Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2

REFERENCES

• Carsetti, R. 2000. The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment. J. Exp. Med. 191: 5–8.
   PubMed Web of Science ®Google Scholar
• Cleary, M. L., S. D. Smith, and J. Sklar. 1986. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19–28.
   PubMed Web of Science ®Google Scholar
• Dedera, D. A., E. K. Waller, D. P. LeBrun, A. Sen-Majumbar, M. E. Stevens, G. S. Barsh, and M. L. Cleary. 1993. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74: 833–843.
   PubMed Web of Science ®Google Scholar
• Drexler, H. G. 1998. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18, and p19 in human leukemia-lymphoma cells. Leukemia 12: 845–859.
   PubMed Web of Science ®Google Scholar
• Eischen, C. M., J. D. Weber, M. F. Roussel, C. J. Sherr, and J. L. Cleveland. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13: 2658–2669.
   PubMed Web of Science ®Google Scholar
• Gannon, J. V., R. Greaves, R. Iggo, and D. P. Lane. 1990. Activating mutations in p53 produce a common conformational effect: a monoclonal antibody specific for the mutant form. EMBO J. 9: 1595–1602.
   PubMed Web of Science ®Google Scholar
• Hardy, R. R., C. E., Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213–1225.
   PubMed Web of Science ®Google Scholar
• Hawley, R. G., F. H. L. Lieu, A. Z. C. Fong, and T. S. Hawley. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1: 136–138.
   PubMed Web of Science ®Google Scholar
• Honda, H., T. Inaba, T. Suzuki, H. Oda, Y. Ebihara, K. Tsuiji, T. Nakahata, T. Ishikawa, Y. Yazaki, and H. Hirai. 1999. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. Blood 93: 2780–2790.
   PubMedGoogle Scholar
• Hueber, A. O., and G. I. Evan. 1998. Traps to catch unwary oncogenes. Trends Genet. 14: 364–367.
   PubMedGoogle Scholar
• Hunger, S. P., K. Ohyashiki, K. Toyama, and M. L. Cleary. 1992. Hlf, a novel hepatic bZIP protein, shows altered DNA binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6: 1608–1620.
   PubMed Web of Science ®Google Scholar
• Hunger, S. P., R. Brown, and M. L. Cleary. 1994. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14: 5986–5996.
   PubMed Web of Science ®Google Scholar
• Ikushima, S., T. Inukai, T. Inaba, S. D. Nimer, J. L. Cleveland, and A. T. Look. 1997. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc. Natl. Acad. Sci. USA 94: 2609–2614.
   PubMed Web of Science ®Google Scholar
• Inaba, T., W. M. Roberts, L. H. Shapiro, K. W. Jolly, S. C. Raimondi, S. D. Smith, and A. T. Look. 1992. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257: 531–534.
   PubMed Web of Science ®Google Scholar
• Inaba, T., T. Inukai, T. Yoshihara, H. Seyschab, R. A. Ashmun, C. E. Canman, S. J. Laken, M. B. Kastan, and A. T. Look. 1996. Reversal of apoptosis by the leukemia-associated E2A-HLF chimaeric transcription factor. Nature 382: 541–544.
   PubMed Web of Science ®Google Scholar
• Inukai, T., T. Inaba, S. Ikushima, and A. T. Look. 1998. The AD1 and AD2 transactivation domains of E2A are essential for the anti-apoptotic activity of the chimeric oncoprotein E2A-HLF. Mol. Cell. Biol. 18: 6035–6043.
   PubMedGoogle Scholar
• Inukai, T., A. Inoue, H. Kurosawa, K. Goi, T. Shinjyo, K. Ozawa, M. Mao, T. Inaba, and A. T. Look. 1999. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4: 343–352.
   PubMedGoogle Scholar
• Jacobs, Y., C. Vierra, and C. Nelson. 1993. E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development. Mol. Cell. Biol. 13: 7321–7333.
   PubMedGoogle Scholar
• Jang, S. K., and E. Wimmer. 1990. Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. Genes Dev. 4: 1560–1572.
   PubMed Web of Science ®Google Scholar
• Kamijo, T., F. Zindy, M. F. Roussel, D. E. Quelle, J. R. Downing, R. A. Ashmun, G., Grosveld, and C. J. Sherr. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649–659.
   PubMed Web of Science ®Google Scholar
• Lavau, C., J. M. Heard, O. Danos, and A. Dejean. 1996. Retroviral vectors for the transduction of the PML-RARα fusion product of acute promyelocytic leukemia. Exp. Hematol. 24: 544–551.
   PubMedGoogle Scholar
• LeBien, T. W. 2000. Fates of human B-cell precursors. Blood 96: 9–23.
   PubMedGoogle Scholar
• Look, A. T. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278: 1059–1064.
   PubMed Web of Science ®Google Scholar
• Maloney, K. W., L. McGavran, L. F. Odom, and S. P. Hunger. 1998. Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations. Leukemia 12: 1417–1421.
   PubMed Web of Science ®Google Scholar
• McLaughlin, J., E. Chianese, and O. N. Witte. 1989. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Mol. Cell. Biol. 9: 1866–1874.
   PubMed Web of Science ®Google Scholar
• Ohnishi, H., R. Hanada, K. Horibe, T. Hongo, M. Kawamura, S. Naritaka, F. Bessho, M. Yanagisawa, T. Nobori, S. Yamamori, and Y. Hayashi. 1996. Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood. Leukemia 10: 1104–1110.
   PubMedGoogle Scholar
• Pear, W., G. Nolan, M. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90: 8392–8396.
   PubMed Web of Science ®Google Scholar
• Randle, D. H., F. Zindy, C. J. Sherr, and M. F. Roussel. 2001. Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Proc. Natl. Acad. Sci. USA 98: 9654–9659.
   PubMedGoogle Scholar
• Rodenhuis, S., J. L. Bos, R. M. Slater, H. Behrendt, M. van't Veer, and L. A. Smets. 1986. Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood. Blood 67: 1698–1704.
   PubMed Web of Science ®Google Scholar
• Rolink, A., and F. Melchers. 1996. B-cell development in the mouse. Immunol. Lett. 54: 157–161.
   PubMedGoogle Scholar
• Scherr, J., and J. D. Weber. 2000. The ARF/p53 pathway. Curr. Opin. Genet. Dev. 10: 94–99.
   PubMedGoogle Scholar
• Smith, K. S., Y. Jacobs, C. P. Chang, and M. L. Cleary. 1997. Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53-independent mechanism that is suppressed by Bcl-2. Oncogene 14: 2917–2926.
   PubMedGoogle Scholar
• Smith, K. S., J. W. Rhee, L. Naumovski, and M. L. Cleary. 1999. Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol. Cell. Biol. 19: 4443–4451.
   PubMedGoogle Scholar
• Whitlock, C. A., G. F. Tidmarsh, C. Muller-Sieburg, and I. L. Weissman. 1987. Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell 48: 1009–1021.
   PubMed Web of Science ®Google Scholar
• Whitlock, C. A., and C. Muller-Sieburg. 1997. Long-term B-lymphoid cultures from murine bone marrow: establishment and cloning by using stromal cell line AC 6.21. Methods Mol. Biol. 75: 231–248.
   PubMedGoogle Scholar
• Zhou, M., L. Gu, T. C. Abshire, A. Homans, A. L. Billett, A. M. Yeager, and H. W. Findley. 2000. Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. Leukemia 14: 61–67.
   PubMed Web of Science ®Google Scholar
• Zou, X., and K. Calame. 1999. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase. J. Biol. Chem. 274: 18141–18144.
   PubMed Web of Science ®Google Scholar