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Mammalian Genetic Models with Minimal or Complex Phenotypes

A Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility

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Pages 4433-4438 | Received 08 Nov 2001, Accepted 19 Feb 2002, Published online: 27 Mar 2023

REFERENCES

  • Armstrong, J. F., K. Pritchard-Jones, W. A. Bickmore, N. D. Hastie, and J. B. Bard. 1993. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech. Dev. 40: 85–97.
  • Barbaux, S., P. Niaudet, M. C. Gubler, J. P. Grunfeld, F. Jaubert, F. Kuttenn, C. N. Fekete, T. N. Souleyreau, E. Thibaud, M. Fellous, and K. McElreavey. 1997. Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nat. Genet. 17: 467–470.
  • Buckler, A. J., J. Pelletier, D. A. Haber, T. Glaser, and D. E. Housman. 1991. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol. Cell. Biol. 11: 1707–1712.
  • Call, K. M., T. Glaser, C. Y. Ito, A. J. Buckler, J. Pelletier, D. A. Haber, E. A. Rose, A. Kral, H. Yeger, and W. H. Lewis. 1990. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60: 509–520.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156–159.
  • Donovan, M. J., T. A. Natoli, K. Sainio, A. Amstutz, R. Jaenisch, H. Sariola, and J. A. Kreidberg. 1999. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev. Genet. 24: 252–262.
  • Gessler, M., A. Poustka, W. Cavenee, R. L. Neve, S. H. Orkin, and G. A. Bruns. 1990. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343: 774–778.
  • Haber, D. A., R. L. Sohn, A. J. Buckler, J. Pelletier, K. M. Call, and D. E. Housman. 1991. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc. Natl. Acad. Sci. USA 88: 9618–9622.
  • Hammes, A., J. K. Guo, G. Lutsch, J. R. Leheste, D. Landrock, U. Ziegler, M. C. Gubler, and A. Schedl. 2001. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106: 319–329.
  • Herzer, U., A. Crocoll, D. Barton, N. Howells, and C. Englert. 1999. The Wilms tumor suppressor gene wt1 is required for development of the spleen. Curr. Biol. 9: 837–840.
  • Hewitt, S. M., and G. F. Saunders. 1996. Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function. Anticancer Res. 16: 621–626.
  • Humpherys, D., K. Eggan, H. Akutsu, K. Hochedlinger, W. M. Rideout III, D. Biniszkiewicz, R. Yanagimachi, and R. Jaenisch. 2001. Epigenetic instability in ES cells and cloned mice. Science 293: 95–97.
  • Joyner, A. L. 1993. Gene targeting: a practical approach. Oxford University Press, New York, N.Y.
  • Kent, J., A. M. Coriat, P. T. Sharpe, N. D. Hastie, and V. van Heyningen. 1995. The evolution of WT1 sequence and expression pattern in the vertebrates. Oncogene 11: 1781–1792.
  • Kreidberg, J. A., T. A. Natoli, L. McGinnis, M. Donovan, J. D. Biggers, and A. Amstutz. 1999. Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct. Mol. Reprod. Dev. 52: 366–375.
  • Kreidberg, J. A., H. Sariola, J. M. Loring, M. Maeda, J. Pelletier, D. Housman, and R. Jaenisch. 1993. WT-1 is required for early kidney development. Cell 74: 679–691.
  • Laird, P. W., A. Zijderveld, K. Linders, M. A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19: 4293.
  • Moore, A. W., L. McInnes, J. Kreidberg, N. D. Hastie, and A. Schedl. 1999. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845–1857.
  • Pelletier, J., W. Bruening, C. E. Kashtan, S. M. Mauer, J. C. Manivel, J. E. Striegel, D. C. Houghton, C. Junien, R. Habib, L. Fouser, et al. 1991. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 67: 437–447.
  • Pelletier, J., M. Schalling, A. J. Buckler, A. Rogers, D. A. Haber, and D. Housman. 1991. Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev. 5: 1345–1356.
  • Pruitt, S. C., and T. A. Natoli. 1992. Inhibition of differentiation by leukemia inhibitory factor distinguishes two induction pathways in P19 embryonal carcinoma cells. Differentiation 50: 57–65.
  • Richard, D. J., V. Schumacher, B. Royer-Pokora, and S. G. Roberts. 2001. Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1. Genes Dev. 15: 328–339.
  • Scharnhorst, V., A. J. van der Eb, and A. G. Jochemsen. 2001. WT1 proteins: functions in growth and differentiation. Gene 273: 141–161.
  • Silberstein, G. B., K. Van Horn, P. Strickland, C. T. Roberts, Jr., and C. W. Daniel. 1997. Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer. Proc. Natl. Acad. Sci. USA 94: 8132–8137.
  • Zhou, J., F. J. Rauscher III, and C. Bondy. 1993. Wilms' tumor (WT1) gene expression in rat decidual differentiation. Differentiation 54: 109–114.

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