Identification of a Binding Region for Human Origin Recognition Complex Proteins 1 and 2 That Coincides with an Origin of DNA Replication

REFERENCES

• Abdurashidova, G., M. Deganuto, R. Klima, S. Riva, G. Biamonti, M. Giacca, and A. Falaschi. 2000. Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science 287: 2023–2026.
   PubMed Web of Science ®Google Scholar
• Antequera, F., and A. Bird. 1993. Number of CpG islands and genes in human and mouse. Proc. Natl. Acad. Sci. USA 90: 11995–11999.
   PubMed Web of Science ®Google Scholar
• Aparicio, O. M., D. M. Weinstein, and S. P. Bell. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91: 59–69.
   PubMed Web of Science ®Google Scholar
• Bell, S. P., and B. Stillman. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357: 128–134.
   PubMed Web of Science ®Google Scholar
• Biamonti, G., M. Giacca, G. Perini, G. Contreas, L. Zentilin, F. Weighardt, M. Guerra, G. Della Valle, S. Saccone, S. Riva, et al. 1992. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S phase. Mol. Cell. Biol. 12: 3499–3506.
   PubMed Web of Science ®Google Scholar
• Biamonti, G., G. Perini, F. Weighardt, S. Riva, M. Giacca, P. Norio, L. Zentilin, S. Diviacco, D. Dimitrova, and A. Falaschi. 1992. A human DNA replication origin: localization and transcriptional characterization. Chromosoma 102: S24–S31.
   PubMedGoogle Scholar
• Bielinsky, A. K. 2001. Where it all starts: eukaryotic origins of DNA replication. J. Cell Sci. 114: 643–651.
   PubMedGoogle Scholar
• Bielinsky, A. K., and S. A. Gerbi. 1998. Discrete start sites for DNA synthesis in the yeast ARS1 origin. Science 279: 95–98.
   PubMedGoogle Scholar
• Chong, J. P., H. M. Mahbubani, C. Y. Khoo, and J. J. Blow. 1995. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375: 418–421.
   PubMed Web of Science ®Google Scholar
• Coleman, T. R., P. B. Carpenter, and W. G. Dunphy. 1996. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87: 53–63.
   PubMed Web of Science ®Google Scholar
• Connelly, M. A., H. Zhang, J. Kieleczawa, and C. W. Anderson. 1998. The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. Genomics 47: 71–83.
   PubMedGoogle Scholar
• Crane-Robinson, C., F. A. Myers, T. R. Hebbes, A. L. Clayton, and A. W. Thorne. 1999. Chromatin immunoprecipitation assays in acetylation mapping of higher eukaryotes. Methods Enzymol. 304: 533–547.
   PubMedGoogle Scholar
• Delgado, S., M. Gomez, A. Bird, and F. Antequera. 1998. Initiation of DNA replication at CpG islands in mammalian chromosomes. EMBO J. 17: 2426–2435.
   PubMed Web of Science ®Google Scholar
• DePamphilis, M. L. 1993. Eukaryotic DNA replication: anatomy of an origin. Annu. Rev. Biochem. 62: 29–63.
   PubMedGoogle Scholar
• DePamphilis, M. L. 1999. Replication origins in metazoan chromosomes: fact or fiction? Bioessays 21: 5–16.
   PubMedGoogle Scholar
• Dhar, S. K., L. Delmolino, and A. Dutta. 2001. Architecture of the human origin recognition complex. J. Biol. Chem. 6: 6.
   Google Scholar
• Dhar, S. K., and A. Dutta 2000. Identification and characterization of the human ORC6 homolog. J. Biol. Chem. 275: 34983–34988.
   PubMed Web of Science ®Google Scholar
• Diffley, J. F., J. H. Cocker, S. J. Dowell, and A. Rowley 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78: 303–316.
   PubMed Web of Science ®Google Scholar
• Diffley, J. F., and B. Stillman. 1988. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. USA 85: 2120–2124.
   PubMed Web of Science ®Google Scholar
• Dulbecco, R. L., and M. Vogt. 1954. Plaque formation and isolation of pure lines with poliomyelitis virus. J. Exp. Med. 99: 167–182.
   PubMed Web of Science ®Google Scholar
• Gavin, K. A., M. Hidaka, and B. Stillman. 1995. Conserved initiator proteins in eukaryotes. Science 270: 1667–1671.
   PubMed Web of Science ®Google Scholar
• Giacca, M., C. Pelizon, and A. Falaschi. 1997. Mapping replication origins by quantifying relative abundance of nascent DNA strands using competitive polymerase chain reaction. Methods 13: 301–312.
   PubMedGoogle Scholar
• Giacca, M., L. Zentilin, P. Norio, S. Diviacco, D. Dimitrova, G. Contreas, G. Biamonti, G. Perini, F. Weighardt, S. Riva, et al. 1994. Fine mapping of a replication origin of human DNA. Proc. Natl. Acad. Sci. USA 91: 7119–7123.
   PubMed Web of Science ®Google Scholar
• Gilbert, D. M. 1998. Replication origins in yeast versus metazoa: separation of the haves and the have nots. Curr. Opin. Genet. Dev. 8: 194–199.
   PubMedGoogle Scholar
• Göhring, F., and F. O. Fackelmayer. 1997. The scaffold/matrix attachment region binding protein hnRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: a chemical cross-linking study. Biochemistry 36: 8276–8283.
   PubMedGoogle Scholar
• Hand, R. 1978. Eucaryotic DNA: organization of the genome for replication. Cell 15: 317–25.
   PubMed Web of Science ®Google Scholar
• Hua, X. H., H. Yan, and J. Newport. 1997. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J. Cell Biol. 137: 183–192.
   PubMedGoogle Scholar
• Jiang, W., N. J. Wells, and T. Hunter. 1999. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA 96: 6193–6198.
   PubMed Web of Science ®Google Scholar
• Johnson, R. T., C. S. Downes, and R. E. Meyns. 1993. The synchronization of mammalian cells, p. 1–24. In P. Fantes, and R. Brooks (ed.), The cell cycle: a practical approach. IRL Press/Oxford University Press, New York, N.Y.
   Google Scholar
• Kreitz, S., M. Ritzi, M. Baack, and R. Knippers. 2001. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa Cells. J. Biol. Chem. 276: 6337–6342.
   PubMed Web of Science ®Google Scholar
• Ladenburger, E. M., F. O. Fackelmayer, H. Hameister, and R. Knippers. 1997. MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-q13. Cytogenet. Cell Genet. 77: 268–270.
   PubMedGoogle Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685.
   PubMed Web of Science ®Google Scholar
• Lee, D. G., and S. P. Bell. 1997. Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol. Cell. Biol. 17: 7159–7168.
   PubMed Web of Science ®Google Scholar
• Madine, M. A., C. Y. Khoo, A. D. Mills, and R. A. Laskey 1995. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375: 421–424.
   PubMed Web of Science ®Google Scholar
• Maiorano, D., J. Moreau, and M. Mechali. 2000. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature 404: 622–625.
   PubMed Web of Science ®Google Scholar
• Marahrens, Y., and B. Stillman. 1992. A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science 255: 817–823.
   PubMed Web of Science ®Google Scholar
• Marheineke, K., and T. Krude. 1998. Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle. J. Biol. Chem. 273: 15279–15286.
   PubMedGoogle Scholar
• Mendez, J., and B. Stillman. 2000. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20: 8602–8612.
   PubMed Web of Science ®Google Scholar
• Natale, D. A., C. J. Li, W. H. Sun, and M. L. DePamphilis. 2000. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G1 transition in mammals. EMBO J. 19: 2728–2738.
   PubMed Web of Science ®Google Scholar
• Newlon, C. S. 1996. DNA replication in yeast, p. 873–914. In M. L. DePamphilis (ed.), DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
   Google Scholar
• Ohtani, K., R. Iwanaga, M. Nakamura, M. Ikeda, N. Yabuta, H. Tsuruga, and H. Nojima. 1999. Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene 18: 2299–2309.
   PubMedGoogle Scholar
• Orlando, V. 2000. Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation. Trends Biochem. Sci. 25: 99–104.
   PubMed Web of Science ®Google Scholar
• Perkins, G., and J. F. Diffley. 1998. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol. Cell 2: 23–32.
   PubMed Web of Science ®Google Scholar
• Quintana, D. G., and A. Dutta. 1999. The metazoan origin recognition complex. Front. Biosci. 4: D805–D815.
   PubMedGoogle Scholar
• Quintana, D. G., Z. Hou, K. C. Thome, M. Hendricks, P. Saha, and A. Dutta. 1997. Identification of HsORC4, a member of the human origin of replication recognition complex. J. Biol. Chem. 272: 28247–28251.
   PubMed Web of Science ®Google Scholar
• Quintana, D. G., K. C. Thome, Z. H. Hou, A. H. Ligon, C. C. Morton, and A. Dutta. 1998. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. J. Biol. Chem. 273: 27137–27145.
   PubMedGoogle Scholar
• Rao, H., and B. Stillman. 1995. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. Proc. Natl. Acad. Sci. USA 92: 2224–2228.
   PubMed Web of Science ®Google Scholar
• Ren, B., F. Robert, J. J. Wyrick, O. Aparicio, E. G. Jennings, I. Simon, J. Zeitlinger, J. Schreiber, N. Hannett, E. Kanin, T. L. Volkert, C. J. Wilson, S. P. Bell, and R. A. Young. 2000. Genome-wide location and function of DNA binding proteins. Science 290: 2306–2309.
   PubMed Web of Science ®Google Scholar
• Ritzi, M., M. Baack, C. Musahl, P. Romanowski, R. A. Laskey, and R. Knippers. 1998. Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. J. Biol. Chem. 273: 24543–24549.
   PubMed Web of Science ®Google Scholar
• Rivella, S., B. Palermo, C. Pelizon, C. Sala, G. Arrigo, and D. Toniolo. 1999. Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression. Genomics 62: 11–20.
   PubMedGoogle Scholar
• Romanowski, P., M. A. Madine, A. Rowles, J. J. Blow, and R. A. Laskey. 1996. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6: 1416–1425.
   PubMed Web of Science ®Google Scholar
• Rowles, A., J. P. Chong, L. Brown, M. Howell, G. I. Evan, and J. J. Blow. 1996. Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87: 287–296.
   PubMed Web of Science ®Google Scholar
• Rowles, A., S. Tada, and J. J. Blow. 1999. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. J. Cell Sci. 112: 2011–2018.
   PubMed Web of Science ®Google Scholar
• Rowley, A., J. H. Cocker, J. Harwood, and J. F. Diffley. 1995. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J. 14: 2631–2641.
   PubMedGoogle Scholar
• Saha, P., J. Chen, K. C. Thome, S. J. Lawlis, Z. H. Hou, M. Hendricks, J. D. Parvin, and A. Dutta. 1998. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol 18: 2758–2767.
   PubMed Web of Science ®Google Scholar
• Schulte, D., R. Burkhart, C. Musahl, B. Hu, C. Schlatterer, H. Hameister, and R. Knippers. 1995. Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm3 replication protein. J. Cell Sci. 108: 1381–1389.
   PubMedGoogle Scholar
• Simmons, D. T. 2000. SV40 large T antigen functions in DNA replication and transformation. Adv. Virus Res. 55: 75–134.
   PubMedGoogle Scholar
• Spradling, A. C. 1999. ORC binding, gene amplification, and the nature of metazoan replication origins. Genes Dev. 13: 2619–2623.
   PubMedGoogle Scholar
• Sun, W., M. Hola, K. Pedley, S. Tada, J. J. Blow, I. T. Todorov, S. E. Kearsey, and R. F. Brooks. 2000. The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. J. Cell Sci. 113: 683–695.
   PubMedGoogle Scholar
• Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76: 4350–4354.
   PubMed Web of Science ®Google Scholar
• Tsuruga, H., N. Yabuta, K. Hashizume, M. Ikeda, Y. Endo, and H. Nojima. 1997. Expression, nuclear localization and interactions of human MCM/P1 proteins. Biochem. Biophys. Res. Commun. 236: 118–125.
   PubMedGoogle Scholar
• Tugal, T., X. H. Zou-Yang, K. Gavin, D. Pappin, B. Canas, R. Kobayashi, T. Hunt, and B. Stillman. 1998. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J. Biol. Chem. 273: 32421–32429.
   PubMed Web of Science ®Google Scholar
• Vashee, S., P. Simancek, M. D. Challberg, and T. J. Kelly. 2001. Assembly of the human origin recognition complex. J. Biol. Chem. 276: 26666–26673.
   PubMed Web of Science ®Google Scholar
• Weinreich, M., C. Liang, and B. Stillman. 1999. The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96: 441–446.
   PubMed Web of Science ®Google Scholar