Opposing Roles of the Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Cascades in Ras-Mediated Downregulation of Tropomyosin

REFERENCES

• Abe, K., I. P. Whitehead, J. P. O'Bryan, and C. J. Der. 1999. Involvement of N-terminal sequences in the negative regulation of Vav signaling and transforming activity. J. Biol. Chem. 274: 30410–30418.
   PubMedGoogle Scholar
• Alaiya, A. A., B. Franzen, K. Fujioka, B. Moberger, K. Schedvins, C. Silfversvard, S. Linder, and G. Auer. 1997. Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. Int. J. Cancer 73: 678–683.
   PubMed Web of Science ®Google Scholar
• Bigey, P., S. Ramchandani, J. Theberge, F. D. Araujo, and M. Szyf. 2000. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene 242: 407–418.
   PubMedGoogle Scholar
• Bishop, A. L., and A. Hall. 2000. Rho GTPases and their effector proteins. Biochem. J. 348(Pt. 2): 241–255.
   PubMed Web of Science ®Google Scholar
• Braverman, R. H., H. L. Cooper, H. S. Lee, and G. L. Prasad. 1996. Anti-oncogenic effects of tropomyosin: isoform specificity and importance of protein coding sequences. Oncogene 13: 537–545.
   PubMedGoogle Scholar
• Button, E., C. Shapland, and D. Lawson. 1995. Actin, its associated proteins, and metastasis. Cell Motil. Cytoskeleton 30: 247–251.
   PubMedGoogle Scholar
• Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294–5299.
   PubMedGoogle Scholar
• Coller, H. A., C. Grandori, P. Tamayo, T. Colbert, E. S. Lander, R. N. Eisenman, and T. R. Golub. 2000. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc. Natl. Acad. Sci. USA 97: 3260–3265.
   PubMed Web of Science ®Google Scholar
• Contente, S., K. Kenyon, P. Sriraman, S. Subramanyan, and R. M. Friedman. 1999. Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. Mol. Cell. Biochem. 194: 79–91.
   PubMedGoogle Scholar
• Cooper, H. L., B. Bhattacharya, R. H. Bassin, and D. S. Salomon. 1987. Suppression of synthesis and utilization of tropomyosin in mouse and rat fibroblasts by transforming growth factor alpha: a pathway in oncogene action. Cancer Res. 47: 4493–4500.
   PubMedGoogle Scholar
• Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137–1146.
   PubMed Web of Science ®Google Scholar
• Deng, C., J. Yang, J. Scott, S. Hanash, and B. C. Richardson. 1998. Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation. Biol. Chem. 379: 1113–1120.
   PubMedGoogle Scholar
• Gabbiani, G., J. Csank-Brassert, J. C. Schneeberger, Y. Kapanci, P. Trenchev, and E. J. Holborow. 1976. Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study. Am. J. Pathol. 83: 457–474.
   PubMed Web of Science ®Google Scholar
• Gangarosa, L. M., N. Sizemore, R. Graves-Deal, S. M. Oldham, C. J. Der, and R. J. Coffey. 1997. A Raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells. J. Biol. Chem. 272: 18926–18931.
   PubMed Web of Science ®Google Scholar
• Gimona, M., J. A. Kazzaz, and D. M. Helfman. 1996. Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proc. Natl. Acad. Sci. USA 93: 9618–9623.
   PubMedGoogle Scholar
• Guan, R. J., Y. Fu, P. R. Holt, and A. B. Pardee. 1999. Association of K-ras mutations with p16 methylation in human colon cancer. Gastroenterology 116: 1063–1071.
   PubMedGoogle Scholar
• Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science 279: 509–514.
   PubMed Web of Science ®Google Scholar
• Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and D. Broek. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279: 558–560.
   PubMedGoogle Scholar
• Hashimoto, Y., N. Shindo-Okada, M. Tani, K. Takeuchi, H. Toma, and J. Yokota. 1996. Identification of genes differentially expressed in association with metastatic potential of K-1735 murine melanoma by messenger RNA differential display. Cancer Res. 56: 5266–5271.
   PubMedGoogle Scholar
• Hemstreet, G. P., J. Rao, R. E. Hurst, R. B. Bonner, P. Waliszewski, H. B. Grossman, M. Liebert, and B. L. Bane. 1996. G-actin as a risk factor and modulatable endpoint for cancer chemoprevention trials. J. Cell Biochem. Suppl. 25: 197–204.
   PubMedGoogle Scholar
• Hendricks, M., and H. Weintraub. 1981. Tropomyosin is decreased in transformed cells. Proc. Natl. Acad. Sci. USA 78: 5633–5637.
   PubMedGoogle Scholar
• Hubank, M., and D. G. Schatz. 1994. Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res. 22: 5640–5648.
   PubMed Web of Science ®Google Scholar
• Jancso, A., and P. Graceffa. 1991. Smooth muscle tropomyosin coiled-coil dimers. Subunit composition, assembly, and end-to-end interaction. J. Biol. Chem. 266: 5891–5897.
   PubMedGoogle Scholar
• Janssen, R. A., and J. W. Mier. 1997. Tropomyosin-2 cDNA lacking the 3′ untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts. Mol. Biol. Cell 8: 897–908.
   PubMedGoogle Scholar
• Janssen, R. A., K. G. Veenstra, P. Jonasch, E. Jonasch, and J. W. Mier. 1998. Ras- and Raf-induced downmodulation of non-muscle tropomyosin are MEK-independent. J. Biol. Chem. 273: 32182–32186.
   PubMed Web of Science ®Google Scholar
• Jo, H., R. Zhang, H. Zhang, T. A. McKinsey, J. Shao, R. D. Beauchamp, D. W. Ballard, and P. Liang. 2000. NF-κB is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene 19: 841–849.
   PubMed Web of Science ®Google Scholar
• Jones, P. A. 1985. Altering gene expression with 5-azacytidine. Cell 40: 485–486.
   PubMed Web of Science ®Google Scholar
• Khosravi-Far, R., M. Chrzanowska-Wodnicka, P. A. Solski, A. Eva, K. Burridge, and C. J. Der. 1994. Vav and Dbl mediate transformation via Ras-independent mitogen activated protein kinase activation. Mol. Cell. Biol. 14: 6848–6857.
   PubMedGoogle Scholar
• Khosravi-Far, R., P. A. Solski, M. S. Kinch, K. Burridge, and C. J. Der. 1995. Activation of Rac and Rho, and mitogen activated protein kinases, are required for Ras transformation. Mol. Cell. Biol. 15: 6443–6453.
   PubMed Web of Science ®Google Scholar
• Lehrer, S. S., and W. F. Stafford. 1991. Preferential assembly of the tropomyosin heterodimer: equilibrium studies. Biochemistry 30: 5682–5688.
   PubMedGoogle Scholar
• Lisitsyn, N., and M. Wigler. 1993. Cloning the differences between two complex genomes. Science 259: 946–951.
   PubMed Web of Science ®Google Scholar
• Ljungdahl, S., S. Linder, B. Franzen, B. Binetruy, G. Auer, and M. C. Shoshan. 1998. Downregulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop. Cell Growth Differ. 9: 565–573.
   PubMedGoogle Scholar
• MacLeod, A. R., J. Rouleau, and M. Szyf. 1995. Regulation of DNA methylation by the Ras signaling pathway. J. Biol. Chem. 270: 11327-11337.
   PubMed Web of Science ®Google Scholar
• Marshall, C. J. 1996. Ras effectors. Curr. Opin. Cell Biol. 8: 197–204.
   PubMed Web of Science ®Google Scholar
• Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22: 355–358.
   PubMed Web of Science ®Google Scholar
• Masuda, A., K. Takenaga, F. Kondoh, H. Fukami, K. Utsumi, and H. Okayama. 1996. Role of a signal transduction pathway which controls disassembly of microfilament bundles and suppression of high-molecular-weight tropomyosin expression in oncogenic transformation of NRK cells. Oncogene 12: 2081–2088.
   PubMedGoogle Scholar
• Matsumura, F., J. J. Lin, S. Yamashiro-Matsumura, G. P. Thomas, and W. C. Topp. 1983. Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells. J. Biol. Chem. 258: 13954–13964.
   PubMedGoogle Scholar
• McFall, A., A. Ulku, Q. T. Lambert, A. Kusa, K. Rogers-Graham, and C. J. Der. 2001. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol. Cell. Biol. 16: 5488–5499.
   Google Scholar
• Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147–1157.
   PubMed Web of Science ®Google Scholar
• Nimnual, A. S., B. A. Yatsula, and D. Bar-Sagi. 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279: 560–563.
   PubMed Web of Science ®Google Scholar
• Oldham, S. M., G. J. Clark, L. M. Gangarosa, R. J. Coffey, Jr., and C. J. Der. 1996. Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc. Natl. Acad. Sci. USA 93: 6924–6928.
   PubMedGoogle Scholar
• Oldham, S. M., A. D. Cox, E. R. Reynolds, N. S. Sizemore, R. J. Coffey, Jr., and C. J. Der. 1998. Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade. Oncogene 16: 2565–2573.
   PubMed Web of Science ®Google Scholar
• Peli, J., M. Schroter, C. Rudaz, M. Hahne, C. Meyer, E. Reichmann, and J. Tschopp. 1999. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 18: 1824–1831.
   PubMed Web of Science ®Google Scholar
• Pittenger, M. F., J. A. Kazzaz, and D. M. Helfman. 1994. Functional properties of non-muscle tropomyosin isoforms. Curr. Opin. Cell Biol. 6: 96–104.
   PubMed Web of Science ®Google Scholar
• Plattner, R., M. J. Anderson, K. Y. Sato, C. L. Fasching, C. J. Der, and E. J. Stanbridge. 1996. Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells. Proc. Natl. Acad. Sci. USA 93: 6665–6670.
   PubMedGoogle Scholar
• Prasad, G. L., R. A. Fuldner, R. Braverman, E. McDuffie, and H. L. Cooper. 1994. Expression, cytoskeletal utilization and dimer formation of tropomyosin derived from retroviral-mediated cDNA transfer. Metabolism of tropomyosin from transduced cDNA. Eur. J. Biochem. 224: 1–10.
   PubMedGoogle Scholar
• Prasad, G. L., R. A. Fuldner, and H. L. Cooper. 1993. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc. Natl. Acad. Sci. USA 90: 7039–7043.
   PubMed Web of Science ®Google Scholar
• Prasad, G. L., L. Masuelli, M. H. Raj, and N. Harindranath. 1999. Suppression of src-induced transformed phenotype by expression of tropomyosin-1. Oncogene 18: 2027–2031.
   PubMed Web of Science ®Google Scholar
• Ramchandani, S., A. R. MacLeod, M. Pinard, E. von Hofe, and M. Szyf. 1997. Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 94: 684–689.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Viciana, P., P. H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370: 527–532.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Viciana, P., P. H. Warne, A. Khwaja, B. M. Marte, D. Pappin, P. Das, M. D. Waterfield, A. Ridley, and J. Downward. 1997. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457–467.
   PubMed Web of Science ®Google Scholar
• Rouleau, J., A. R. MacLeod, and M. Szyf. 1995. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J. Biol. Chem. 270: 1595–1601.
   PubMedGoogle Scholar
• Rountree, M. R., K. E. Bachman, J. G. Herman, and S. B. Baylin. 2001. DNA methylation, chromatin inheritance, and cancer. Oncogene 20: 3156–3165.
   PubMed Web of Science ®Google Scholar
• Schulze, A., K. Lehmann, H. B. Jefferies, M. McMahon, and J. Downward. 2001. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 15: 981–994.
   PubMed Web of Science ®Google Scholar
• Secker-Walker, L. M. 1998. General Report on the European Union Concerted Action Workshop on 11q23. Leukemia 12: 776–778.
   PubMedGoogle Scholar
• Shah, V., R. Braverman, and G. L. Prasad. 1998. Suppression of neoplastic transformation and regulation of cytoskeleton by tropomyosins. Somat. Cell Mol. Genet. 24: 273–280.
   PubMedGoogle Scholar
• Shields, J. M., S. Powers, and C. J. Der. 2001. Identification of Ras-regulated genes by representational difference analysis. Methods Enzymol. 332: 221–232.
   PubMedGoogle Scholar
• Shields, J. M., K. Pruitt, A. McFall, A. Shaub, and C. J. Der. 2000. Understanding Ras: “it ain't over 'til it's over.” Trends Cell Biol. 10: 147–153.
   PubMed Web of Science ®Google Scholar
• Shields, J. M., K. Rogers-Graham, and C. J. Der. Loss of transgelin in breast and colon tumors and in RIE-1 cells by ras deregulation of gene expression through Raf-independent pathways. J. Biol. Chem., in press.
   Google Scholar
• Shirasawa, S., M. Furuse, N. Yokoyama, and T. Sasazuki. 1993. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260: 85–88.
   PubMed Web of Science ®Google Scholar
• Szyf, M., J. Theberge, and V. Bozovic. 1995. Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. J. Biol. Chem. 270: 12690–12696.
   PubMed Web of Science ®Google Scholar
• Takenaga, K., and A. Masuda. 1994. Restoration of microfilament bundle organization in v-raf-transformed NRK cells after transduction with tropomyosin 2 cDNA. Cancer Lett. 87: 47–53.
   PubMedGoogle Scholar
• Takenaga, K., Y. Nakamura, and S. Sakiyama. 1988. Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells. Mol. Cell. Biol. 8: 3934–3937.
   PubMedGoogle Scholar
• Takenaga, K., Y. Nakamura, and S. Sakiyama. 1988. Suppression of synthesis of tropomyosin isoform 2 in metastatic v-Ha-ras-transformed NIH3T3 cells. Biochem. Biophys. Res. Commun. 157: 1111–1116.
   PubMedGoogle Scholar
• Thirman, M. J., H. J. Gill, R. C. Burnett, D. Mbangkollo, N. R. McCabe, H. Kobayashi, S. Ziemin-van der Poel, Y. Kaneko, R. Morgan, and A. A. Sandberg. 1993. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N. Engl. J. Med. 329: 909–914.
   PubMed Web of Science ®Google Scholar
• Vertino, P. M., R. W. Yen, J. Gao, and S. B. Baylin. 1996. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol. Cell. Biol. 16: 4555–4565.
   PubMed Web of Science ®Google Scholar
• Wang, F. L., Y. Wang, W. K. Wong, Y. Liu, F. J. Addivinola, P. Liang, L. B. Chen, P. W. Kantoff, and A. B. Pardee. 1996. Two differentially expressed genes in normal human prostate tissue and in carcinoma. Cancer Res. 56: 3634–3637.
   PubMed Web of Science ®Google Scholar
• Wirth, P. J., L. D. Luo, Y. Fujimoto, and H. C. Bisgaard. 1992. Two-dimensional electrophoretic analysis of transformation-sensitive polypeptides during chemically, spontaneously, and oncogene-induced transformation of rat liver epithelial cells. Electrophoresis 13: 305–320.
   PubMed Web of Science ®Google Scholar
• Xie, S., Z. Wang, M. Okano, M. Nogami, Y. Li, W. W. He, K. Okumura, and E. Li. 1999. Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236: 87–95.
   PubMed Web of Science ®Google Scholar
• Yoder, J. A., R. W. C. Yen, P. M. Vertino, T. H. Bestor, and S. B. Baylin. 1996. New 5′ regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J. Biol. Chem. 271: 31092–31097.
   PubMedGoogle Scholar
• Zohn, I. M., S. L. Campbell, R. Khosravi-Far, K. L. Rossman, and C. J. Der. 1998. Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17: 1415–1438.
   PubMed Web of Science ®Google Scholar