The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development

REFERENCES

• Britsch, S., L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, and D. Riethmacher. 1998. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12: 1825–1836.
   PubMed Web of Science ®Google Scholar
• Burden, S., and Y. Yarden. 1997. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18: 847–855.
   PubMed Web of Science ®Google Scholar
• Carraway, K. L., and L. C. Cantley. 1994. A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78: 5–8.
   PubMed Web of Science ®Google Scholar
• Fong, G. H., J. Rossant, M. Gertsenstein, and M. L. Breitman. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66–70.
   PubMed Web of Science ®Google Scholar
• Fowler, K. J., F. Walker, W. Alexander, M. L. Hibbs, E. C. Nice, R. M. Bohmer, G. B. Mann, C. Thumwood, R. Maglitto, and J. A. Danks. 1995. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc. Natl. Acad. Sci. USA 92: 1465–1469.
   PubMed Web of Science ®Google Scholar
• Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, and G. Lemke. 1995. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390–394.
   PubMed Web of Science ®Google Scholar
• Graus-Porta, D., R. R. Beerli, J. M. Daly, and N. E. Hynes. 1997. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16: 1647–1655.
   PubMed Web of Science ®Google Scholar
• Guy, P. M., J. V. Platko, L. C. Cantley, R. A. Cerione, and K. L. Carraway. 1994. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 91: 8132–8136.
   PubMed Web of Science ®Google Scholar
• Hiratsuka, S., O. Minowa, J. Kuno, T. Noda, and M. Shibuya. 1998. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 95: 9349–9354.
   PubMed Web of Science ®Google Scholar
• Joyner, A. L. 1993. Gene targeting—a practical approach. Oxford University Press, New York, N.Y.
   Google Scholar
• Karunagaran, D., E. Tzahar, R. R. Beerli, X. Chen, D. Graus-Porta, B. J. Ratzkin, R. Seger, N. E. Hynes, and Y. Yarden. 1996. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15: 254–264.
   PubMed Web of Science ®Google Scholar
• Lee, K. F., H. Simon, H. Chen, B. Bates, M. C. Hung, and C. Hauser. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394–398.
   PubMed Web of Science ®Google Scholar
• Lin, W., H. B. Sanchez, T. Deerinck, J. K. Morris, M. Ellisman, and K. F. Lee. 2000. Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc. Natl. Acad. Sci. USA 97: 1299–1304.
   PubMedGoogle Scholar
• Luetteke, N. C., H. K. Phillips, T. H. Qiu, N. G. Copeland, H. S. Earp, N. A. Jenkins, and D. C. Lee. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev. 8: 399–413.
   PubMed Web of Science ®Google Scholar
• Meyer, D., and C. Birchmeier. 1995. Multiple essential functions of neuregulin in development. Nature 378: 386–390.
   PubMed Web of Science ®Google Scholar
• Morin, X., H. Cremer, M. R. Hirsch, R. P. Kapur, C. Goridis, and J. F. Brunet. 1997. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron 18: 411–423.
   PubMed Web of Science ®Google Scholar
• Morris, J. K., W. Lin, C. Hauser, Y. Marchuk, D. Getman, and K. F. Lee. 1999. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron 23: 273–283.
   PubMedGoogle Scholar
• Pinkas-Kramarski, R., M. Shelly, B. C. Guarino, L. M. Wang, L. Lyass, I. Alroy, M. Alimandi, A. Kuo, J. D. Moyer, S. Lavi, M. Eisenstein, B. J. Ratzkin, R. Seger, S. S. Bacus, J. H. Pierce, G. C. Andrews, Y. Yarden, and M. Alamandi. 1998. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol. Cell. Biol 18: 6090–6101.
   PubMed Web of Science ®Google Scholar
• Pinkas-Kramarski, R., L. Soussan, H. Waterman, G. Levkowitz, I. Alroy, L. Klapper, S. Lavi, R. Seger, B. J. Ratzkin, M. Sela, and Y. Yarden. 1996. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 15: 2452–2467.
   PubMed Web of Science ®Google Scholar
• Qian, X., W. C. Dougall, M. E. Hellman, and M. I. Greene. 1994. Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation. Oncogene 9: 1507–1514.
   PubMedGoogle Scholar
• Qian, X., C. M. LeVea, J. K. Freeman, W. C. Dougall, and M. I. Greene. 1994. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc. Natl. Acad. Sci. USA 91: 1500–1504.
   PubMedGoogle Scholar
• Riethmacher, D., E. Sonnenberg-Riethmacher, V. Brinkmann, T. Yamaai, G. R. Lewin, and C. Birchmeier. 1997. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389: 725–730.
   PubMed Web of Science ®Google Scholar
• Siegel, P. M., D. L. Dankort, W. R. Hardy, and W. J. Muller. 1994. Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. Mol. Cell. Biol. 14: 7068–7077.
   PubMed Web of Science ®Google Scholar
• Siegel, P. M., E. D. Ryan, R. D. Cardiff, and W. J. Muller. 1999. Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J. 18: 2149–2164.
   PubMed Web of Science ®Google Scholar
• Valarche, I., J. P. Tissier-Seta, M. R. Hirsch, S. Martinez, C. Goridis, and J. F. Brunet. 1993. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development 119: 881–896.
   PubMedGoogle Scholar
• Wallasch, C., F. U. Weiss, G. Niederfellner, B. Jallal, W. Issing, and A. Ullrich. 1995. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J. 14: 4267–4275.
   PubMed Web of Science ®Google Scholar
• Webster, M. A., J. N. Hutchinson, M. J. Rauh, S. K. Muthuswamy, M. Anton, C. G. Tortorice, R. D. Cardiff, F. L. Graham, J. A. Hassell, and W. J. Muller. 1998. Requirement for both Shc and phosphatidylinositol 3" kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol. Cell. Biol. 18: 2344–2359.
   PubMed Web of Science ®Google Scholar
• Weiner, D. B., Y. Kokai, T. Wada, J. A. Cohen, W. V. Williams, and M. I. Greene. 1989. Linkage of tyrosine kinase activity with transforming ability of the p185neu oncoprotein. Oncogene 4: 1175–1183.
   PubMedGoogle Scholar
• Wilkinson, D. G., and M. A. Nieto. 1993. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225: 361–373.
   PubMedGoogle Scholar
• Yarden, Y., and A. Ullrich. 1988. Growth factor receptor tyrosine kinases. Annu. Rev. Biochem. 57: 443–478.
   PubMed Web of Science ®Google Scholar