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Gene Expression

Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression

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Pages 510-525 | Received 25 Apr 2002, Accepted 07 Oct 2002, Published online: 27 Mar 2023

REFERENCES

  • Anwar, A., N. Ali, R. Tanveer, and A. Siddiqui. 2000. Hepatitis C Virus IRES-mediated translation Initiation: demonstration of functional requirement of polypyrimidine tract-binding protein (PTB) by SELEX RNA. J. Biol. Chem. 275: 34231–34235.
  • Ashiya, M., and P. J. Grabowski. 1997. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. RNA 3: 996–1015.
  • Ashwell, J. D., F. W. Lu, and M. S. Vacchio. 1992. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18: 309–345.
  • Belshamm, G. J., and N. Sonenberg. 1996. RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol. Rev. 60: 499–511.
  • Beutler, B., and V. Kruys. 1995. Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J. Cardiovasc. Pharm. 25: S1–S8.
  • Bothwell, A. L., D. W. Ballard, W. M. Philbrick, G. Lindwall, S. E. Maher, M. M. Bridgett, S. F. Jamison, and M. A. Garcia-Blanco. 1991. Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain. J. Biol. Chem. 266: 24657–24663.
  • Carballo, E., W. S. Lai, and P. J. Blackshear. 1998. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001–1005.
  • Chen, C. Y., N. Xu, and A. B. Shyu. 1995. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15: 5777–5788.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156–159.
  • Chou, M. Y., J. G. Underwood, J. Nikolic, M. H. Luu, and D. L. Black. 2000. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol. Cell 5: 949–957.
  • Conte, M. R., T. Grune, J. Ghuman, G. Kelly, A. Ladas, S. Matthews, and S. Curry. 2000. Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. EMBO J. 19: 3132–3141.
  • Cron, R. Q., L. A. Schubert, D. B. Lewis, and C. C. Hughes. 1997. Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes. J. Immunol. Methods 205: 145–150.
  • Cron, R. Q., S. R. Bartz, A. Clausell, S. J. Bort, S. J. Klebanoff, and D. B. Lewis. 2000. NFAT1 enhances HIV-gene expression in primary human CD4 T cells. Clin. Immunol. 94: 179–191.
  • Dean, J. L., R. Wait, K. R. Mahtani, G. Sully, A. R. Clark, and J. Saklatvala. 2001. The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol. Cell. Biol. 21: 721–730.
  • Ford, G. S., B. Barnhart, S. Shone, and L. R. Covey. 1999. Regulation of CD154 (CD40 ligand) mRNA stability during T cell activation. J. Immunol. 162: 4037–4044.
  • Foy, T. M., et. al. 1996. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14: 591–617.
  • Fuleihan, R., N. Ramesh, A. Horner, D. Ahern, P. J. Belshaw, D. G. Alberg, I. Stamenkovic, W. Harmon, and R. S. Geha. 1994. Cyclosporin A inhibits CD40 ligand expression in human T lymphocytes. J. Clin. Investig. 93: 1315–1320.
  • Garcia-Blanco, M. A., S. F. Jamison, and P. A. Sharp. 1989. Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev. 3: 1874–1886.
  • Ghetti, A., S. Pinol-Roma, W. M. Michael, C. Morandi, and G. Dreyfuss. 1992. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20: 3671–3678.
  • Gil, A., P. A. Sharp, S. F. Jamison, and M. A. Garcia-Blanco. 1991. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev. 5: 1224–1236.
  • Gosert, R., K. H. Chang, R. Rijnbrand, M. Yi, D. V. Sangar, and S. M. Lemon. 2000. Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites In vivo. Mol. Cell. Biol. 20: 1583–1595.
  • Grewal, I. S., and R. A. Flavell 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16: 111–135.
  • Hahm, B., O. H. Cho, J. E. Kim, Y. K. Kim, J. H. Kim, Y. L. Oh, and S. K. Jang. 1998. Polypyrimidine tract-binding protein interacts with hnRNP L. FEBS Lett. 425: 401–406.
  • Hamilton, B. J., E. Nagy, J. S. Malter, B. A. Arrick, and W. F. C. Rigby. 1993. Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. J. Biol. Chem. 268: 8881–8887.
  • Hollenbaugh, D., H. D. Ochs, R. J. Noelle, J. A. Ledbetter, and A. Aruffo. 1994. The role of CD40 and its ligand in the regulation of the immune response. Immunol. Rev. 138: 23–37.
  • Kontoyiannis, D., M. Pasparakis, T. T. Pizarro, F. Cominelli, and G. Kollias. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10: 387–398.
  • Lagnado, C. A., C. Y. Brown, and G. J. Goodall. 1994. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol. Cell. Biol. 14: 7984–7995.
  • Lane, P., A. Traunecker, S. Hubele, S. Inui, A. Lanzavecchia, and D. Gray. 1992. Activated human T cells express a ligand for the human B cell-associated antigen CD40, which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22: 2573–2578.
  • Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339–343.
  • Markovtsov, V., J. M. Nikolic, J. A. Goldman, C. W. Turck, M. Y. Chou, and D. L. Black. 2000. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol. Cell. Biol. 20: 7463–7479.
  • Murakami, K., W. Ma, R. Fuleihan, and J. S. Pober. 1999. Human endothelial cells augment early CD40 ligand expression in activated CD4+ T cells through LFA-3-mediated stabilization of mRNA. J. Immunol. 163: 2667–2673.
  • Nagy, E., and W. F. C. Rigby. 1995. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD+-binding region (Rossmann fold). J. Biol. Chem. 270: 2755–2763.
  • Nichols, R. C., X. W. Wang, J. Tang, B. J. Hamilton, F. A. High, H. R. Herschman, and W. F. C. Rigby. 2000. The RGG domain in hnRNP A2 affects sub-celluar localization. Exp. Cell Res. 256: 522–532.
  • Noelle, R. J. 1996. CD40 and its ligand in host defense. Immunity 4: 415–419.
  • Nusslein, H. G., K. H. Frosch, W. Woith, P. Lane, J. R. Kalden, and B. Manger. 1996. Increase of intracellular calcium is the essential signal for the expression of CD40 ligand. Eur. J. Immunol. 26: 846–850.
  • Oh, Y. L., B. Hahm, Y. K. Kim, H. K. Lee, J. W. Lee, O. Song, K. Tsukiyama-Kohara, M. Kohara, A. Nomoto, and S. K. Jang. 1998. Determination of functional domains in polypyrimidine-tract-binding protein. Biochem. J. 331: 169–175.
  • Patton, J. G., S. A. Mayer, P. Tempst, and B. Nadal-Ginard. 1991. Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 5: 1237–1251.
  • Peng, S. S., C. Y. Chen, N. Xu, and A. B. Shyu. 1998. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J. 17: 3461–3470.
  • Perez, I., J. G. McAfee, and J. G. Patton. 1997. Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein. Biochemistry 36: 11881–11890.
  • Piecyk, M., S. Wax, A. R. Beck, N. Kedersha, M. Gupta, B. Maritim, S. Chen, C. Gueydan, V. Kruys, M. Streuli, and P. Anderson. 2000. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 19: 4154–4163.
  • Pinol-Roma, S., and G. Dreyfuss. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355: 730–732.
  • Polydorides, A. D., H. J. Okano, Y. Y. Yang, G. Stefani, and R. B. Darnell. 2000. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc. Natl. Acad. Sci. USA 97: 6350–6355.
  • Rajagopalan, L. E., and J. S. Malter. 1996. Turnover and translation of in vitro synthesized messenger RNAs in transfected, normal cells. J. Biol. Chem. 271: 19871–19876.
  • Rigby, W. F. C., M. G. Waugh, and B. J. Hamilton. 1999. Characterization of RNA binding proteins associated with CD40 ligand (CD154) mRNA turnover in human T lymphocytes. J. Immunol. 163: 4199–4206.
  • Romanelli, M. G., F. Weighardt, G. Biamonti, S. Riva, and C. Morandi. 1997. Sequence determinants for hnRNP I protein nuclear localization. Exp. Cell Res. 235: 300–304.
  • Romanelli, M. G., P. Lorenzi, and C. Morandi. 2000. Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene. Gene 255: 267–272.
  • Ross, J. 1988. Messenger RNA turnover in eukaryotic cells. Mol. Biol. Med. 5: 1–14.
  • Roy, M., T. Waldschmidt, A. Aruffo, J. A. Ledbetter, and R. J. Noelle. 1993. The regulation of the expression of gp39 on normal and cloned CD4+ T cells. J. Immunol. 151: 2497–2510.
  • Roy, M., A. Aruffo, J. A. Ledbetter, P. Linsley, M. Kehry, and R. Noelle. 1994. Studies on the independence of gp39 and B7 expression and function during antigen-specific immune responses. Eur. J. Immunol. 25: 596–603.
  • Schubert, L. A., G. King, R. Q. Cron, D. B. Lewis, A. Aruffo, and D. Hollenbaugh. 1995. The human gp39 promoter: two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J. Biol. Chem. 15: 29264–29627.
  • Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659–669.
  • Shih, S. C., and K. P. Claffey. 1999. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J. Biol. Chem. 274: 1359–1365.
  • Shyu, A.-B., M. E. Greenberg, and J. G. Belasco. 1989. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 3: 60–72.
  • Sigal, N. H., and F. J. Dumont. 1992. Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10: 519–560.
  • Singh, R., J. Valcarcel, and M. R. Green. 1995. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science 268: 1173–1176.
  • Suarez, A., L. Mozo, A. Gayo, J. Zamorano, and C. Gutierrez. 1997. Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand. Involvement of transcriptional and posttranscriptional mechanisms. Eur. J. Immunol. 27: 2822–2829.
  • Valcarcel, J., and F. Gebauer. 1997. Post-transcriptional regulation: the dawn of PTB. Curr. Biol. 7: R705–708.
  • Wagner, E. J., and M. A. Garcia-Blanco. 2001. Polypyrimidine tract binding protein antagonizes exon definition. Mol. Cell. Biol. 21: 3281–3288.
  • Wollerton, M. C., C. Gooding, F. Robinson, E. C. Brown, R. J. Jackson, and C. W. Smith. 2001. Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA 7: 819–832.
  • Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15: 2219–2230.

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