The Rab27a/Granuphilin Complex Regulates the Exocytosis of Insulin-Containing Dense-Core Granules

REFERENCES

• Bahadoran, P., E. Aberdam, F. Mantoux, R. Buscà, K. Bille, N. Yalman, G. de Saint-Basile, R. Casaroli-Marano, J.-P. Ortonne, and R. Ballotti. 2001. Rab27a: a key to melanosome transport in human melanocytes. J. Cell Biol. 152: 843–849.
   PubMed Web of Science ®Google Scholar
• Bartel, P. L., and S. Fields. 1995. Analyzing protein-protein interactions using two-hybrid system. Methods Enzymol. 254: 241–263.
   PubMedGoogle Scholar
• Baumart, M., G. Fischer von Mollard, R. Jahn, and T. C. Südhof. 1993. Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem. J. 293: 157–163.
   PubMedGoogle Scholar
• Bock, J. B., H. T. Matern, A. A. Peden, and R. H. Scheller. 2001. A genomic perspective on membrane compartment organization. Nature 409: 839–841.
   PubMed Web of Science ®Google Scholar
• Brondyk, W. H., C. J. McKiernan, K. A. Fortner, P. Stabila, R. W. Holz, and I. G. Macara. 1995. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Mol. Cell. Biol. 15: 1137–1143.
   PubMedGoogle Scholar
• Castillo, P. E., R. Janz, T. C. Südhof, T. Tzounopoulos, R. C. Melanke, and R. A. Nicoll. 1997. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature 388: 590–593.
   PubMedGoogle Scholar
• Chen, D., J. Guo, T. Miki, M. Tachibana, and W. A. Gahl. 1997. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochem. Mol. Med. 60: 27–37.
   PubMedGoogle Scholar
• Coombs, D. H. 1975. Density gradient fractionation by piston displacement. Anal. Biochem. 68: 95–101.
   PubMedGoogle Scholar
• Coombs, D. H., and N. R. M. Watts. 1985. Generating sucrose gradients in three minutes by tilted tube rotation. Anal. Biochem. 148: 254–259.
   PubMedGoogle Scholar
• Detter, J. C., Q. Zhang, E. H. Mules, E. K. Novak, V. S. Mishra, W. Li, E. B. McMurtrie, V. T. Tchernev, M. R. Wallace, M. C. Seabra, R. T. Swank, and S. F. Kingsmore. 2000. Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Proc. Natl. Acad. Sci. USA 97: 4144–4149.
   PubMed Web of Science ®Google Scholar
• Geppert, M., Y. Goda, C. F. Stevens, and T. C. Südhof. 1997. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387: 810–814.
   PubMedGoogle Scholar
• Griffith, G., A. McDowall, R. Back, and J. Dubochet. 1984. On the preparation of cryosections for immunocytochemistry. J. Ultrastruct. Res. 89: 65–78.
   PubMedGoogle Scholar
• Griscelli, C., A. Durandy, D. Guy-Grand, F. Daguillard, C. Herzog, and M. Prunieras. 1978. A syndrome associating partial albinism and immunodeficiency. Am. J. Med. 65: 691–702.
   PubMed Web of Science ®Google Scholar
• Haddad, E. K., X. Wu, J. A. Hammer III, and P. A. Henkart. 2001. Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J. Cell Biol. 152: 835–841.
   PubMed Web of Science ®Google Scholar
• Hirayama, I., H. Tamemoto, H. Yokota, S.-K. Kubo, J. Wang, H. Kuwano, Y. Nagamachi, T. Takeuchi, and T. Izumi. 1999. Insulin receptor-related receptor is expressed in pancreatic β-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes 48: 1237–1244.
   PubMed Web of Science ®Google Scholar
• Hoffman, C. S., and F. Winston. 1987. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57: 267–272.
   PubMed Web of Science ®Google Scholar
• Hollenberg, S. M., R. Sternglanz, P. F. Cheng, and H. Weintraub. 1995. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15: 3813–3822.
   PubMedGoogle Scholar
• Holz, R. W., W. H. Brondyk, R. A. Senter, L. Kuizon, and I. G. Macara. 1994. Evidence for the involvement of Rab3A in Ca2+-dependent exocytosis from adrenal chromaffin cells. J. Biol. Chem. 269: 10229–10234.
   PubMedGoogle Scholar
• Hume, A. N., L. M. Collinson, A. Repak, A. Q. Gomes, C. R. Hopkins, and M. C. Seabra. 2001. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J. Cell Biol. 152: 795–808.
   PubMed Web of Science ®Google Scholar
• Jahn, R., and T. C. Südhof. 1999. Membrane fusion and exocytosis. Annu. Rev. Biochem. 68: 863–911.
   PubMed Web of Science ®Google Scholar
• Klumperman, J., R. Kuliawat, J. M. Griffith, H. J. Geuze, and P. Arvan. 1998. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles. J. Cell Biol. 141: 359–371.
   PubMed Web of Science ®Google Scholar
• Kuliawat, R., J. Klumperman, T. Ludwig, and P. Arvan. 1997. Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic β-cells. J. Cell Biol. 137: 595–608.
   PubMed Web of Science ®Google Scholar
• Lonart, G., R. Janz, K. M. Johnson, and T. C. Südhof. 1998. Mechanism of action of rab3A in mossy fiber LTP. Neuron 21: 1141–1150.
   PubMedGoogle Scholar
• McBride, H. M., V. Rybin, C. Murphy, A. Giner, R. Teasdale, and M. Zerial. 1999. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell 98: 377–386.
   PubMed Web of Science ®Google Scholar
• Ménasché, G., E. Pastural, J. Feldmann, S. Certain, F. Ersoy, S. Dupuis, N. Wulffraat, D. Bianchi, A. Fischer, F. Le Deist, and G. de Saint Basile. 2000. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat. Genet. 25: 173–176.
   PubMed Web of Science ®Google Scholar
• Miyake, S., M. Makimura, Y. Kanegae, S. Harada, Y. Sato, K. Takamori, C. Tokuda, and I. Saito. 1996. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA 93: 1320–1324.
   PubMedGoogle Scholar
• Nagata, K., H. Sakagami, H. Kondo, and Y. Nozawa. 1995. Identification and localization of gene expression of a low Mr GTP-binding protein, ram p25 in pituitary gland. Biochem. Biophys. Res. Commun. 217: 1223–1230.
   PubMedGoogle Scholar
• Nagata, K., T. Satoh, H. Itoh, T. Kozasa, Y. Okano, T. Doi, Y. Kaziro, and Y. Nozawa. 1990. The ram: a novel low molecular weight GTP-binding protein cDNA from a rat megakaryocyte library. FEBS Lett. 275: 29–32.
   PubMedGoogle Scholar
• Olkkonen, V. M., and H. Stenmark. 1997. Role of Rab GTPases in membrane traffic. Int. Rev. Cytol. 176: 1–85.
   PubMedGoogle Scholar
• Pfeffer, S. R. 1999. Transport-vesicle targeting: tethers before SNAREs. Nat. Cell Biol. 1: E17-E22.
   PubMedGoogle Scholar
• Reetz, A., M. Solimena, M. Matteoli, F. Folli, K. Takei, and P. De Camilli. 1991. GABA and pancreatic β-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J. 10: 1275–1284.
   PubMed Web of Science ®Google Scholar
• Regazzi, R., M. Ravazzola, M. Iezzi, J. Lang, A. Zahraoui, E. Andereggen, P. Morel, Y. Takai, and C. B. Wollheim. 1996. Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. J. Cell Sci. 109: 2265–2273.
   PubMedGoogle Scholar
• Seabra, M. C., Y. K. Ho, and J. S. Anant. 1995. Deficient geranylgeranylation of ram/rab27 in choroideremia. J. Biol. Chem. 270: 24420–24427.
   PubMed Web of Science ®Google Scholar
• Stinchcombe, J. C., and G. M. Griffiths. 1999. Regulated secretion from hemopoietic cells. J. Cell Biol. 147: 1–5.
   PubMedGoogle Scholar
• Stinchcombe, J. C., D. C. Barral, E. H. Mules, S. Booth, A. N. Hume, L. M. Machesky, M. C. Seabra, and G. M. Griffiths. 2001. Rab27A is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152: 825–833.
   PubMedGoogle Scholar
• Torii, S., D. A. Egan, R. A. Evans, and J. C. Reed. 1999. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs). EMBO J. 18: 6037–6049.
   PubMedGoogle Scholar
• Wang, J., T. Takeuchi, H. Yokota, and T. Izumi. 1999. Novel rabphilin3-like protein associates with insulin-containing granules in pancreatic beta cells. J. Biol. Chem. 274: 28542–28548.
   PubMedGoogle Scholar
• Wilson, S. M., R. Yip, D. A. Swing, T. N. O'Sullivan, Y. Zhang, E. K. Novak, R. T. Swank, L. B. Russell, N. G. Copeland, and N. A. Jenkins. 2000. A mutation in Rab27A causes the vesicle transport defects observed in ashen mice. Proc. Natl. Acad. Sci. USA 97: 7933–7938.
   PubMed Web of Science ®Google Scholar