Molecular and Cellular Biology, Volume 22, Issue 4 (2002)

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Molecular and Cellular Biology, Volume 22, Issue 4 (2002)

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Cell Growth and Development

Article
Role for the Adaptor Protein Grb10 in the Activation of Akt
Thomas Jahn, Petra Seipel, Susanne Urschel, Christian Peschel & Justus Duyster
Pages: 979-991
Published online: 28 Mar 2023
AbstractforRole for the Adaptor Protein Grb10 in the Activation of Akt | Full Text | References | PDF (503.6 KB)
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Article
Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6
Junko Mizukami, Giichi Takaesu, Hiroyuki Akatsuka, Hiroaki Sakurai, Jun Ninomiya-Tsuji, Kunihiro Matsumoto & Naoki Sakurai
Pages: 992-1000
Published online: 28 Mar 2023
AbstractforReceptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6 | Full Text | References | PDF (318.9 KB)
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Article
Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses
Koko Katagiri, Masakazu Hattori, Nagahiro Minato & Tatsuo Kinashi
Pages: 1001-1015
Published online: 28 Mar 2023
AbstractforRap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses | Full Text | References | PDF (660.6 KB)
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Article
Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1
Rachel Zhande, John J. Mitchell, Jiong Wu & Xiao Jian Sun
Pages: 1016-1026
Published online: 28 Mar 2023
AbstractforMolecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1 | Full Text | References | PDF (396.3 KB)
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Article
Cytokine-Responsive Induction of SAF-1 Activity Is Mediated by a Mitogen-Activated Protein Kinase Signaling Pathway
Alpana Ray, Guang-Yao Yu & Bimal K. Ray
Pages: 1027-1035
Published online: 28 Mar 2023
AbstractforCytokine-Responsive Induction of SAF-1 Activity Is Mediated by a Mitogen-Activated Protein Kinase Signaling Pathway | Full Text | References | PDF (312.7 KB)
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Article
Activation of NF-κB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis
Markus Müller, Alessandro Morotti & Carola Ponzetto
Pages: 1060-1072
Published online: 28 Mar 2023
AbstractforActivation of NF-κB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis | Full Text | References | PDF (494.9 KB)
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Article
The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development
Richard Chan, William R. Hardy, Michael A. Laing, Sarah E. Hardy & William J. Muller
Pages: 1073-1078
Published online: 28 Mar 2023
AbstractforThe Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development | Full Text | References | PDF (554.1 KB)
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Article
Atypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation
Yuri V. Fedorov, Nathan C. Jones & Bradley B. Olwin
Pages: 1140-1149
Published online: 28 Mar 2023
AbstractforAtypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation | Full Text | References | PDF (624.6 KB)
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Article
The Neurofibromatosis Type 2 Gene Product, merlin, Reverses the F-Actin Cytoskeletal Defects in Primary Human Schwannoma Cells
Anne-Marie Bashour, J.-J. Meng, Wallace Ip, Mia MacCollin & Nancy Ratner
Pages: 1150-1157
Published online: 28 Mar 2023
AbstractforThe Neurofibromatosis Type 2 Gene Product, merlin, Reverses the F-Actin Cytoskeletal Defects in Primary Human Schwannoma Cells | Full Text | References | PDF (243 KB)
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Article
The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function
Xiaoyu Li, Xia Bu, Binfeng Lu, Hava Avraham, Richard A. Flavell & Bing Lim
Pages: 1158-1171
Published online: 28 Mar 2023
AbstractforThe Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function | Full Text | References | PDF (708.7 KB)
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Article
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
Eek-hoon Jho, Tong Zhang, Claire Domon, Choun-Ki Joo, Jean-Noel Freund & Frank Costantini
Pages: 1172-1183
Published online: 28 Mar 2023
AbstractforWnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway | Full Text | References | PDF (760.7 KB)
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Article
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
Barbara Lustig, Boris Jerchow, Martin Sachs, Sigrid Weiler, Torsten Pietsch, Uwe Karsten, Marc van de Wetering, Hans Clevers, Peter M. Schlag, Walter Birchmeier & Jürgen Behrens
Pages: 1184-1193
Published online: 28 Mar 2023
AbstractforNegative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors | Full Text | References | PDF (620 KB)
  • 314 Views
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Article
Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation
Jill Thyboll, Jarkko Kortesmaa, Renhai Cao, Raija Soininen, Ling Wang, Antti Iivanainen, Lydia Sorokin, Mårten Risling, Yihai Cao & Karl Tryggvason
Pages: 1194-1202
Published online: 28 Mar 2023
AbstractforDeletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation | Full Text | References | PDF (614.3 KB)
  • 91 Views
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Article
Focal Adhesions Require Catalytic Activity of Src Family Kinases To Mediate Integrin-Matrix Adhesion
Leiming Li, Masaya Okura & Akira Imamoto
Pages: 1203-1217
Published online: 28 Mar 2023
AbstractforFocal Adhesions Require Catalytic Activity of Src Family Kinases To Mediate Integrin-Matrix Adhesion | Full Text | References | PDF (739.7 KB)
  • 41 Views
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Article
Convergence of TOR-Nitrogen and Snf1-Glucose Signaling Pathways onto Gln3
Paula G. Bertram, Jae H. Choi, John Carvalho, Ting-Fung Chan, Wandong Ai & X. F. Steven Zheng
Pages: 1246-1252
Published online: 28 Mar 2023
AbstractforConvergence of TOR-Nitrogen and Snf1-Glucose Signaling Pathways onto Gln3 | Full Text | References | PDF (323.3 KB)
  • 32 Views
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Dna Dynamics and Chromosome Structure

Article
Identification of a Binding Region for Human Origin Recognition Complex Proteins 1 and 2 That Coincides with an Origin of DNA Replication
Eva-Maria Ladenburger, Christian Keller & Rolf Knippers
Pages: 1036-1048
Published online: 28 Mar 2023
AbstractforIdentification of a Binding Region for Human Origin Recognition Complex Proteins 1 and 2 That Coincides with an Origin of DNA Replication | Full Text | References | PDF (524.4 KB)
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Article
Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation
Bo Xu, Seong-Tae Kim, Dae-Sik Lim & Michael B. Kastan
Pages: 1049-1059
Published online: 28 Mar 2023
AbstractforTwo Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation | Full Text | References | PDF (373.3 KB)
  • 79 Views
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Article
Identification of Residues in Yeast Spo11p Critical for Meiotic DNA Double-Strand Break Formation
Robert L. Diaz, Alston D. Alcid, James M. Berger & Scott Keeney
Pages: 1106-1115
Published online: 28 Mar 2023
AbstractforIdentification of Residues in Yeast Spo11p Critical for Meiotic DNA Double-Strand Break Formation | Full Text | References | PDF (594.4 KB)
  • 41 Views
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Article
The AT-Hook Protein D1 Is Essential for Drosophila melanogaster Development and Is Implicated in Position-Effect Variegation
Nathalie Aulner, Caroline Monod, Guillaume Mandicourt, Denis Jullien, Olivier Cuvier, Alhousseynou Sall, Sam Janssen, Ulrich K. Laemmli & Emmanuel Käs
Pages: 1218-1232
Published online: 28 Mar 2023
AbstractforThe AT-Hook Protein D1 Is Essential for Drosophila melanogaster Development and Is Implicated in Position-Effect Variegation | Full Text | References | PDF (1.3 MB)
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Article
Developmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B
Jessica M. Y. Ng, Harry Vrieling, Kaoru Sugasawa, Marja P. Ooms, J. Anton Grootegoed, Jan T. M. Vreeburg, Pim Visser, Rudolph B. Beems, Theo G. M. F. Gorgels, Fumio Hanaoka, Jan H. J. Hoeijmakers & Gijsbertus T. J. van der Horst
Pages: 1233-1245
Published online: 28 Mar 2023
AbstractforDevelopmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B | Full Text | References | PDF (1.2 MB)
  • 39 Views
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Article
Functional Multimerization of Human Telomerase Requires an RNA Interaction Domain in the N Terminus of the Catalytic Subunit
Tara J. Moriarty, Sylvain Huard, Sophie Dupuis & Chantal Autexier
Pages: 1253-1265
Published online: 28 Mar 2023
AbstractforFunctional Multimerization of Human Telomerase Requires an RNA Interaction Domain in the N Terminus of the Catalytic Subunit | Full Text | References | PDF (605.5 KB)
  • 13 Views
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Transcriptional Regulation

Article
Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences
Cyril F. Bourgeois, Young Kyeung Kim, Mark J. Churcher, Michelle J. West & Jonathan Karn
Pages: 1079-1093
Published online: 28 Mar 2023
AbstractforSpt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences | Full Text | References | PDF (660.4 KB)
  • 19 Views
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control
Jene Choi, Bonnie Nannenga, Oleg N. Demidov, Dmitry V. Bulavin, Austin Cooney, Cory Brayton, Yongxin Zhang, Innocent N. Mbawuike, Allan Bradley, Ettore Appella & Lawrence A. Donehower
Pages: 1094-1105
Published online: 28 Mar 2023
AbstractforMice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control | Full Text | References | PDF (797.6 KB)
  • 67 Views
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Gene Expression

Article
A Human Mitochondrial Transcription Factor Is Related to RNA Adenine Methyltransferases and Binds S-Adenosylmethionine
Vicki McCulloch, Bonnie L. Seidel-Rogol & Gerald S. Shadel
Pages: 1116-1125
Published online: 28 Mar 2023
AbstractforA Human Mitochondrial Transcription Factor Is Related to RNA Adenine Methyltransferases and Binds S-Adenosylmethionine | Full Text | References | PDF (615.4 KB)
  • 31 Views
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Nucleocytoplasmic Communication

Article
Unique Motif for Nucleolar Retention and Nuclear Export Regulated by Phosphorylation
Frédéric Catez, Monique Erard, Nathalie Schaerer-Uthurralt, Karine Kindbeiter, Jean-Jacques Madjar & Jean-Jacques Diaz
Pages: 1126-1139
Published online: 28 Mar 2023
AbstractforUnique Motif for Nucleolar Retention and Nuclear Export Regulated by Phosphorylation | Full Text | References | PDF (846.8 KB)
  • 10 Views
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Article
Ribosomal Protein L12 Uses a Distinct Nuclear Import Pathway Mediated by Importin 11
Scott M. Plafker & Ian G. Macara
Pages: 1266-1275
Published online: 28 Mar 2023
AbstractforRibosomal Protein L12 Uses a Distinct Nuclear Import Pathway Mediated by Importin 11 | Full Text | References | PDF (461.5 KB)
  • 39 Views
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Author's Correction

Correction
TDAG51 Is Not Essential for Fas/CD95 Regulation and Apoptosis In Vivo
Page: 1276
Published online: 28 Mar 2023
CitationforTDAG51 Is Not Essential for Fas/CD95 Regulation and Apoptosis In Vivo | Full Text | PDF (16 KB)
  • 108 Views
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