Coupling of Enhancer and Insulator Properties Identified in Two Retrotransposons Modulates Their Mutagenic Impact on Nearby Genes

REFERENCES

• Ahmad, K., and K. G. Golic. 1996. Somatic reversion of chromosomal position effects in Drosophila melanogaster. Genetics 144: 657-670.
   PubMedGoogle Scholar
• Arkhipova, I. R. 1995. Promoter elements in Drosophila melanogaster revealed by sequence analysis. Genetics 139: 1359–1369.
   PubMedGoogle Scholar
• Bell, A. C., and G. Felsenfeld. 1999. Stopped at the border: boundaries and insulators. Curr. Opin. Genet. Dev. 9: 191–198.
   PubMed Web of Science ®Google Scholar
• Cai, H., and M. Levine. 1997. The gypsy insulator can function as a promoter-specific silencer in the Drosophila embryo. EMBO J. 16: 1732–1741.
   PubMed Web of Science ®Google Scholar
• Cai, H. N., and P. Shen. 2001. Effects of cis arrangement of chromatin insulators on enhancer-blocking activity. Science 291: 493–495.
   PubMedGoogle Scholar
• Chung, J. H., A. C. Bell, and G. Felsenfeld. 1997. Characterization of the chicken beta-globin insulator. Proc. Natl. Acad. Sci. USA 94: 575–580.
   PubMed Web of Science ®Google Scholar
• Chung, J. H., M. Whiteley, and G. Felsenfeld. 1993. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74: 505–514.
   PubMed Web of Science ®Google Scholar
• Conte, C., V. Calco, S. Desset, P. Leblanc, B. Dastugue, and C. Vaury. 2000. Impact of multiple insertions of two retroelements, ZAM and Idefix at an euchromatic locus. Genetica 109: 53–59.
   PubMedGoogle Scholar
• Desset, S., C. Conte, P. Dimitri, V. Calco, B. Dastugue, and C. Vaury. 1999. Mobilization of two retroelements, ZAM and Idefix, in a novel unstable line of Drosophila melanogaster. Mol. Biol. Evol. 16: 54–66.
   PubMedGoogle Scholar
• Evans, B. A., and A. J. Howells. 1978. Control of drosopterin synthesis in Drosophila melanogaster: mutants showing an altered pattern of GTP cyclohydrolase activity during development. Biochem. Genet. 16: 13–26.
   PubMedGoogle Scholar
• Geyer, P. K. 1997. The role of insulator elements in defining domains of gene expression. Curr. Opin. Genet. Dev. 7: 242–248.
   PubMedGoogle Scholar
• Ke, N., and D. F. Voytas. 1997. High frequency cDNA recombination of the saccharomyces retrotransposon Ty5: the LTR mediates formation of tandem elements. Genetics 147: 545–556.
   PubMedGoogle Scholar
• Kellum, R., and S. C. Elgin. 1998. Chromatin boundaries: punctuating the genome. Curr. Biol. 8: R521–R524.
   PubMedGoogle Scholar
• Kellum, R., and P. Schedl. 1992. A group of scs elements function as domain boundaries in an enhancer-blocking assay. Mol. Cell. Biol. 12: 2424–2431.
   PubMed Web of Science ®Google Scholar
• Kellum, R., and P. Schedl. 1991. A position-effect assay for boundaries of higher order chromosomal domains. Cell 64: 941–950.
   PubMed Web of Science ®Google Scholar
• Lajoinie, O., M. E. Drake, B. Dastugue, and C. Vaury. 1995. Aberrant pre-mRNA maturation is caused by LINE insertions into introns of the white gene of Drosophila melanogaster. Nucleic Acids Res. 23: 4015–4022.
   PubMedGoogle Scholar
• Leblanc, P., B. Dastugue, and C. Vaury. 1999. The integration machinery of ZAM. a retroelement from Drosophila melanogaster, acts as a sequence-specific endonuclease. J. Virol. 73: 7061–7064.
   PubMedGoogle Scholar
• Leblanc, P., S. Desset, B. Dastugue, and C. Vaury. 1997. Invertebrate retroviruses: ZAM a new candidate in D. melanogaster. EMBO J. 16: 7521–7531.
   Google Scholar
• Leblanc, P., S. Desset, F. Glorgi, A. R. Taddei, A. M. Fausto, M. Mazzini, B. Dastugue, and C. Vaury. 2000. Life cycle of an endogenous retrovirus, ZAM, in Drosophila melanogaster. J. Virol. 74: 10658–10669.
   PubMedGoogle Scholar
• Li, X., and M. Noll. 1994. Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions. Nature 367: 83–87.
   PubMedGoogle Scholar
• Muravyova, E., A. Golovnin, E. Gracheva, A. Parshikov, T. Belenkaya, V. Pirrotta, and P. Georgiev. 2001. Loss of insulator activity by paired Su(Hw) chromatin insulators. Science 291: 495–498.
   PubMedGoogle Scholar
• O'Donnell, K. H., C. T. Chen, and P. C. Wensink. 1994. Insulating DNA directs ubiquitous transcription of the Drosophila melanogaster alpha 1-tubulin gene. Mol. Cell. Biol. 14: 6398–6408.
   PubMed Web of Science ®Google Scholar
• Ohtsuki, S., and M. Levine. 1998. GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo. Genes Dev. 12: 3325–3330.
   PubMedGoogle Scholar
• Pirrotta, V. 1988. Vector for P-mediated transformation in Drosophila. Bio/Technology 10: 437–456.
   PubMedGoogle Scholar
• Pirrotta, V. 1997. Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends Genet. 13: 314–318.
   PubMed Web of Science ®Google Scholar
• Qian, S., B. Varjavand, and V. Pirrotta. 1992. Molecular analysis of the zeste-white interaction reveals a promoter-proximal element essential for distant enhancer-promoter communication. Genetics 131: 79–90.
   PubMedGoogle Scholar
• Rubin, G. M., and A. C. Spradling. 1982. Genetic transformation of Drosophila with transposable element vectors. Science 218: 348–353.
   PubMed Web of Science ®Google Scholar
• Sandmeyer, S. B., L. J. Hansen, and D. L. Chalker. 1990. Integration specificity of retrotransposons and retroviruses. Annu. Rev. Genet. 24: 491–518.
   PubMed Web of Science ®Google Scholar
• SanMiguel, P., A. Tikhonov, Y. K. Jin, N. Motchoulskaia, D. Zakharov, A. Melake-Berhan, P. S. Springer, K. J. Edwards, M. Lee, Z. Avramova, and J. L. Bennetzen. 1996. Nested retrotransposons in the intergenic regions of the maize genome. Science 274: 765–768.
   PubMed Web of Science ®Google Scholar
• Udvardy, A. 1999. Dividing the empire: boundary chromatin elements delimit the territory of enhancers. EMBO J. 18: 1–8.
   PubMedGoogle Scholar
• Udvardy, A., E. Maine, and P. Schedl. 1985. The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains. J. Mol. Biol. 185: 341–358.
   PubMed Web of Science ®Google Scholar