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Cell Growth and Development

Two Ras Pathways in Fission Yeast Are Differentially Regulated by Two Ras Guanine Nucleotide Exchange Factors

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Pages 4598-4606 | Received 20 Dec 2001, Accepted 11 Mar 2002, Published online: 27 Mar 2023

REFERENCES

  • Alfa, C., P. Fantes, J. Hyams, M. McLeod, and E. Warbrick. 1993. Experiments with fission yeast. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Boriack-Sjodin, P. A., S. M. Margarit, D. Bar-Sagi, and J. Kuriyan. 1998. The structural basis of the activation of Ras by Sos. Nature 394: 337–343.
  • Chang, E., G. Bartholomeusz, R. Pimental, J. Chen, H. Lai, L.-H. L. Wang, P. Yang, and S. Marcus. 1999. Direct binding and in vivo regulation of the fission yeast p21-activated kinase Shk1 by the SH3 domain protein Scd2. Mol. Cell. Biol. 19: 8066–8074.
  • Chang, E. C., M. Barr, Y. Wang, V. Jung, H. Xu, and H. M. Wigler. 1994. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 79: 131–141.
  • Chen, C.-R., Y.-C. Li, J. Chen, M. C. Hou, P. Papadaki, and E. C. Chang. 1999. Moe1, a novel conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc. Natl. Acad. Sci. USA 96: 517–522.
  • Chen, R. A., T. Michaeli, L. Van Aelst, and R. Ballester. 2000. A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor. Genetics 154: 1473–1484.
  • Cooper, J. P., Y. Watanabe, and P. Nurse. 1998. Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature 392: 828–831.
  • Daniels, R. H., F. T. Zenke, and G. M. Bokoch. 1999. alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J. Biol. Chem. 274: 6047–6050.
  • Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. 1998. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082–1086.
  • Farnsworth, C. L., N. W. Freshney, L. B. Rosen, A. Ghosh, M. E. Greenberg, and L. A. Feig. 1995. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376: 524–527.
  • Forsburg, S. L., and D. A. Sherman. 1997. General purpose tagging vectors for fission yeast. Gene 191: 191–195.
  • Fukui, Y., and M. Yamamoto. 1988. Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1−. Mol. Gen. Genet. 215: 26–31.
  • Gross, A., S. Winograd, I. Marbach, and A. Levitzki. 1999. The N-terminal half of Cdc25 is essential for processing glucose signaling in Saccharomyces cerevisiae. Biochemistry 38: 13252–13262.
  • Hughes, D. A., Y. Fukui, and M. Yamamoto. 1990. Homologous activators of ras in fission yeast and budding yeast. Nature 344: 355–357.
  • Hughes, D. A., N. Yabana, and M. Yamamoto. 1994. Transcriptional regulation of a Ras nucleotide-exchange factor gene by extracellular signals in fission yeast. J. Cell Sci. 107: 3635–3642.
  • Jones, M. K., and J. H. Jackson. 1998. Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo. J. Biol. Chem. 273: 1782–1787.
  • Lai, C. C., M. Boguski, D. Broek, and S. Powers. 1993. Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol. Cell. Biol. 13: 1345–1352.
  • Li, Y.-C., C.-R. Chen, and E. C. Chang. 2000. Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation. Genetics 156: 995–1004.
  • Mach, K. E., K. A. Furge, and C. F. Albright. 2000. Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics 155: 611–622.
  • Mata, J., and P. Nurse. 1997. tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell. Cell 89: 939–949.
  • Maundrell, K. 1993. Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 123: 127–130.
  • Nadin-Davis, S. A., A. Nasim, and D. Beach. 1986. Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J. 5: 2963–2971.
  • Petersen, J., M. J. Heitz, and I. M. Hagan. 1998. Conjugation in S. pombe: identification of a microtubule-organising centre, a requirement for microtubules and a role for Mad2. Curr. Biol. 8: 963–966.
  • Petersen, J., O. Nielsen, R. Egel, and I. M. Hagan. 1998. F-actin distribution and function during sexual differentiation in Schizosaccharomyces pombe. J. Cell Sci. 111: 867–876.
  • Pichová, A., and E. Streiblová. 1992. Features of the cell periphery in the deformed ras1− cells of Schizosaccharomyces pombe. Exp. Mycol. 16: 178–187.
  • Reuther, G. W., and C. J. Der. 2000. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr. Opin. Cell Biol. 12: 157–165.
  • Schlessinger, J. 1994. How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18: 273–275.
  • Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18: 3091–3092.
  • Shields, J. M., K. Pruitt, A. McFall, A. Shaub, and C. J. Der. 2000. Understanding Ras: ‘it ain't over 'til it's over'. Trends Cell Biol. 10: 147–154.
  • Tratner, I., A. Fourticq-Esqueöute, J. Tillit, and G. Baldacci. 1997. Cloning and characterization of the S. pombe gene efc25+, a new putative guanine nucleotide exchange factor. Gene 193: 203–210.
  • Wang, Y., H.-P. Xu, M. Riggs, L. Rodgers, and M. Wigler. 1991. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Mol. Cell. Biol. 11: 3554–3563.
  • Wood, V., R. Gwilliam, M. A. Rajandream, M. Lyne, R. Lyne, A. Stewart, J. Sgouros, N. Peat, J. Hayles, S. Baker, D. Basham, S. Bowman, K. Brooks, D. Brown, S. Brown, T. Chillingworth, C. Churcher, M. Collins, R. Connor, A. Cronin, P. Davis, T. Feltwell, A. Fraser, S. Gentles, A. Goble, N. Hamlin, D. Harris, J. Hidalgo, G. Hodgson, S. Holroyd, T. Hornsby, S. Howarth, E. J. Huckle, S. Hunt, K. Jagels, K. James, L. Jones, M. Jones, S. Leather, S. McDonald, J. McLean, P. Mooney, S. Moule, K. Mungall, L. Murphy, D. Niblett, C. Odell, K. Oliver, S. O'Neil, D. Pearson, M. A. Quail, E. Rabbinowitsch, K. Rutherford, S. Rutter, D. Saunders, K. Seeger, S. Sharp, J. Skelton, M. Simmonds, R. Squares, S. Squares, K. Stevens, K. Taylor, R. G. Taylor, A. Tivey, S. Walsh, T. Warren, S. Whitehead, J. Woodward, G. Volckaert, R. Aert, J. Robben, B. Grymonprez, I. Weltjens, E. Vanstreels, M. Rieger, M. Schafer, S. Muller-Auer, C. Gabel, M. Fuchs, C. Fritzc, E. Holzer, D. Moestl, H. Hilbert, K. Borzym, I. Langer, A. Beck, H. Lehrach, R. Reinhardt, T. M. Pohl, P. Eger, W. Zimmermann, H. Wedler, R. Wambutt, B. Purnelle, A. Goffeau, E. Cadieu, S. Dreano, S. Gloux, V. Lelaure, et al. 2002. The genome sequence of Schizosaccharomyces pombe. Nature 415: 871–880.
  • Xu, H. P., M. White, S. Marcus, and M. Wigler. 1994. Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Mol. Cell. Biol. 14: 50–58.
  • Yen, H.-C. S., and E. C. Chang. 2000. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc. Natl. Acad. Sci. USA 97: 14370–14375.
  • Zhou, K., Y. Wang, J. L. Gorski, N. Nomura, J. Collard, and G. M. Bokoch. 1998. Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42. J. Biol. Chem. 273: 16782–16786.

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