25
Views
83
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Estrogen Withdrawal-Induced NF-κB Activity and Bcl-3 Expression in Breast Cancer Cells: Roles in Growth and Hormone Independence

, , , , , & show all
Pages 6887-6900 | Received 10 Apr 2003, Accepted 10 Jun 2003, Published online: 27 Mar 2023

REFERENCES

  • Ausubel, F. M., R. Brent, R. E Kingston, D. D. Moore, J. G. Seidman, J. Smith, and K. Struhl. 1989. Short protocols in molecular biology, 3rd ed. John Wiley & Sons, New York, N.Y.
  • Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87: 13–20.
  • Baichwal, V. R., and P. A. Baeuerle. 1997. Apoptosis: activate NF-κB or die? Curr. Biol. 7: R94–R96.
  • Beg, A. A., S. M. Ruben, R. I. Scheinman, S. Haskill, C. A. Rosen, and A. S. Baldwin, Jr. 1992. IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention. Genes Dev. 6: 1899–1923.
  • Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNFα-induced death. Science 274: 782–784.
  • Beraud, C., W. J. Henzel, and P. A. Baeuerle. 1999. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc. Natl. Acad. Sci. USA 96: 429–434.
  • Biswas, D. K., S.-C. Dai, A. Cruz, B. Weiser, E. Graner, and A. B. Pardee. 2001. The nuclear factor kappa B (NF-κB): a potential therapeutic target for estrogen receptor negative breast cancers. Proc. Natl. Acad. Sci. USA 98: 10386–10391.
  • Braiser, A. R., M. Lu, T. Hai, Y. Lu, and I. Boldogh. 2001. NF-κB-inducible Bcl-3 expression is an autoregulatory loop controlling nuclear p50/NF-κB1 residence. J. Biol. Chem. 276: 32080–32093.
  • Brunner, N., V. Boulay, A. Fojo, C. E. Freter, M. E. Lippman, and R. Clarke. 1993. Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications. Cancer Res. 53: 283–290.
  • Bui, N. T., A. Livolsi, J.-F. Peyron, and J. H. M Prehn. 2001. Activation of nuclear factor κB and bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IκBα. J. Cell Biol. 152: 753–763.
  • Cerillo, G., A. Rees, N. Manchanda, C. Reilly, I. Brogan, A. White, and M. Needham. 1998. The oestrogen receptor regulates NF-κB and AP-1 activity in a cell-specific manner. J. Steroid Biochem. Mol. Biol. 67: 79–88.
  • Chen, F., V. Castronova, and X. Shi. 2001. New insights into the role of nuclear factor-κB in cell growth regulation. Am. J. Pathol. 159: 387–397.
  • Cho, H., P. A. Ng, and B. S. Katzenellenbogen. 1991. Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines. Mol. Endocrinol. 5: 1323–1330.
  • Clarke, R., N. Brunner, B. S. Katzenellenbogen, E. W. Thompson, M. J. Norman, C. Koppi, S. Paik, M. E. Lippman, and R. B. Dickson. 1989. Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo. Proc. Natl. Acad. Sci. USA 86: 3649–3653.
  • Clarke, R., E. W. Thompson, F. Leonessa, M. Lippman, M. McGarvey, T. L. Frandsen, and N. Brunner. 1993. Hormone resistance, invasiveness and metastatic potential in breast cancer. Breast Cancer Res. Treat. 24: 227–239.
  • Cogswell, P. C., D. C. Guttridge, W. K. Funkhouser, and A. S. Baldwin. 2000. Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB/p52 and for Bcl-3. Oncogene 19: 1123–1131.
  • Delfino, F., and W. H. Walker. 1999. Hormonal regulation of the NF-κB signaling pathway. Mol. Cell. Endocrinol. 157: 1–9.
  • Deveraux, Q. L., S. L. Schendel, and J. C. Reed. 2001. Anti-apoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families. Cardiol. Clin. 19: 57–74.
  • Finco, T. S., and A. S. Baldwin, Jr. 1993. Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor B requires Raf-1. J. Biol. Chem. 268: 17676–17679.
  • Fruehauf, J. P., E. G. Mimnaugh, and B. K. Sinha. 1991. Doxorubicin-induced cross-resistance to tumor necrosis factor (TNF) related to differential TNF processing. J. Immunother. 10: 165–173.
  • Gross, A., J. M. McDonnell, and S. J. Korsmeyer. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13: 1899–1911.
  • Higgins, K. A., J. R. Perez, T. A. Coleman, K. Dorshkind, W. A. McComas, U. M. Sarmiento, C. A. Rosen, and R. Narayanan. 1993. Antisense inhibition of the p65 subunits of NF-κB blocks tumorigenicity and causes tumor regression. Proc. Natl. Acad. Sci. USA 90: 9901–9905.
  • Hinz, M., D. Krappmann, A. Eichten, A. Heder, C. Scheidereit, and M. Strauss. 1999. NF-κB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 19: 2690–2698.
  • Hiroasu, N., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95: 3537–3542.
  • Horwitz, K. B. 1993. Mechanisms of hormone resistance in breast cancer. Breast Cancer Res. Treat. 26: 119–130.
  • Huxford, T., D.-B. Huang, S. Malek, and G. Ghosh. 1998. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 95: 759–770.
  • Iimuro Y., T. Nishiura, C. Hellerbrand, K. E. Behrns, R. Schoonhoven, J. W. Grisham, and D. A. Brenner. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101: 802–811.
  • Kim, D. W., M. A. Sovak, G. Zanieski, G. Nonet, R. Romieu-Mourez, A. W. Lau, L. J. Hafer, P. Yaswen, M. Stampfer, A. E. Rogers, J. Russo, and G. E. Sonenshein. 2000. Activation of NF-κB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21: 871–879.
  • Kyprianou, N., H. F. English, N. E. Davidson, and J. T. Isaacs. 1991. Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res. 51: 162–166.
  • Malek, S., T. Huxford, and S. Ghosh. 1996. IκBα functions through direct contacts with the nuclear localization signals and DNA binding sequences of NF-κB. J. Biol. Chem. 273: 25427–25435.
  • May, M. J., and S. Ghosh. 1997. Rel/NF-κB proteins: an overview. Semin. Cancer Biol. 8: 63–73.
  • Mayo, M. W., and A. S. Baldwin. 2000. The transcription factor NF-kappa B: control of oncogenesis and cancer chemotherapy resistance. Biochem. Biophys. Acta 1470: M55–M62.
  • McGuire, W. L., G. C. Chamness, and S. A. W. Fuqua. 1991. Estrogen receptor variants in clinical breast cancer. Mol. Endocrinol. 5: 1571–1577.
  • Murphy, L. C., and H. Dotzlaw. 1989. Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples. Mol. Endocrinol. 3: 687–693.
  • Na, S.-Y., J.-E. Choi, H.-J. Kim, B. H. Jhun, Y.-C. Lee, and J. W. Lee. 1999. Bcl-3, an IκB protein, stimulates activating protein-1 transactivation and cellular proliferation. J. Biol. Chem. 274: 28491–28496.
  • Nakshatri, H., P. Bhat-Nakshatri, D. A. Martin, R. J. Goulet, and G. W. Sledge. 1997. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17: 3629–3639.
  • Nechushtan, A., C. L. Smith, Y.-T. Hsu, and R. J. Youle. 1999. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 18: 2330–2341.
  • Nemoto, S., J. A. Di Donato, and A. Lin. 1998. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase-1 and NF-κB-inducing kinase. Mol. Cell. Biol. 18: 7336–7343.
  • O'Connor, P. M., J. Jackman, I. Bae, T. G. Myers, S. Fan, M. Mutoh, D. A. Scudiero, A. Monks, E. A. Sausville, J. N. Weinstein, S. Friend, A. J. Fornace, and K. W. Kohn. 1997. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute Anticancer Drug Screen and correlation with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57: 4285–4300.
  • Ohno, H., G. Takimoto, and T. W. McKeithan. 1990. The candidate protooncogene Bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60: 991–999.
  • Osborn, L., S. Kunkel, and G. J. Nabel. 1989. Tumor necrosis factor alpha and interleukin 1 stimulate human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 86: 2336–2340.
  • Pahl, H. L. 1999. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18: 6853–6866.
  • Perillo, B., A. Sasso, C. Abbondanza, and G. Palumbo. 2000. 17β-Estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements in the coding sequence. Mol. Cell. Biol. 20: 2890–2901.
  • Pratt, M. A. C., S. Krajewski, M. Menard, M. Krajewska, H. Macleod, and J. C. Reed. 1998. Estrogen withdrawal-induced human breast cancer tumour regression in nude mice is prevented by Bcl-2. FEBS Lett. 440: 403–408.
  • Price, J. E., A. Polyzos, R. D. Zhang, and L. M. Daniels. 1990. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res. 50: 717–721.
  • Rayet, B., and C. Gelinas. 1999. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938–6947.
  • Rebollo, A., L. Dumoutier, J.-C. Renauld, A. Zaballos, V. Ayllón, and C. Martínez-A. 2000. Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors. Mol. Cell. Biol. 20: 3407–3416.
  • Santen, R., A. Manni, H. Harvey, and C. Redmond. 1990. Endocrine treatment of breast cancer in women. Endocrine Rev. 11: 221–265.
  • Sommers, C. L., S. W. Byers, E. W. Thompson, J. A. Torri, and E. P. Gelmann. 1994. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res. Treat. 31: 325–335.
  • Sovak, M. A., R. E. Bellas, D. W. Kim, G. J. Zanieski, A. E. Rogers, A. M. Traish, and G. E. Sonenshein. 1997. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Investig. 100: 2952–2960.
  • Tamatani, M., Y. H. Che, H. Matsuzaki, S. Ogawa, H. Okado, S. Miyake, T. Mizuno, and M. Tohyama. 1999. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J. Biol. Chem. 274: 8531–8538.
  • Teixeira, C., J. C. Reed, and M. A. C. Pratt. 1995. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 protooncogene expression in human breast cancer cells. Cancer Res. 55: 3902–3907.
  • Valentine, J. E., E. Kalkhoven, R. White, S. Hoare, and M. G. Parker. 2000. Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression. J. Biol. Chem. 275: 25322–25329.
  • Wang, C.-Y., J. C. Cusack, R. Liu, and A. S. Baldwin. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat. Med. 5: 412–417.
  • Westerheide, S. D., M. W. Mayo, V. Anest, J. L. Hanson, and A. S. Baldwin, Jr. 2001. The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G1 transition. Mol. Cell. Biol. 21: 8428–8436.
  • Yoza, B. K., J. Y. Q. Hu, and C. E. McCall. 1996. Protein tyrosine-kinase activation is required for lipopolysaccharide induction of interleukin 1β and NF-κB activation, but not NF-κB nuclear translocation. J. Biol. Chem. 271: 18306–18309.
  • Zhou, P. B., M. C.-T. Hu, S. A. Miller, Z. Yu, W. Xia, S.-Y. Lin, and M.-C. Hung. 2000. Her-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathway. J. Biol. Chem. 275: 8027–8031.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.