The ETS Domain Transcription Factor Elk-1 Contains a Novel Class of Repression Domain

REFERENCES

• Beitel, G. J., Tuck, S., Greenwald, I., and Horvitz, H. R. 1995. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9: 3149–3162.
   PubMedGoogle Scholar
• Bojovic, B. B., and J. A. Hassell. 2001. The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding. J. Biol. Chem. 276: 4509–4521.
   PubMedGoogle Scholar
• Cahill, M. A., R. Janknecht, and A. NordheimA. 1995. Signal uptake by the c-fos serum response element, p. 39–72. In P. A. Bauerle (ed.), Inducible gene expression. Birkhauser, Boston, Mass.
   Google Scholar
• Criqui-Filipe, P., C. Ducret, S. M. Maira, and B. Wasylyk. 1999. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 18: 3392–3403.
   PubMedGoogle Scholar
• Ducret, C., S. M. Maira, Y. Lutz, and B. Wasylyk. 2000. The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. Oncogene 19: 5063–5072.
   PubMedGoogle Scholar
• Enslen, H., J. Raingeaud, and R. J. Davis. 1998. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J. Biol. Chem. 273: 1741–1748.
   PubMed Web of Science ®Google Scholar
• Gille, H., M. Kortenjann, O. Thomae, C. Moomaw, C. Slaughter, M. H. Cobb, and P. E. Shaw. 1995. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14: 951–962.
   PubMed Web of Science ®Google Scholar
• Giovane, A., A. Pintzas, S. M. Maira, P. Sobieszczuk, and B. Wasylyk. 1994. Net, a new ets transcription factor that is activated by Ras. Genes Dev. 8: 1502–1513.
   PubMed Web of Science ®Google Scholar
• Hassler, M., and T. J. Richmond 2001. The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. EMBO J. 20: 3018–3028.
   PubMedGoogle Scholar
• Herrera, R. E., P. E. Shaw, and A. Nordheim. 1989. Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature 340: 68–70.
   PubMedGoogle Scholar
• Iniguez-Lluhi, J. A., and D. Pearce. 2000. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell. Biol. 20: 6040–6050.
   PubMedGoogle Scholar
• Jacobs, D., D. Glossip, H. Xing, A. J. Muslin, and K. Kornfeld. 1999. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev. 13: 163–175.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., R. Zinck, W. H. Ernst, and A. Nordheim. 1994. Functional dissection of the transcription factor Elk-1. Oncogene 9: 1273–1278.
   PubMedGoogle Scholar
• Janknecht, R., W. H. Ernst, and A. Nordheim. 1995. SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene 10: 1209–1216.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., and A. Nordheim. 1996. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228: 831–837.
   PubMed Web of Science ®Google Scholar
• Kamano, H., B. Burk, K. Noben-Trauth, and K. H. Klempnauer. 1995. Differential splicing of the mouse B-myb gene. Oncogene 11: 2575–2582.
   PubMedGoogle Scholar
• Lemercier, C., A. Verdel, B. Galloo, S. Curtet, M. P. Brocard, S. and Khochbin. 2000. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275: 15594–15599.
   PubMed Web of Science ®Google Scholar
• Maira, S. M., J. M. Wurtz, and B. Wasylyk. 1996. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. EMBO J. 15: 5849–5865.
   PubMedGoogle Scholar
• Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265: 966–970.
   PubMed Web of Science ®Google Scholar
• Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73: 381–393.
   PubMed Web of Science ®Google Scholar
• Ng, H. H., and A. Bird. 2000. Histone deacetylases: silencers for hire. Trends Biochem. Sci. 25: 121–126.
   PubMed Web of Science ®Google Scholar
• Price, M. A., A. E. Rogers, and R. Treisman. 1995. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J. 14: 2589–2601.
   PubMed Web of Science ®Google Scholar
• Ruden, D. M., J. Ma, Y. Li, K. Wood, and M. Ptashne. 1991. Generating yeast transcriptional activators containing no yeast protein sequences. Nature 350: 250–252.
   PubMedGoogle Scholar
• Saha, S., J. M. Brickman, N. Lehming, and M. Ptashne. 1993. New eukaryotic transcriptional repressors. Nature 363: 648–652.
   PubMedGoogle Scholar
• Seth, A., F. A. Gonzalez, S. Gupta, D. L. Raden, and R. J. Davis. 1992. Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem. 267: 24796–24804.
   PubMedGoogle Scholar
• Sharrocks, A. D. 2001. The ETS-domain transcription factor family. Nat. Rev. Mol. Cell Biol. 2: 827–837.
   PubMed Web of Science ®Google Scholar
• Shore, P., and A. D. Sharrocks. 1994. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol. Cell. Biol. 14: 3283–3291.
   PubMedGoogle Scholar
• Shore, P., A. J. Whitmarsh, R. Bhaskaran, J. Waltho, R. J. Davis, and A. D. Sharrocks. 1996. Determinants of DNA binding specificity of ETS-domain transcription factors. Mol. Cell. Biol. 16: 3338–3349.
   PubMed Web of Science ®Google Scholar
• Snowden, A. W., L. A. Anderson, G. A. Webster, and N. D. Perkins. 2000. A novel transcriptional repression domain mediates p21(WAF1/CIP1)induction of p300 transactivation. Mol. Cell. Biol. 20: 2676–2686.
   PubMedGoogle Scholar
• Tan, P. B., M. R. Lackner, and S. K. Kim. 1998. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93: 569–580.
   PubMedGoogle Scholar
• Treisman, R. 1994. Ternary complex factors: growth regulated transcriptional activators. Curr. Opin. Gen. Dev. 4: 96–101.
   PubMedGoogle Scholar
• Wasylyk, B., J. Hagman, and A. Gutierrez-Hartmann. 1998. Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signalling pathway. Trends Biochem. Sci. 23: 213–216.
   PubMed Web of Science ®Google Scholar
• Webster, G. A., and N. D. Perkins. 1999. Transcriptional cross talk between NF-kappaB and p53, Mol. Cell. Biol. 19: 3485–3495.
   Google Scholar
• Yaffe, M. B., G. G. Leparc, J. Lai, T. Obata, S. Volinia, and L. C. Cantley. 2001. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19: 348–353.
   PubMed Web of Science ®Google Scholar
• Yang, S-H., P. R. Yates, A. J. Whitmarsh, R. J. Davis, and A. D. Sharrocks. 1998. The Elk-1 ETS-domain transcription factor contains a MAP kinase targeting motif. Mol. Cell. Biol. 18: 710–720.
   PubMedGoogle Scholar
• Yang, S-H., A. J. Whitmarsh, R. J. Davis, and A. D. Sharrocks. 1998. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 17: 1740–1749.
   PubMed Web of Science ®Google Scholar
• Yang, S-H., P. R. Yates, and A. D. Sharrocks. 1999. The ETS-domain transcription factors: lessons from the TCF subfamily. Gene Ther. Mol. Biol. 3: 355–371.
   Google Scholar
• Yang, S-H., A. Galanis, and A. D. Sharrocks. 1999. Targeting of p38 MAPKs to MEF2 transcription factors. Mol. Cell. Biol. 19: 4028–4038.
   PubMedGoogle Scholar
• Yang, S-H., E. Vickers, A. Brehm, T. Kouzarides, and A. D. Sharrocks. 2001. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS-domain transcription factor, Elk-1. Mol. Cell. Biol. 21: 2802–2814.
   PubMed Web of Science ®Google Scholar
• Yates, P. R., G. T. Atherton, R. W. Deed, J. D. Norton, and A. D. Sharrocks. 1999. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 18: 968–976.
   PubMedGoogle Scholar