Chondromodulin I Is Dispensable during Enchondral Ossification and Eye Development

REFERENCES

• Aszódi, A., D. Chan, E. Hunziker, J. F. Bateman, and R. Fässler. 1998. Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J. Cell Biol. 143: 1399–1412.
   PubMed Web of Science ®Google Scholar
• Aszódi, A., J. F. Bateman, E. Hirsch, M. Baranyi, E. B. Hunzicker, Z. Bösze, and R. Fässler. 1999. Normal skeletal development of mice lacking matrilin-1: redundant function of matrilins in cartilage? Mol. Cell. Biol. 19: 7841–7845.
   PubMedGoogle Scholar
• Aszódi, A., L. Módis, A. Páldi, A. Rencendorj, I. Kiss, and Z. Bösze. 1994. The zonal expression of chicken cartilage matrix protein in the developing skeleton of transgenic mice. Matrix Biol. 14: 181–190.
   PubMed Web of Science ®Google Scholar
• Azizan, A., N. Holaday, and P. J. Neame. 2001. Post-translational processing of bovine chondromodulin-I. J. Biol. Chem. 276: 23632–23638.
   PubMed Web of Science ®Google Scholar
• Babarina, A. V., U. Mollers, K. Bittner, P. Vischer, and P. Bruckner. 2001. Role of the subchondral vascular system in endochondral ossification: endothelial cell-derived proteinases derepress late cartilage differentiation in vitro. Matrix Biol. 20: 205–213.
   PubMedGoogle Scholar
• Brachtendorf, G., A. Kuhn, U. Samulowitz, R. Knorr, E. Gustafsson, A. J. Potocnik, R. Fässler, and D. Vestweber. 2001. Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoietic clusters in the dorsal aorta. Dev. Dyn. 222: 410–419.
   PubMedGoogle Scholar
• Brandau, O., A. Meindl, R. Fässler, and A. Aszódi. 2001. A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I. Dev. Dyn. 221: 72–80.
   PubMed Web of Science ®Google Scholar
• Colnot, C. I., and J. A. Helms. 2001. A molecular analysis of matrix remodeling and angiogenesis during long bone development. Mech. Dev. 100: 245–250.
   PubMedGoogle Scholar
• Dangelo, M., D. P. Sarment, P. C. Billings, and M. Pacifici. 2001. Activation of transforming growth factor beta in chondrocytes undergoing endochondral ossification. J. Bone Miner. Res. 16: 2339–2347.
   PubMed Web of Science ®Google Scholar
• Eklund, L., J. Piuhola, J. Komulainen, R. Sormunen, C. Ongvarrasopone, R. Fässler, A. Muona, M. Ilves, H. Ruskoaho, T. E. Takala, and T. Pihlajaniemi. 2001. Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc. Natl. Acad. Sci. USA 98: 1194–1199.
   PubMed Web of Science ®Google Scholar
• Fässler, R., and M. Meyer. 1995. Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 9: 1896–1908.
   PubMed Web of Science ®Google Scholar
• Funaki, H., S. Sawaguchi, K. Yaoeda, Y. Koyama, E. Yaoita, S. Funaki, M. Shirakashi, Y. Oshima, C. Shukunami, Y. Hiraki, H. Abe, and T. Yamamoto. 2001. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye. Investig. Ophthalmol. Vis. Sci. 42: 1193–1200.
   PubMed Web of Science ®Google Scholar
• Garcia-Ramirez, M., N. Toran, P. Andaluz, A. Carrascosa, and L. Audi. 2000. Vascular endothelial growth factor is expressed in human fetal growth cartilage. J. Bone Miner. Res. 15: 534–540.
   PubMed Web of Science ®Google Scholar
• Harper, J., and M. Klagsbrun. 1999. Cartilage to bone—angiogenesis leads the way. Nat. Med. 5: 617–618.
   PubMedGoogle Scholar
• Hayami, T., C. Shukunami, K. Mitsui, N. Endo, K. Tokunaga, J. Kondo, H. E. Takahashi, and Y. Hiraki. 1999. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. FEBS Lett. 458: 436–440.
   PubMed Web of Science ®Google Scholar
• Hiraki, Y., H. Inoue, K. Iyama, A. Kamizono, M. Ochiai, C. Shukunami, S. Iijima, F. Suzuki, and J. Kondo. 1997. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage. J. Biol. Chem. 272: 32419–32426.
   PubMed Web of Science ®Google Scholar
• Hiraki, Y., H. Tanaka, H. Inoue, J. Kondo, A. Kamizono, and F. Suzuki. 1991. Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Biochem. Biophys. Res. Commun. 175: 971–977.
   PubMed Web of Science ®Google Scholar
• Hiraki, Y., T. Kono, M. Sato, C. Shukunami, and J. Kondo. 1997. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I. FEBS Lett. 415: 321–324.
   PubMed Web of Science ®Google Scholar
• Horner, A., N. J. Bishop, S. Bord, C. Beeton, A. W. Kelsall, N. Coleman, and J. E. Compston. 1999. Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage. J. Anat. 194: 519–524.
   PubMedGoogle Scholar
• Horner, A., P. Kemp, C. Summers, S. Bord, N. J. Bishop, A. W. Kelsall, N. Coleman, and J. E. Compston. 1998. Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone. Bone 23: 95–102.
   PubMedGoogle Scholar
• Kaartinen, V., J. W. Voncken, C. Shuler, D. Warburton, D. Bu, N. Heisterkamp, and J. Groffen. 1995. Abnormal lung development and cleft palate in mice lacking TGF-beta-3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11: 415–421.
   PubMed Web of Science ®Google Scholar
• Liu, C., Z. M. Shao, L. Zhang, P. Beatty, M. Sartippour, T. Lane, E. Livingston, and M. Nguyen. 2001. Human endomucin is an endothelial marker. Biochem. Biophys. Res. Commun. 288: 129–136.
   PubMedGoogle Scholar
• Matsunaga, S., T. Yamamoto, and K. Fukumura. 1999. Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate. Int. J. Oncol. 14: 1063–1067.
   PubMedGoogle Scholar
• Neame, P. J., J. T. Treep, and C. N. Young. 1990. An 18-kDa glycoprotein from bovine nasal cartilage. Isolation and primary structure of small, cartilage-derived glycoprotein. J. Biol. Chem. 265: 9628–9633.
   PubMedGoogle Scholar
• Osoegawa, K., M. Tateno, P. Y. Woon, E. Frengen, A. G. Mammoser, J. J. Catanese, Y. Hayashizaki, and P. J. de Jong. 2000. Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res. 10: 116–128.
   PubMed Web of Science ®Google Scholar
• Pepper, M. S., R. Montesano, J. D. Vassalli, and L. Orci. 1991. Chondrocytes inhibit endothelial sprout formation in vitro. Evidence for involvement of a transforming growth factor-β. J. Cell. Physiol. 146: 170–179.
   PubMedGoogle Scholar
• Proetzel, G., S. A. Pawlowski, M. V. Wiles, M. Yin, G. P. Boivin, P. N. Howles, J. Ding, M. W. J. Ferguson, and T. Doetschman. 1995. Transforming growth factor-beta-3 is required for secondary palate fusion. Nat. Genet. 11: 409–414.
   PubMed Web of Science ®Google Scholar
• Sanford, L. P., I. Ormsby, A. C. Gittenberger-de Groot, H. Sariola, R. Friedman, G. P. Boivin, E. L. Cardell, and T. Doetschman. 1997. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659–2670.
   PubMed Web of Science ®Google Scholar
• Shukunami, C., and Y. Hiraki. 1998. Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro. Biochem. Biophys. Res. Commun. 249: 885–890.
   PubMedGoogle Scholar
• Shukunami, C., K. Iyama, H. Inoue, and Y. Hiraki. 1999. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation. Int. J. Dev. Biol. 43: 39–49.
   PubMed Web of Science ®Google Scholar
• Shukunami, C., Y. Oshima, and Y. Hiraki. 2001. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene. Biochem. Biophys. Res. Commun. 280: 1323–1327.
   PubMed Web of Science ®Google Scholar
• Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693–699.
   PubMed Web of Science ®Google Scholar
• Tada, K., T. Fukunaga, Y. Wakabayashi, S. Masumi, Y. Sato, H. Izumi, K. Kohno, and M. Kuwano. 1994. Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor beta: a model for avascularity in human cartilage. Biochim. Biophys. Acta 1201: 135–142.
   PubMed Web of Science ®Google Scholar
• Takeda, S., J.-P. Bonnamy, M. J. Owen, P. Ducy, and G. Karsenty. 2001. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 15: 467–481.
   PubMed Web of Science ®Google Scholar
• Thorp, B. H., I. Anderson, and S. B. Jakowlew. 1992. Transforming growth factor-beta 1, -beta 2 and -beta 3 in cartilage and bone cells during endochondral ossification in the chick. Development 114: 907–911.
   PubMedGoogle Scholar
• Yamana, K., H. Wada, Y. Takahashi, H. Sato, Y. Kasahara, and M. Kiyoki. 2001. Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I. Biochem. Biophys. Res. Commun. 280: 1101–1106.
   PubMed Web of Science ®Google Scholar