3
Views
48
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

, , , , , , & show all
Pages 5269-5281 | Received 15 Nov 2002, Accepted 28 Apr 2003, Published online: 27 Mar 2023

REFERENCES

  • Akagi, T., H. Ono, and K. Shimotohno. 1996. Expression of cell-cycle regulatory genes in HTLV-1 infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1. Oncogene 12: 1645–1652.
  • Amon, A. 1999. The spindle checkpoint. Curr. Opin. Genet. Dev. 9: 69–75.
  • Amon, A. 2001. Together until separin do us part. Nat. Cell Biol. 3: 12–14.
  • Breeden, L. L. 2000. Cyclin transcription: timing is everything. Curr. Biol. 10: 586–588.
  • Burke, D. J. 2000. Complexity in the spindle checkpoint. Curr. Opin. Genet. Dev. 10: 26–31.
  • Chu, Z. L., Y. A. Shin, J. M. Yang, J. A. Di Donato, and L. H. Ballard, D. W. 1999. IKKγ mediates the interaction of cellular IκB kinases with the tax transforming protein of human T-cell leukemia virus type 1. J. Biol. Chem. 274: 15297–15300.
  • Cohen-Fix, O., and D. Koshland. 1999. Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exit. Genes Dev. 13: 1950–1959.
  • de la Fuente, C., F. Santiago, S. Y. Chong, L. Deng, T. Mayhood, P. Fu, D. Stein, T. Denny, F. Coffman, N. Azimi, R. Mahieux, and F. Kashanchi. 2000. Overexpression of p21 waf1 in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2. J. Virol. 74: 7270–7283.
  • Fitch, I., C. Dahmann, U. Surana, A. Amon, K. Nasmyth, L. Goetsch, B. Byers, and B. Futcher. 1992. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3: 805–818.
  • Fujimoto, T., T. Hata, T. Itoyama, H. Nakamura, K. Tsukasaki, Y. Yamada, S. Ikeda, N. Sadamori, and M. Tomonaga. 1999. High rate of chromosomal abnormalities in HTLV-1-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: a study of IL-2-stimulated colony formation in methylcellulose. Cancer Genet. Cytogenet. 109: 1–13.
  • Gardner, R. D., and D. J. Burke. 2000. The spindle checkpoint: two transitions, two pathways. Trends Cell Biol. 10: 154–158.
  • Grosskortenhaus, R., and F. Sprenger. 2002. Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev. Cell 2: 29–40.
  • Grossman, W. J., J. T. Kimata, F. H. Wong, M. Zutter, T. J. Ley, and L. Ratner. 1995. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 92: 1057–1061.
  • Hagting, A., N. Den Elzen, H. C. Vodermaier, I. C. Waizenegger, J. M. Peters, and J. Pines. 2002. Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157: 1125–1137.
  • Haller, K., T. Ruckes, I. Schmitt, D. Saul, E. Derow, and R. Grassmann. 2000. Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells. AIDS Res. Hum. Retroviruses 16: 1683–1688.
  • Harhaj, E. W., and L. H. Sun, S. C. 1999. IKKγ serves as a docking subunit of the ΙκB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J. Biol. Chem. 274: 22911–22914.
  • Hsu, J. Y., J. D. Reimann, C. S. Sorensen, J. Lukas, and P. K. Jackson. 2002. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat. Cell Biol. 4: 433–442.
  • Iha, H., T. Kasai, K. V. Kibler, Y. Iwanaga, K. Tsurugi, and K. T. Jeang. 2000. Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-κB activation. AIDS Res. Hum. Retroviruses 16: 1633–1638.
  • Jallepalli, P. V., I. C. Waizenegger, F. Bunz, S. Langer, M. R. Speicher, J. M. Peters, K. W. Kinzler, B. Vogelstein, and C. Lengauer. 2001. Securin is required for chromosomal stability in human cells. Cell 105: 445–457.
  • Jin, D. Y., V. Giordano, K. V. Kibler, H. Nakano, and L. H. Jeang. 1999. Role of adapter function in oncoprotein-mediated activation of NF-κB. Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ. J. Biol. Chem. 274: 17402–17405.
  • Jin, D. Y., F. Spencer, and K. T. Jeang. 1998. Human T-cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93: 81–91.
  • Kamihira, S. 1992. Hemato-cytological aspects of adult T-cell leukemia. Gann Monogr. Cancer Res. 39: 17–32.
  • Kasai, T., Y. Iwanaga, H. Iha, and K. T. Jeang. 2002. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. J. Biol. Chem. 277: 5187–5193.
  • Lemasson, I., S. Thebault, C. Sardet, C. Devaux, and L. H. Mesnard, J. M. 1998. Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16INK4A-negative T-cell line. J. Biol. Chem. 273:23598–23604.
  • Liang, M. H., T. Geisbert, Y. Yao, S. H. Hinrichs, and C. Z. Giam. 2002. Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J. Virol. 76: 4022–4033.
  • Matutes, E., and D. Catovsky. 1994. ATLL of Caribbean origin, p. 113–138. In Adult T-cell leukemia. Oxford University Press, Oxford, England.
  • Minshull, J., A. Straight, A. D. Rudner, A. F. Dernburg, A. Belmont, and A. W. Murray. 1996. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr. Biol. 6: 1609–1620.
  • Nasmyth, K. 2002. Segregating sister genomes: the molecular biology of chromosome separation. Science 297: 559–565.
  • Nerenberg, M., S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay. 1987. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237: 1324–1329.
  • Neuveut, C., and K. T. Jeang. 2000. HTLV-1 Tax and cell cycle progression. Prog. Cell Cycle Res. 4: 157–162.
  • Neuveut, C., K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and L. H. Jeang. 1998. Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol. Cell. Biol. 18: 3620–3632.
  • Ohtani, K., R. Iwanaga, M. Arai, Y. Huang, Y. Matsumura, and M. Nakamura. 2000. Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. J. Biol. Chem. 275: 11154–11163.
  • Peters, J. M. 2002. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9: 931–943.
  • Pfleger, C. M., and M. W. Kirschner. 2000. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14: 655–665.
  • Pfleger, C. M., E. Lee, and M. W. Kirschner. 2001. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 15: 2396–2407.
  • Pozzatti, R., J. Vogel, and G. Jay. 1990. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol. Cell. Biol. 10: 413–417.
  • Sacher, R. A., N. L. Luban, D. I. Ameti, S. Friend, G. B. Schreiber, and E. L. Murphy. 1999. Low prevalence of flower cells in USA blood donors infected with human T-lymphotropic virus types I and II. Br. J. Haematol. 105: 758–763.
  • Schmitt, I., O. Rosin, P. Rohwer, M. Gossen, and R. Grassmann. 1998. Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein. J. Virol. 72: 633–640.
  • Stemmann, O., H. Zou, S. A. Gerber, S. P. Gygi, and M. W. Kirschner. 2001. Dual inhibition of sister chromatid separation at metaphase. Cell 107: 715–726.
  • Surana, U., H. Robitsch, C. Price, T. Schuster, I. Fitch, A. B. Futcher, and K. Nasmyth. 1991. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65: 145–161.
  • Tinker-Kulberg, R. L., and D. O. Morgan. 1999. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev. 13: 1936–1949.
  • Vodermaier, H. C., and J. M. Peters. 2002. Conspiracy to disarm APC in interphase. Nat. Cell Biol. 4: 119–120.
  • Wang, Z., R. Yu, and S. Melmed. 2001. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol. Endocrinol. 15: 1870–1879.
  • Weinstein, J. 1997. Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc, a mammalian homolog of CDC20/Fizzy/slp1. J. Biol. Chem. 272: 28501–28511.
  • Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93: 1231–1240.
  • Yamaoka, S., H. Inoue, M. Sakurai, T. Sugiyama, M. Hazama, T. Yamada, and M. Hatanaka. 1996. Constitutive activation of NF-κ B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J. 15: 873–887.
  • Zachariae, W., and K. Nasmyth. 1999. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13: 2039–2058.
  • Zou, H., T. J. McGarry, T. Bernal, and M. W. Kirschner. 1999. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285: 418–422.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.