14
Views
76
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development

, , , , , , , & show all
Pages 6713-6724 | Received 04 Feb 2003, Accepted 25 Jun 2003, Published online: 27 Mar 2023

REFERENCES

  • Ahlgren, U., J. Jonsson, and H. Edlund. 1996. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409–1416.
  • Ahlgren, U., J. Jonsson, L. Jonsson, K. Simu, and H. Edlund. 1998. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 12: 1763–1768.
  • Ang, S. L., and J. Rossant. 1994. HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78: 561–574.
  • Becker-André, M., E. André, and J. F. DeLamarter 1993. Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem. Biophys. Res. Commun. 194: 1371–1379.
  • Boj, S. F., M. Parrizas, M. A. Maestro, and J. Ferrer. 2001. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc. Natl. Acad. Sci. USA 98: 14481–14486.
  • Bouwens, L., and D. G. Pipeleers. 1998. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia 41: 629–633.
  • Brissova, M., M. Shiota, W. E. Nicholson, M. Gannon, S. M. Knobel, D. W. Piston, C. V. Wright, and A. C. Powers. 2002. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J. Biol. Chem. 277: 11225–11232.
  • Byrne, M. M., J. Sturis, S. Menzel, K. Yamagata, S. S. Fajans, M. J. Dronsfield, S. C. Bain, A. T. Hattersley, G. Velho, P. Froguel, G. I. Bell, and K. S. Polonsky. 1996. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 45: 1503–1510.
  • del Castillo-Olivares, A., and G. Gil. 2001. Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism. Nucleic Acids Res. 29: 4035–4042.
  • Dolle, P., and D. Duboule. 1989. Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads. EMBO J. 8: 1507–1515.
  • Duncan, S. A., M. A. Navas, D. Dufort, J. Rossant, and M. Stoffel. 1998. Regulation of a transcription factor network required for differentiation and metabolism. Science 281: 692–695.
  • Dusing, M. R., E. A. Florence, and D. A. Wiginton. 2001. Pdx-1 is required for activation in vivo from a duodenum-specific enhancer. J. Biol. Chem. 276: 14434–14442.
  • Edlund, H. 2002. Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat. Rev. Genet. 3: 524–532.
  • Edlund, H. 1998. Transcribing pancreas. Diabetes 47: 1817–1823.
  • Ellinger-Ziegelbauer, H., A. K. Hihi, V. Laudet, H. Keller, W. Wahli, and C. Dreyer. 1994. Ftz-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis. Mol. Cell. Biol. 14: 2786–2797.
  • Elsasser, H. P., A. Biederbick, and H. Kern. 1994. Growth of rat pancreatic acinar cells quantitated with a monoclonal antibody against the proliferating cell nuclear antigen. Cell Tissue Res. 276: 603–609.
  • Fajas, L., R. L. Landsberg, Y. Huss-Garcia, C. Sardet, J. A. Lees, and J. Auwerx. 2002. E2Fs regulate adipocyte differentiation. Dev. Cell 3: 39–49.
  • Galarneau, L., R. Drouin, and L. Bèlanger. 1998. Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization. Cytogenet. Cell Genet. 82: 269–270.
  • Galarneau, L., J.-F. Paré, D. Allard, D. Hamel, L. Lévesque, J. D. Tugwood, S. Green, and L. Bélanger. 1996. The α1-fetoprotein locus is activated by a nuclear receptor of the drosphila Ftz-F1 family. Mol. Cell. Biol. 16: 3853–3865.
  • Gerrish, K., M. Gannon, D. Shih, E. Henderson, M. Stoffel, C. V. Wright, and R. Stein. 2000. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J. Biol. Chem. 275: 3485–3492.
  • Githens, S. 1988. The pancreatic duct cell: proliferative capabilities, specific characteristics, metaplasia, isolation, and culture. J. Pediatr. Gastroenterol. Nutr. 7: 486–506.
  • Goodwin, B., S. A. Jones, R. R. Price, M. A. Watson, D. D. McKee, L. B. Moore, C. Galardi, J. G. Wilson, M. C. Lewis, M. E. Roth, P. R. Maloney, T. M. Willson, and S. A. Kliewer. 2000. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6: 517–526.
  • Hani, E. H., D. A. Stoffers, J. C. Chevre, E. Durand, V. Stanojevic, C. Dina, J. F. Habener, and P. Froguel. 1999. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J. Clin. Investig. 104: R41–R48.
  • Inokuchi, A., E. Hinoshita, Y. Iwamoto, K. Kohno, M. Kuwano, and T. Uchiumi. 2001. Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter. J. Biol. Chem. 276: 46822–46829.
  • Jonsson, J., U. Ahlgren, T. Edlund, and H. Edlund. 1995. IPF1, a homeodomain protein with a dual function in pancreas development. Int. J. Dev. Biol. 39: 789–798.
  • Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606–609.
  • Kawaguchi, Y., B. Cooper, M. Gannon, M. Ray, R. J. MacDonald, and C. V. Wright. 2002. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32: 128–134.
  • Krapp, A., M. Knofler, B. Ledermann, K. Burki, C. Berney, N. Zoerkler, O. Hagenbuchle, and P. K. Wellauer. 1998. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12: 3752–3763.
  • Kudo, T., and S. Sutou. 1997. Molecular cloning of chicken FTZ-F1-related orphan receptors. Gene 2197: 261–268.
  • Lavorgna, G., H. Ueda, J. Clos, and C. Wu. 1991. FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu. Science 252: 848–851.
  • Lee, C. S., N. J. Sund, M. Z. Vatamaniuk, F. M. Matschinsky, D. A. Stoffers, and K. H. Kaestner. 2002. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes 51: 2546–2551.
  • Lee, Y. H., B. Sauer, and F. J. Gonzalez. 1998. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol. Cell. Biol. 18: 3059–3068.
  • Lehto, M., T. Tuomi, M. M. Mahtani, E. Widen, C. Forsblom, L. Sarelin, M. Gullstrom, B. Isomaa, M. Lehtovirta, A. Hyrkko, T. Kanninen, M. Orho, S. Manley, R. C. Turner, T. Brettin, A. Kirby, J. Thomas, G. Duyk, E. Lander, M. R. Taskinen, and L. Groop. 1997. Characterization of the MODY3 phenotype. Early onset diabetes caused by an insulin secretion defect. J. Clin. Investig. 99: 582–591.
  • Li, M., Y.-H. Xie, Y.-Y. Kong, X. Wu, L. Zhu, and Y. Wang. 1998. Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J. Biol. Chem. 273: 29022–29031.
  • Liu, D., Y. Le Drean, M. Ekker, F. Xiong, and C. L. Hew. 1997. Teleost FTZ-F1 homolog and its splicing variant determine the expression of the salmon gonadotropin IIbeta subunit gene. Mol. Endocrinol. 11: 877–890.
  • Liu, Y., R. J. MacDonald, and G. H. Swift. 2001. DNA binding and transcriptional activation by a PDX1. PBX1b. MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J. Biol. Chem. 276: 17985–17993.
  • Lu, T. T., M. Makishima, J. J. Repa, K. Schoonjans, T. A. Kerr, J. Auwerx, and D. J. Mangelsdorf. 2000. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell 6: 507–515.
  • Luo, Y., C. P. Liang, and A. R. Tall. 2001. The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J. Biol. Chem. 276: 24767–24773.
  • Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, E. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83: 835–839.
  • Muller, R., R. Laucke, B. Trimper, L. Cossel, and D. D. R. Frauenklinik Stendal. 1990. Pancreatic cell proliferation in normal rats studied by in vivo autoradiography with 3H-thymidine. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 59: 133–136.
  • Nakajima, T., M. Takase, I. Miura, and M. Nakamura. 2000. Two isoforms of FTZ-F1 messenger RNA: molecular cloning and their expression in the frog testis. Gene 248: 203–212.
  • Nishigori, H., H. Tomura, N. Tonooka, M. Kanamori, S. Yamada, K. Sho, I. Inoue, N. Kikuchi, K. Onigata, I. Kojima, T. Kohama, K. Yamagata, Q. Yang, Y. Matsuzawa, T. Miki, S. Seino, M. Y. Kim, H. S. Choi, Y. K. Lee, D. D. Moore, and J. Takeda. 2001. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc. Natl. Acad. Sci. USA 98: 575–580.
  • Nitta, M., S. Ku, C. Brown, A. Y. Okamoto, and B. Shan. 1999. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Natl. Acad. Sci. USA 96: 6660–6665.
  • Offield, M. F., T. L. Jetton, P. A. Labosky, M. Ray, R. W. Stein, M. A. Magnuson, B. L. Hogan, and C. V. Wright. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122: 983–995.
  • Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12: 4251–4259.
  • Ohlsson, H., S. Thor, and T. Edlund. 1991. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells. Mol. Endocrinol. 5: 897–904.
  • Paré, J. F., S. Roy, L. Galarneau, and L. Belanger. 2001. The mouse fetoprotein transcription factor (ftf) gene promoter is regulated by three gata elements with tandem e box and nkx motifs, and ftf in turn activates the hnf3beta, hnf4alpha, and hnf1alpha gene promoters. J. Biol. Chem. 276: 13136–13144.
  • Parker, K. L. 1998. The roles of steroidogenic factor 1 in endocrine development and function. Mol. Cell Endocrinol. 140: 59–63.
  • Rausa, F. M., L. Galarneau, L. Bélanger, and R. H. Costa. 1999. The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3β in the developing murine liver, intestine and pancreas. Mech. Dev. 89: 185–188.
  • Schoonjans, K., J. S. Annicotte, T. Huby, O. A. Botrugno, E. Fayard, Y. Ueda, J. Chapman, and J. Auwerx. 2002. Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep. 3: 1181–1187.
  • Schoonjans, K., J. Peinado-Onsurbe, A. M. Lefebvre, R. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx. 1996. PPARα and PPARγ activators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15: 5336–5348.
  • Serup, P., J. Jensen, F. G. Andersen, M. C. Jorgensen, N. Blume, J. J. Holst, and O. D. Madsen. 1996. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc. Natl. Acad. Sci. USA 93: 9015–9020.
  • Shih, D. Q., M. Heimesaat, S. Kuwajima, R. Stein, C. V. Wright, and M. Stoffel. 2002. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc. Natl. Acad. Sci. USA 99: 3818–3823.
  • Shih, D. Q., S. Screenan, K. N. Munoz, L. Philipson, M. Pontoglio, M. Yaniv, K. S. Polonsky, and M. Stoffel. 2001. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes 50: 2472–2480.
  • Shih, D. Q., and M. Stoffel. 2001. Dissecting the transcriptional network of pancreatic islets during development and differentiation. Proc. Natl. Acad. Sci. USA 98: 14189–14191.
  • Stoffers, D. A., J. Ferrer, W. L. Clarke, and J. F. Habener. 1997. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat. Genet. 17: 138–139.
  • Sund, N. J., S. L. Ang, S. D. Sackett, W. Shen, N. Daigle, M. A. Magnuson, and K. H. Kaestner. 2000. Hepatocyte nuclear factor 3β (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol. Cell. Biol. 20: 5175–5183.
  • Swift, G. H., Y. Liu, S. D. Rose, L. J. Bischof, S. Steelman, A. M. Buchberg, C. V. Wright, and R. J. MacDonald. 1998. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol. Cell. Biol. 18: 5109–5120.
  • Tanaka, T., T. Takeno, Y. Watanabe, Y. Uchiyama, T. Murakami, H. Yamashita, A. Suzuki, R. Aoi, H. Iwanari, S. Jiang, M. Naito, K. Tachibana, T. Doi, A. I. Shulman, D. J. Mangelsdorf, R. Reiter, J. Auwerx, T. Hamakubo, and T. Kodama. 2002. The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J. Atheroscler. Thromb. 9: 233–242.
  • Thomas, H., K. Jaschkowitz, M. Bulman, T. M. Frayling, S. M. Mitchell, S. Roosen, A. Lingott-Frieg, C. J. Tack, S. Ellard, G. U. Ryffel, and A. T. Hattersley. 2001. A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young. Hum. Mol. Genet. 10: 2089–2097.
  • Waeber, G., N. Thompson, P. Nicod, and C. Bonny. 1996. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol. Endocrinol. 10: 1327–1334.
  • Watada, H., Y. Kajimoto, J. Miyagawa, T. Hanafusa, K. Hamaguchi, T. Matsuoka, K. Yamamoto, Y. Matsuzawa, R. Kawamori, and Y. Yamasaki. 1996. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 45: 1826–1831.
  • Weinstein, D. C., A. Ruiz i Altaba, W. S. Chen, P. Hoodless, V. R. Prezioso, T. M. Jessell, and J. E. Darnell, Jr. 1994. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell 78:575–588.
  • Yamagata, K., H. Furuta, N. Oda, P. J. Kaisaki, S. Menzel, N. J. Cox, S. S. Fajans, S. Signorini, M. Stoffel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384: 458–460.
  • Zhang, C. K., W. Lin, Y. N. Cai, P. L. Xu, H. Dong, M. Li, Y. Y. Kong, G. Fu, Y. H. Xie, G. M. Huang, and Y. Wang. 2001. Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene. Gene 273: 239–249.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.