Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism

REFERENCES

• Bandara, L. R., V. M. Buck, M. Zamanian, L. H. Johnston, and N. B. La Thangue. 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J. 12: 4317–4324.
   PubMed Web of Science ®Google Scholar
• Beijersbergen, R. L., R. M. Kerkhoven, L. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8: 2680–2690.
   PubMed Web of Science ®Google Scholar
• Bookstein, R., J. Y. Shew, P. L. Chen, P. Scully, and W. H. Lee. 1990. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247: 712–715.
   PubMed Web of Science ®Google Scholar
• Botz, J., K. Zerfass-Thome, D. Spitkovsky, H. Delius, B. Vogt, M. Eilers, A. Hatzigeorgiou, and P. Jansen-Durr. 1996. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16: 3401–3409.
   PubMed Web of Science ®Google Scholar
• Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597–601.
   PubMed Web of Science ®Google Scholar
• Buchkovich, K., L. A. Duffy, and E. Harlow. 1989. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58: 1097–1105.
   PubMed Web of Science ®Google Scholar
• Canhoto, A. J., A. Chestukhin, L. Litovchick, and J. A. DeCaprio. 2000. Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells. Oncogene 19: 5116–5122.
   PubMedGoogle Scholar
• Chen, T. T., and J. Y. Wang. 2000. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol. Cell. Biol. 20: 5571–5580.
   PubMed Web of Science ®Google Scholar
• Christensen, J. B., and M. J. Imperiale. 1995. Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen. J. Virol. 69: 3945–3948.
   PubMedGoogle Scholar
• Cinti, C., P. P. Claudio, C. M. Howard, L. M. Neri, Y. Fu, L. Leoncini, G. M. Tosi, N. M. Maraldi, and A. Giordano. 2000. Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors. Cancer Res. 60: 383–389.
   PubMed Web of Science ®Google Scholar
• Claudio, P. P., A. De Luca, C. M. Howard, A. Baldi, E. J. Firpo, A. Koff, M. G. Paggi, and A. Giordano. 1996. Functional analysis of pRb2/p130 interaction with cyclins. Cancer Res. 56: 2003–2008.
   PubMed Web of Science ®Google Scholar
• Claudio, P. P., C. M. Howard, A. Baldi, A. De Luca, Y. Fu, G. Condorelli, Y. Sun, N. Colburn, B. Calabretta, and A. Giordano. 1994. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54: 5556–5560.
   PubMed Web of Science ®Google Scholar
• Claudio, P. P., C. M. Howard, Y. Fu, C. Cinti, L. Califano, P. Micheli, E. W. Mercer, M. Caputi, and A. Giordano. 2000. Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res. 60: 8–12.
   PubMed Web of Science ®Google Scholar
• Claudio, P. P., C. M. Howard, C. Pacilio, C. Cinti, G. Romano, C. Minimo, N. M. Maraldi, J. D. Minna, L. Gelbert, L. Leoncini, G. M. Tosi, P. Hicheli, M. Caputi, G. G. Giordano, and A. Giordano. 2000. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res. 60: 372–382.
   PubMed Web of Science ®Google Scholar
• Dahiya, A., M. R. Gavin, R. X. Luo, and D. C. Dean. 2000. Role of the LXCXE binding site in Rb function. Mol. Cell. Biol. 20: 6799–6805.
   PubMed Web of Science ®Google Scholar
• Dalal, S. N., C. M. Schweitzer, J. Gan, and J. A. DeCaprio. 1999. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19: 4465–4479.
   PubMed Web of Science ®Google Scholar
• Dalton, S. 1992. Cell cycle regulation of the human cdc2 gene. EMBO J. 11: 1797–1804.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54: 275–283.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Piwnica-Worms, C. M. Huang, and D. M. Livingston. 1989. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58: 1085–1095.
   PubMed Web of Science ®Google Scholar
• Dick, F. A., E. Sailhamer, and N. J. Dyson. 2000. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. Mol. Cell. Biol. 20: 3715–3727.
   PubMedGoogle Scholar
• Dou, Q. P., P. J. Markell, and A. B. Pardee. 1992. Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. Proc. Natl. Acad. Sci. USA 89: 3256–3260.
   PubMedGoogle Scholar
• Dunaief, J. L., B. E. Strober, S. Guha, P. A. Khavari, K. Alin, J. Luban, M. Begemann, G. R. Crabtree, and S. P. Goff. 1994. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79: 119–130.
   PubMed Web of Science ®Google Scholar
• Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934–937.
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., Y. G. Xing, J. B. Lawrence, and D. M. Livingston. 1991. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66: 1155–1164.
   PubMed Web of Science ®Google Scholar
• Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8: 2159–2165.
   PubMed Web of Science ®Google Scholar
• Fischer, U., J. Huber, W. C. Boelens, I. W. Mattaj, and R. Luhrmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 475–483.
   PubMed Web of Science ®Google Scholar
• Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051–1060.
   PubMed Web of Science ®Google Scholar
• Friend, S. H., R. Bernards, S. Rogelj, R. A. Weinberg, J. M. Rapaport, D. M. Albert, and T. P. Dryja. 1986. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643–646.
   PubMed Web of Science ®Google Scholar
• Gill, R. M., and P. A. Hamel. 2000. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J. Cell Biol. 148: 1187–1201.
   PubMedGoogle Scholar
• Ginsberg, D., G. Vairo, T. Chittenden, Z. X. Xiao, G. Xu, K. L. Wydner, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 8: 2665–2679.
   PubMed Web of Science ®Google Scholar
• Hagting, A., C. Karlsson, P. Clute, M. Jackman, and J. Pines. 1998. MPF localization is controlled by nuclear export. EMBO J. 17: 4127–4138.
   PubMed Web of Science ®Google Scholar
• Hannon, G. J., D. Demetrick, and D. Beach. 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev. 7: 2378–2391.
   PubMed Web of Science ®Google Scholar
• Hansen, K., T. Farkas, J. Lukas, K. Holm, L. Ronnstrand, and J. Bartek. 2001. Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block. EMBO J. 20: 422–432.
   PubMedGoogle Scholar
• Harlow, E., L. V. Crawford, D. C. Pim, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39: 861–869.
   PubMed Web of Science ®Google Scholar
• Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y.
   Google Scholar
• Heidebrecht, H. J., F. Buck, J. Steinmann, R. Sprenger, H. H. Wacker, and R. Parwaresch. 1997. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Blood 90: 226–233.
   PubMed Web of Science ®Google Scholar
• Helin, K., K. Holm, A. Niebuhr, H. Eiberg, N. Tommerup, S. Hougaard, H. S. Poulsen, M. Spang-Thomsen, and P. Norgaard. 1997. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc. Natl. Acad. Sci. USA 94: 6933–6938.
   PubMed Web of Science ®Google Scholar
• Helin, K., C. L. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7: 1850–1861.
   PubMed Web of Science ®Google Scholar
• Hijmans, E. M., P. M. Voorhoeve, R. L. Beijersbergen, L. J. van ’t Veer, and R. Bernards. 1995. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol. 15: 3082–3089.
   PubMedGoogle Scholar
• Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993–1006.
   PubMed Web of Science ®Google Scholar
• Hu, Q. J., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9: 1147–1155.
   PubMed Web of Science ®Google Scholar
• Hurford, R. K., D. Cobrinik, M. H. Lee, and N. Dyson. 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11: 1447–1463.
   PubMed Web of Science ®Google Scholar
• Johnson, L. F. 1992. G1 events and the regulation of genes for S-phase enzymes. Curr. Opin. Cell Biol. 4: 149–154.
   PubMedGoogle Scholar
• Kaelin, W. G., Jr., M. E. Ewen, and D. M. Livingston. 1990. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10: 3761–3769.
   PubMed Web of Science ®Google Scholar
• Krek, W., D. M. Livingston, and S. Shirodkar. 1993. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262: 1557–1560.
   PubMed Web of Science ®Google Scholar
• Kudo, N., H. Taoka, T. Toda, M. Yoshida, and S. Horinouchi. 1999. A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1. J. Biol. Chem. 274: 15151–15158.
   PubMed Web of Science ®Google Scholar
• Li, Y., C. Graham, S. Lacy, A. M. Duncan, and P. Whyte. 1993. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 7: 2366–2377.
   PubMed Web of Science ®Google Scholar
• Lindeman, G. J., S. Gaubatz, D. M. Livingston, and D. Ginsberg. 1997. The subcellular localization of E2F-4 is cell-cycle dependent. Proc. Natl. Acad. Sci. USA 94: 5095–5100.
   PubMedGoogle Scholar
• Magae, J., C. L. Wu, S. Illenye, E. Harlow, and N. H. Heintz. 1996. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J. Cell Sci. 109: 1717–1726.
   PubMedGoogle Scholar
• Magnaghi-Jaulin, L., R. Groisman, I. Naguibneva, P. Robin, S. Lorain, J. P. Le Villain, F. Troalen, D. Trouche, and A. Harel-Bellan. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391: 601–605.
   PubMed Web of Science ®Google Scholar
• Mayol, X., J. Garriga, and X. Grana. 1995. Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130. Oncogene 11: 801–808.
   PubMed Web of Science ®Google Scholar
• Mayol, X., J. Garriga, and X. Grana. 1996. G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4. Oncogene 13: 237–246.
   PubMedGoogle Scholar
• Mayol, X., and X. Grana. 1998. The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions. Front. Biosci. 3: D11–24.
   PubMedGoogle Scholar
• Mayol, X., X. Grana, A. Baldi, N. Sang, Q. Hu, and A. Giordano. 1993. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8: 2561–2566.
   PubMed Web of Science ®Google Scholar
• Means, A. L., J. E. Slansky, S. L. McMahon, M. W. Knuth, and P. J. Farnham. 1992. The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol. Cell. Biol. 12: 1054–1063.
   PubMedGoogle Scholar
• Middeler, G., K. Zerf, S. Jenovai, A. Thulig, M. Tschodrich-Rotter, U. Kubitscheck, and R. Peters. 1997. The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene 14: 1407–1417.
   PubMedGoogle Scholar
• Mittnacht, S., and R. A. Weinberg. 1991. G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 65: 381–393.
   PubMed Web of Science ®Google Scholar
• Moberg, K., M. A. Starz, and J. A. Lees. 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436–1449.
   PubMed Web of Science ®Google Scholar
• Muller, H., M. C. Moroni, E. Vigo, B. O. Petersen, J. Bartek, and K. Helin. 1997. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol. Cell. Biol. 17: 5508–5520.
   PubMedGoogle Scholar
• Neumann, G., M. T. Hughes, and Y. Kawaoka. 2000. Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. EMBO J. 19: 6751–6758.
   PubMedGoogle Scholar
• Ogris, E., H. Rotheneder, I. Mudrak, A. Pichler, and E. Wintersberger. 1993. A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J. Virol. 67: 1765–1771.
   PubMedGoogle Scholar
• Ohtani, K., J. DeGregori, and J. R. Nevins. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92: 12146–12150.
   PubMed Web of Science ®Google Scholar
• Pinol-Roma, S., and G. Dreyfuss. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355: 730–732.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning. a laboratory manual, 2nd ed., vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Sardet, C., M. Vidal, D. Cobrinik, Y. Geng, C. Onufryk, A. Chen, and R. A. Weinberg. 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA 92: 2403–2407.
   PubMedGoogle Scholar
• Schluter, C., M. Duchrow, C. Wohlenberg, M. H. Becker, G. Key, H. D. Flad, and J. Gerdes. 1993. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123: 513–522.
   PubMed Web of Science ®Google Scholar
• Schulze, A., K. Zerfass, D. Spitkovsky, S. Middendorp, J. Berges, K. Helin, P. Jansen-Durr, and B. Henglein. 1995. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc. Natl. Acad. Sci. USA 92: 11264–11268.
   PubMedGoogle Scholar
• Slansky, J. E., and P. J. Farnham. 1996. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208: 1–30.
   PubMed Web of Science ®Google Scholar
• Slansky, J. E., Y. Li, W. G. Kaelin, and P. J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13: 1610–1618. (Erratum, 13: 7201.)
   PubMed Web of Science ®Google Scholar
• Smith, E. J., G. Leone, and J. R. Nevins. 1998. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ. 9: 297–303.
   PubMedGoogle Scholar
• Stade, K., C. S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90: 1041–1050.
   PubMed Web of Science ®Google Scholar
• Starborg, M., K. Gell, E. Brundell, and C. Hoog. 1996. The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J. Cell Sci. 109: 143–153.
   PubMed Web of Science ®Google Scholar
• Strober, B. E., J. L. Dunaief, S. Guha, and S. P. Goff. 1996. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol. 16: 1576–1583.
   PubMed Web of Science ®Google Scholar
• Stubdal, H., J. Zalvide, K. S. Campbell, C. Schweitzer, T. M. Roberts, and J. A. DeCaprio. 1997. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17: 4979–4990.
   PubMedGoogle Scholar
• Tommasi, S., and G. P. Pfeifer. 1995. In vivo structure of the human cdc2 promoter: release of a p130–E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol. 15: 6901–6913.
   PubMedGoogle Scholar
• Trouche, D., C. Le Chalony, C. Muchardt, M. Yaniv, and T. Kouzarides. 1997. RB and hbrm cooperate to repress the activation functions of E2F1. Proc. Natl. Acad. Sci. USA 94: 11268–11273.
   PubMed Web of Science ®Google Scholar
• Turpin, P., B. Ossareh-Nazari, and C. Dargemont. 1999. Nuclear transport and transcriptional regulation. FEBS Lett. 452: 82–86.
   PubMedGoogle Scholar
• Verona, R., K. Moberg, S. Estes, M. Starz, J. P. Vernon, and J. A. Lees. 1997. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17: 7268–7282.
   PubMed Web of Science ®Google Scholar
• Weber, J. D., L. J. Taylor, M. F. Roussel, C. J. Sherr, and D. Bar-Sagi. 1999. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1: 20–26.
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
   PubMed Web of Science ®Google Scholar
• Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334: 124–129.
   PubMed Web of Science ®Google Scholar
• Wiechens, N., and F. Fagotto. 2001. CRM1- and Ran-independent nuclear export of beta-catenin. Curr. Biol. 11: 18–27.
   PubMedGoogle Scholar
• Wolf, D. A., H. Hermeking, T. Albert, T. Herzinger, P. Kind, and D. Eick. 1995. A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. Oncogene 10: 2067–2078.
   PubMedGoogle Scholar
• Wu, C. L., L. R. Zukerberg, C. Ngwu, E. Harlow, and J. A. Lees. 1995. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. 15: 2536–2546.
   PubMed Web of Science ®Google Scholar
• Xiao, Z. X., D. Ginsberg, M. Ewen, and D. M. Livingston. 1996. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA 93: 4633–4637.
   PubMedGoogle Scholar
• Zacksenhaus, E., R. Bremner, R. A. Phillips, and B. L. Gallie. 1993. A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. Mol. Cell. Biol. 13: 4588–4599.
   PubMedGoogle Scholar
• Zacksenhaus, E., Z. Jiang, Y. J. Hei, R. A. Phillips, and B. L. Gallie. 1999. Nuclear localization conferred by the pocket domain of the retinoblastoma gene product. Biochim. Biophys. Acta 1451: 288–296.
   PubMedGoogle Scholar
• Zalvide, J., and J. A. DeCaprio. 1995. Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol. Cell. Biol. 15: 5800–5810.
   PubMedGoogle Scholar
• Zalvide, J., H. Stubdal, and J. A. DeCaprio. 1998. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol. Cell. Biol. 18: 1408–1415.
   PubMedGoogle Scholar
• Zerfass, K., A. Schulze, D. Spitkovsky, V. Friedman, B. Henglein, and P. Jansen-Durr. 1995. Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J. Virol. 69: 6389–6399.
   PubMedGoogle Scholar
• Zhu, L., S. van den Heuvel, K. Helin, A. Fattaey, M. Ewen, D. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7: 1111–1125.
   PubMed Web of Science ®Google Scholar