of transcription and pre-mRNA splicing: nuclear architecture meets nuclear function. J. Cell Sci. 113: 1841–1849.
  • Ross, E. M., and T. M. Wilkie. 2000. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69: 795–827.
  • Saitoh, O., I. Masuho, I. Terakawa, S. Nomoto, T. Asano, and Y. Kubo. 2001. Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels. J. Biol. Chem. 276: 5052–5058.
  • Stein, G. S., A. J. van Wijnen, J. L. Stein, J. B. Lian, S. H. Pockwinse, and S. McNeil. 1999. Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. FASEB J. 13: S157–S166.
  • Tang, Y., R. H. Getzenberg, B. N. Vietmeier, M. R. Stallcup, M. Eggert, R. Renkawitz, and D. B. DeFranco. 1998. The DNA-binding and tau2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal. Mol. Endocrinol. 12: 1420–1431.
  • Terada, Y., M. Tatsuka, F. Suzuki, Y. Yasuda, S. Fujita, and M. Otsu. 1998. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J. 17: 667–676.
  • van Lohuizen, M., M. Tijms, J. W. Voncken, A. Schumacher, T. Magnuson, and E. Wientjens. 1998. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol. Cell. Biol. 18: 3572–3579.
  • Waldman, T., C. Lengauer, K. W. Kinzler, and B. Vogelstein. 1996. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713–716.
  • Wan, K. M., J. A. Nickerson, G. Krockmalnic, and S. Penman. 1999. The nuclear matrix prepared by amine modification. Proc. Natl. Acad. Sci. USA 96: 933–938.
  • Weber, J. D., M. L. Kuo, B. Bothner, E. L. DiGiammarino, R. W. Kriwacki, M. F. Roussel, and C. J. Sherr. 2000. Cooperative signals governing ARF-Mdm2 interaction and nucleolar localization of the complex. Mol. Cell. Biol. 20: 2517–2528.
  • Wei, X., S. Somanathan, J. Samarabandu, and R. Berezney. 1999. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles. J. Cell Biol. 146: 543–558.
  • Zeng, C., A. J. van Wijnen, J. L. Stein, S. Meyers, W. Sun, L. Shopland, J. B. Lawrence, S. Penman, J. B. Lian, G. S. Stein, and S. W. Hiebert. 1997. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc. Natl. Acad. Sci. USA 94: 6746–6751.
  • Zhang, H. S., M. Gavin, A. Dahiya, A. A. Postigo, D. Ma, R. X. Luo, J. W. Harbour, and D. C. Dean. 2000. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101: 79–89.
  • Zhang, J. H., V. A. Barr, Y. Mo, A. M. Rojkova, S. Liu, and W. F. Simonds. 2001. Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain. J. Biol. Chem. 276: 10284–10289.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.