26
Views
74
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of Platelets

&
Pages 4764-4777 | Received 11 Dec 2002, Accepted 21 Apr 2003, Published online: 27 Mar 2023

REFERENCES

  • Alon, R., P. D. Kassner, M. W. Carr, E. B. Finger, M. E. Hemler, and T. A. Springer. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128: 1243–1253.
  • Barnes, M. J., C. G. Knight, and R. W. Farndale. 1998. The collagen-platelet interaction. Curr. Opin. Hematol. 5: 314–320.
  • Berlanga, O., R. Bobe, M. Becker, G. Murphy, M. Leduc, C. Bon, F. A. Barry, J. M. Gibbins, P. Garcia, J. Frampton, and S. P. Watson. 2000. Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation. Blood 96: 2740–2745.
  • Burger, S. R., M. M. Zutter, S. Sturgill-Koszycki, and S. A. Santoro. 1992. Induced cell surface expression of functional α2β1 integrin during megakaryocytic differentiation of K562 leukemic cells. Exp. Cell Res. 202: 28–35.
  • Chacko, G. W., A. M. Duchemin, K. M. Coggeshall, J. M. Osborne, J. T. Brandt, and C. L. Anderson. 1994. Clustering of the platelet Fc gamma receptor induces noncovalent association with the tyrosine kinase p72syk. J. Biol. Chem. 269: 32435–32440.
  • Chen, H., D. Locke, Y. Liu, C. Liu, and M. L. Kahn. 2002. The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion. J. Biol. Chem. 277: 3011–3019.
  • Chen, J., T. G. Diacovo, D. G. Grenache, S. A. Santoro, and M. M. Zutter. 2002. The α2 integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis. Am. J. Pathol. 161: 337–344.
  • Clemetson, J. M., J. Polgar, E. Magnenat, T. N. Wells, and K. J. Clemetson. 1999. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors. J. Biol. Chem. 274: 29019–29024.
  • Coller, B. S., J. H. Beer, L. E. Scudder, and M. H. Steinberg. 1989. Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins. Blood 74: 182–192.
  • Gao, J., K. E. Zoller, M. H. Ginsberg, J. S. Brugge, and S. J. Shattil. 1997. Regulation of the pp72syk protein tyrosine kinase by platelet integrin αIIbβ3. EMBO J. 16: 6414–6425.
  • Holtkotter, O., B. Nieswandt, N. Smyth, W. Muller, M. Hafner, V. Schulte, T. Krieg, and B. Eckes. 2002. Integrin α2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J. Biol. Chem. 277: 10789–10794.
  • Inoue, O., K. Suzuki-Inoue, W. L. Dean, J. Frampton, and S. P. Watson. 2003. Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2. J. Cell Biol. 160: 769–780.
  • Jennings, L. K., S. M. Slack, C. D. Wall, and T. H. Mondoro. 1996. Immunological comparisons of integrin alpha IIb beta 3 (GPIIb-IIIa) expressed on platelets and human erythroleukemia cells: evidence for cell specific differences. Blood Cells Mol. Dis. 22: 23–35.
  • Judd, B. A., P. S. Myung, L. Leng, A. Obergfell, W. S. Pear, S. J. Shattil, and G. A. Koretzky. 2000. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors. Proc. Natl. Acad. Sci. USA 97: 12056–12061.
  • Judd, B. A., P. S. Myung, A. Obergfell, E. E. Myers, A. M. Cheng, S. P. Watson, W. S. Pear, D. Allman, S. J. Shattil, and G. A. Koretzky. 2002. Differential requirement for LAT and SLP-76 in GPVI versus T-cell receptor signaling. J. Exp. Med. 195: 705–717.
  • Jung, S. M., and M. Moroi. 1998. Platelets interact with soluble and insoluble collagens through characteristically different reactions. J. Biol. Chem. 273: 14827–14837.
  • Jung, S. M., and M. Moroi. 2000. Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin α2β1. J. Biol. Chem. 275: 8016–8026.
  • Keely, P. J., and L. V. Parise. 1996. The α2β1 integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase Cγ2 in platelets. J. Biol. Chem. 271: 26668–26676.
  • Kehrel, B., L. Balleisen, R. Kokott, R. Mesters, W. Stenzinger, K. J. Clemetson, and J. van de Loo. 1988. Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder. Blood 71: 1074–1078.
  • Kimura, T., H. Kihara, S. Bhattacharyya, H. Sakamoto, E. Appella, and R. P. Siraganian. 1996. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high-affinity IgE receptor. J. Biol. Chem. 271: 27962–27968.
  • Locke, D., H. Chen, Y. Liu, C. Liu, and M. L. Kahn. 2002. Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI. J. Biol. Chem. 277: 18801–18809.
  • Lusis, A. J. 2000. Atherosclerosis. Nature 407: 233–241.
  • Marcinkiewicz, C., R. R. Lobb, M. M. Marcinkiewicz, J. L. Daniel, J. B. Smith, C. Dangelmaier, P. H. Weinreb, D. A. Beacham, and S. Niewiarowski. 2000. Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the α2β1 integrin. Biochemistry 39: 9859–9867.
  • McKenzie, S. E., S. M. Taylor, P. Malladi, H. Yuhan, D. L. Cassel, P. Chien, E. Schwartz, A. D. Schreiber, S. Surrey, and M. P. Reilly. 1999. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J. Immunol. 162: 4311–4318.
  • Mendrick, D. L., D. M. Kelly, S. S. duMont, and D. J. Sandstrom. 1995. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Lab. Investig. 72: 367–375.
  • Moroi, M., S. M. Jung, M. Okuma, and K. Shinmyozu. 1989. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J. Clin. Investig. 84: 1440–1445.
  • Nieswandt, B., W. Bergmeier, V. Schulte, K. Rackebrandt, J. E. Gessner, and H. Zirngibl. 2000. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRγ chain. J. Biol. Chem. 275: 23998–24002.
  • Nieswandt, B., C. Brakebusch, W. Bergmeier, V. Schulte, D. Bouvard, R. Mokhtari-Nejad, T. Lindhout, J. W. Heemskerk, H. Zirngibl, and R. Fassler. 2001. Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen. EMBO J. 20: 2120–2130.
  • Nieswandt, B., V. Schulte, W. Bergmeier, R. Mokhtari-Nejad, K. Rackebrandt, J. P. Cazenave, P. Ohlmann, C. Gachet, and H. Zirngibl. 2001. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J. Exp. Med. 193: 459–469.
  • Nieuwenhuis, H. K., J. W. Akkerman, W. P. Houdijk, and J. J. Sixma. 1985. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nature 318: 470–472.
  • O'Toole, T. E., D. Mandelman, J. Forsyth, S. J. Shattil, E. F. Plow, and M. H. Ginsberg. 1991. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science 254: 845–847.
  • Obergfell, A., B. A. Judd, M. A. del Pozo, M. A. Schwartz, G. A. Koretzky, and S. J. Shattil. 2001. The molecular adapter SLP-76 relays signals from platelet integrin αIIbβ3 to the actin cytoskeleton. J. Biol. Chem. 276: 5916–5923.
  • Pasquet, J. M., B. Gross, L. Quek, N. Asazuma, W. Zhang, C. L. Sommers, E. Schweighoffer, V. Tybulewicz, B. Judd, J. R. Lee, G. Koretzky, P. E. Love, L. E. Samelson, and S. P. Watson. 1999. LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI. Mol. Cell. Biol. 19: 8326–8334.
  • Santoro, S. A. 1986. Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. Cell 46: 913–920.
  • Savage, B., M. H. Ginsberg, and Z. M. Ruggeri. 1999. Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow. Blood 94: 2704–2715.
  • Schulte, V., D. Snell, W. Bergmeier, H. Zirngibl, S. P. Watson, and B. Nieswandt. 2001. Evidence for two distinct epitopes within collagen for activation of murine platelets. J. Biol. Chem. 276: 364–368.
  • Snell, D. C., V. Schulte, G. E. Jarvis, K. Arase, D. Sakurai, T. Saito, S. P. Watson, and B. Nieswandt. 2002. Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands. Biochem. J. 368: 293–300.
  • Wilner, G. D., H. L. Nossel, and E. C. LeRoy. 1968. Aggregation of platelets by collagen. J. Clin. Investig. 47: 2616–2621.
  • Wonerow, P., A. Obergfell, J. I. Wilde, R. Bobe, N. Asazuma, T. Brdicka, A. Leo, B. Schraven, V. Horejsi, S. J. Shattil, and S. P. Watson. 2002. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cγ2 regulation in platelets. Biochem. J. 364: 755–765.
  • Woodside, D. G., A. Obergfell, L. Leng, J. L. Wilsbacher, C. K. Miranti, J. S. Brugge, S. J. Shattil, and M. H. Ginsberg. 2001. Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains. Curr. Biol. 11: 1799–1804.
  • Zhang, W., R. P. Trible, and L. E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T-cell activation. Immunity 9: 239–246.
  • Zutter, M. M., S. A. Santoro, J. E. Wu, T. Wakatsuki, S. K. Dickeson, and E. L. Elson. 1999. Collagen receptor control of epithelial morphogenesis and cell cycle progression. Am. J. Pathol. 155: 927–940.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.