Role for the Adaptor Protein Grb10 in the Activation of Akt

REFERENCES

• Ahmed, N. N., T. F. Franke, A. Bellacosa, K. Datta, M. E. Gonzalez-Portal, T. Taguchi, J. R. Testa, and P. N. Tsichlis. 1993. The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene 8: 1957–1963.
   PubMed Web of Science ®Google Scholar
• Altomare, D. A., K. Guo, J. Q. Cheng, G. Sonoda, K. Walsh, and J. R. Testa. 1995. Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene 11: 1055–1060.
   PubMed Web of Science ®Google Scholar
• Altomare, D. A., G. E. Lyons, Y. Mitsuuchi, J. Q. Cheng, and J. R. Testa. 1998. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene 16: 2407–2411.
   PubMedGoogle Scholar
• Andjelkovic, M., D. R. Alessi, R. Meier, A. Fernandez, N. J. Lamb, M. Frech, P. Cron, P. Cohen, J. M. Lucocq, and B. A. Hemmings. 1997. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272: 31515–31524.
   Google Scholar
• Bai, R. Y., T. Jahn, S. Schrem, G. Munzert, K. M. Weidner, J. Y. Wang, and J. Duyster. 1998. The SH2-containing adapter protein GRB10 interacts with BCR-ABL. Oncogene 17: 941–948.
   PubMedGoogle Scholar
• Bellacosa, A., T. F. Franke, M. E. Gonzalez-Portal, K. Datta, T. Taguchi, J. Gardner, J. Q. Cheng, J. R. Testa, and P. N. Tsichlis. 1993. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene 8: 745–754.
   PubMed Web of Science ®Google Scholar
• Biggs, W. H., III, J. Meisenhelder, T. Hunter, W. K. Cavenee, and K. C. Arden. 1999. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96: 7421–7426.
   PubMed Web of Science ®Google Scholar
• Blume-Jensen, P., R. Janknecht, and T. Hunter. 1998. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr. Biol. 8: 779–782.
   PubMed Web of Science ®Google Scholar
• Blume-Jensen, P., G. Jiang, R. Hyman, K. F. Lee, S. O'Gorman, and T. Hunter. 2000. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility. Nat. Genet. 24: 157–162.
   PubMed Web of Science ®Google Scholar
• Brodbeck, D., P. Cron, and B. A. Hemmings. 1999. A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J. Biol. Chem. 274: 9133–9136.
   PubMed Web of Science ®Google Scholar
• Brunet, A., A. Bonni, M. J. Zigmond, M. Z. Lin, P. Juo, L. S. Hu, M. J. Anderson, K. C. Arden, J. Blenis, and M. E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857–868.
   PubMed Web of Science ®Google Scholar
• Cardone, M. H., N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Frisch, and J. C. Reed. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318–1321.
   PubMed Web of Science ®Google Scholar
• Cheng, J. Q., B. Ruggeri, W. M. Klein, G. Sonoda, D. A. Altomare, D. K. Watson, and J. R. Testa. 1996. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA 93: 3636–3641.
   PubMed Web of Science ®Google Scholar
• Coffer, P. J., and J. R. Woodgett. 1991. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem. 201: 475–481. (Erratum, 205: 1217, 1992.)
   PubMedGoogle Scholar
• Coutinho, S., T. Jahn, M. Lewitzky, S. Feller, P. Hutzler, C. Peschel, and J. Duyster. 2000. Characterization of Grb4, an adapter protein interacting with Bcr-Abl. Blood 96: 618–624.
   PubMedGoogle Scholar
• Currie, R. A., K. S. Walker, A. Gray, M. Deak, A. Casamayor, C. P. Downes, P. Cohen, D. R. Alessi, and J. Lucocq. 1999. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337: 575–583.
   PubMedGoogle Scholar
• Daly, R. J. 1998. The Grb7 family of signalling proteins. Cell. Signalling 10: 613–618.
   PubMed Web of Science ®Google Scholar
• Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231–241.
   PubMed Web of Science ®Google Scholar
• Dong, L. Q., H. Du, S. G. Porter, L. F. Kolakowski, Jr., A. V. Lee, L. J. Mandarino, J. Fan, D. Yee, and F. Liu. 1997. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. J. Biol. Chem. 272: 29104–29112. (Erratum, 273: 4288, 1998.)
   PubMedGoogle Scholar
• Dong, L. Q., S. Porter, D. Hu, and F. Liu. 1998. Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization. J. Biol. Chem. 273: 17720–17725.
   PubMedGoogle Scholar
• Franke, T. F., D. R. Kaplan, L. C. Cantley, and A. Toker. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275: 665–668.
   PubMed Web of Science ®Google Scholar
• Franke, T. F., S. I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727–736.
   PubMed Web of Science ®Google Scholar
• Jones, P. F., T. Jakubowicz, F. J. Pitossi, F. Maurer, and B. A. Hemmings. 1991. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc. Natl. Acad. Sci. USA 88: 4171–4175.
   PubMed Web of Science ®Google Scholar
• Kanakura, Y., T. Furitsu, T. Tsujimura, J. H. Butterfield, L. K. Ashman, H. Ikeda, H. Kitayama, Y. Kanayama, Y. Matsuzawa, and Y. Kitamura. 1994. Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. Leukemia 8(Suppl. 1): S18–S22.
   PubMedGoogle Scholar
• Kissel, H., I. Timokhina, M. P. Hardy, G. Rothschild, Y. Tajima, V. Soares, M. Angeles, S. R. Whitlow, K. Manova, and P. Besmer. 2000. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J. 19: 1312–1326.
   PubMed Web of Science ®Google Scholar
• Langlais, P., L. Q. Dong, D. Hu, and F. Liu. 2000. Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family. Oncogene 19: 2895–2903.
   PubMedGoogle Scholar
• Liu, F., and R. A. Roth. 1995. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc. Natl. Acad. Sci. USA 92: 10287–10291.
   PubMed Web of Science ®Google Scholar
• Maira, S. M., I. Galetic, D. P. Brazil, S. Kaech, E. Ingley, M. Thelen, and B. A. Hemmings. 2001. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science 294: 374–380.
   PubMed Web of Science ®Google Scholar
• Mano, H., K. Ohya, A. Miyazato, Y. Yamashita, W. Ogawa, J. Inazawa, U. Ikeda, K. Shimada, K. Hatake, M. Kasuga, K. Ozawa, and S. Kajigaya. 1998. Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase. Genes Cells 3: 431–441.
   PubMed Web of Science ®Google Scholar
• Meier, R., D. R. Alessi, P. Cron, M. Andjelkovic, and B. A. Hemmings. 1997. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J. Biol. Chem. 272: 30491–30497.
   PubMed Web of Science ®Google Scholar
• Morrione, A. 2000. Grb10 proteins in insulin-like growth factor and insulin receptor signaling. Int. J. Mol. Med. 5: 151–154.
   PubMedGoogle Scholar
• Morrione, A., P. Plant, B. Valentinis, O. Staub, S. Kumar, D. Rotin, and R. Baserga. 1999. mGrb10 interacts with Nedd4. J. Biol. Chem. 274: 24094–24099.
   PubMed Web of Science ®Google Scholar
• Morrione, A., B. Valentinis, M. Resnicoff, S. Xu, and R. Baserga. 1997. The role of mGrb10alpha in insulin-like growth factor I-mediated growth. J. Biol. Chem. 272: 26382–26387.
   PubMedGoogle Scholar
• Mounier, C., and B. Posner. 2001. Specific inhibition by hGrb10zeta of insulin-induced glycogen sythase activation: evidence for a novel signaling pathway. Mol. Cell. Endocrinol. 173: 15–27.
   PubMedGoogle Scholar
• Nantel, A., M. Huber, and D. Y. Thomas. 1999. Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool. J. Biol. Chem. 274: 35719–35724.
   PubMed Web of Science ®Google Scholar
• Nantel, A., K. Mohammad-Ali, J. Sherk, B. I. Posner, and D. Y. Thomas. 1998. Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases. J. Biol. Chem. 273: 10475–10484.
   PubMed Web of Science ®Google Scholar
• Okano, J., I. Gaslightwala, M. J. Birnbaum, A. K. Rustgi, and H. Nakagawa. 2000. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J. Biol. Chem. 275: 30934–30942.
   PubMed Web of Science ®Google Scholar
• O'Neill, T. J., D. W. Rose, T. S. Pillay, K. Hotta, J. M. Olefsky, and T. A. Gustafson. 1996. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J. Biol. Chem. 271: 22506–22513.
   PubMed Web of Science ®Google Scholar
• Ooi, J., V. Yajnik, D. Immanuel, M. Gordon, J. J. Moskow, A. M. Buchberg, and B. Margolis. 1995. The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene 10: 1621–1630.
   PubMedGoogle Scholar
• Pandey, A., H. Duan, P. P. Di Fiore, and V. M. Dixit. 1995. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J. Biol. Chem. 270: 21461–21463.
   PubMedGoogle Scholar
• Piao, X., R. Paulson, P. van der Geer, T. Pawson, and A. Bernstein. 1996. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA 93: 14665–14669.
   PubMed Web of Science ®Google Scholar
• Reilly, J. F., G. Mickey, and P. A. Maher. 2000. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J. Biol. Chem. 275: 7771–7778.
   PubMed Web of Science ®Google Scholar
• Sable, C. L., N. Filippa, C. Filloux, B. A. Hemmings, and E. Van Obberghen. 1998. Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J. Biol. Chem. 273: 29600–29606.
   PubMedGoogle Scholar
• Serve, H., N. S. Yee, G. Stella, L. Sepp-Lorenzino, J. C. Tan, and P. Besmer. 1995. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14: 473–483.
   PubMed Web of Science ®Google Scholar
• Skorski, T., A. Bellacosa, M. Nieborowska-Skorska, M. Majewski, R. Martinez, J. K. Choi, R. Trotta, P. Wlodarski, D. Perrotti, T. O. Chan, M. A. Wasik, P. N. Tsichlis, and B. Calabretta. 1997. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 16: 6151–6161.
   PubMed Web of Science ®Google Scholar
• Songyang, Z., D. Baltimore, L. C. Cantley, D. R. Kaplan, and T. F. Franke. 1997. Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. USA 94: 11345–11350.
   PubMed Web of Science ®Google Scholar
• Stein, E. G., T. A. Gustafson, and S. R. Hubbard. 2001. The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors. FEBS Lett. 493: 106–111.
   PubMed Web of Science ®Google Scholar
• Tanaka, S., K. Sugimachi, H. Kawaguchi, H. Saeki, S. Ohno, and J. R. Wands. 2000. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. J. Cell. Physiol. 183: 411–415.
   PubMed Web of Science ®Google Scholar
• Tsujimura, T., K. Hashimoto, H. Kitayama, H. Ikeda, H. Sugahara, I. Matsumura, T. Kaisho, N. Terada, Y. Kitamura, and Y. Kanakura. 1999. Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site. Blood 93: 1319–1329.
   PubMedGoogle Scholar
• Wang, J., H. Dai, N. Yousaf, M. Moussaif, Y. Deng, A. Boufelliga, O. R. Swamy, M. E. Leone, and H. Riedel. 1999. Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis. Mol. Cell. Biol. 19: 6217–6228.
   PubMed Web of Science ®Google Scholar
• Wijkander, J., L. S. Holst, T. Rahn, S. Resjo, I. Castan, V. Manganiello, P. Belfrage, and E. Degerman. 1997. Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate. J. Biol. Chem. 272: 21520–21526.
   PubMed Web of Science ®Google Scholar
• Wojcik, J., J. A. Girault, G. Labesse, J. Chomilier, J. P. Mornon, and I. Callebaut. 1999. Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4.1/JEF domains and in the Grb7/10/14 adapter family. Biochem. Biophys. Res. Commun. 259: 113–120.
   PubMed Web of Science ®Google Scholar
• Zhou, B. P., Y. Liao, W. Xia, B. Spohn, M. H. Lee, and M. C. Hung. 2001. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat. Cell Biol. 3: 245–252.
   PubMed Web of Science ®Google Scholar