43
Views
83
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter

, , , &
Pages 4522-4534 | Received 16 Oct 2001, Accepted 27 Mar 2002, Published online: 27 Mar 2023

REFERENCES

  • Alepuz, P. M., A. Jovanovic, V. Reiser, and G. Ammerer. 2001. Stress-induced MAP kinase hog1 is part of transcription activation complexes. Mol. Cell 7: 767–777.
  • Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270: 27489–27494.
  • Angel, P., M. Imagawa, R. Chiu, B. Stein, C. Jonat, and M. Karin. 1987. Phorbol-ester inducible genes contain a common cis-element recognized by a TPA-modulated trans-acting factor. Cell 49: 729–739.
  • Bannister, A. J., T. Oehler, D. Wilhelm, P. Angel, and T. Kouzarides. 1995. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11: 2509–2514.
  • Benkoussa, M., B. Nomine, A. Mouchon, B. Lefebvre, J. M. Bernardon, P. Formstecher, and P. Lefebvre. 1997. Limited proteolysis for assaying ligand binding affinities of nuclear receptors. Recept. Signal. Transduct. 7: 257–267.
  • Bourguet, W., V. Vivat, J. M. Wurtz, P. Chambon, H. Gronemeyer, and D. Moras. 2000. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol. Cell 5: 289–298.
  • Caelles, C., J. M. Gonzalez-Sancho, and A. Munoz. 1997. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11: 3351–3364.
  • Castano, E., P. Gross, Z. X. Wang, R. G. Roeder, and T. Oelgeschlager. 2000. The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts. Proc. Natl. Acad. Sci. USA 97: 7184–7189.
  • Chen, J. Y., S. Penco, J. Ostrowski, P. Balaguer, M. Pons, J. E. Starrett, P. Reczek, P. Chambon, and H. Gronemeyer. 1995. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 14: 1187–1197.
  • Cook, S. J., N. Aziz, and M. McMahon. 1999. The repertoire of Fos and Jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol. Cell. Biol. 19: 330–341.
  • DeBosscher, K., W. V. Berghe, L. Vermeulen, S. Plaisance, E. Boone, and G. Haegeman. 2000. Glucocorticoids repress NF-kappa B-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc. Natl. Acad. Sci. USA 97: 3919–3924.
  • de Groot, R. P., J. Auwerx, M. Bourouis, and P. Sassone-Corsi. 1993. Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene 8: 841–847.
  • Delmotte, M. H., A. Tahayato, P. Formstecher, and P. Lefebvre. 1999. Serine 157, a retinoic acid receptor alpha residue phosphorylated by protein kinase C in vitro, is involved in RXR.RARalpha heterodimerization and transcriptional activity. J. Biol. Chem. 274: 38225–38231.
  • Depoix, C., M. H. Delmotte, P. Formstecher, and P. Lefebvre. 2001. Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. J. Biol. Chem. 276: 9452–9459.
  • Dominguez, I., K. Itoh, and S. Y. Sokol. 1995. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc. Natl. Acad. Sci. USA 92: 8498–8502.
  • Efimova, T., P. LaCelle, J. F. Welter, and R. L. Eckert. 1998. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J. Biol. Chem. 273: 24387–24395.
  • Fanjul, A., M. I. Dawson, P. D. Hobbs, L. Jong, J. F. Cameron, E. Harlev, G. Graupner, X. P. Lu, and M. Pfahl. 1994. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372: 107–111.
  • Hazzalin, C. A., R. Le Panse, E. Cano, and L. C. Mahadevan. 1998. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol. Cell. Biol. 18: 1844–1854.
  • He, X., J. P. Saint-Jeannet, J. R. Woodgett, H. E. Varmus, and I. B. Dawid. 1995. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374: 617–622.
  • Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S. C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403–414.
  • Karin, M. 1996. The regulation of AP-1 activity by mitogen-activated protein kinases. Philos. Trans. R. Soc. Lond. Biol. 351: 127–134.
  • Klein, E. S., M. E. Pino, A. T. Johnson, P. J. Davies, S. Nagpal, S. M. Thacher, G. Krasinski, and R. A. Chandraratna. 1996. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J. Biol. Chem. 271: 22692–22696.
  • Klein, P. S., and D. A. Melton. 1996. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93: 8455–8459.
  • Lee, H.-Y., N. Sueoka, W.-K. Hong, D. J. Mangelsdorf, F. X. Claret, and J. M. Kurie. 1999. All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Mol. Cell Biol. 19: 1973–1980.
  • Lefebvre, B., A. Mouchon, P. Formstecher, and P. Lefebvre. 1998. H11-H12 loop retinoic acid receptor mutants exhibit distinct trans-activating and trans-repressing activities in the presence of natural or synthetic retinoids. Biochemistry 37: 9240–9249.
  • Lefebvre, B., C. Rachez, P. Formstecher, and P. Lefebvre. 1995. Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha. Biochemistry 34: 5477–5485.
  • Lefebvre, P., M. P. Gaub, A. Tahayato, C. Rochette-Egly, and P. Formstecher. 1995. Protein phosphatases 1 and 2A regulate the transcriptional and DNA binding activities of retinoic acid receptors. J. Biol. Chem. 270: 10806–10816.
  • Leppa, S., R. Saffrich, W. Ansorge, and D. Bohmann. 1998. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17: 4404–4413.
  • Li, Y., Y. Hashimoto, A. Agadir, H. Kagechika, and X. Zhang. 1999. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem. 274: 15360–15366.
  • Liu, M., A. Iavarone, and L. P. Freedman. 1996. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor—correlation with retinoid induction of U937 cell differentiation. J. Biol. Chem. 271: 31723–31728.
  • Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73: 381–393.
  • Martiny-Baron, G., M. G. Kazanietz, H. Misschak, P. M. Blumberg, G. Kochs, G. Hug, D. Marme, and C. Schachtele. 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. Proc. Natl. Acad. Sci. USA 268: 9194–9197.
  • McBride, K., and M. Nemer. 1998. The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers. Mol. Cell. Biol. 18: 5073–5081.
  • Metz, R., T. Kouzarides, and R. Bravo. 1994. A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth. EMBO J. 13: 3832–3842.
  • Mouchon, A., M.-H. Delmotte, P. Formstecher, and P. Lefebvre. 1999. Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA. Mol. Cell. Biol. 19: 3073–3085.
  • Nagpal, S., J. Athanikar, and R. A. S. Chandraratna. 1995. Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha. J. Biol. Chem. 270: 923–927.
  • Nicholson, R. C., S. Mader, S. Nagpal, M. Leid, C. Rochette-Egly, and P. Chambon. 1990. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J. 9: 4443–4454.
  • Nikolakaki, E., P. J. Coffer, R. Hemelsoet, J. R. Woodgett, and L. H. K. Defize. 1993. Glycogen synthase kinase-3 phosphorylates jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8: 833–840.
  • Perez, P., A. Schonthal, and A. Aranda. 1993. Repression of c-fos gene expression by thyroid hormone and retinoic acid receptors. J. Biol. Chem. 268: 23538–23543.
  • Philips, A., P. Roux, V. Coulon, J. M. Bellanger, A. Vie, M. L. Vignais, and J. M. Blanchard. 2000. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts. J. Biol. Chem. 275: 5911–5917.
  • Rachez, C., P. Sautiere, P. Formstecher, and P. Lefebvre. 1996. Identification of amino acids critical for the DNA binding and dimerization properties of the human retinoic acid receptor alpha. Importance of lysine 360, lysine 365, and valine 361. J. Biol. Chem. 271: 17996–18006.
  • Rachez, C., Z. Suldan, J. Ward, C. P. B. Chang, D. Burakov, H. Erdjument-Bromage, P. Tempst, and L. P. Freedman. 1998. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12: 1787–1800.
  • Rosenberger, S. F., J. S. Finch, A. Gupta, and G. T. Bowden. 1999. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of JunD and FosB is required for okadaic acid-induced activator protein 1 activation. J. Biol. Chem. 274: 1124–1130.
  • Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and L. I. Zon. 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372: 794–798.
  • Schule, R., P. Rangarajan, N. Yang, S. Kliewer, L. J. Ransone, J. Bolado, I. M. Verma, and R. M. Evans. 1991. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. USA 88: 6092–6096.
  • Stambolic, V., L. Ruel, and J. R. Woodgett. 1996. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol. 6: 1664–1668.
  • Tahayato, A., P. Lefebvre, P. Formstecher, and M. Dautrevaux. 1993. A protein kinase C-dependent activity modulates retinoic acid-induced transcription. Mol. Endocrinol. 7: 1642–1653.
  • Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Peret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovski. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266: 15771–15781.
  • Towers, T. L., T. P. Staeva, and L. P. Freedman. 1999. A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun. Mol. Cell. Biol. 19: 4191–4199.
  • Vega-Diaz, B., M. C. Lenoir, A. Ladoux, C. Frelin, M. Démarchez, and S. Michel. 2000. Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids. J. Biol. Chem. 275: 642–650.
  • Wisdon, R., and I. M. Verma. 1993. Transformation by Fos proteins requires a C-terminal transactivation domain. Mol. Cell. Biol. 13: 7429–7438.
  • Xu, L., C. K. Glass, and M. G. Rosenfeld. 1999. Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev. 9: 140–147.
  • Yamamoto, S., Y. Watanabe, P. J. van der Spek, T. Watanabe, H. Fujimoto, F. Hanaoka, and Y. Ohkuma. 2001. Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation. Mol. Cell. Biol. 21: 1–15.
  • Young, M. R., J. J. Li, M. Rincon, R. A. Flavell, B. K. Sathyanarayana, R. Hunziker, and N. Colburn. 1999. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc. Natl. Acad. Sci. USA 96: 9827–9832.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.