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Transcriptional Regulation

Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation

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Pages 4781-4791 | Received 23 Oct 2001, Accepted 28 Mar 2002, Published online: 27 Mar 2023

REFERENCES

  • Athanassakis-Vassiliadis I., D. Thanos and J. Papamatheakis. 1989. Induction of class II major histocompatibility complex antigens in murine placenta by 5′-azacytidine and interferon-gamma involves different cell populations. Eur. J. Immunol. 19:2341–2348.
  • Beresford G. W. and J. M. Boss. 2001. CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Nat. Immunol. 2:652–657.
  • Boss J. M. 1999. A common set of factors control the expression of the MHC class II, invariant chain, and HLA-DM genes. Microbes Infect. 1:847–853.
  • Boss J. M. and J. L. Strominger. 1986. Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts. Proc. Natl. Acad. Sci. USA 83:9139–9143.
  • Chakravarti D., V. Ogryzko, H. Y. Kao, A. Nash, H. Chen, Y. Nakatani and R. M. Evans. 1999. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell 96:393–403.
  • Chang C.-H., J. D. Fontes, B. M. Peterlin and R. A. Flavell. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180:1367–1374.
  • Clark S. J., J. Harrison, C. L. Paul and M. Frommer. 1994. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 22:2990–2997.
  • Coffee B., F. Zhang, S. T. Warren and D. Reines. 1999. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. Nat. Genet. 22:98–101.
  • Collins T., A. J. Korman, C. T. Wake, J. M. Boss, D. J. Kappes, W. Fiers, K. A. Ault, M. A. Gimbrone Jr., J. L. Strominger and J. S. Pober. 1984. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc. Natl. Acad. Sci. USA 81:4917–4921.
  • DeSandro A., U. M. Nagarajan and J. M. Boss. 2000. Associations and interactions among the bare lymphocyte syndrome factors. Mol. Cell. Biol. 20:6587–6599.
  • Fontes J. D., B. Jiang and B. M. Peterlin. 1997. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. Nucleic Acids Res. 25:2522–2528.
  • Fontes J. D., S. Kanazawa, D. Jean and B. M. Peterlin. 1999. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19:941–947.
  • Glimcher L. H. and C. J. Kara. 1992. Sequences and factors: a guide to MHC class II transcription, p. 13-50. In W. E. Paul, C. Garrison-Fathman, and H. Metzger (ed.), Annual reviews in immunology. Annual Reviews, Inc., Palo Alto, Calif.
  • Gourley T. S. and C. H. Chang. 2001. Cutting edge: the class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression. J. Immunol. 166:2917–2921.
  • Grant P. A., D. E. Sterner, L. J. Duggan, J. L. Workman and S. L. Berger. 1998. The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes. Trends Cell Biol. 8:193–197.
  • Hamilton T. A., N. Bredon, Y. Ohmori and C. S. Tannenbaum. 1989. IFN-γ and IFN-β independently stimulate the expression of lipopolysaccharide-inducible genes in murine peritoneal macrophages. J. Immunol. 142:2325–2331.
  • Hasegawa S. L. and J. M. Boss. 1991. Two distinct B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters. Nucleic Acids Res. 19:6269–6276.
  • Hasegawa S. L., J. L. Riley, J. H. Sloan and J. M. Boss. 1993. Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells. J. Immunol. 150:1781–1793.
  • Hobart M., V. Ramassar, N. Goes, J. Urmson and P. F. Halloran. 1997. IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo. J. Immunol. 158:4260–4269.
  • Jones P. L., G. J. Veenstra, P. A. Wade, D. Vermaak, S. U. Kass, N. Landsberger and A. P. Wolffe. 1998. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19:187–191.
  • Kanazawa S., T. Okamoto and B. M. Peterlin. 2000. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity 12:61–70.
  • Kretsovali A., T. Agalioti, C. Spilianakis, E. Tzortzakaki and M. Merika. 1998. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18:6777–6783.
  • Kuo M.-H., J. Zhou, P. Jambeck, M. E. A. Churchill and C. D. Allis. 1998. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev. 12:627–639.
  • Lee J. Y. and K. E. Sullivan. 2001. Gamma interferon and lipopolysaccharide interact at the level of transcription to induce tumor necrosis factor alpha expression. Infect. Immun. 69:2847–2852.
  • Lewis J. D., R. R Meehan, W. J. Henzel, I. Maurer-Fogy, P. Jeppesen, F. Klein and A. Bird. 1992. Purification, sequence, and cellular localization of a novel chromosonal protein that binds to methylated DNA. Cell 69:905–914.
  • Magner W. J., A. L. Kazim, C. Stewart, M. A. Romano, G. Catalano, C. Grande, F. Santaniello and T. B. Tomasi. 2001. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J. Immunol. 165:7017–7024.
  • Mahanta S. K., T. Scholl, F.-C. Yang and J. L. Strominger. 1997. Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA 94:6324–6329.
  • Meraz M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431.
  • Morris A. C., J. L. Riley, W. H. Fleming and J. M. Boss. 1998. MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression. Am. J. Reprod. Immunol. 40:385–394.
  • Morris A. C., W. E. Spangler and J. M. Boss. 2000. Methylation of class II trans-activator promoter IV: a novel mechansim of MHC class II gene control. J. Immunol. 164:4143–4149.
  • Muhlethaler-Mottet A., W. Di Berardino, L. A. Otten, and B. Mach. 1998. Activation of the MHC class II transactivator CIITA by interferon gamma requires cooperative interaction between Stat1 and USF-1. Immunity 8:157–166.
  • Muhlethaler-Mottet A., L. A. Otten, V. Steimle and B. Mach. 1997. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:2851–2860.
  • Murphy S. P. and T. B. Tomasi. 1998. Absence of MHC class II antigen expression in trophoblast cells results from a lack of class II transactivator (CIITA) gene expression. Mol. Reprod. Dev. 51:1–12.
  • Peyman J. A., P. J. Nelson and G. L. Hammond. 1992. HLA-DR genes are silenced in human trophoblasts and stimulation of signal transduction pathways does not circumvent IFN-γ unresponsiveness. Transplant. Proc. 24:470–471.
  • Piskurich J. F., M. W. Linhoff, Y. Wang and J. P.-T. Ting. 1999. Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor β. Mol. Cell. Biol. 19:431–440.
  • Reith W. and B. Mach. 2001. The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 19:331–373.
  • Riley J. L. and J. M. Boss. 1993. Class II MHC transcriptional mutants are defective in higher order complex formation. J. Immunol. 151:6942–6953.
  • Selker E. U. 1998. Trichostatin A causes selective loss of DNA methylation in Neurospora. Proc. Natl. Acad. Sci. USA 95:9430–9435.
  • Spilianakis C., J. Papamatheakis and A. Kretsovali. 2000. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 20:8489–8498.
  • Steimle V., C.-A. Siegrist, A. Mottet, B. Lisowska-Grospierre and B. Mach. 1994. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265:106–108.
  • Sterner D. E. and S. L. Berger. 2000. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64:435–459.
  • Taniguchi T., K. Ogasawara, A. Takaoka and N. Tanaka. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:623–655.
  • Towbin H., T. Staehelin and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
  • Unanue E. R., C. V. Harding, I. F. Luescher and R. W. Roof. 1989. Antigen-binding function of class II MHC molecules. Cold Spring Harbor Symp. Quant. Biol. 54:383–392.
  • Utley R. T., K. Ikeda, P. A. Grant, J. Cote, D. J. Steger, A. Eberharter, S. John and J. L. Workman. 1998. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature 394:498–502.
  • van den Elsen P. J., N. van der Stoep, H. E. Vietor, L. Wilson, M. van Zutphen, and S. J. P. Gobin. 2000. Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-γ-inducible promoter (PIV) of CIITA. Hum. Immunol. 61:850–862.
  • van der Stoep N., P. Biesta, E. Quinten and P. J. van den Elsen. 2002. Lack of IFN-γ-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines. Int. J. Cancer 97:501–507.
  • Van Lint C., S. Emiliani, M. Ott and E. Verdin. 1996. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15:1112–1120.
  • Wadburger J. M., T. Suter, A. Fontana, H. Acha-Orbea and W. Reith. 2001. Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene. J. Exp. Med. 19:393–406.
  • Zuckermann F. A. and J. R. Head. 1986. Expression of MHC antigens on murine trophoblast and their modulation by interferon. J. Immunol. 137:846–853.

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