Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1

REFERENCES

• Abu Hatoum, O., S. Gross-Mesilaty, K. Breitschopf, A. Hoffman, H. Gonen, A. Ciechanover, and E. Bengal. 1998. Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding. Mol. Cell. Biol. 18: 5670–5677.
   PubMed Web of Science ®Google Scholar
• Aster, J. C., E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar. 1997. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J. Biol. Chem. 272: 11336–11343.
   PubMedGoogle Scholar
• Aster, J. C., L. Xu, F. G. Karnell, V. Patriub, J. C. Pui, and W. S. Pear. 2000. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1. Mol. Cell. Biol. 20: 7505–7515.
   PubMed Web of Science ®Google Scholar
• Axelrod, J. D., K. Matsuno, S. Artavanis-Tsakonas, and N. Perrimon. 1996. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 271: 1826–1832.
   PubMed Web of Science ®Google Scholar
• Bettenhausen, B., M. Hrabe de Angelis, D. Simon, J. L. Guenet, and A. Gossler. 1995. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121: 2407–2418.
   PubMedGoogle Scholar
• Borges, M., R. I. Linnoila, H. J. van de Velde, H. Chen, B. D. Nelkin, M. Mabry, S. B. Baylin, and D. W. Ball. 1997. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 386: 852–855.
   PubMed Web of Science ®Google Scholar
• Breitschopf, K., E. Bengal, T. Ziv, A. Admon, and A. Ciechanover. 1998. A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J. 17: 5964–5973.
   PubMed Web of Science ®Google Scholar
• Brou, C., F. Logeat, N. Gupta, C. Bessia, O. LeBail, J. R. Doedens, A. Cumano, P. Roux, R. A. Black, and A. Israel. 2000. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5: 207–216.
   PubMed Web of Science ®Google Scholar
• Cabrera, C. V. 1990. Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta. Development 109: 733–742. (Author's correction, 110: 733-742.)
   Google Scholar
• Cau, E., G. Gradwohl, S. Casarosa, R. Kageyama, and F. Guillemot. 2000. Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development 127: 2323–2332.
   PubMed Web of Science ®Google Scholar
• Chen, H., M. A. Biel, M. W. Borges, A. Thiagalingam, B. D. Nelkin, S. B. Baylin, and D. W. Ball. 1997. Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ. 8: 677–686.
   PubMedGoogle Scholar
• Chen, H., A. Thiagalingam, H. Chopra, M. W. Borges, J. N. Feder, B. D. Nelkin, S. B. Baylin, and D. W. Ball. 1997. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl. Acad. Sci. USA 94: 5355–5360.
   PubMedGoogle Scholar
• Cubas, P., J. F. de Celis, S. Campuzano, and J. Modolell. 1991. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5: 996–1008.
   PubMed Web of Science ®Google Scholar
• de la Pompa, J. L., A. Wakeham, K. M. Correia, E. Samper, S. Brown, R. J. Aguilera, T. Nakano, T. Honjo, T. W. Mak, J. Rossant, and R. A. Conlon. 1997. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124: 1139–1148.
   PubMedGoogle Scholar
• Dick, L. R., A. A. Cruikshank, A. T. Destree, L. Grenier, T. A. McCormack, F. D. Melandri, S. L. Nunes, V. J. Palombella, L. A. Parent, L. Plamondon, and R. L. Stein. 1997. Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J. Biol. Chem. 272: 182–188.
   PubMed Web of Science ®Google Scholar
• Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar. 1991. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649–661.
   PubMed Web of Science ®Google Scholar
• Feder, J. N., L. Li, L. Y. Jan, and Y. N. Jan. 1994. Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. Genomics 20: 56–61.
   PubMedGoogle Scholar
• Fisher, A. L., S. Ohsako, and M. Caudy. 1996. The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16: 2670–2677.
   PubMed Web of Science ®Google Scholar
• Floyd, Z. E., J. S. Trausch-Azar, E. Reinstein, A. Ciechanover, and A. L. Schwartz. 2001. The nuclear ubiquitin-proteasome system degrades MyoD. J. Biol. Chem. 276: 22468–22475.
   PubMedGoogle Scholar
• Guo, M., L. Y. Jan, and Y. N. Jan. 1996. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17: 27–41.
   PubMed Web of Science ®Google Scholar
• He, T. C., S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, and B. Vogelstein. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95: 2509–2514.
   PubMed Web of Science ®Google Scholar
• Heitzler, P., and P. Simpson. 1991. The choice of cell fate in the epidermis of Drosophila. Cell 64: 1083–1092.
   PubMed Web of Science ®Google Scholar
• Hershko, A., and A. Ciechanover. 1998. The ubiquitin system. Annu. Rev. Biochem. 67: 425–479.
   PubMed Web of Science ®Google Scholar
• Hsieh, J. J.-D., T. Henkel, P. Salmon, E. Robey, M. G. Peterson, and S. D. Hayward. 1996. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol. 16: 952–959.
   PubMedGoogle Scholar
• Hsieh, J. J., S. Zhou, L. Chen, D. B. Young, and S. D. Hayward. 1999. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc. Natl. Acad. Sci. USA 96: 23–28.
   PubMed Web of Science ®Google Scholar
• Ishibashi, M., S. L. Ang, K. Shiota, S. Nakanishi, R. Kageyama, and F. Guillemot. 1995. Targeted disruption of mammalian hairy and enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9: 3136–3148.
   PubMed Web of Science ®Google Scholar
• Iso, T., V. Sartorelli, G. Chung, T. Shichinohe, L. Kedes, and Y. Hamamori. 2001. HERP, a new primary target of Notch regulated by ligand binding. Mol. Cell. Biol. 21: 6071–6079.
   PubMed Web of Science ®Google Scholar
• Iso, T., V. Sartorelli, C. Poizat, S. Iezzi, H. Y. Wu, G. Chung, L. Kedes, and Y. Hamamori. 2001. HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol. Cell. Biol. 21: 6080–6089.
   PubMed Web of Science ®Google Scholar
• Ito, T., N. Udaka, T. Yazawa, K. Okudela, H. Hayashi, T. Sudo, F. Guillemot, R. Kageyama, and H. Kitamura. 2000. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 127: 3913–3921.
   PubMed Web of Science ®Google Scholar
• Jarriault, S., C. Brou, F. Logeat, E. H. Schroeter, R. Kopan, and A. Israel. 1995. Signalling downstream of activated mammalian Notch. Nature 377: 355–358.
   PubMed Web of Science ®Google Scholar
• Jarriault, S., O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël. 1998. Delta-1 activation of Notch-1 signaling results in HES-1 transactivation. Mol. Cell. Biol. 18: 7423–7431.
   PubMed Web of Science ®Google Scholar
• Jeffries, S., and A. J. Capobianco. 2000. Neoplastic transformation by Notch requires nuclear localization. Mol. Cell. Biol. 20: 3928–3941.
   PubMed Web of Science ®Google Scholar
• Johnson, J. E., S. J. Birren, T. Saito, and D. J. Anderson. 1992. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc. Natl. Acad. Sci. USA 89: 3596–3600.
   PubMedGoogle Scholar
• Kim, H. K., and G. Siu. 1998. The Notch pathway intermediate HES-1 silences CD4 gene expression. Mol. Cell. Biol. 18: 7166–7175.
   PubMedGoogle Scholar
• Koyano-Nakagawa, N., J. Kim, D. Anderson, and C. Kintner. 2000. Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation. Development 127: 4203–4216.
   PubMedGoogle Scholar
• Kuroda, K., S. Tani, K. Tamura, S. Minoguchi, H. Kurooka, and T. Honjo. 1999. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J. Biol. Chem. 274: 7238–7244.
   PubMed Web of Science ®Google Scholar
• Lardelli, M., J. Dahlstrand, and U. Lendahl. 1994. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech. Dev. 46: 123–136.
   PubMedGoogle Scholar
• Lardelli, M., and U. Lendahl. 1993. Motch A and motch B—two mouse Notch homologues coexpressed in a wide variety of tissues. Exp. Cell Res. 204: 364–372.
   PubMedGoogle Scholar
• Lindsell, C. E., C. J. Shawber, J. Boulter, and G. Weinmaster. 1995. Jagged: a mammalian ligand that activates Notch1. Cell 80: 909–917.
   PubMed Web of Science ®Google Scholar
• Linnoila, R. I., B. Zhao, J. L. DeMayo, B. D. Nelkin, S. B. Baylin, F. J. DeMayo, and D. W. Ball. 2000. Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Res. 60: 4005–4009.
   PubMed Web of Science ®Google Scholar
• Massari, M. E., and C. Murre. 2000. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20: 429–440.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., D. Eastman, T. Mitsiades, A. M. Quinn, M. L. Carcanciu, P. Ordentlich, T. Kadesch, and S. Artavanis-Tsakonas. 1998. Human deltex is a conserved regulator of Notch signalling. Nat. Genet. 19: 74–78.
   PubMed Web of Science ®Google Scholar
• Morrison, S. J., S. E. Perez, Z. Qiao, J. M. Verdi, C. Hicks, G. Weinmaster, and D. J. Anderson. 2000. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell 101: 499–510.
   PubMed Web of Science ®Google Scholar
• Mumm, J. S., E. H. Schroeter, M. T. Saxena, A. Griesemer, X. Tian, D. J. Pan, W. J. Ray, and R. Kopan. 2000. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol. Cell 5: 197–206.
   PubMed Web of Science ®Google Scholar
• Murre, C., P. S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56: 777–783.
   PubMed Web of Science ®Google Scholar
• Murre, C., P. S. McCaw, H. Vaessin, M. Caudy, L. Y. Jan, Y. N. Jan, C. V. Cabrera, J. N. Buskin, S. D. Hauschka, A. B. Lassar, et al. 1989. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58: 537–544.
   PubMed Web of Science ®Google Scholar
• Nishimura, M., F. Isaka, M. Ishibashi, K. Tomita, H. Tsuda, S. Nakanishi, and R. Kageyama. 1998. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Genomics 49: 69–75.
   PubMedGoogle Scholar
• Nofziger, D., A. Miyamoto, K. M. Lyons, and G. Weinmaster. 1999. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development 126: 1689–1702.
   PubMedGoogle Scholar
• Ohtsuka, T., M. Ishibashi, G. Gradwohl, S. Nakanishi, F. Guillemot, and R. Kageyama. 1999. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 18: 2196–2207.
   PubMedGoogle Scholar
• Ordentlich, P., A. Lin, C. P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsakonas, and T. Kadesch. 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18: 2230–2239.
   PubMed Web of Science ®Google Scholar
• Persson, P., A. Jogi, A. Grynfeld, S. Pahlman, and H. Axelson. 2000. HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. Biochem. Biophys. Res. Commun. 274: 22–31.
   PubMed Web of Science ®Google Scholar
• Pui, J. C., D. Allman, L. Xu, S. DeRocco, F. G. Karnell, S. Bakkour, J. Y. Lee, T. Kadesch, R. R. Hardy, J. C. Aster, and W. S. Pear. 1999. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11: 299–308.
   PubMed Web of Science ®Google Scholar
• Robbins, J., B. J. Blondel, D. Gallahan, and R. Callahan. 1992. Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J. Virol. 66: 2594–2599.
   PubMedGoogle Scholar
• Shawber, C., J. Boulter, C. E. Lindsell, and G. Weinmaster. 1996. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev. Biol. 180: 370–376.
   PubMedGoogle Scholar
• Shawber, C., D. Nofziger, J. J. Hsieh, C. Lindsell, O. Bogler, D. Hayward, and G. Weinmaster. 1996. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 122: 3765–3773.
   PubMedGoogle Scholar
• Sheaff, R. J., J. D. Singer, J. Swanger, M. Smitherman, J. M. Roberts, and B. E. Clurman. 2000. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol. Cell 5: 403–410.
   PubMed Web of Science ®Google Scholar
• Shimizu, K., S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai. 2000. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol. Cell. Biol. 20: 6913–6922.
   PubMedGoogle Scholar
• Shou, J., P. C. Rim, and A. L. Calof. 1999. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor. Nat. Neurosci. 2: 339–345.
   PubMedGoogle Scholar
• Skeath, J. B., and S. B. Carroll. 1991. Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5: 984–995.
   PubMedGoogle Scholar
• Song, A., Q. Wang, M. G. Goebl, and M. A. Harrington. 1998. Phosphorylation of nuclear MyoD is required for its rapid degradation. Mol. Cell. Biol. 18: 4994–4999.
   PubMed Web of Science ®Google Scholar
• Stifani, S., C. M. Blaumueller, N. J. Redhead, R. E. Hill, and S. Artavanis-Tsakonas. 1992. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat. Genet. 2: 119–127. (Erratum, 2: 343.)
   PubMed Web of Science ®Google Scholar
• Struhl, G., and A. Adachi. 1998. Nuclear access and action of notch in vivo. Cell 93: 649–660.
   PubMed Web of Science ®Google Scholar
• Uyttendaele, H., G. Marazzi, G. Wu, Q. Yan, D. Sassoon, and J. Kitajewski. 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122: 2251–2259.
   PubMed Web of Science ®Google Scholar
• Varshavsky, A. 1996. The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. USA 93: 12142–12149.
   PubMed Web of Science ®Google Scholar
• Weinmaster, G., V. J. Roberts, and G. Lemke. 1992. Notch2: a second mammalian Notch gene. Development 116: 931–941.
   PubMed Web of Science ®Google Scholar
• Zhou, S., M. Fujimuro, J. J. Hsieh, L. Chen, A. Miyamoto, G. Weinmaster, and S. D. Hayward. 2000. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol. Cell. Biol. 20: 2400–2410.
   PubMed Web of Science ®Google Scholar